JP2022535745A5 - - Google Patents
Info
- Publication number
- JP2022535745A5 JP2022535745A5 JP2021570364A JP2021570364A JP2022535745A5 JP 2022535745 A5 JP2022535745 A5 JP 2022535745A5 JP 2021570364 A JP2021570364 A JP 2021570364A JP 2021570364 A JP2021570364 A JP 2021570364A JP 2022535745 A5 JP2022535745 A5 JP 2022535745A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- percent
- codon
- viral vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855506P | 2019-05-31 | 2019-05-31 | |
| US62/855,506 | 2019-05-31 | ||
| PCT/US2020/035584 WO2020243717A1 (en) | 2019-05-31 | 2020-06-01 | Optimized phenylalanine hydroxylase expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022535745A JP2022535745A (ja) | 2022-08-10 |
| JP2022535745A5 true JP2022535745A5 (enExample) | 2023-06-08 |
Family
ID=73553945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570364A Pending JP2022535745A (ja) | 2019-05-31 | 2020-06-01 | 最適化されたフェニルアラニンヒドロキシラーゼ発現 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220162643A1 (enExample) |
| EP (1) | EP3976076A4 (enExample) |
| JP (1) | JP2022535745A (enExample) |
| KR (1) | KR20220068954A (enExample) |
| CN (1) | CN113905768A (enExample) |
| AU (1) | AU2020283069A1 (enExample) |
| BR (1) | BR112021024124A2 (enExample) |
| CA (1) | CA3137698A1 (enExample) |
| IL (1) | IL288400A (enExample) |
| WO (1) | WO2020243717A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| CN116064678A (zh) | 2016-01-15 | 2023-05-05 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| WO2017139065A1 (en) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Hiv vaccination and immunotherapy |
| WO2017156311A2 (en) | 2016-03-09 | 2017-09-14 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | SYSTEM FOR THE NON-INTEGRAL VIRAL ISSUE AND PROCEDURE RELATING TO IT |
| AU2017292582C1 (en) | 2016-07-08 | 2021-11-11 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| EP3487507A4 (en) | 2016-07-21 | 2020-04-08 | American Gene Technologies International, Inc. | VIRAL VECTORS FOR THE TREATMENT OF PARKINSON'S DISEASE |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| JP2020524996A (ja) | 2017-06-16 | 2020-08-27 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物 |
| US11939601B2 (en) | 2017-11-22 | 2024-03-26 | Modernatx, Inc. | Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria |
| EP4214309A4 (en) * | 2020-09-16 | 2025-07-16 | Generation Bio Co | CLOSED-END DNA VECTORS AND RELATED USES FOR EXPRESSING PHENYLALANINE HYDROXYLASE (PAH) |
| MX2024003186A (es) * | 2021-09-16 | 2024-04-23 | Generation Bio Co | Casetes de expresión específicos del hígado, vectores y usos de estos para expresar proteínas terapéuticas. |
| CN115772503B (zh) * | 2022-08-16 | 2023-10-17 | 广东省南山医药创新研究院 | 一种表达pah的基因修饰细胞药物及其制备方法与应用 |
| WO2025064507A1 (en) * | 2023-09-19 | 2025-03-27 | Poseida Therapeutics, Inc. | Compositions and methods for integration of viral vectors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013151665A2 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| JP6506749B2 (ja) * | 2013-10-22 | 2019-04-24 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | フェニルケトン尿症のためのｍＲＮＡ療法 |
| EP3283126B1 (en) * | 2015-04-16 | 2019-11-06 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
| US20180363000A1 (en) * | 2015-12-14 | 2018-12-20 | The Trustees Of The University Of Pennsylvania | Aav-anti pcsk9 antibody constructs and uses thereof |
| EP3825400B1 (en) * | 2016-04-08 | 2024-12-25 | Translate Bio, Inc. | Multimeric coding nucleic acid and uses thereof |
| KR102738752B1 (ko) * | 2016-12-30 | 2024-12-06 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 페닐케톤뇨증을 치료하기 위한 유전자 치료 |
| US11820999B2 (en) * | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| CA3077355A1 (en) * | 2017-10-02 | 2019-04-11 | American Gene Technologies International Inc. | Vectors with promoter and enhancer combinations for treating phenylketonuria |
-
2020
- 2020-06-01 BR BR112021024124A patent/BR112021024124A2/pt unknown
- 2020-06-01 JP JP2021570364A patent/JP2022535745A/ja active Pending
- 2020-06-01 US US17/610,111 patent/US20220162643A1/en active Pending
- 2020-06-01 CA CA3137698A patent/CA3137698A1/en active Pending
- 2020-06-01 CN CN202080040373.5A patent/CN113905768A/zh active Pending
- 2020-06-01 EP EP20814445.1A patent/EP3976076A4/en active Pending
- 2020-06-01 AU AU2020283069A patent/AU2020283069A1/en not_active Abandoned
- 2020-06-01 KR KR1020217042390A patent/KR20220068954A/ko active Pending
- 2020-06-01 WO PCT/US2020/035584 patent/WO2020243717A1/en not_active Ceased
-
2021
- 2021-11-25 IL IL288400A patent/IL288400A/en unknown