JP2022542562A5 - - Google Patents
Info
- Publication number
- JP2022542562A5 JP2022542562A5 JP2022504132A JP2022504132A JP2022542562A5 JP 2022542562 A5 JP2022542562 A5 JP 2022542562A5 JP 2022504132 A JP2022504132 A JP 2022504132A JP 2022504132 A JP2022504132 A JP 2022504132A JP 2022542562 A5 JP2022542562 A5 JP 2022542562A5
- Authority
- JP
- Japan
- Prior art keywords
- poloxamer
- less
- composition according
- lipid nanoparticles
- stable composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025177461A JP2026012822A (ja) | 2019-07-23 | 2025-10-22 | ｍＲＮＡ担持脂質ナノ粒子の安定性組成物および作製のプロセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962877597P | 2019-07-23 | 2019-07-23 | |
| US62/877,597 | 2019-07-23 | ||
| PCT/US2020/043223 WO2021016430A1 (en) | 2019-07-23 | 2020-07-23 | Stable compositions of mrna-loaded lipid nanoparticles and processes of making |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025177461A Division JP2026012822A (ja) | 2019-07-23 | 2025-10-22 | ｍＲＮＡ担持脂質ナノ粒子の安定性組成物および作製のプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022542562A JP2022542562A (ja) | 2022-10-05 |
| JP2022542562A5 true JP2022542562A5 (https=) | 2023-07-31 |
| JP7764363B2 JP7764363B2 (ja) | 2025-11-05 |
Family
ID=72088362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022504132A Active JP7764363B2 (ja) | 2019-07-23 | 2020-07-23 | ｍＲＮＡ担持脂質ナノ粒子の安定性組成物および作製のプロセス |
| JP2025177461A Pending JP2026012822A (ja) | 2019-07-23 | 2025-10-22 | ｍＲＮＡ担持脂質ナノ粒子の安定性組成物および作製のプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025177461A Pending JP2026012822A (ja) | 2019-07-23 | 2025-10-22 | ｍＲＮＡ担持脂質ナノ粒子の安定性組成物および作製のプロセス |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12144871B2 (https=) |
| EP (1) | EP4003311A1 (https=) |
| JP (2) | JP7764363B2 (https=) |
| KR (1) | KR20220038365A (https=) |
| CN (1) | CN114401748A (https=) |
| AU (1) | AU2020315962B2 (https=) |
| BR (1) | BR112022001192A2 (https=) |
| CA (1) | CA3146675A1 (https=) |
| IL (2) | IL289944A (https=) |
| MX (1) | MX2022000934A (https=) |
| WO (1) | WO2021016430A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA42543A (fr) | 2015-07-30 | 2018-06-06 | Modernatx Inc | Arn épitope peptidiques concatémériques |
| AU2016341309A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Cancer vaccines |
| MA46766A (fr) | 2016-11-11 | 2019-09-18 | Modernatx Inc | Vaccin antigrippal |
| WO2018170245A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| HRP20240586T1 (hr) | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| CA3169669A1 (en) * | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| JP2023526284A (ja) * | 2020-05-15 | 2023-06-21 | トランスレイト バイオ， インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子製剤 |
| WO2022099003A1 (en) | 2020-11-06 | 2022-05-12 | Sanofi | Lipid nanoparticles for delivering mrna vaccines |
| WO2022115645A1 (en) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| EP4274607A1 (en) | 2021-01-11 | 2023-11-15 | ModernaTX, Inc. | Seasonal rna influenza virus vaccines |
| JP2024509743A (ja) * | 2021-02-16 | 2024-03-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | ｉｎ ｖｉｔｒｏおよびｉｎ ｖｉｖｏトランスフェクションのための規定サイズのプラスミドＤＮＡ／脂質粒子の調製方法 |
| CN113509542A (zh) * | 2021-04-20 | 2021-10-19 | 嘉晨西海(杭州)生物技术有限公司 | 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法 |
| EP4326227A1 (en) * | 2021-04-23 | 2024-02-28 | ModernaTX, Inc. | Stabilized formulations |
| WO2022226318A1 (en) * | 2021-04-23 | 2022-10-27 | Modernatx, Inc. | Isoquinoline-stabilized lipid nanoparticle formulations |
| GB202108444D0 (en) * | 2021-06-14 | 2021-07-28 | Imperial College Innovations Ltd | Sub-micron particle |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| KR20230053998A (ko) | 2021-10-15 | 2023-04-24 | (주)지노믹트리 | mRNA 발현을 위한 유전자 구조체 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| MX2024005462A (es) | 2021-11-05 | 2024-05-22 | Sanofi Sa | Vacuna de arn del virus respiratorio sincitial. |
| JP2024542635A (ja) | 2021-11-30 | 2024-11-15 | サノフィ パスツール インコーポレイテッド | ヒトメタニューモウイルスワクチン |
| EP4448777A1 (en) * | 2021-12-15 | 2024-10-23 | ModernaTX, Inc. | Determination of encapsulation efficiency of lipid nanoparticles |
| JP2025500880A (ja) | 2021-12-17 | 2025-01-15 | サノフイ | ライム病ｒｎａワクチン |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2023156487A1 (en) | 2022-02-15 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating tear film composition to treat corneal defects |
| CA3256897A1 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for the administration of nucleic acids and their methods of use |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| EP4565209A1 (en) | 2022-08-04 | 2025-06-11 | Sanofi Pasteur Inc. | Quantitative assessment of rna encapsulation |
| WO2024057237A1 (en) * | 2022-09-16 | 2024-03-21 | Pfizer Inc. | Lipid nanoparticles |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| CN120202025A (zh) * | 2022-11-03 | 2025-06-24 | 深圳鸿生生物科技有限公司 | 用于增强核酸递送的组合物 |
| KR20250099727A (ko) | 2022-11-04 | 2025-07-02 | 사노피 파스퇴르 인크 | 호흡기 세포융합 바이러스 rna 백신접종 |
| WO2024112717A1 (en) * | 2022-11-21 | 2024-05-30 | Avstera Therapeutics Corp. | Mrna composition for preventing and treating cancer |
| EP4637813A1 (en) | 2022-12-20 | 2025-10-29 | Sanofi Pasteur | Rhinovirus mrna vaccine |
| CN120813371A (zh) | 2023-03-02 | 2025-10-17 | 赛诺菲巴斯德有限公司 | 用于在衣原体病的治疗中使用的组合物 |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024231565A1 (en) | 2023-05-10 | 2024-11-14 | Sanofi | Combination respiratory mrna vaccines |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| EP4713003A1 (en) | 2023-05-17 | 2026-03-25 | Institut National de la Santé et de la Recherche Médicale | Lipc variant in the treatment of hypercholesterolemia and atherosclerotic cardiovascular disease |
| EP4722368A1 (en) | 2023-05-26 | 2026-04-08 | Samsung Biologics Co., Ltd. | Novel nucleic acid construct comprising poly(a) tail having secondary or tertiary structure and uses thereof |
| KR20250018367A (ko) | 2023-07-28 | 2025-02-05 | 한국과학기술원 | 히스톤 코드 리더 도메인을 포함하는 폴리펩티드 및 이의 용도 |
| WO2025051975A1 (en) | 2023-09-06 | 2025-03-13 | Sanofi | Modified influenza b hemagglutinin polypeptides and nucleic acids and uses thereof |
| WO2025073054A1 (en) | 2023-10-05 | 2025-04-10 | Nanovation Therapeutics Inc. | Method of delivery of dna or rna cargo using unshielded lipid nanoparticles |
| WO2025186293A1 (en) | 2024-03-06 | 2025-09-12 | Institut National de la Santé et de la Recherche Médicale | Chmp2b mutants for use for treating infection |
| WO2025202213A1 (en) | 2024-03-26 | 2025-10-02 | Institut National de la Santé et de la Recherche Médicale | Lipid nanoparticle loaded with antitumoral agent and functionnalized to target immosuppressive cells |
| WO2025210592A1 (en) | 2024-04-05 | 2025-10-09 | Sanofi Pasteur Inc. | Muscle cell lnp-mrna quality control assays |
| WO2026008743A1 (en) | 2024-07-02 | 2026-01-08 | Sanofi Pasteur Inc. | Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid |
| WO2026027730A1 (en) | 2024-07-31 | 2026-02-05 | Sanofi | Modified h5 influenza hemagglutinin polypeptides and nucleic acids and uses thereof |
| WO2026033123A1 (en) | 2024-08-08 | 2026-02-12 | Sanofi Pasteur Inc. | Lipid nanoparticle formulations for mrna delivery |
| WO2026052773A1 (en) | 2024-09-06 | 2026-03-12 | Sanofi | Modified influenza a hemagglutinin polypeptides and nucleic acids and uses thereof |
Family Cites Families (49)
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| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
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| US4401796A (en) | 1981-04-30 | 1983-08-30 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
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| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
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| CA3043033A1 (en) | 2016-11-10 | 2018-05-17 | Translate Bio, Inc. | Improved ice-based lipid nanoparticle formulation for delivery of mrna |
| US11260149B2 (en) * | 2017-05-28 | 2022-03-01 | Niloofar Eslahi | Hydrogel for cartilage tissue regeneration |
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-
2020
- 2020-07-23 CA CA3146675A patent/CA3146675A1/en active Pending
- 2020-07-23 WO PCT/US2020/043223 patent/WO2021016430A1/en not_active Ceased
- 2020-07-23 JP JP2022504132A patent/JP7764363B2/ja active Active
- 2020-07-23 EP EP20757429.4A patent/EP4003311A1/en active Pending
- 2020-07-23 BR BR112022001192A patent/BR112022001192A2/pt unknown
- 2020-07-23 MX MX2022000934A patent/MX2022000934A/es unknown
- 2020-07-23 CN CN202080065024.9A patent/CN114401748A/zh active Pending
- 2020-07-23 AU AU2020315962A patent/AU2020315962B2/en active Active
- 2020-07-23 KR KR1020227003695A patent/KR20220038365A/ko active Pending
- 2020-07-23 US US16/936,909 patent/US12144871B2/en active Active
-
2022
- 2022-01-13 IL IL289944A patent/IL289944A/en unknown
- 2022-01-13 IL IL289984A patent/IL289984A/en unknown
-
2024
- 2024-10-09 US US18/910,694 patent/US20250049954A1/en active Pending
-
2025
- 2025-10-22 JP JP2025177461A patent/JP2026012822A/ja active Pending
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