JP2022552249A5 - - Google Patents

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Publication number
JP2022552249A5
JP2022552249A5 JP2022521139A JP2022521139A JP2022552249A5 JP 2022552249 A5 JP2022552249 A5 JP 2022552249A5 JP 2022521139 A JP2022521139 A JP 2022521139A JP 2022521139 A JP2022521139 A JP 2022521139A JP 2022552249 A5 JP2022552249 A5 JP 2022552249A5
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Japan
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agent according
modified oligonucleotide
nucleic acid
pnpla3
compound targeting
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JP2022521139A
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JP7757277B2 (ja
JP2022552249A (ja
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Priority claimed from PCT/IB2020/059566 external-priority patent/WO2021074772A1/en
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Publication of JP2022552249A5 publication Critical patent/JP2022552249A5/ja
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JP2022521139A 2019-10-14 2020-10-12 Ｐｎｐｌａ３発現のモジュレーター Active JP7757277B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962914660P 2019-10-14 2019-10-14
US62/914,660 2019-10-14
PCT/IB2020/059566 WO2021074772A1 (en) 2019-10-14 2020-10-12 Modulators of pnpla3 expression

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JP2022552249A JP2022552249A (ja) 2022-12-15
JP2022552249A5 true JP2022552249A5 (enExample) 2023-10-20
JP7757277B2 JP7757277B2 (ja) 2025-10-21

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US (1) US20260234631A1 (enExample)
EP (1) EP4045062A1 (enExample)
JP (1) JP7757277B2 (enExample)
CN (1) CN114728017B (enExample)
WO (1) WO2021074772A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017021053A2 (en) 2015-04-13 2018-08-14 Alnylam Pharmaceuticals, Inc. angiopoietin type 3 (angpt13) irna compositions and methods of use thereof
TWI869213B (zh) 2018-09-19 2025-01-01 美商Ionis製藥公司 Pnpla3表現之調節劑
WO2021154791A1 (en) 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
TW202313974A (zh) * 2021-06-08 2023-04-01 瑞典商阿斯特捷利康公司 用於治療肝病之組合療法
EP4604955A1 (en) * 2022-10-18 2025-08-27 Pfizer Inc. Use of patatin-like phospholipase domain-containing protein 3 compounds
CN117904108A (zh) * 2022-12-12 2024-04-19 北京福元医药股份有限公司 用于抑制pnpla3基因表达的双链核糖核酸及其修饰物、缀合物和用途
WO2025098440A1 (zh) * 2023-11-08 2025-05-15 浙江扬厉医药技术有限公司 抑制PNPLA3表达的双链siRNA以及其缀合物
TW202539705A (zh) * 2024-04-03 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｎｐｌａ３表現之抑制劑的劑量依賴性投予

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