JP2024512608A5 - - Google Patents

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Publication number
JP2024512608A5
JP2024512608A5 JP2023558899A JP2023558899A JP2024512608A5 JP 2024512608 A5 JP2024512608 A5 JP 2024512608A5 JP 2023558899 A JP2023558899 A JP 2023558899A JP 2023558899 A JP2023558899 A JP 2023558899A JP 2024512608 A5 JP2024512608 A5 JP 2024512608A5
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JP
Japan
Prior art keywords
seq
cells
section
population
manipulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023558899A
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English (en)
Japanese (ja)
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JP2024512608A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/021820 external-priority patent/WO2022204443A1/en
Publication of JP2024512608A publication Critical patent/JP2024512608A/ja
Publication of JP2024512608A5 publication Critical patent/JP2024512608A5/ja
Pending legal-status Critical Current

Links

JP2023558899A 2021-03-24 2022-03-24 Tリンパ球における効率的なtcr遺伝子編集 Pending JP2024512608A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163165509P 2021-03-24 2021-03-24
US63/165,509 2021-03-24
US202263323065P 2022-03-24 2022-03-24
US63/323,065 2022-03-24
PCT/US2022/021820 WO2022204443A1 (en) 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes

Publications (2)

Publication Number Publication Date
JP2024512608A JP2024512608A (ja) 2024-03-19
JP2024512608A5 true JP2024512608A5 (enExample) 2025-03-28

Family

ID=81308117

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023558899A Pending JP2024512608A (ja) 2021-03-24 2022-03-24 Tリンパ球における効率的なtcr遺伝子編集

Country Status (7)

Country Link
US (2) US12239664B2 (enExample)
JP (1) JP2024512608A (enExample)
KR (1) KR20230160885A (enExample)
AU (1) AU2022245323A1 (enExample)
BR (1) BR112023019195A2 (enExample)
CA (1) CA3214486A1 (enExample)
WO (1) WO2022204443A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL300994A (en) * 2020-08-28 2023-04-01 Arsenal Biosciences Inc Transgenic immune cells with priming receptors
WO2022204443A1 (en) 2021-03-24 2022-09-29 Genentech, Inc. Efficient tcr gene editing in t lymphocytes
US20260232734A1 (en) 2023-02-27 2026-08-13 Adaptive Biotechnologies Corporation Therapeutic T-Cell Receptors Targeting KRAS G12D
CN119320771A (zh) * 2023-07-17 2025-01-17 北京艺妙神州医药科技有限公司 用于敲除t细胞中的trac和b2m的试剂和方法
WO2025189017A1 (en) * 2024-03-06 2025-09-12 R.P. Scherer Technologies, Llc Methods for genetically engineering mammalian cells using serial delivery
WO2025217891A1 (zh) * 2024-04-19 2025-10-23 深圳市先康达生命科学有限公司 IFN-γ基因片段及其应用
WO2025259591A2 (en) * 2024-06-10 2025-12-18 Shennon Biotechnologies Inc. Engineered immune cells and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
EP2364368B1 (en) 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
EP3144673B1 (en) 2010-05-06 2019-07-10 Adaptive Biotechnologies Corporation Monitoring lymphoid neoplasm status using clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
HK1201565A1 (en) 2011-10-21 2015-09-04 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
PT2831276T (pt) 2012-05-08 2016-07-26 Adaptive Biotechnologies Corp Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex
AU2013274366A1 (en) 2012-06-11 2015-01-22 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
AU2013273987B2 (en) 2012-06-15 2018-08-09 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
EP2904111B1 (en) 2012-10-01 2017-12-06 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
ES2748204T3 (es) 2013-02-22 2020-03-13 Adaptive Biotechnologies Corp Procedimiento para seleccionar clonotipos raros
CA2906218A1 (en) 2013-03-15 2014-09-18 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2014337063A1 (en) 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
EP3092318A4 (en) 2014-01-10 2017-08-16 Adaptive Biotechnologies Corp. Methods for defining and predicting immune response to allograft
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3498866B1 (en) 2014-11-25 2026-02-25 Adaptive Biotechnologies Corp. Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
BR112017020750A2 (en) * 2015-03-27 2018-06-26 President And Fellows Of Harvard College modified t-cells and methods of producing and using them
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2017112944A1 (en) 2015-12-23 2017-06-29 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
EP3703712A4 (en) * 2017-10-30 2021-09-22 PACT Pharma, Inc. EDITING PRIMARY CELL GENES
WO2020123871A1 (en) * 2018-12-12 2020-06-18 The Regents Of The University Of California Compositions and methods for modifying a target nucleic acid
WO2022204443A1 (en) 2021-03-24 2022-09-29 Genentech, Inc. Efficient tcr gene editing in t lymphocytes

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