JP2025160318A5 - - Google Patents
Info
- Publication number
- JP2025160318A5 JP2025160318A5 JP2025123923A JP2025123923A JP2025160318A5 JP 2025160318 A5 JP2025160318 A5 JP 2025160318A5 JP 2025123923 A JP2025123923 A JP 2025123923A JP 2025123923 A JP2025123923 A JP 2025123923A JP 2025160318 A5 JP2025160318 A5 JP 2025160318A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutically acceptable
- polymorph
- stereoisomer
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110159956.6 | 2021-02-05 | ||
| CN202110159956 | 2021-02-05 | ||
| CN202110533304 | 2021-05-17 | ||
| CN202110533304.4 | 2021-05-17 | ||
| CN202110718245.8 | 2021-06-28 | ||
| CN202110718245 | 2021-06-28 | ||
| CN202110936768 | 2021-08-16 | ||
| CN202110936768.X | 2021-08-16 | ||
| CN202111355330.9 | 2021-11-16 | ||
| CN202111355330 | 2021-11-16 | ||
| PCT/CN2022/074328 WO2022166762A1 (zh) | 2021-02-05 | 2022-01-27 | 喜树碱类化合物及其制备方法和应用 |
| JP2023544762A JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Division JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025160318A JP2025160318A (ja) | 2025-10-22 |
| JP2025160318A5 true JP2025160318A5 (https=) | 2026-02-24 |
Family
ID=82741966
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Active JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
| JP2025123923A Pending JP2025160318A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
| JP2025123921A Pending JP2025160317A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Active JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025123921A Pending JP2025160317A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20240158410A1 (https=) |
| EP (3) | EP4628165A3 (https=) |
| JP (3) | JP7821188B2 (https=) |
| KR (3) | KR20250120438A (https=) |
| CN (3) | CN116829561A (https=) |
| AU (1) | AU2022216696A1 (https=) |
| CA (1) | CA3209426A1 (https=) |
| MX (1) | MX2023008716A (https=) |
| WO (1) | WO2022166762A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023003778A (es) | 2020-09-30 | 2023-04-26 | Duality Biologics Suzhou Co Ltd | Compuesto antitumoral, metodo de preparacion y uso del mismo. |
| US20250276078A1 (en) * | 2020-10-12 | 2025-09-04 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | Camptothecin Derivative And Ligand-drug Conjugate Thereof |
| KR20250120438A (ko) * | 2021-02-05 | 2025-08-08 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| CA3228345A1 (en) * | 2021-08-19 | 2023-02-23 | Zhen Li | Camptothecin derivative, and pharmaceutical composition and use thereof |
| CN118119594A (zh) * | 2021-10-26 | 2024-05-31 | 上海弼领生物技术有限公司 | 一种喜树碱类衍生物中间体、其制备方法和用途 |
| EP4434548A1 (en) | 2021-11-15 | 2024-09-25 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| CN118696048A (zh) * | 2022-05-09 | 2024-09-24 | 同宜医药（苏州）有限公司 | 一种喜树碱衍生物，基于其的抗体-药物偶联物和药物组合物，及其应用 |
| EP4524140A1 (en) | 2022-05-13 | 2025-03-19 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor and use thereof |
| KR20250075560A (ko) | 2022-07-15 | 2025-05-28 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항-trop2 항체 및 이의 접합체 |
| EP4562051A1 (en) * | 2022-07-26 | 2025-06-04 | Immunome, Inc. | Immunoconjugates and methods |
| JP2025511436A (ja) * | 2022-09-02 | 2025-04-16 | メルク・シャープ・アンド・ドーム・エルエルシー | エキサテカン由来トポイソメラーゼ－１阻害薬医薬組成物及びその使用 |
| CN121064209A (zh) * | 2022-09-09 | 2025-12-05 | 杭州爱科瑞思生物医药有限公司 | 喜树碱-7-乙基胺衍生物及其制备方法和应用 |
| EP4594327A1 (en) * | 2022-09-30 | 2025-08-06 | BeiGene Switzerland GmbH | Ligand-drug conjugate of exatecan analogue, and medical use thereof |
| PE20252282A1 (es) | 2022-10-09 | 2025-09-18 | Lanova Medicines Ltd | Compuestos, composiciones y metodos |
| CN120417935A (zh) * | 2022-10-25 | 2025-08-01 | 默沙东有限责任公司 | 依喜替康衍生的adc接头-载荷及其药物组合物和用途 |
| EP4623936A1 (en) * | 2022-11-22 | 2025-10-01 | Keymed Biosciences (Chengdu) Co., Ltd. | Fused ring compound, conjugate thereof and use thereof |
| WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| CN116712563A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | N-卤代烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116870187A (zh) * | 2022-12-29 | 2023-10-13 | 杭州爱科瑞思生物医药有限公司 | N-氧杂环烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116712562A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | N-叠氮烷基取代的喜树碱衍生物的抗体偶联药物 |
| JP2026504160A (ja) * | 2023-01-25 | 2026-02-03 | イムノーム，インク． | エキサテカン免疫コンジュゲート |
| CN119630672B (zh) * | 2023-02-23 | 2026-01-30 | 一线医药（杭州）有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| TW202502774A (zh) * | 2023-03-01 | 2025-01-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種茚并［１，２－ｂ］喹啉－１０，１３－二酮衍生物的製備方法 |
| EP4692091A1 (en) * | 2023-04-07 | 2026-02-11 | Changchun Genescience Pharmaceutical Co., Ltd. | Camptothecin derivative, and pharmaceutical composition, preparation method therefor and use thereof |
| CN116478051B (zh) * | 2023-04-13 | 2024-06-21 | 戊言医药科技（上海）有限公司 | 一种贝洛替康盐酸盐及其关键中间体的制备方法 |
| WO2024227432A1 (zh) * | 2023-04-30 | 2024-11-07 | 泰诚思(上海)生物医药有限公司 | 喜树碱衍生物、其制备方法及用途、抗体药物偶联物及其应用 |
| WO2024227439A1 (zh) * | 2023-05-04 | 2024-11-07 | 四川科伦博泰生物医药股份有限公司 | 具有靶向作用的偶联物及其制备方法和用途 |
| CN117417346B (zh) * | 2023-09-11 | 2025-07-25 | 常州合全药业有限公司 | 喜树碱类衍生物的制备方法 |
| KR20250059577A (ko) | 2023-10-24 | 2025-05-07 | 삼성디스플레이 주식회사 | 표시 장치 |
| TW202527997A (zh) * | 2023-11-15 | 2025-07-16 | 大陸商四川科倫博泰生物醫藥股份有限公司 | 靶向ｅｇｆｒ／ｃ—ｍｅｔ之抗體—藥物結合物以及其製備方法及用途 |
| CN120058720A (zh) * | 2024-01-08 | 2025-05-30 | 杭州爱科瑞思生物医药有限公司 | 7-含羟胺结构取代的烷基喜树碱衍生物的制备及其应用 |
| CN120058721A (zh) * | 2024-01-08 | 2025-05-30 | 杭州爱科瑞思生物医药有限公司 | 7-氟烷基取代的喜树碱衍生物的制备及其应用 |
| WO2025162049A1 (zh) * | 2024-02-02 | 2025-08-07 | 长春金赛药业有限责任公司 | 卤代烯烃类喜树碱衍生物、药物组合物及其制备方法和应用 |
| WO2025242090A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技（成都）有限公司 | 喜树碱衍生物及其中间体的制备方法 |
| WO2026046398A1 (en) * | 2024-08-30 | 2026-03-05 | Hansoh Bio Llc | Novel camptothecin derivative and conjugate thereof, preparation method therefor and application thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| BR9608639A (pt) * | 1995-06-21 | 1999-06-29 | Sod Conseils Rech Applic | Análogo de camptotecina composto processo de preparação dos compostos produtoos industriaia medicamentos composições farmacêuticas e utilização de produtos |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| CN100408582C (zh) * | 2004-02-12 | 2008-08-06 | 中国人民解放军第二军医大学 | 高喜树碱类化合物及其制备方法和用途 |
| US11091498B2 (en) * | 2016-04-04 | 2021-08-17 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| CN110891942B (zh) * | 2017-07-14 | 2022-06-07 | 四川科伦博泰生物医药股份有限公司 | 噁二唑类衍生物、其制备方法及其在医药上的应用 |
| EP3725798B1 (en) * | 2017-12-15 | 2026-03-04 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive conjugate, preparation method therefor and use thereof |
| CA3094313A1 (en) * | 2018-04-06 | 2019-10-10 | Seattle Genetics, Inc. | Camptothecin peptide conjugates |
| TWI851577B (zh) * | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| WO2020063676A1 (zh) * | 2018-09-26 | 2020-04-02 | 江苏恒瑞医药股份有限公司 | 依喜替康类似物的配体-药物偶联物及其制备方法和应用 |
| CN112543771B (zh) * | 2018-09-30 | 2023-04-11 | 江苏豪森药业集团有限公司 | 抗b7h3抗体-依喜替康类似物偶联物及其医药用途 |
| HUE060364T2 (hu) * | 2019-03-29 | 2023-02-28 | Medimmune Ltd | Vegyületek és konjugátumaik |
| JP7561141B2 (ja) | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| CN111689980A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种喜树碱药物及其抗体偶联物 |
| CN110357897A (zh) * | 2019-07-26 | 2019-10-22 | 上海健康医学院 | 一种具有抗肿瘤活性的喜树碱衍生物及其制备方法和应用 |
| CN112125915A (zh) * | 2019-09-18 | 2020-12-25 | 四川百利药业有限责任公司 | 一种喜树碱衍生物及其偶联物 |
| MX2022008474A (es) * | 2020-01-22 | 2022-08-02 | Jiangsu Hengrui Medicine Co | Conjugado de anticuerpo anti-trop-2-analogo de exatecan y uso medico del mismo. |
| CA3186295A1 (en) * | 2020-06-08 | 2021-12-16 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof |
| EP4227309A4 (en) * | 2020-10-12 | 2024-11-27 | Sichuan Baili Pharmaceutical Co. Ltd. | DEUTERATED CAMPTOTHECIN DERIVATIVE AND ANTIBODY-DRUG CONJUGATE THEREOF |
| KR20250120438A (ko) * | 2021-02-05 | 2025-08-08 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| CA3218527A1 (en) * | 2021-06-02 | 2022-12-08 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Antibody drug conjugate, and preparation method therefor and use thereof |
| US20240252665A1 (en) * | 2021-06-02 | 2024-08-01 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Chemical coupling linker and use thereof |
| US11814394B2 (en) * | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| CN117567487A (zh) * | 2023-11-27 | 2024-02-20 | 金宏气体股份有限公司 | 双核Ag(I)配合物晶体、制备方法、负载物、装置及应用 |
-
2022
- 2022-01-27 KR KR1020257024905A patent/KR20250120438A/ko active Pending
- 2022-01-27 AU AU2022216696A patent/AU2022216696A1/en active Pending
- 2022-01-27 KR KR1020237025527A patent/KR20230142710A/ko active Pending
- 2022-01-27 US US18/262,821 patent/US20240158410A1/en active Pending
- 2022-01-27 CN CN202280008418.XA patent/CN116829561A/zh active Pending
- 2022-01-27 EP EP25191607.8A patent/EP4628165A3/en active Pending
- 2022-01-27 CA CA3209426A patent/CA3209426A1/en active Pending
- 2022-01-27 CN CN202510232225.8A patent/CN120058723A/zh active Pending
- 2022-01-27 KR KR1020257024904A patent/KR20250119655A/ko active Pending
- 2022-01-27 CN CN202311518671.2A patent/CN117567478B/zh active Active
- 2022-01-27 EP EP25191605.2A patent/EP4613335A3/en active Pending
- 2022-01-27 EP EP22749041.4A patent/EP4289851A4/en active Pending
- 2022-01-27 JP JP2023544762A patent/JP7821188B2/ja active Active
- 2022-01-27 MX MX2023008716A patent/MX2023008716A/es unknown
- 2022-01-27 WO PCT/CN2022/074328 patent/WO2022166762A1/zh not_active Ceased
-
2025
- 2025-07-24 JP JP2025123923A patent/JP2025160318A/ja active Pending
- 2025-07-24 US US19/279,242 patent/US20250346606A1/en active Pending
- 2025-07-24 JP JP2025123921A patent/JP2025160317A/ja active Pending
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