CN113302193A - 双环吡咯并三唑酮化合物及其使用方法 - Google Patents

双环吡咯并三唑酮化合物及其使用方法 Download PDF

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Publication number
CN113302193A
CN113302193A CN202080008933.9A CN202080008933A CN113302193A CN 113302193 A CN113302193 A CN 113302193A CN 202080008933 A CN202080008933 A CN 202080008933A CN 113302193 A CN113302193 A CN 113302193A
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Prior art keywords
disease
compound
pharmaceutically acceptable
fluoro
acceptable salt
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CN202080008933.9A
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English (en)
Chinese (zh)
Inventor
S·帕特尔
G·汉密尔顿
赵桂玲
陈慧芬
B·达涅尔斯
C·斯蒂瓦拉
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN113302193A publication Critical patent/CN113302193A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080008933.9A 2019-01-11 2020-01-09 双环吡咯并三唑酮化合物及其使用方法 Pending CN113302193A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962791118P 2019-01-11 2019-01-11
US62/791,118 2019-01-11
PCT/US2020/012908 WO2020146615A1 (en) 2019-01-11 2020-01-09 Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
CN113302193A true CN113302193A (zh) 2021-08-24

Family

ID=69528972

Family Applications (1)

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CN202080008933.9A Pending CN113302193A (zh) 2019-01-11 2020-01-09 双环吡咯并三唑酮化合物及其使用方法

Country Status (7)

Country Link
US (2) US12344612B2 (https=)
EP (1) EP3908586B1 (https=)
JP (1) JP7585205B2 (https=)
CN (1) CN113302193A (https=)
AR (1) AR119673A1 (https=)
TW (1) TW202043229A (https=)
WO (1) WO2020146615A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL307250A (en) * 2021-04-02 2023-11-01 Hoffmann La Roche Processes for preparing bicyclic ketone compounds
CA3256884A1 (en) 2022-05-19 2023-11-23 Merck Sharp & Dohme Llc RIPK1 INHIBITORS AND METHODS OF USE

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US20250282788A1 (en) 2025-09-11
US12344612B2 (en) 2025-07-01
JP7585205B2 (ja) 2024-11-18
AR119673A1 (es) 2022-01-05
EP3908586A1 (en) 2021-11-17
US20210340151A1 (en) 2021-11-04
EP3908586B1 (en) 2022-12-21
TW202043229A (zh) 2020-12-01
WO2020146615A1 (en) 2020-07-16
JP2022516651A (ja) 2022-03-01

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