JP2022542399A5 - - Google Patents
Info
- Publication number
- JP2022542399A5 JP2022542399A5 JP2022506196A JP2022506196A JP2022542399A5 JP 2022542399 A5 JP2022542399 A5 JP 2022542399A5 JP 2022506196 A JP2022506196 A JP 2022506196A JP 2022506196 A JP2022506196 A JP 2022506196A JP 2022542399 A5 JP2022542399 A5 JP 2022542399A5
- Authority
- JP
- Japan
- Prior art keywords
- soluble
- cells
- concentration
- interleukin
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962881311P | 2019-07-31 | 2019-07-31 | |
| US62/881,311 | 2019-07-31 | ||
| US201962932342P | 2019-11-07 | 2019-11-07 | |
| US62/932,342 | 2019-11-07 | ||
| PCT/US2020/044033 WO2021021907A1 (en) | 2019-07-31 | 2020-07-29 | Methods and compositions for enhanced expansion and cytotoxicity of natural killer cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022542399A JP2022542399A (ja) | 2022-10-03 |
| JP2022542399A5 true JP2022542399A5 (enExample) | 2023-08-03 |
| JP7724765B2 JP7724765B2 (ja) | 2025-08-18 |
Family
ID=74229259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506196A Active JP7724765B2 (ja) | 2019-07-31 | 2020-07-29 | ナチュラルキラー細胞の増殖を亢進する、および細胞障害性を増強するための方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220411754A1 (enExample) |
| EP (1) | EP4003379A4 (enExample) |
| JP (1) | JP7724765B2 (enExample) |
| KR (1) | KR20220038439A (enExample) |
| CN (1) | CN114450015A (enExample) |
| AU (1) | AU2020321354A1 (enExample) |
| CA (1) | CA3144724A1 (enExample) |
| IL (1) | IL289902A (enExample) |
| MX (1) | MX2022001255A (enExample) |
| WO (1) | WO2021021907A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| CN114174325A (zh) * | 2019-06-04 | 2022-03-11 | 恩卡尔塔公司 | 用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合 |
| KR20230084470A (ko) * | 2020-08-14 | 2023-06-13 | 카이트 파마 인코포레이티드 | 면역 세포 기능의 향상 |
| IL300903A (en) * | 2020-09-02 | 2023-04-01 | Nkarta Inc | Expansion and enhanced cytotoxicity of natural killer cells and their uses |
| KR20240051112A (ko) | 2021-07-01 | 2024-04-19 | 인답타 세라뷰틱스 인코포레이티드 | 조작된 자연 살해(nk) 세포 및 관련 방법 |
| CA3223666A1 (en) * | 2021-07-28 | 2023-02-02 | James Barnaby Trager | Selection of optimal cell donors and methods and compositions for enhanced expansion and cytotoxicity of donor cells |
| CN116236461B (zh) * | 2021-12-08 | 2026-03-24 | 深圳先进技术研究院 | 一种氧化还原型纳米颗粒和活细胞载体及其应用 |
| US20250375524A1 (en) | 2022-06-30 | 2025-12-11 | Indapta Therapeutics, Inc. | Combination of engineered natural killer (nk) cells and antibody therapy and related methods |
| WO2024163619A1 (en) * | 2023-02-01 | 2024-08-08 | Nkarta, Inc. | Methods for expanding immune cells and related compositions and uses thereof |
| WO2025150751A1 (ko) * | 2024-01-11 | 2025-07-17 | 사회복지법인 삼성생명공익재단 | Nk 세포의 활성화 및 증폭용 배양보조세포 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101684456A (zh) * | 2008-09-28 | 2010-03-31 | 江门罗森生物制药有限公司 | 一种体外培养条件下扩增人nk细胞的方法 |
| EP3805371A1 (en) * | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| AU2015339447B2 (en) * | 2014-10-27 | 2021-08-12 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for natural killer cells |
| EP3452580B1 (en) * | 2016-05-02 | 2023-08-16 | Cerus Corporation | Compositions and methods for improved nk cell therapies |
| CN106085958A (zh) * | 2016-08-04 | 2016-11-09 | 英普乐孚生物技术(上海)有限公司 | 一种nk细胞的制备方法 |
| US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
| MX2019011570A (es) * | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
-
2020
- 2020-07-29 AU AU2020321354A patent/AU2020321354A1/en active Pending
- 2020-07-29 KR KR1020227005973A patent/KR20220038439A/ko active Pending
- 2020-07-29 MX MX2022001255A patent/MX2022001255A/es unknown
- 2020-07-29 CN CN202080068418.XA patent/CN114450015A/zh active Pending
- 2020-07-29 EP EP20848600.1A patent/EP4003379A4/en active Pending
- 2020-07-29 CA CA3144724A patent/CA3144724A1/en active Pending
- 2020-07-29 US US17/628,105 patent/US20220411754A1/en active Pending
- 2020-07-29 WO PCT/US2020/044033 patent/WO2021021907A1/en not_active Ceased
- 2020-07-29 JP JP2022506196A patent/JP7724765B2/ja active Active
-
2022
- 2022-01-16 IL IL289902A patent/IL289902A/en unknown
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