MX379899B - Terapia de combinacion de activador de miosina cardiaca e inhibidor de corriente if del nodo sinusal - Google Patents

Terapia de combinacion de activador de miosina cardiaca e inhibidor de corriente if del nodo sinusal

Info

Publication number
MX379899B
MX379899B MX2017016347A MX2017016347A MX379899B MX 379899 B MX379899 B MX 379899B MX 2017016347 A MX2017016347 A MX 2017016347A MX 2017016347 A MX2017016347 A MX 2017016347A MX 379899 B MX379899 B MX 379899B
Authority
MX
Mexico
Prior art keywords
sinus node
cardiac myosin
combination therapy
current inhibitor
myosin activator
Prior art date
Application number
MX2017016347A
Other languages
English (en)
Other versions
MX2017016347A (es
Inventor
Robert Andrew Donald Scott
Scott Wasserman
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of MX2017016347A publication Critical patent/MX2017016347A/es
Publication of MX379899B publication Critical patent/MX379899B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen en la presente terapias de combinación para el tratamiento de insuficiencia cardíaca mediante el uso del activador de miosina cardíaca, tal como omecamtiv mecarbil, y un inhibidor de corriente If del nodo sinusal. Se describen adicionalmente en la presente composiciones que comprenden un activador de miosina cardíaca y un inhibidor de corriente If del nodo sinusal.
MX2017016347A 2015-06-26 2016-06-24 Terapia de combinacion de activador de miosina cardiaca e inhibidor de corriente if del nodo sinusal MX379899B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562185306P 2015-06-26 2015-06-26
PCT/US2016/039198 WO2016210240A1 (en) 2015-06-26 2016-06-24 Combination therapy of cardiac myosin activator and sinus node if current inhibitor

Publications (2)

Publication Number Publication Date
MX2017016347A MX2017016347A (es) 2018-08-15
MX379899B true MX379899B (es) 2025-03-11

Family

ID=56409184

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016347A MX379899B (es) 2015-06-26 2016-06-24 Terapia de combinacion de activador de miosina cardiaca e inhibidor de corriente if del nodo sinusal

Country Status (7)

Country Link
US (2) US10543215B2 (es)
EP (1) EP3313444B1 (es)
JP (1) JP6858716B2 (es)
AU (1) AU2016282985B2 (es)
CA (1) CA2988796A1 (es)
MX (1) MX379899B (es)
WO (1) WO2016210240A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005264988B2 (en) 2004-06-17 2011-09-22 Cytokinetics, Inc. Substituted urea derivatives for treating cardiac diseases
DK2970123T3 (da) * 2013-03-14 2019-10-21 Amgen Inc Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf
SG10202111790YA (en) 2017-06-30 2021-12-30 Amgen Inc Synthesis of omecamtiv mecarbil
DK3645002T3 (da) * 2017-06-30 2024-12-16 Amgen Inc Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer
AU2018332887B2 (en) 2017-09-13 2022-12-08 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof
HUE052049T2 (hu) 2018-07-09 2021-04-28 Fis Fabbrica Italiana Sintetici Spa Kristályos 2-fluor-3-nitrotoluol és eljárás annak elõállítására
WO2020037164A1 (en) 2018-08-17 2020-02-20 Amgen Inc. Salts and crystal forms of omecamtiv mecarbil
US12442027B2 (en) 2018-12-18 2025-10-14 Amgen Inc. Method of reducing aromatic nitro compounds
US12194039B2 (en) 2020-11-12 2025-01-14 Amgen Inc Methods of treating heart failure by administering omecamtiv mecarbil
TW202300479A (zh) 2021-03-10 2023-01-01 美商安進公司 奧美卡替莫卡必爾之合成
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
AU2005264988B2 (en) 2004-06-17 2011-09-22 Cytokinetics, Inc. Substituted urea derivatives for treating cardiac diseases
FR3001151B1 (fr) * 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
DK2970123T3 (da) * 2013-03-14 2019-10-21 Amgen Inc Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf

Also Published As

Publication number Publication date
US20200108076A1 (en) 2020-04-09
JP6858716B2 (ja) 2021-04-14
EP3313444B1 (en) 2020-10-21
JP2018518501A (ja) 2018-07-12
EP3313444A1 (en) 2018-05-02
WO2016210240A1 (en) 2016-12-29
US20180140611A1 (en) 2018-05-24
CA2988796A1 (en) 2016-12-29
US10543215B2 (en) 2020-01-28
MX2017016347A (es) 2018-08-15
AU2016282985A1 (en) 2017-12-14
AU2016282985B2 (en) 2021-07-29

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