JP2023025151A5 - - Google Patents
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- JP2023025151A5 JP2023025151A5 JP2022192575A JP2022192575A JP2023025151A5 JP 2023025151 A5 JP2023025151 A5 JP 2023025151A5 JP 2022192575 A JP2022192575 A JP 2022192575A JP 2022192575 A JP2022192575 A JP 2022192575A JP 2023025151 A5 JP2023025151 A5 JP 2023025151A5
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- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- cell
- receptor
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 41
- 150000003839 salts Chemical class 0.000 claims 39
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 150000001413 amino acids Chemical group 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 8
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 6
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 6
- 102000005962 receptors Human genes 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 4
- 102000000853 LDL receptors Human genes 0.000 claims 4
- 108010001831 LDL receptors Proteins 0.000 claims 4
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- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- VVEJUSYNERNRME-XGFVQVCISA-N (4r,7s,10r,13s,16r,19s,22r,25s,28r,31s)-13,28-bis(4-aminobutyl)-25-(2-amino-2-oxoethyl)-31-[[2-[[(2s)-2-aminopropanoyl]amino]acetyl]amino]-19,22-dibenzyl-10-[(1r)-1-hydroxyethyl]-7-(hydroxymethyl)-16-(1h-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30-nonaoxo- Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N1)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 VVEJUSYNERNRME-XGFVQVCISA-N 0.000 claims 2
- QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 claims 2
- VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 claims 2
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- BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510489560.2A CN106466484B (zh) | 2015-08-11 | 2015-08-11 | 一种具有细胞内吞介导功能的多靶向配体-药物偶联体 |
| CN201510489556.6 | 2015-08-11 | ||
| CN201510489556.6A CN106466485B (zh) | 2015-08-11 | 2015-08-11 | 一种具有细胞内吞介导功能的靶向配体-药物偶联体 |
| CN201510489560.2 | 2015-08-11 | ||
| JP2020164335A JP7573401B2 (ja) | 2015-08-11 | 2020-09-30 | 多リガンド－薬物複合体及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020164335A Division JP7573401B2 (ja) | 2015-08-11 | 2020-09-30 | 多リガンド－薬物複合体及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023025151A JP2023025151A (ja) | 2023-02-21 |
| JP2023025151A5 true JP2023025151A5 (https=) | 2023-03-29 |
Family
ID=57983917
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568345A Active JP6772199B2 (ja) | 2015-08-11 | 2016-08-11 | 多リガンド−薬物複合体及びその使用 |
| JP2020164335A Active JP7573401B2 (ja) | 2015-08-11 | 2020-09-30 | 多リガンド－薬物複合体及びその使用 |
| JP2022192575A Pending JP2023025151A (ja) | 2015-08-11 | 2022-12-01 | 多リガンド－薬物複合体及びその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568345A Active JP6772199B2 (ja) | 2015-08-11 | 2016-08-11 | 多リガンド−薬物複合体及びその使用 |
| JP2020164335A Active JP7573401B2 (ja) | 2015-08-11 | 2020-09-30 | 多リガンド－薬物複合体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11571480B2 (https=) |
| EP (1) | EP3334500B1 (https=) |
| JP (3) | JP6772199B2 (https=) |
| KR (2) | KR102464778B1 (https=) |
| CN (3) | CN108135881B (https=) |
| AU (2) | AU2016305703B2 (https=) |
| CA (1) | CA2987322C (https=) |
| DK (1) | DK3334500T3 (https=) |
| ES (1) | ES2877409T3 (https=) |
| MX (1) | MX381031B (https=) |
| RU (1) | RU2722449C2 (https=) |
| WO (1) | WO2017025057A1 (https=) |
| ZA (1) | ZA201707464B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5836940B2 (ja) | 2009-06-26 | 2015-12-24 | ソリシメド・バイオファーマ・インコーポレーテッド | ソリシジン由来ペプチドならびにｔｒｐｖ−６がんの検出および薬剤送達のための方法 |
| CN108135881B (zh) * | 2015-08-11 | 2020-11-13 | 同宜医药（苏州）有限公司 | 多配体药物偶联体及其用途 |
| CA3083950A1 (en) * | 2017-12-01 | 2019-06-06 | Soricimed Biopharma Inc. | Trpv6 inhibitors and combination therapies for treating cancers |
| WO2019109188A1 (en) * | 2017-12-06 | 2019-06-13 | Ontario Institute For Cancer Research (Oicr) | Acyl hydrazone linkers, methods and uses thereof |
| WO2019119141A1 (en) | 2017-12-22 | 2019-06-27 | Ontario Institute For Cancer Research (Oicr) | Heterocyclic acyl hydrazone linkers, methods and uses thereof |
| WO2019134018A1 (en) * | 2018-01-05 | 2019-07-11 | Telethon Kids Institute | Vaccine conjugates and uses thereof |
| US20220175761A1 (en) * | 2019-01-30 | 2022-06-09 | Coherent Biopharma (Suzhou), Limited | Bi-ligand drug conjugate and use thereof |
| WO2021016392A1 (en) * | 2019-07-22 | 2021-01-28 | Purdue Research Foundation | Multivalent fibroblast-targeted agents and methods of use |
| WO2021031109A1 (zh) * | 2019-08-20 | 2021-02-25 | 深圳华大智造极创科技有限公司 | 一种基于发光标记物光信号动力学及二次发光信号对多核苷酸进行测序的方法 |
| KR20220140750A (ko) * | 2020-02-13 | 2022-10-18 | 이스케이프 테라퓨틱스, 인코퍼레이티드 | 흑색종 치료제 |
| EP4274595A4 (en) * | 2021-01-07 | 2026-01-21 | Purdue Research Foundation | FOLATE RECEPTOR-TARGETED CONJUGATES, COMPOSITIONS AND ADMINISTRATION TO THE CENTRAL NERVOUS SYSTEM |
| CA3224741A1 (en) * | 2021-06-25 | 2022-12-29 | Coherent Biopharma (Suzhou), Limited | Ligand-drug conjugate and use thereof |
| CN116059392B (zh) * | 2021-09-03 | 2025-02-28 | 同宜医药（苏州）有限公司 | 配体偶联物及其应用 |
| JP2024533395A (ja) * | 2021-09-08 | 2024-09-12 | 同宜医藥（蘇州）有限公司 | 薬物製剤及びその製造方法と用途 |
| CA3235106A1 (en) * | 2021-10-19 | 2023-04-27 | Sixiang FAN | Conjugate pharmaceutical preparation, preparation method therefor and use thereof______________ |
| CN116196408B (zh) * | 2021-12-30 | 2026-01-06 | 思格(苏州)生物科技有限公司 | 一种新型免疫佐剂及其制备方法和应用 |
| TW202404643A (zh) * | 2022-04-20 | 2024-02-01 | 大陸商同宜醫藥（蘇州）有限公司 | 化合物及用途 |
| WO2024099387A1 (zh) * | 2022-11-09 | 2024-05-16 | 同宜医药（苏州）有限公司 | 通过施用配体-药物偶联体治疗癌症 |
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