JP2023036953A5 - - Google Patents
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- JP2023036953A5 JP2023036953A5 JP2023000606A JP2023000606A JP2023036953A5 JP 2023036953 A5 JP2023036953 A5 JP 2023036953A5 JP 2023000606 A JP2023000606 A JP 2023000606A JP 2023000606 A JP2023000606 A JP 2023000606A JP 2023036953 A5 JP2023036953 A5 JP 2023036953A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- protein
- carrier protein
- crm197
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 6
- 102000014914 Carrier Proteins Human genes 0.000 claims 3
- 108010078791 Carrier Proteins Proteins 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024084665A JP7796163B2 (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463216P | 2017-02-24 | 2017-02-24 | |
| US62/463,216 | 2017-02-24 | ||
| US201762555444P | 2017-09-07 | 2017-09-07 | |
| US62/555,444 | 2017-09-07 | ||
| JP2019546002A JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| PCT/US2018/018729 WO2018156491A1 (en) | 2017-02-24 | 2018-02-20 | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Division JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084665A Division JP7796163B2 (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023036953A JP2023036953A (ja) | 2023-03-14 |
| JP2023036953A5 true JP2023036953A5 (https=) | 2023-05-25 |
Family
ID=63254065
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Active JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| JP2023000606A Pending JP2023036953A (ja) | 2017-02-24 | 2023-01-05 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| JP2024084665A Active JP7796163B2 (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546002A Active JP7680185B2 (ja) | 2017-02-24 | 2018-02-20 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084665A Active JP7796163B2 (ja) | 2017-02-24 | 2024-05-24 | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11090374B2 (https=) |
| EP (1) | EP3589314A4 (https=) |
| JP (3) | JP7680185B2 (https=) |
| KR (2) | KR20240011879A (https=) |
| CN (1) | CN110337307A (https=) |
| AU (1) | AU2018225099B2 (https=) |
| BR (1) | BR112019017560A2 (https=) |
| CA (1) | CA3050120A1 (https=) |
| MX (3) | MX2019009867A (https=) |
| WO (1) | WO2018156491A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3311836A1 (en) * | 2005-04-08 | 2018-04-25 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| BR112016015835B1 (pt) | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| KR102225282B1 (ko) * | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110366428B (zh) | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| CN110225757A (zh) * | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| EP4656208A3 (en) | 2017-01-31 | 2026-03-04 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX2020002558A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Procesos para la formulacion de polisacaridos neumococicos para la conjugacion a una proteina transportadora. |
| WO2019050814A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| MX394767B (es) | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| MX394768B (es) | 2017-09-07 | 2025-03-21 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| ES3058336T3 (es) | 2017-12-06 | 2026-03-10 | Merck Sharp & Dohme Llc | Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| MX2021003358A (es) * | 2018-09-23 | 2021-05-27 | Biological E Ltd | Polisacaridos capsulares purificados de streptococcus pneumoniae. |
| CR20210333A (es) * | 2018-12-19 | 2021-08-18 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso |
| WO2020208502A1 (en) * | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| KR20220017996A (ko) * | 2019-06-05 | 2022-02-14 | 머크 샤프 앤드 돔 코포레이션 | 면역원성 혈청형 35b 폐렴구균 폴리사카라이드-단백질 접합체 및 그를 제조하기 위한 접합 방법 |
| CN110804097B (zh) * | 2019-10-30 | 2021-02-26 | 云南沃森生物技术股份有限公司 | 一种同时制备两种单克隆抗体的方法 |
| WO2021146681A1 (en) * | 2020-01-17 | 2021-07-22 | Inventprise, Llc | Multivalent streptococcus vaccines |
| WO2021156861A1 (en) * | 2020-02-03 | 2021-08-12 | Anagog Ltd. | Distributed content serving |
| EP4143564B1 (en) * | 2020-04-28 | 2024-06-05 | Janssen Pharmaceuticals, Inc. | Method for identification and quantification of polysaccharides in complex glycoconjugate compositions |
| JP7804673B2 (ja) | 2020-11-10 | 2026-01-22 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| JP2024521847A (ja) * | 2021-05-28 | 2024-06-04 | ファイザー・インク | コンジュゲート化莢膜糖抗原を含む免疫原性組成物およびその使用 |
| CN114965784B (zh) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | 多糖活化度的测定方法 |
| WO2024059161A1 (en) * | 2022-09-16 | 2024-03-21 | Merck Sharp & Dohme Llc | Method for quantification of polysaccharide content in conjugate vaccines |
| EP4622665A2 (en) | 2022-11-22 | 2025-10-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PE20252774A1 (es) | 2023-03-30 | 2025-12-22 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y usos de estos |
| AU2024255922A1 (en) | 2023-04-14 | 2025-10-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025219904A1 (en) * | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| EP3311836A1 (en) | 2005-04-08 | 2018-04-25 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CN101155833B (zh) | 2005-04-08 | 2011-04-20 | 惠氏公司 | 通过pH操作将污染物与肺炎链球菌多糖分离 |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| DK2074221T3 (da) | 2006-10-10 | 2010-09-06 | Wyeth Llc | Forbedrede fremgangsmåder til separation af streptococcus pneumoniae type 3 polysakkarider |
| CN101663327B (zh) | 2007-03-23 | 2014-05-07 | 惠氏公司 | 产生肺炎链球菌(streptococcus pneumoniae)荚膜多糖的缩短的纯化方法 |
| US8540955B2 (en) | 2007-07-10 | 2013-09-24 | Wyeth Llc | Process for producing aluminum phosphate |
| ES2749952T3 (es) | 2008-12-18 | 2020-03-24 | Wyeth Llc | Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono |
| BRPI0922981A8 (pt) | 2008-12-18 | 2019-11-26 | Wyeth Llc | método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae |
| SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| PL2575870T3 (pl) | 2010-06-04 | 2017-05-31 | Wyeth Llc | Preparaty szczepionek |
| CA2819366A1 (en) | 2010-12-10 | 2012-06-14 | Merck Sharp & Dohme Corp. | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| JP6502262B2 (ja) | 2012-12-20 | 2019-04-17 | ファイザー・インク | 糖複合化方法 |
| BR112016015835B1 (pt) | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| PL3096786T3 (pl) * | 2014-01-21 | 2021-11-08 | Pfizer Inc. | Polisacharydy otoczkowe streptococcus pneumoniae i ich koniugaty |
| CN110859957B (zh) | 2014-01-21 | 2024-04-12 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| WO2016020499A2 (en) | 2014-08-08 | 2016-02-11 | Glycovaxyn Ag | Modified host cells for use in bioconjugate production |
| HUE062499T2 (hu) | 2015-01-15 | 2023-11-28 | Pfizer | Pneumococcus-vakcinákban történõ alkalmazásra szolgáló immunogén készítmények |
| MY182282A (en) | 2015-05-04 | 2021-01-18 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| KR102225282B1 (ko) * | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| EP3377613A1 (en) | 2015-11-17 | 2018-09-26 | Pfizer Inc | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
| JP6884145B2 (ja) | 2015-11-20 | 2021-06-09 | ファイザー・インク | 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物 |
| CA3031799A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110366428B (zh) * | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| BR112019014833A2 (pt) | 2017-01-20 | 2020-04-14 | Pfizer | composições imunogênicas para uso em vacinas pneumococais |
| EP4656208A3 (en) | 2017-01-31 | 2026-03-04 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| CN110225757A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| MX2019009869A (es) | 2017-02-24 | 2019-10-02 | Merck Sharp & Dohme | Formulaciones de vacunas de conjugado de neumococos. |
| US11219680B2 (en) | 2017-02-24 | 2022-01-11 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier |
| EP3585427A4 (en) | 2017-02-24 | 2020-12-30 | Merck Sharp & Dohme Corp. | METHODS FOR IMPROVING THE FILTRABILITY OF POLYSACCHARIDE CONJUGATE WITH PROTEIN REACTIONS |
| CN110996992A (zh) | 2017-08-16 | 2020-04-10 | 默沙东公司 | 肺炎球菌缀合物疫苗制剂 |
| MX394767B (es) | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| WO2019050814A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| CN111093650B (zh) * | 2017-09-07 | 2024-03-01 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| MX2020002558A (es) * | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Procesos para la formulacion de polisacaridos neumococicos para la conjugacion a una proteina transportadora. |
| MX394768B (es) * | 2017-09-07 | 2025-03-21 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20200077538A (ko) | 2017-10-25 | 2020-06-30 | 머크 샤프 앤드 돔 코포레이션 | 아주반트 첨가된 백신 |
| ES3058336T3 (es) * | 2017-12-06 | 2026-03-10 | Merck Sharp & Dohme Llc | Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US20210223262A1 (en) | 2018-06-07 | 2021-07-22 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| CR20210333A (es) | 2018-12-19 | 2021-08-18 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso |
| WO2020208502A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| KR20220017996A (ko) | 2019-06-05 | 2022-02-14 | 머크 샤프 앤드 돔 코포레이션 | 면역원성 혈청형 35b 폐렴구균 폴리사카라이드-단백질 접합체 및 그를 제조하기 위한 접합 방법 |
| BR112021024491A8 (pt) | 2019-06-05 | 2023-04-11 | Merck Sharp & Dohme | Composição imunogênica, e, método para prevenir, tratar ou melhorar uma infecção, doença ou condição |
-
2018
- 2018-02-20 JP JP2019546002A patent/JP7680185B2/ja active Active
- 2018-02-20 WO PCT/US2018/018729 patent/WO2018156491A1/en not_active Ceased
- 2018-02-20 KR KR1020247001331A patent/KR20240011879A/ko active Pending
- 2018-02-20 KR KR1020197027396A patent/KR20190121330A/ko not_active Ceased
- 2018-02-20 EP EP18757315.9A patent/EP3589314A4/en active Pending
- 2018-02-20 BR BR112019017560A patent/BR112019017560A2/pt unknown
- 2018-02-20 US US16/487,550 patent/US11090374B2/en active Active
- 2018-02-20 CN CN201880013793.7A patent/CN110337307A/zh active Pending
- 2018-02-20 CA CA3050120A patent/CA3050120A1/en active Pending
- 2018-02-20 MX MX2019009867A patent/MX2019009867A/es unknown
- 2018-02-20 AU AU2018225099A patent/AU2018225099B2/en active Active
-
2019
- 2019-08-19 MX MX2023001947A patent/MX2023001947A/es unknown
- 2019-08-19 MX MX2023001948A patent/MX2023001948A/es unknown
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2021
- 2021-07-07 US US17/369,230 patent/US20210330778A1/en not_active Abandoned
- 2021-07-07 US US17/369,177 patent/US20210330777A1/en not_active Abandoned
-
2023
- 2023-01-05 JP JP2023000606A patent/JP2023036953A/ja active Pending
- 2023-06-22 US US18/339,723 patent/US12295998B2/en active Active
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2024
- 2024-05-24 JP JP2024084665A patent/JP7796163B2/ja active Active
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