JP2022541761A5 - - Google Patents

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Publication number
JP2022541761A5
JP2022541761A5 JP2022502074A JP2022502074A JP2022541761A5 JP 2022541761 A5 JP2022541761 A5 JP 2022541761A5 JP 2022502074 A JP2022502074 A JP 2022502074A JP 2022502074 A JP2022502074 A JP 2022502074A JP 2022541761 A5 JP2022541761 A5 JP 2022541761A5
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Japan
Prior art keywords
protein
target protein
constituent polypeptide
fused
domain
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JP2022502074A
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English (en)
Japanese (ja)
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JP7772687B2 (ja
JP2022541761A (ja
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Priority claimed from PCT/IB2020/056657 external-priority patent/WO2021009692A1/en
Publication of JP2022541761A publication Critical patent/JP2022541761A/ja
Publication of JP2022541761A5 publication Critical patent/JP2022541761A5/ja
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Publication of JP7772687B2 publication Critical patent/JP7772687B2/ja
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JP2022502074A 2019-07-15 2020-07-15 タンパク質二量体化の三分子システム及び使用方法 Active JP7772687B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962874025P 2019-07-15 2019-07-15
US62/874,025 2019-07-15
PCT/IB2020/056657 WO2021009692A1 (en) 2019-07-15 2020-07-15 Tripartite systems for protein dimerization and methods of use

Publications (3)

Publication Number Publication Date
JP2022541761A JP2022541761A (ja) 2022-09-27
JP2022541761A5 true JP2022541761A5 (https=) 2023-07-18
JP7772687B2 JP7772687B2 (ja) 2025-11-18

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JP2022502074A Active JP7772687B2 (ja) 2019-07-15 2020-07-15 タンパク質二量体化の三分子システム及び使用方法

Country Status (5)

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US (1) US20220380801A1 (https=)
EP (1) EP3999091A1 (https=)
JP (1) JP7772687B2 (https=)
CN (1) CN114127304B (https=)
WO (1) WO2021009692A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL310578A (en) * 2021-08-09 2024-03-01 Harbour Biomed Shanghai Co Ltd Cldn18.2-targeting antibody, bispecific antibody and use thereof
EP4601680A2 (en) * 2022-10-10 2025-08-20 MedImmune, LLC Compositions and methods of treating cancer with chimeric antigen receptors targeting claudin 18.2
WO2024261323A1 (en) 2023-06-23 2024-12-26 Astrazeneca Ab Molecular switches
CN116925190B (zh) * 2023-07-27 2026-03-24 浙江大学 一种靶向抑制DEF-p65复合物的多肽、多肽药物及其应用
CN117299070B (zh) * 2023-10-11 2025-09-12 安徽工业大学 一种Ca/Mg矿物凝胶的制备方法及应用

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US20040040047A1 (en) * 1998-03-30 2004-02-26 Spencer David M. Regulated apoptosis using chemically induced dimerization of apoptosis factors
JP2002534084A (ja) 1999-01-08 2002-10-15 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウイルスｎｓ３プロテアーゼの修飾形
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
ES2582091T3 (es) 2005-10-18 2016-09-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
US8633297B2 (en) 2007-10-31 2014-01-21 Medimmune, Llc Protein scaffolds
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
WO2011130324A1 (en) 2010-04-13 2011-10-20 Medimmune, Llc Fibronectin type iii domain-based multimeric scaffolds
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
WO2015110048A1 (en) * 2014-01-23 2015-07-30 Sunshine Lake Pharma Co., Ltd. Bridged ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof
US10954500B2 (en) * 2015-10-23 2021-03-23 Fred Hutchinson Cancer Research Center Methods to create chemically-induced dimerizing protein systems for regulation of cellular events
CN108239656A (zh) * 2016-12-27 2018-07-03 天津天锐生物科技有限公司 一种小分子药物控制的蛋白功能开关系统
US11939379B2 (en) * 2017-05-19 2024-03-26 The Regents Of The University Of California Antibody chemically induced dimerizer (AbCID) as molecular switches for regulating cellular therapies
CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法

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