JP2023544683A5 - - Google Patents
Info
- Publication number
- JP2023544683A5 JP2023544683A5 JP2023515813A JP2023515813A JP2023544683A5 JP 2023544683 A5 JP2023544683 A5 JP 2023544683A5 JP 2023515813 A JP2023515813 A JP 2023515813A JP 2023515813 A JP2023515813 A JP 2023515813A JP 2023544683 A5 JP2023544683 A5 JP 2023544683A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- capsid protein
- muscle
- aav capsid
- terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20306005 | 2020-09-10 | ||
| EP20306005.8 | 2020-09-10 | ||
| PCT/EP2021/074964 WO2022053630A1 (en) | 2020-09-10 | 2021-09-10 | Peptide-modified aav capsid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023544683A JP2023544683A (ja) | 2023-10-25 |
| JP2023544683A5 true JP2023544683A5 (enExample) | 2024-09-19 |
| JP7834725B2 JP7834725B2 (ja) | 2026-03-24 |
Family
ID=72717827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023515813A Active JP7834725B2 (ja) | 2020-09-10 | 2021-09-10 | ペプチド改変されたａａｖカプシド |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240209030A1 (enExample) |
| EP (2) | EP4421179A3 (enExample) |
| JP (1) | JP7834725B2 (enExample) |
| CN (1) | CN116096431A (enExample) |
| CA (1) | CA3193128A1 (enExample) |
| DK (1) | DK4211231T3 (enExample) |
| ES (1) | ES2984259T3 (enExample) |
| FI (1) | FI4211231T3 (enExample) |
| PL (1) | PL4211231T3 (enExample) |
| PT (1) | PT4211231T (enExample) |
| WO (1) | WO2022053630A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12552838B2 (en) | 2020-04-20 | 2026-02-17 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| US20240165271A1 (en) | 2021-03-26 | 2024-05-23 | The Board Of Regents Of The University Of Texas System | Nucleotide editing to reframe dmd transcripts by base editing and prime editing |
| EP4381077A1 (en) | 2021-08-04 | 2024-06-12 | Genethon | Hybrid promoters for gene expression in muscles and in the cns |
| EP4504952A4 (en) * | 2022-04-07 | 2026-04-08 | Kate Therapeutics Inc | COMPOSITIONS AND METHODS FOR MUSCULAR DISORDERS |
| CN116925192B (zh) * | 2022-04-12 | 2025-04-29 | 合肥星眸生物科技有限公司 | 一种融合型腺相关病毒及其应用 |
| WO2023237731A1 (en) | 2022-06-09 | 2023-12-14 | Genethon | N-terminal truncated gde for the treatment of glycogen storage disease iii |
| ES3057171T3 (en) | 2022-06-10 | 2026-02-26 | Genethon | Peptide-modified aav capsid with enhanced muscle transduction efficiency |
| CN120112308A (zh) | 2022-10-07 | 2025-06-06 | 吉尼松公司 | 使用抗fap car-t细胞免疫治疗骨骼肌病 |
| EP4609882A1 (en) * | 2022-10-12 | 2025-09-03 | CPC Corporation | Gene introduction method, gene therapy method, and tissue regeneration method |
| EP4677073A1 (en) | 2023-03-10 | 2026-01-14 | Genethon | Induction of immune tolerance by aav vector comprising the combination of a liver detargeted capsid and a tandem liver-muscle specific promoter |
| WO2024191778A1 (en) | 2023-03-10 | 2024-09-19 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| CN121420060A (zh) | 2023-06-29 | 2026-01-27 | 吉尼松公司 | 用于治疗糖原贮积病iii的n-端截短的糖原脱支酶 |
| WO2025048709A1 (en) * | 2023-08-25 | 2025-03-06 | Agency For Science, Technology And Research | Composition and methods for identification of novel aav variants for differentiated gene delivery to cardiomyoctes and/or skeletal myofibers |
| WO2025133247A1 (en) | 2023-12-21 | 2025-06-26 | Genethon | Methods for aav vector re-administration |
| WO2025165162A1 (ko) * | 2024-02-01 | 2025-08-07 | 주식회사 글루진테라퓨틱스 | 평활근 세포 특이적 유전자 전달이 가능한 아데노연관바이러스 벡터 |
| TW202545971A (zh) | 2024-02-08 | 2025-12-01 | 美商戴諾治療公司 | 殼體多肽及其使用方法 |
| WO2026017727A1 (en) | 2024-07-16 | 2026-01-22 | Genethon | Alternative barcoding method to assess transduction efficiency of aav vectors |
| CN119751599B (zh) * | 2024-07-16 | 2025-08-19 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| WO2026064442A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2026064428A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2026064444A1 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1222673A1 (zh) * | 2013-07-12 | 2017-07-07 | The Children's Hospital Of Philadelphia | Aav载体和用於抗aav(腺相关病毒)中和抗体的检测 |
| IL305149A (en) * | 2016-07-26 | 2023-10-01 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| MA51353B1 (fr) | 2018-04-05 | 2022-09-30 | Univ Sorbonne | Sérotype du virus adéno-associé recombinant hybride entre aav9 et aavrh74 possédant un tropisme hépatique réduit |
| US20210363193A1 (en) * | 2018-04-27 | 2021-11-25 | Universität Heidelberg | Modified aav capsid polypeptides for treatment of muscular diseases |
-
2021
- 2021-09-10 EP EP24183857.2A patent/EP4421179A3/en not_active Withdrawn
- 2021-09-10 EP EP21777271.4A patent/EP4211231B1/en active Active
- 2021-09-10 WO PCT/EP2021/074964 patent/WO2022053630A1/en not_active Ceased
- 2021-09-10 CA CA3193128A patent/CA3193128A1/en active Pending
- 2021-09-10 PT PT217772714T patent/PT4211231T/pt unknown
- 2021-09-10 DK DK21777271.4T patent/DK4211231T3/da active
- 2021-09-10 CN CN202180055064.XA patent/CN116096431A/zh active Pending
- 2021-09-10 JP JP2023515813A patent/JP7834725B2/ja active Active
- 2021-09-10 US US18/024,103 patent/US20240209030A1/en active Pending
- 2021-09-10 PL PL21777271.4T patent/PL4211231T3/pl unknown
- 2021-09-10 ES ES21777271T patent/ES2984259T3/es active Active
- 2021-09-10 FI FIEP21777271.4T patent/FI4211231T3/fi active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023544683A5 (enExample) | ||
| FI4211231T3 (fi) | Peptidimodifioitu aav-kapsidi | |
| JP2021520203A5 (enExample) | ||
| JP7707261B2 (ja) | 筋疾患の治療のための改変ａａｖカプシドポリペプチド | |
| CN114127089A (zh) | 重组腺相关病毒及其用途 | |
| JP2020534788A5 (enExample) | ||
| WO2019169144A1 (en) | A modular system for gene and protein delivery based on aav | |
| US20230049066A1 (en) | Novel aav3b variants that target human hepatocytes in the liver of humanized mice | |
| FI4536686T3 (fi) | Lihaksen parannetun transduktiotehokkuuden omaava peptidimodifioitu aav-kapsidi | |
| JP2022531861A5 (enExample) | ||
| JP2023535620A5 (enExample) | ||
| KR20220004072A (ko) | 뇌에 지향성을 가지는 aav 돌연변이체 | |
| JP2023534037A5 (enExample) | ||
| RU2019126509A (ru) | Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе | |
| CN114276419B (zh) | 肌肉高亲和性的新型腺相关病毒衣壳蛋白及其应用 | |
| CN118108810A (zh) | 一种靶向骨骼肌的重组腺相关病毒及其应用 | |
| JP2024503091A5 (enExample) | ||
| CN113121651B (zh) | 低中和抗体腺相关病毒衣壳蛋白 | |
| CN113121654B (zh) | 腺相关病毒衣壳蛋白及包含其的腺相关病毒载体 | |
| US20240335506A1 (en) | Aqp1 gene therapy to prevent radiation induced salivary hypofunction | |
| WO2024184781A1 (en) | Engineered aav capsids | |
| CN112961220B (zh) | 腺相关病毒衣壳蛋白及包含其的腺相关病毒载体 | |
| CN117003833A (zh) | 肝脏特异性的腺相关病毒血清型及应用 | |
| RU2020136195A (ru) | РЕКОМБИНАНТНЫЙ АДЕНОАССОЦИИРОВАННЫЙ ВИРУС, ЯВЛЯЮЩИЙСЯ ГИБРИДОМ СЕРОТИПОВ AAV9 И AAVrh74, С ПОНИЖЕННЫМ ТРОПИЗМОМ К ПЕЧЕНОЧНОЙ ТКАНИ | |
| US20260091140A1 (en) | Gene therapy for foxg1 syndrome |