|
DE1620508A1
(de)
|
1965-07-23 |
1969-09-18 |
Thomae Gmbh Dr K |
Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
|
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US3948903A
(en)
|
1972-12-15 |
1976-04-06 |
Parke, Davis & Company |
Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
EP0102324A3
(de)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipide und Tenside in wässriger Phase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
GB8610530D0
(en)
|
1986-04-30 |
1986-06-04 |
Fbc Ltd |
Herbicides
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5112596A
(en)
|
1990-04-23 |
1992-05-12 |
Alkermes, Inc. |
Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
|
|
US5268164A
(en)
|
1990-04-23 |
1993-12-07 |
Alkermes, Inc. |
Increasing blood-brain barrier permeability with permeabilizer peptides
|
|
ATE191853T1
(de)
|
1992-07-27 |
2000-05-15 |
Us Health |
Zielgerichte liposome zur blut-hirne schranke
|
|
US6080772A
(en)
|
1995-06-07 |
2000-06-27 |
Sugen, Inc. |
Thiazole compounds and methods of modulating signal transduction
|
|
EP1007042A4
(en)
|
1997-06-13 |
2001-07-04 |
Sugen Inc |
NEW HETEROCYCLIC COMPOUNDS FOR MODULATING THE PROTEIN-TYROSIN-ENZYME-RELATED CELLULAR SIGNAL TRANSDUCTION
|
|
WO2001058869A2
(en)
|
2000-02-11 |
2001-08-16 |
Bristol-Myers Squibb Company |
Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
|
|
US6514221B2
(en)
|
2000-07-27 |
2003-02-04 |
Brigham And Women's Hospital, Inc. |
Blood-brain barrier opening
|
|
US20020065259A1
(en)
|
2000-08-30 |
2002-05-30 |
Schatzberg Alan F. |
Glucocorticoid blocking agents for increasing blood-brain barrier permeability
|
|
US7034036B2
(en)
|
2000-10-30 |
2006-04-25 |
Pain Therapeutics, Inc. |
Inhibitors of ABC drug transporters at the blood-brain barrier
|
|
DE10121982B4
(de)
|
2001-05-05 |
2008-01-24 |
Lts Lohmann Therapie-Systeme Ag |
Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
|
|
JP4202250B2
(ja)
|
2001-07-25 |
2008-12-24 |
バイオマリン ファーマシューティカル インコーポレイテッド |
血液脳関門輸送を調節するための組成物および方法
|
|
US20030162695A1
(en)
|
2002-02-27 |
2003-08-28 |
Schatzberg Alan F. |
Glucocorticoid blocking agents for increasing blood-brain barrier permeability
|
|
KR101050700B1
(ko)
|
2002-08-26 |
2011-07-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
칼슘 수용체 조절 화합물 및 이의 용도
|
|
CN101284136A
(zh)
|
2002-12-03 |
2008-10-15 |
布朗歇特洛克菲勒神经科学研究所 |
传输物质穿过血脑屏障的人工低密度脂蛋白载体
|
|
ATE410161T1
(de)
|
2003-05-02 |
2008-10-15 |
Elan Pharm Inc |
4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
|
|
US20050089473A1
(en)
|
2003-09-10 |
2005-04-28 |
Cedars-Sinai Medical Center |
Potassium channel mediated delivery of agents through the blood-brain barrier
|
|
EP2083009A1
(de)
|
2008-01-22 |
2009-07-29 |
Grünenthal GmbH |
Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
|
|
RU2628616C2
(ru)
|
2011-11-03 |
2017-08-21 |
Ф. Хоффманн-Ля Рош Аг |
Бициклические соединения пиперазина
|
|
EP2852584B1
(en)
|
2012-05-22 |
2018-02-28 |
F. Hoffmann-La Roche AG |
Substituted dipyridylamines and uses thereof
|
|
CA2896187A1
(en)
|
2013-01-18 |
2014-07-24 |
F. Hoffmann-La Roche Ag |
3-substituted pyrazoles and use as dlk inhibitors
|
|
TWI648274B
(zh)
|
2013-02-15 |
2019-01-21 |
英商葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之雜環醯胺類 （二）
|
|
PH12019502378A1
(en)
|
2013-05-01 |
2022-05-11 |
Hoffmann La Roche |
Biheteroaryl compounds and uses thereof
|
|
CA2907912A1
(en)
|
2013-05-01 |
2014-11-06 |
F. Hoffmann-La Roche Ag |
C-linked heterocycloalkyl substituted pyrimidines and their uses
|
|
WO2015006280A1
(en)
|
2013-07-10 |
2015-01-15 |
Vertex Pharmaceuticals Incorporated |
Fused piperidine amides as modulators of ion channels
|
|
MX2016008110A
(es)
|
2013-12-20 |
2016-08-19 |
Hoffmann La Roche |
Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos.
|
|
WO2015144609A1
(en)
|
2014-03-26 |
2015-10-01 |
F. Hoffmann-La Roche Ag |
Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
|
|
RU2017109122A
(ru)
|
2014-08-21 |
2018-09-21 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
Способы лечения с использованием гетероциклических амидов в качестве ингибиторов киназы
|
|
WO2016142310A1
(en)
|
2015-03-09 |
2016-09-15 |
F. Hoffmann-La Roche Ag |
Tricyclic dlk inhibitors and uses thereof
|
|
TWI730959B
(zh)
|
2015-05-19 |
2021-06-21 |
英商葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之雜環醯胺
|
|
TWI763630B
(zh)
*
|
2015-07-02 |
2022-05-11 |
瑞士商赫孚孟拉羅股份公司 |
雙環內醯胺及其使用方法
|
|
CN108602809B
(zh)
*
|
2015-12-04 |
2022-09-30 |
戴纳立制药公司 |
异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂
|
|
WO2017109724A1
(en)
|
2015-12-21 |
2017-06-29 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides as kinase inhibitors
|
|
MA44007A
(fr)
|
2016-02-05 |
2018-12-19 |
Denali Therapeutics Inc |
Inhibiteurs du récepteur interagissant avec protéine kinase 1
|
|
US11180493B2
(en)
*
|
2016-11-08 |
2021-11-23 |
Cyclerion Therapeutics, Inc. |
SGC stimulators
|
|
US11071721B2
(en)
|
2016-12-02 |
2021-07-27 |
Genentech, Inc. |
Bicyclic amide compounds and methods of use thereof
|
|
US11072607B2
(en)
*
|
2016-12-16 |
2021-07-27 |
Genentech, Inc. |
Inhibitors of RIP1 kinase and methods of use thereof
|
|
US11098058B2
(en)
*
|
2017-07-14 |
2021-08-24 |
Genentech, Inc. |
Bicyclic ketone compounds and methods of use thereof
|
|
PE20211246A1
(es)
*
|
2017-10-11 |
2021-07-13 |
Hoffmann La Roche |
Compuestos biciclicos para su uso como inhibidores de rip1 quinasa
|
|
SG11202002877RA
(en)
|
2017-10-31 |
2020-04-29 |
Hoffmann La Roche |
Bicyclic sulfones and sulfoxides and methods of use thereof
|