|
DE1620508A1
(de)
|
1965-07-23 |
1969-09-18 |
Thomae Gmbh Dr K |
Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
|
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US3948903A
(en)
|
1972-12-15 |
1976-04-06 |
Parke, Davis & Company |
Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
EP0102324A3
(de)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipide und Tenside in wässriger Phase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
GB8610530D0
(en)
|
1986-04-30 |
1986-06-04 |
Fbc Ltd |
Herbicides
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5112596A
(en)
|
1990-04-23 |
1992-05-12 |
Alkermes, Inc. |
Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
|
|
US5268164A
(en)
|
1990-04-23 |
1993-12-07 |
Alkermes, Inc. |
Increasing blood-brain barrier permeability with permeabilizer peptides
|
|
ATE191853T1
(de)
|
1992-07-27 |
2000-05-15 |
Us Health |
Zielgerichte liposome zur blut-hirne schranke
|
|
US6080772A
(en)
|
1995-06-07 |
2000-06-27 |
Sugen, Inc. |
Thiazole compounds and methods of modulating signal transduction
|
|
CA2293400A1
(en)
|
1997-06-13 |
1998-12-17 |
Gerald Mcmahon |
Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction
|
|
WO2001058869A2
(en)
|
2000-02-11 |
2001-08-16 |
Bristol-Myers Squibb Company |
Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
|
|
US6514221B2
(en)
|
2000-07-27 |
2003-02-04 |
Brigham And Women's Hospital, Inc. |
Blood-brain barrier opening
|
|
US20020065259A1
(en)
|
2000-08-30 |
2002-05-30 |
Schatzberg Alan F. |
Glucocorticoid blocking agents for increasing blood-brain barrier permeability
|
|
US7034036B2
(en)
|
2000-10-30 |
2006-04-25 |
Pain Therapeutics, Inc. |
Inhibitors of ABC drug transporters at the blood-brain barrier
|
|
DE10121982B4
(de)
|
2001-05-05 |
2008-01-24 |
Lts Lohmann Therapie-Systeme Ag |
Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
|
|
AU2002322720B2
(en)
|
2001-07-25 |
2008-11-13 |
Raptor Pharmaceutical Inc. |
Compositions and methods for modulating blood-brain barrier transport
|
|
US20030162695A1
(en)
|
2002-02-27 |
2003-08-28 |
Schatzberg Alan F. |
Glucocorticoid blocking agents for increasing blood-brain barrier permeability
|
|
EP1572113B1
(en)
|
2002-08-26 |
2017-05-17 |
Takeda Pharmaceutical Company Limited |
Calcium receptor modulating compound and use thereof
|
|
JP4995423B2
(ja)
|
2002-12-03 |
2012-08-08 |
ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート |
物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア
|
|
JP2006526015A
(ja)
|
2003-05-02 |
2006-11-16 |
エラン ファーマシューティカルズ,インコーポレイテッド |
炎症疾患治療のためのブラジキニンb1受容体アンタゴニストとしての4−ブロモ−5−(2−クロロ−ベンゾイルアミノ)−1h−ピラゾール−3−カルボン酸アミド誘導体および関連化合物
|
|
JP2007505142A
(ja)
|
2003-09-10 |
2007-03-08 |
セダーズ−シナイ メディカル センター |
血液脳関門を通過する薬剤のカリウムチャネル媒介性送達
|
|
EP2083009A1
(de)
|
2008-01-22 |
2009-07-29 |
Grünenthal GmbH |
Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
|
|
MX2014005285A
(es)
|
2011-11-03 |
2014-05-30 |
Hoffmann La Roche |
Compuestos biciclicos de piperazina.
|
|
CN104271566B
(zh)
|
2012-05-22 |
2017-05-31 |
霍夫曼-拉罗奇有限公司 |
取代的联吡啶胺及其用途
|
|
JP6199991B2
(ja)
|
2013-01-18 |
2017-09-20 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
3置換ピラゾール及びdlk阻害剤としての使用
|
|
TWI637951B
(zh)
|
2013-02-15 |
2018-10-11 |
英商葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之雜環醯胺類
|
|
JP6523251B2
(ja)
|
2013-05-01 |
2019-05-29 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
C−結合ヘテロシクロアルキル置換ピリミジン類及びそれらの用途
|
|
AR096151A1
(es)
|
2013-05-01 |
2015-12-09 |
Hoffmann La Roche |
Compuestos de biheteroarilo y usos de los mismos
|
|
CN105473554B
(zh)
|
2013-07-10 |
2019-08-13 |
沃泰克斯药物股份有限公司 |
作为离子通道调节剂的稠合的哌啶酰胺类
|
|
MX2016008110A
(es)
|
2013-12-20 |
2016-08-19 |
Hoffmann La Roche |
Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos.
|
|
EA032357B1
(ru)
|
2014-03-26 |
2019-05-31 |
Ф. Хоффманн-Ля Рош Аг |
Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
|
|
CN106573006A
(zh)
|
2014-08-21 |
2017-04-19 |
葛兰素史密斯克莱知识产权发展有限公司 |
作为药物的rip1激酶抑制剂杂环酰胺
|
|
CN107406462B
(zh)
|
2015-03-09 |
2020-11-10 |
豪夫迈·罗氏有限公司 |
三环dlk抑制剂及其用途
|
|
TWI730959B
(zh)
*
|
2015-05-19 |
2021-06-21 |
英商葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之雜環醯胺
|
|
EP3317269B1
(en)
*
|
2015-07-02 |
2022-09-21 |
F. Hoffmann-La Roche AG |
Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases
|
|
WO2017096301A1
(en)
*
|
2015-12-04 |
2017-06-08 |
Denali Therapeutics Inc. |
Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (ripk 1)
|
|
US10961258B2
(en)
|
2015-12-21 |
2021-03-30 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides as kinase inhibitors
|
|
IL287136B2
(en)
|
2016-02-05 |
2023-09-01 |
Denali Therapeutics Inc |
Receptor inhibitors - interacting with protein kinase 1
|
|
CN110267949A
(zh)
*
|
2016-11-08 |
2019-09-20 |
塞科里昂医疗股份有限公司 |
sGC刺激剂
|
|
US11071721B2
(en)
|
2016-12-02 |
2021-07-27 |
Genentech, Inc. |
Bicyclic amide compounds and methods of use thereof
|
|
US11072607B2
(en)
*
|
2016-12-16 |
2021-07-27 |
Genentech, Inc. |
Inhibitors of RIP1 kinase and methods of use thereof
|
|
BR112020000771A2
(pt)
*
|
2017-07-14 |
2020-07-14 |
F. Hoffmann-La Roche Ag |
compostos de cetona bicíclica e métodos de uso dos mesmos
|
|
RU2020114670A
(ru)
*
|
2017-10-11 |
2021-11-12 |
Ф. Хоффманн-Ля Рош Аг |
Бициклические соединения для применения в качестве ингибиторов rip1 киназы
|
|
AR113811A1
(es)
|
2017-10-31 |
2020-06-10 |
Hoffmann La Roche |
Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos
|