JP2022516389A - 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞 - Google Patents

血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞 Download PDF

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JP2022516389A
JP2022516389A JP2020566903A JP2020566903A JP2022516389A JP 2022516389 A JP2022516389 A JP 2022516389A JP 2020566903 A JP2020566903 A JP 2020566903A JP 2020566903 A JP2020566903 A JP 2020566903A JP 2022516389 A JP2022516389 A JP 2022516389A
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inkt
chain variable
variable fragment
scfv
car
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JPWO2019232477A5 (https=
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ジョン・エフ・ディパージオ
マシュー・クーパー
ジュリー・オニール
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Washington University in St Louis WUSTL
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JP2020566903A 2018-05-31 2019-05-31 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞 Pending JP2022516389A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862678883P 2018-05-31 2018-05-31
US62/678,883 2018-05-31
PCT/US2019/035052 WO2019232477A2 (en) 2018-05-31 2019-05-31 Genome-edited invariant natural killer t (inkt) cells for the treatment of hematologic malignancies

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JP2022516389A true JP2022516389A (ja) 2022-02-28
JPWO2019232477A5 JPWO2019232477A5 (https=) 2022-06-07
JP2022516389A5 JP2022516389A5 (https=) 2022-06-07

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US (2) US20200040056A1 (https=)
EP (1) EP3801568A4 (https=)
JP (1) JP2022516389A (https=)
CN (1) CN112584844A (https=)
WO (1) WO2019232477A2 (https=)

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JP2022526340A (ja) * 2019-03-25 2022-05-24 マックス－デルブリュック－ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ－ゲマインシャフト Ｅｂａｇ９を阻害することによる細胞溶解性ｔ細胞の活性の増強
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AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
KR20230093329A (ko) * 2020-10-28 2023-06-27 베이롤 칼리지 오브 메드신 암의 치료를 위한 면역조절 치료제로서 면역 세포에서 src-3의 표적화
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
EP4039808A1 (en) * 2021-02-08 2022-08-10 Ospedale San Raffaele S.r.l. Guide rnas and uses thereof
CN112961854B (zh) * 2021-02-20 2022-03-29 中国人民解放军总医院第五医学中心 一种靶向IL-16基因的sgRNA、质粒组及基因敲除方法和应用
CN112980800A (zh) * 2021-03-08 2021-06-18 河北森朗生物科技有限公司 Car-t细胞、其构建方法及其应用
CN113061624B (zh) * 2021-03-09 2023-08-18 矫士平 一种敲除Tim-3基因以延长T细胞体内生存的方法
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
CN115989244A (zh) * 2021-08-06 2023-04-18 上海驯鹿生物技术有限公司 Cd5和cd7双靶点的全人源嵌合抗原受体(car)及其应用
US20250170240A1 (en) * 2022-02-23 2025-05-29 Tinkeso Therapeutics, Inc. Modified invariant natural killer t cells expressing a chimeric antigen receptor and uses thereof
CN114644716A (zh) * 2022-04-07 2022-06-21 苏州大学 一种抗bxmas1嵌合抗原受体及其修饰的免疫细胞及应用
CA3264498A1 (en) * 2022-08-23 2024-02-29 Imperial College Innovations Limited CHIMERIC ANTIGENIC RECEPTOR (CAR) WITH A VARIABLE REGION OF TCR BETA CHAIN
CN119529098B (zh) * 2025-01-22 2025-05-30 北京可瑞生物科技有限公司 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白

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