JP2023078467A5 - - Google Patents

Download PDF

Info

Publication number
JP2023078467A5
JP2023078467A5 JP2023057334A JP2023057334A JP2023078467A5 JP 2023078467 A5 JP2023078467 A5 JP 2023078467A5 JP 2023057334 A JP2023057334 A JP 2023057334A JP 2023057334 A JP2023057334 A JP 2023057334A JP 2023078467 A5 JP2023078467 A5 JP 2023078467A5
Authority
JP
Japan
Prior art keywords
molecule
polypeptide
seq
polypeptides
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023057334A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023078467A (ja
JP7635291B2 (ja
Filing date
Publication date
Priority claimed from PCT/US2018/015595 external-priority patent/WO2018140821A1/en
Application filed filed Critical
Publication of JP2023078467A publication Critical patent/JP2023078467A/ja
Publication of JP2023078467A5 publication Critical patent/JP2023078467A5/ja
Priority to JP2024195763A priority Critical patent/JP2025020347A/ja
Application granted granted Critical
Publication of JP7635291B2 publication Critical patent/JP7635291B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023057334A 2017-01-26 2023-03-31 組織特異的Wntシグナル増強分子およびその使用 Active JP7635291B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024195763A JP2025020347A (ja) 2017-01-26 2024-11-08 組織特異的Wntシグナル増強分子およびその使用

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762450804P 2017-01-26 2017-01-26
US62/450,804 2017-01-26
US201762487135P 2017-04-19 2017-04-19
US62/487,135 2017-04-19
PCT/US2018/015595 WO2018140821A1 (en) 2017-01-26 2018-01-26 Tissue-specific wnt signal enhancing molecules and uses thereof
JP2019541341A JP7305543B2 (ja) 2017-01-26 2018-01-26 組織特異的Wntシグナル増強分子およびその使用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2019541341A Division JP7305543B2 (ja) 2017-01-26 2018-01-26 組織特異的Wntシグナル増強分子およびその使用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024195763A Division JP2025020347A (ja) 2017-01-26 2024-11-08 組織特異的Wntシグナル増強分子およびその使用

Publications (3)

Publication Number Publication Date
JP2023078467A JP2023078467A (ja) 2023-06-06
JP2023078467A5 true JP2023078467A5 (https=) 2023-08-25
JP7635291B2 JP7635291B2 (ja) 2025-02-25

Family

ID=62978866

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019541341A Active JP7305543B2 (ja) 2017-01-26 2018-01-26 組織特異的Wntシグナル増強分子およびその使用
JP2023057334A Active JP7635291B2 (ja) 2017-01-26 2023-03-31 組織特異的Wntシグナル増強分子およびその使用
JP2024195763A Withdrawn JP2025020347A (ja) 2017-01-26 2024-11-08 組織特異的Wntシグナル増強分子およびその使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2019541341A Active JP7305543B2 (ja) 2017-01-26 2018-01-26 組織特異的Wntシグナル増強分子およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024195763A Withdrawn JP2025020347A (ja) 2017-01-26 2024-11-08 組織特異的Wntシグナル増強分子およびその使用

Country Status (7)

Country Link
US (2) US11958891B2 (https=)
EP (1) EP3574019A4 (https=)
JP (3) JP7305543B2 (https=)
CN (1) CN110234662A (https=)
AU (1) AU2018211985B2 (https=)
CA (1) CA3050133A1 (https=)
WO (1) WO2018140821A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7617603B2 (ja) 2017-01-11 2025-01-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー R-スポンジン(rspo)サロゲート分子
JP7305543B2 (ja) 2017-01-26 2023-07-10 スロゼン オペレーティング, インコーポレイテッド 組織特異的Wntシグナル増強分子およびその使用
EP3732201A4 (en) 2017-12-19 2022-04-20 Surrozen Operating, Inc. WNT SURROGATES AND THEIR USES
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CN111655729B (zh) 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
JP2021530223A (ja) * 2018-07-09 2021-11-11 スロゼン, インコーポレイテッド 組織特異性Wntシグナル増強分子及びその使用
US20220041753A1 (en) * 2018-12-27 2022-02-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for membrane clearance of target receptors
JP7663501B2 (ja) * 2019-02-11 2025-04-16 スロゼン オペレーティング, インコーポレイテッド 眼障害におけるwntシグナル伝達の調節
US20220175884A1 (en) * 2019-04-02 2022-06-09 Surrozen Operating, Inc. Modulation of wnt signaling in auditory disorders
CN120025448A (zh) * 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
US11713461B2 (en) 2019-06-21 2023-08-01 Regeneran Pharmaceuticals, Inc. Treatment of decreased bone mineral density with zinc and ring finger 3 (ZNRF3) inhibitors
KR102192471B1 (ko) * 2019-10-18 2020-12-17 주식회사 인코스팜 탈모 완화 및 모발 성장을 촉진시키는 펩타이드 및 이를 포함하는 화장료 조성물
US20240000890A1 (en) * 2020-01-09 2024-01-04 Retinal Solutions, LLC Neural regeneration with synthetic protein administration
CN115427446A (zh) * 2020-02-24 2022-12-02 瑟罗泽恩奥普瑞汀公司 Wnt超级激动剂
CN116745318A (zh) * 2020-11-10 2023-09-12 斯克里普斯研究学院 用于阿片样物质治疗的抗体
TW202233656A (zh) * 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
CN112386687B (zh) * 2020-12-09 2021-05-04 爱龄医美国际健康咨询服务(北京)有限公司 一种干细胞外泌体及其在药品和化妆品中的应用
CN113307882B (zh) * 2021-05-12 2022-12-20 东北大学 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物
CN113293214A (zh) * 2021-06-17 2021-08-24 深圳华因康基因科技有限公司 一种检测神经母细胞瘤复发转移基因wnt2扩增的引物探针及其应用
AU2022311529A1 (en) * 2021-07-15 2024-01-25 Centre National De La Recherche Scientifique (Cnrs) Recombinant variants of r-spondin proteins and their use
JPWO2023080159A1 (https=) * 2021-11-02 2023-05-11
CN116789843B (zh) * 2022-03-16 2024-09-17 伯桢生物科技(杭州)有限公司 Wnt重组蛋白及其应用
CN116836274B (zh) * 2022-03-23 2024-11-22 东莞市朋志生物科技有限公司 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒
CN119403570A (zh) * 2022-06-21 2025-02-07 瑟罗泽恩奥普瑞汀公司 Wnt信号传导在角膜病中的调节作用
CN119744268A (zh) * 2022-09-09 2025-04-01 德国癌症研究中心公共法律基金会 靶向pd-l1降解
WO2025146152A1 (zh) * 2024-01-04 2025-07-10 上海宝济药业股份有限公司 一种药物组合物及其应用
CN120647751B (zh) * 2025-08-18 2025-12-02 成都迈科康生物科技有限公司 抗人乳头瘤病毒e1蛋白的抗体或其试剂盒和相关应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044409A1 (en) 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
PL2157192T3 (pl) 2003-10-10 2014-01-31 Deutsches Krebsforsch Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin)
DE102004050620A1 (de) 2004-10-13 2006-04-20 Eberhard-Karls-Universität Tübingen Monoklonaler Antikörper gegen Frizzled-Rezeptoren
DE102005035568A1 (de) 2005-07-25 2007-02-01 M-Phasys Gmbh Frizzled 9 als Biomarker für Substrukturen des humanen Gehirns
EP3611266B1 (en) 2005-08-23 2022-11-09 The Trustees of the University of Pennsylvania Rna containing modified nucleosides and methods of use thereof
CN101573383B (zh) 2006-06-21 2015-05-13 肿瘤疗法科学股份有限公司 靶向肿瘤的针对卷曲同源物10的单克隆抗体及其用途
AU2007285217B2 (en) 2006-08-14 2013-02-07 Forerunner Pharma Research Co., Ltd Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies
WO2008093646A1 (ja) 2007-02-01 2008-08-07 National University Corporation NARA Institute of Science and Technology Wntシグナル伝達系活性化ペプチド
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
ES2579909T3 (es) 2009-02-03 2016-08-17 Koninklijke Nederlandse Akademie Van Wetenschappen Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre
WO2010092457A1 (en) 2009-02-10 2010-08-19 Nokia Corporation Method, apparatus and computer program product for transfer of capability support information in a multi-rat environment
EP2305274A1 (en) 2009-09-21 2011-04-06 Centre National de la Recherche Scientifique (CNRS) Use of WNT stimulators for treating demyelinating diseases
PT2510012T (pt) 2009-12-09 2017-07-13 Bayer Pharma AG Anticorpos anti-c4.4a e utilizações dos mesmos
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
CA2796464C (en) 2010-04-16 2021-08-03 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
SG10201602394QA (en) 2011-03-29 2016-05-30 Roche Glycart Ag Antibody FC Variants
EP2694660B1 (en) 2011-04-03 2018-08-08 The General Hospital Corporation Efficient protein expression in vivo using modified rna (mod-rna)
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN109111523B (zh) 2011-10-14 2022-06-07 诺华股份有限公司 用于Wnt途径相关疾病的抗体和方法
WO2013071047A1 (en) 2011-11-11 2013-05-16 Children's Medical Center Corporation Compositions and methods for in vitro transcription of rna
WO2013078199A2 (en) 2011-11-23 2013-05-30 Children's Medical Center Corporation Methods for enhanced in vivo delivery of synthetic, modified rnas
EP2820151B1 (en) 2012-02-28 2020-03-25 Novartis AG Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
EP2882775B1 (en) 2012-08-09 2018-02-14 Roche Glycart AG Asgpr antibodies and uses thereof
WO2014093924A1 (en) 2012-12-13 2014-06-19 Moderna Therapeutics, Inc. Modified nucleic acid molecules and uses thereof
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US20160022840A1 (en) 2013-03-09 2016-01-28 Moderna Therapeutics, Inc. Heterologous untranslated regions for mrna
MA39896A (fr) 2014-04-21 2017-03-01 Abbvie Stemcentrx Llc Nouveaux anticorps antii-rnf43 et méthodes d'utilisation
US11142577B2 (en) 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
US10259874B2 (en) 2014-10-27 2019-04-16 Agency For Science, Technology And Research Anti-TIM-3 antibodies
WO2016073879A2 (en) 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related antibodies and uses thereof
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
CA2983008A1 (en) 2015-04-17 2016-10-20 Merrimack Pharmaceuticals, Inc. Combination treatments with seribantumab
CA3002957A1 (en) * 2015-10-23 2017-04-27 Koninklijke Nederlandse Akademie Van Wetenschappen Binding molecules that inhibit cancer growth
AU2016365834B2 (en) 2015-12-08 2023-09-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for internalizing enzymes
US20170349659A1 (en) 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
WO2018107116A1 (en) 2016-12-09 2018-06-14 Abbvie Stemcentrx Llc Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby
JP7617603B2 (ja) 2017-01-11 2025-01-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー R-スポンジン(rspo)サロゲート分子
JP7305543B2 (ja) 2017-01-26 2023-07-10 スロゼン オペレーティング, インコーポレイテッド 組織特異的Wntシグナル増強分子およびその使用
EP3619238A4 (en) 2017-05-02 2021-02-24 Chugai Seiyaku Kabushiki Kaisha CYTOTOXICITY INDUCING THERAPEUTIC
GB201708330D0 (en) 2017-05-24 2017-07-05 Koninklijke Nederlandse Akademie Van Wetenschappen Fusion protein for enhancing intestinal regeneration
EP3732201A4 (en) 2017-12-19 2022-04-20 Surrozen Operating, Inc. WNT SURROGATES AND THEIR USES
CN111655729B (zh) 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CA3104526A1 (en) 2018-07-05 2020-01-09 Surrozen, Inc. Multi-specific wnt surrogate molecules and uses thereof
JP2021530223A (ja) 2018-07-09 2021-11-11 スロゼン, インコーポレイテッド 組織特異性Wntシグナル増強分子及びその使用
US20220064337A1 (en) 2018-12-19 2022-03-03 Surrozen, Inc. Antigen binding formats for receptor complexes
JP7663501B2 (ja) 2019-02-11 2025-04-16 スロゼン オペレーティング, インコーポレイテッド 眼障害におけるwntシグナル伝達の調節
US20220195053A1 (en) 2019-03-11 2022-06-23 Surrozen Operating Inc. Modulation of wnt signaling in gastrointestinal disorders
US20220175884A1 (en) 2019-04-02 2022-06-09 Surrozen Operating, Inc. Modulation of wnt signaling in auditory disorders
CN120025448A (zh) 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
US11050604B2 (en) 2019-07-01 2021-06-29 Rampart Communications, Inc. Systems, methods and apparatuses for modulation-agnostic unitary braid division multiplexing signal transformation
CN115427446A (zh) 2020-02-24 2022-12-02 瑟罗泽恩奥普瑞汀公司 Wnt超级激动剂
TW202233656A (zh) 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
JP2024509266A (ja) 2021-03-10 2024-02-29 スロゼン オペレーティング, インコーポレイテッド 胃腸障害におけるwntシグナル伝達のモジュレーション

Similar Documents

Publication Publication Date Title
JP2023078467A5 (https=)
JP2021530223A5 (https=)
JP2020506701A5 (https=)
JPWO2020014271A5 (https=)
Mertens et al. Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.
AU2016289492B2 (en) Vaccine against RSV
JP2025184979A5 (https=)
RU2010122053A (ru) Иммуносупрессорные полипептиды и нуклеиновые кислоты
JP2020023517A5 (https=)
JP2016052315A5 (https=)
NO995689D0 (no) Forbindelser for immunoterapi og diagnose av tuberkulose og metoder for deres anvendelse
JP2014510518A5 (https=)
JP2005120106A5 (https=)
KR960704038A (ko) 세포 표면 수용체 Hek와 결합하는 사이토킨(Cytokines That Bind the Cell Surface Receptor Hek)
RU2012113162A (ru) Белок слияния, содержащий тимусный стромальный лимфопоэтический белок, вакцина, содержащая эскпрессионный вектор для экспресии белка, и вакцина, содержащая указанный вектор для экспрессии
JP2017512063A5 (https=)
JP2018537087A5 (https=)
JP2023029902A5 (https=)
JP2005245460A5 (https=)
JP2009525757A5 (https=)
CN115443288A (zh) 一种免疫球蛋白降解酶IdeE的突变体
RU2218402C2 (ru) Выделенный полипептид, имеющий гомологию относительно комплемент родственного белка адипоцитов (варианты), гибридный белок (варианты), экспрессирующий вектор, способ получения полипептида, поликлональное антитело, фрагмент выделенного полинуклеотида (варианты)
FI4034555T3 (fi) Dap10/dap12-fuusiopolypeptidit
RU2008138536A (ru) Химерные вакцинные антигены против вируса классической чумы свиней
JP2020517260A5 (https=)