JP2024512608A - Ｔリンパ球における効率的なｔｃｒ遺伝子編集 - Google Patents

Ｔリンパ球における効率的なｔｃｒ遺伝子編集 Download PDF

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JP2024512608A
JP2024512608A JP2023558899A JP2023558899A JP2024512608A JP 2024512608 A JP2024512608 A JP 2024512608A JP 2023558899 A JP2023558899 A JP 2023558899A JP 2023558899 A JP2023558899 A JP 2023558899A JP 2024512608 A JP2024512608 A JP 2024512608A
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cells
tcr
engineered
cell
alpha
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JP2024512608A5 (enExample
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ルッツ，サーシャ
ジョセフ ヘイリー，ベンジャミン
マディレディ，シュラバン
オ，ソヨン
ショー，デイビッド
ハリウェル センガー，ケイト
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Genentech Inc
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Genentech Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K35/14—Blood; Artificial blood
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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JP2023558899A 2021-03-24 2022-03-24 Ｔリンパ球における効率的なｔｃｒ遺伝子編集 Pending JP2024512608A (ja)

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US202163165509P 2021-03-24 2021-03-24
US63/165,509 2021-03-24
US202263323065P 2022-03-24 2022-03-24
US63/323,065 2022-03-24
PCT/US2022/021820 WO2022204443A1 (en) 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes

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JP2024512608A true JP2024512608A (ja) 2024-03-19
JP2024512608A5 JP2024512608A5 (enExample) 2025-03-28

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US (2) US12239664B2 (enExample)
JP (1) JP2024512608A (enExample)
KR (1) KR20230160885A (enExample)
AU (1) AU2022245323A1 (enExample)
BR (1) BR112023019195A2 (enExample)
CA (1) CA3214486A1 (enExample)
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US20260232734A1 (en) 2023-02-27 2026-08-13 Adaptive Biotechnologies Corporation Therapeutic T-Cell Receptors Targeting KRAS G12D
CN119320771A (zh) * 2023-07-17 2025-01-17 北京艺妙神州医药科技有限公司 用于敲除t细胞中的trac和b2m的试剂和方法
WO2025189017A1 (en) * 2024-03-06 2025-09-12 R.P. Scherer Technologies, Llc Methods for genetically engineering mammalian cells using serial delivery
WO2025217891A1 (zh) * 2024-04-19 2025-10-23 深圳市先康达生命科学有限公司 IFN-γ基因片段及其应用
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