CN114127304B - 用于蛋白二聚化的三部分型系统和使用方法 - Google Patents

用于蛋白二聚化的三部分型系统和使用方法

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Publication number
CN114127304B
CN114127304B CN202080050513.7A CN202080050513A CN114127304B CN 114127304 B CN114127304 B CN 114127304B CN 202080050513 A CN202080050513 A CN 202080050513A CN 114127304 B CN114127304 B CN 114127304B
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protein
domain
seq
target protein
prsim
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CN114127304A (zh
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L·班伯
R·B·多德
S·莱格
T·V·默里
D·G·里斯
A·G·西瓜尔达多蒂尔
N·J·蒂格
L·M·K·维纳利
C·辛德勒
B·塔德斯
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MedImmune Ltd
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MedImmune Ltd
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    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C07K16/118—Hepatitis C virus; GB virus C [GBV-C]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/14—Hydrolases (3)
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN202080050513.7A 2019-07-15 2020-07-15 用于蛋白二聚化的三部分型系统和使用方法 Active CN114127304B (zh)

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US201962874025P 2019-07-15 2019-07-15
US62/874025 2019-07-15
PCT/IB2020/056657 WO2021009692A1 (en) 2019-07-15 2020-07-15 Tripartite systems for protein dimerization and methods of use

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IL310578A (en) * 2021-08-09 2024-03-01 Harbour Biomed Shanghai Co Ltd Cldn18.2-targeting antibody, bispecific antibody and use thereof
EP4601680A2 (en) * 2022-10-10 2025-08-20 MedImmune, LLC Compositions and methods of treating cancer with chimeric antigen receptors targeting claudin 18.2
WO2024261323A1 (en) 2023-06-23 2024-12-26 Astrazeneca Ab Molecular switches
CN116925190B (zh) * 2023-07-27 2026-03-24 浙江大学 一种靶向抑制DEF-p65复合物的多肽、多肽药物及其应用
CN117299070B (zh) * 2023-10-11 2025-09-12 安徽工业大学 一种Ca/Mg矿物凝胶的制备方法及应用

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CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法

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