JP2022516651A5 - - Google Patents

Info

Publication number
JP2022516651A5
JP2022516651A5 JP2021539523A JP2021539523A JP2022516651A5 JP 2022516651 A5 JP2022516651 A5 JP 2022516651A5 JP 2021539523 A JP2021539523 A JP 2021539523A JP 2021539523 A JP2021539523 A JP 2021539523A JP 2022516651 A5 JP2022516651 A5 JP 2022516651A5
Authority
JP
Japan
Prior art keywords
disease
disorder
pyrrolo
triazole
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021539523A
Other languages
English (en)
Japanese (ja)
Other versions
JP7585205B2 (ja
JP2022516651A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/012908 external-priority patent/WO2020146615A1/en
Publication of JP2022516651A publication Critical patent/JP2022516651A/ja
Publication of JP2022516651A5 publication Critical patent/JP2022516651A5/ja
Application granted granted Critical
Publication of JP7585205B2 publication Critical patent/JP7585205B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021539523A 2019-01-11 2020-01-09 二環式ピロロトリアゾールケトン化合物及びその使用方法 Active JP7585205B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962791118P 2019-01-11 2019-01-11
US62/791,118 2019-01-11
PCT/US2020/012908 WO2020146615A1 (en) 2019-01-11 2020-01-09 Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2022516651A JP2022516651A (ja) 2022-03-01
JP2022516651A5 true JP2022516651A5 (https=) 2023-01-19
JP7585205B2 JP7585205B2 (ja) 2024-11-18

Family

ID=69528972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021539523A Active JP7585205B2 (ja) 2019-01-11 2020-01-09 二環式ピロロトリアゾールケトン化合物及びその使用方法

Country Status (7)

Country Link
US (2) US12344612B2 (https=)
EP (1) EP3908586B1 (https=)
JP (1) JP7585205B2 (https=)
CN (1) CN113302193A (https=)
AR (1) AR119673A1 (https=)
TW (1) TW202043229A (https=)
WO (1) WO2020146615A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL307250A (en) * 2021-04-02 2023-11-01 Hoffmann La Roche Processes for preparing bicyclic ketone compounds
CA3256884A1 (en) 2022-05-19 2023-11-23 Merck Sharp & Dohme Llc RIPK1 INHIBITORS AND METHODS OF USE

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620508A1 (de) 1965-07-23 1969-09-18 Thomae Gmbh Dr K Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3948903A (en) 1972-12-15 1976-04-06 Parke, Davis & Company Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
GB8610530D0 (en) 1986-04-30 1986-06-04 Fbc Ltd Herbicides
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
ATE191853T1 (de) 1992-07-27 2000-05-15 Us Health Zielgerichte liposome zur blut-hirne schranke
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
CA2293400A1 (en) 1997-06-13 1998-12-17 Gerald Mcmahon Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction
WO2001058869A2 (en) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
US6514221B2 (en) 2000-07-27 2003-02-04 Brigham And Women's Hospital, Inc. Blood-brain barrier opening
US20020065259A1 (en) 2000-08-30 2002-05-30 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
US7034036B2 (en) 2000-10-30 2006-04-25 Pain Therapeutics, Inc. Inhibitors of ABC drug transporters at the blood-brain barrier
DE10121982B4 (de) 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20030162695A1 (en) 2002-02-27 2003-08-28 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
EP1572113B1 (en) 2002-08-26 2017-05-17 Takeda Pharmaceutical Company Limited Calcium receptor modulating compound and use thereof
JP4995423B2 (ja) 2002-12-03 2012-08-08 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア
JP2006526015A (ja) 2003-05-02 2006-11-16 エラン ファーマシューティカルズ,インコーポレイテッド 炎症疾患治療のためのブラジキニンb1受容体アンタゴニストとしての4−ブロモ−5−(2−クロロ−ベンゾイルアミノ)−1h−ピラゾール−3−カルボン酸アミド誘導体および関連化合物
JP2007505142A (ja) 2003-09-10 2007-03-08 セダーズ−シナイ メディカル センター 血液脳関門を通過する薬剤のカリウムチャネル媒介性送達
EP2083009A1 (de) 2008-01-22 2009-07-29 Grünenthal GmbH Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
MX2014005285A (es) 2011-11-03 2014-05-30 Hoffmann La Roche Compuestos biciclicos de piperazina.
CN104271566B (zh) 2012-05-22 2017-05-31 霍夫曼-拉罗奇有限公司 取代的联吡啶胺及其用途
JP6199991B2 (ja) 2013-01-18 2017-09-20 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 3置換ピラゾール及びdlk阻害剤としての使用
TWI637951B (zh) 2013-02-15 2018-10-11 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類
JP6523251B2 (ja) 2013-05-01 2019-05-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft C−結合ヘテロシクロアルキル置換ピリミジン類及びそれらの用途
AR096151A1 (es) 2013-05-01 2015-12-09 Hoffmann La Roche Compuestos de biheteroarilo y usos de los mismos
CN105473554B (zh) 2013-07-10 2019-08-13 沃泰克斯药物股份有限公司 作为离子通道调节剂的稠合的哌啶酰胺类
MX2016008110A (es) 2013-12-20 2016-08-19 Hoffmann La Roche Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos.
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
CN106573006A (zh) 2014-08-21 2017-04-19 葛兰素史密斯克莱知识产权发展有限公司 作为药物的rip1激酶抑制剂杂环酰胺
CN107406462B (zh) 2015-03-09 2020-11-10 豪夫迈·罗氏有限公司 三环dlk抑制剂及其用途
TWI730959B (zh) * 2015-05-19 2021-06-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺
EP3317269B1 (en) * 2015-07-02 2022-09-21 F. Hoffmann-La Roche AG Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases
WO2017096301A1 (en) * 2015-12-04 2017-06-08 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (ripk 1)
US10961258B2 (en) 2015-12-21 2021-03-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
IL287136B2 (en) 2016-02-05 2023-09-01 Denali Therapeutics Inc Receptor inhibitors - interacting with protein kinase 1
CN110267949A (zh) * 2016-11-08 2019-09-20 塞科里昂医疗股份有限公司 sGC刺激剂
US11071721B2 (en) 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
US11072607B2 (en) * 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
BR112020000771A2 (pt) * 2017-07-14 2020-07-14 F. Hoffmann-La Roche Ag compostos de cetona bicíclica e métodos de uso dos mesmos
RU2020114670A (ru) * 2017-10-11 2021-11-12 Ф. Хоффманн-Ля Рош Аг Бициклические соединения для применения в качестве ингибиторов rip1 киназы
AR113811A1 (es) 2017-10-31 2020-06-10 Hoffmann La Roche Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos

Similar Documents

Publication Publication Date Title
JP7642098B2 (ja) カルボキシ-ベンズイミダゾールglp-1r調節化合物
JP7010935B2 (ja) Usp30の阻害剤としての活性を有するシアノ置換ヘテロ環
AU2018202148B2 (en) Substituted pyridine and pyrazine compounds as PDE4 inhibitors
JP6964576B2 (ja) 置換4−アザインドール及びglun2b受容体調節因子としてのそれらの使用
JP4814783B2 (ja) ピラゾロピリジン誘導体
JP7558334B2 (ja) PI3K-γ阻害剤としてのアミノピラジンジオール化合物
CN105764514B (zh) 作为tam族激酶抑制剂的氨基吡啶衍生物
AU2002366388B2 (en) Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
US20210253596A1 (en) Sulfonimidamide compounds as inhibitors of interleukin-1 activity
JP2021532124A (ja) Nlrp3インフラマソーム阻害剤
US9839629B2 (en) Inhibitors of the renal outer medullary potassium channel
JP7029388B2 (ja) 抗がん活性を有するmdm2-p53相互作用のイソインドリノン阻害剤
KR102616949B1 (ko) 고리형 구조를 갖는 화합물
JP2016523911A5 (https=)
JP2017193592A5 (https=)
JP6662846B2 (ja) 6,7−ジヒドロピラゾロ[1,5−a]ピラジン−4(5H)−オン化合物およびMGLUR2受容体の負のアロステリック調節因子としてのそれらの使用
JP2020526549A5 (https=)
RU2019132212A (ru) Селективные ингибиторы hdac6
JP2009510043A5 (https=)
CN105530932A (zh) 作为bik抑制剂的伯甲酰胺
US20160045505A1 (en) Compounds and compositions for the treatment of parasitic diseases
JP6661605B2 (ja) 6,7−ジヒドロピラゾロ[1,5−a]ピラジン−4(5H)−オン化合物およびMGLUR2受容体の負のアロステリック調節因子としてのそれらの使用
AU2004227833A1 (en) Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5
US9090632B2 (en) Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors
JP2020520925A5 (https=)