|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US20070258987A1
(en)
|
2000-11-28 |
2007-11-08 |
Seattle Genetics, Inc. |
Recombinant Anti-Cd30 Antibodies and Uses Thereof
|
|
AR048098A1
(es)
|
2004-03-15 |
2006-03-29 |
Wyeth Corp |
Conjugados de caliqueamicina
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
JP2008521828A
(ja)
|
2004-11-29 |
2008-06-26 |
シアトル ジェネティックス， インコーポレイテッド |
操作された抗体およびイムノコンジュゲート
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
WO2008122039A2
(en)
|
2007-04-02 |
2008-10-09 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Selenocysteine mediated hybrid antibody molecules
|
|
WO2008138561A1
(en)
|
2007-05-10 |
2008-11-20 |
R & D Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
EP2167963B1
(en)
|
2007-05-23 |
2019-04-17 |
Ventana Medical Systems, Inc. |
Polymeric carriers for immunohistochemistry and in situ hybridization
|
|
EP2181101A2
(en)
|
2007-07-20 |
2010-05-05 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Tubulysin d analogues
|
|
US8476451B2
(en)
|
2007-07-20 |
2013-07-02 |
The Regents Of The University Of California |
Tubulysin D analogues
|
|
CN101909441B
(zh)
|
2007-10-25 |
2015-05-13 |
恩多塞特公司 |
微管蛋白抑制剂及其制备方法
|
|
SG189817A1
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Potent conjugates and hydrophilic linkers
|
|
EP2174947A1
(en)
|
2008-09-25 |
2010-04-14 |
Universität des Saarlandes |
Bioactive pre-tubulysins and use thereof
|
|
KR101000067B1
(ko)
|
2008-12-30 |
2010-12-10 |
엘지전자 주식회사 |
고효율 태양전지용 레이저 소성장치 및 고효율 태양전지 제조방법
|
|
IT1394860B1
(it)
*
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
SI2528625T1
(sl)
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
US20130244905A1
(en)
|
2010-07-06 |
2013-09-19 |
Ed Grabczyk |
Reporter for RNA Polymerase II Termination
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
CN110078789A
(zh)
|
2011-05-27 |
2019-08-02 |
Ambrx 公司 |
含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
BR112014009070B1
(pt)
|
2011-10-14 |
2021-11-23 |
Medimmune Limited |
Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
CN103997893B
(zh)
|
2011-10-14 |
2019-04-12 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
EP2751111B1
(en)
|
2011-10-14 |
2017-04-26 |
MedImmune Limited |
Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
CA2873112A1
(en)
|
2012-05-11 |
2013-11-14 |
Alexander Krantz |
Site-specific labeling and targeted delivery of proteins for the treatment of cancer
|
|
ES2781523T3
(es)
|
2012-07-12 |
2020-09-02 |
Hangzhou Dac Biotech Co Ltd |
Conjugados de moléculas de unión celular con agentes citotóxicos
|
|
CN105142672B
(zh)
|
2012-10-23 |
2019-04-05 |
西纳福克斯股份有限公司 |
经修饰的抗体、抗体-缀合物及其制备方法
|
|
LT2956173T
(lt)
|
2013-02-14 |
2017-06-26 |
Bristol-Myers Squibb Company |
Tubulizino junginiai, gavimo ir panaudojimo būdai
|
|
US20140249315A1
(en)
|
2013-03-01 |
2014-09-04 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
|
WO2014160360A1
(en)
|
2013-03-14 |
2014-10-02 |
Mersana Therapeutics Inc. |
Tubulysin compounds and conjugates thereof
|
|
GB201309807D0
(en)
|
2013-05-31 |
2013-07-17 |
Pharma Mar Sau |
Antibody drug conjugates
|
|
TWI641620B
(zh)
*
|
2013-08-21 |
2018-11-21 |
再生元醫藥公司 |
抗－ｐｒｌｒ抗體及其用途
|
|
KR102442906B1
(ko)
|
2013-12-19 |
2022-09-14 |
씨젠 인크. |
표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
|
|
WO2015113760A1
(en)
|
2014-01-28 |
2015-08-06 |
Tube Pharmaceuticals Gmbh |
Cytotoxic tubulysin compounds for conjugation
|
|
EA032203B1
(ru)
|
2014-04-11 |
2019-04-30 |
МЕДИММЬЮН ЭлЭлСи |
Производные тубулизина
|
|
FI3900742T3
(fi)
|
2014-09-11 |
2024-08-16 |
Seagen Inc |
Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen
|
|
TW201617081A
(zh)
|
2014-09-25 |
2016-05-16 |
安德賽特公司 |
以妥布賴森（Ｔｕｂｕｌｙｓｉｎ）結合物治療癌症之方法
|
|
US10077287B2
(en)
*
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
WO2016089879A1
(en)
|
2014-12-01 |
2016-06-09 |
Endocyte, Inc. |
Conjugates of garftase inhibitors
|
|
AU2015358532C1
(en)
|
2014-12-03 |
2020-10-29 |
Genentech, Inc. |
Quaternary amine compounds and antibody-drug conjugates thereof
|
|
US10808007B2
(en)
|
2015-02-25 |
2020-10-20 |
William Marsh Rice University |
Desacetoxytubulysin H and analogs thereof
|
|
CA2978304A1
(en)
|
2015-03-01 |
2016-09-09 |
Endocyte, Inc. |
Methods of treating cancer with a psma ligand-tubulysin compound
|
|
US20180110871A1
(en)
|
2015-04-17 |
2018-04-26 |
Endocyte, Inc. |
Dual disulfide drug conjugates
|
|
WO2017031209A1
(en)
|
2015-08-18 |
2017-02-23 |
Endocyte, Inc. |
Tubulysin analogs and methods
|
|
MY192146A
(en)
|
2015-11-10 |
2022-08-01 |
Medimmune Llc |
Binding molecules specific for asct2 and uses thereof
|
|
EP3411371A1
(en)
|
2016-02-01 |
2018-12-12 |
Pfizer Inc |
Tubulysin analogs and methods for their preparation
|
|
US11129910B2
(en)
|
2016-02-04 |
2021-09-28 |
Hangzhou Dac Biotech Co., Ltd. |
Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
|
|
EP3419670A2
(en)
|
2016-02-26 |
2019-01-02 |
Regeneron Pharmaceuticals, Inc. |
Optimized transglutaminase site-specific antibody conjugation
|
|
CN109069665A
(zh)
|
2016-05-10 |
2018-12-21 |
百时美施贵宝公司 |
具有增强的稳定性的微管溶素类似物的抗体-药物缀合物
|
|
TWI851531B
(zh)
|
2016-08-09 |
2024-08-11 |
美商思進公司 |
具有改善之生理化學性質之具自我穩定連接子之藥物結合物
|
|
MY199468A
(en)
|
2016-09-23 |
2023-10-31 |
Regeneron Pharma |
Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
|
|
US20180125992A1
(en)
*
|
2016-11-04 |
2018-05-10 |
Endocyte, Inc. |
Drug delivery conjugates of tertiary amine containing drugs
|
|
MX2020004691A
(es)
|
2017-11-07 |
2020-08-20 |
Regeneron Pharma |
Enlazadores hidrofilicos para conjugados anticuerpo-farmaco.
|
|
EP3621652A4
(en)
|
2017-12-31 |
2021-01-13 |
Hangzhou DAC Biotech Co, Ltd |
CONJUGATE OF ANALOGUE OF TUBULYSIN WITH BRANCHED LINKS
|
|
JP7590328B2
(ja)
|
2018-12-21 |
2024-11-26 |
レゲネロン ファーマシューティカルス，インコーポレーテッド |
ツブリシン及びタンパク質－ツブリシンコンジュゲート
|
|
CN114040781A
(zh)
|
2019-06-24 |
2022-02-11 |
杭州多禧生物科技有限公司 |
Tubulysin衍生物与细胞结合分子偶联物的制剂配方
|
|
KR20220148200A
(ko)
*
|
2020-02-28 |
2022-11-04 |
리제너론 파마슈티칼스 인코포레이티드 |
Her2에 결합하는 이중특이적 항원 결합 분자 및 이의 사용 방법
|
|
WO2021262910A2
(en)
|
2020-06-24 |
2021-12-30 |
Regeneron Pharmaceuticals, Inc. |
Tubulysins and protein-tubulysin conjugates
|
|
CA3190569A1
(en)
*
|
2020-10-22 |
2022-04-28 |
Christopher Daly |
Anti-fgfr2 antibodies and methods of use thereof
|