CN112584844A - 用于治疗血液系统恶性肿瘤的基因组编辑的恒定自然杀伤t(inkt)细胞 - Google Patents

用于治疗血液系统恶性肿瘤的基因组编辑的恒定自然杀伤t(inkt)细胞 Download PDF

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CN112584844A
CN112584844A CN201980050974.1A CN201980050974A CN112584844A CN 112584844 A CN112584844 A CN 112584844A CN 201980050974 A CN201980050974 A CN 201980050974A CN 112584844 A CN112584844 A CN 112584844A
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inkt
cell
car
variable fragment
scfv
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J·F·迪珀西奥
M·库珀
J·奥尼尔
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University of Washington
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University of Washington
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CN201980050974.1A 2018-05-31 2019-05-31 用于治疗血液系统恶性肿瘤的基因组编辑的恒定自然杀伤t(inkt)细胞 Pending CN112584844A (zh)

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Application Number Priority Date Filing Date Title
US201862678883P 2018-05-31 2018-05-31
US62/678883 2018-05-31
PCT/US2019/035052 WO2019232477A2 (en) 2018-05-31 2019-05-31 Genome-edited invariant natural killer t (inkt) cells for the treatment of hematologic malignancies

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CN112584844A true CN112584844A (zh) 2021-03-30

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US (2) US20200040056A1 (https=)
EP (1) EP3801568A4 (https=)
JP (1) JP2022516389A (https=)
CN (1) CN112584844A (https=)
WO (1) WO2019232477A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109735558A (zh) * 2018-12-12 2019-05-10 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
CN112961854A (zh) * 2021-02-20 2021-06-15 中国人民解放军总医院第五医学中心 一种靶向IL-16基因的sgRNA、质粒组及基因敲除方法和应用
CN114644716A (zh) * 2022-04-07 2022-06-21 苏州大学 一种抗bxmas1嵌合抗原受体及其修饰的免疫细胞及应用
CN115989244A (zh) * 2021-08-06 2023-04-18 上海驯鹿生物技术有限公司 Cd5和cd7双靶点的全人源嵌合抗原受体(car)及其应用
CN119529098A (zh) * 2025-01-22 2025-02-28 北京可瑞生物科技有限公司 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ750256A (en) 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11202104524YA (en) 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
JP2022526340A (ja) * 2019-03-25 2022-05-24 マックス－デルブリュック－ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ－ゲマインシャフト Ｅｂａｇ９を阻害することによる細胞溶解性ｔ細胞の活性の増強
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
US20230113157A1 (en) * 2020-05-06 2023-04-13 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
KR20230093329A (ko) * 2020-10-28 2023-06-27 베이롤 칼리지 오브 메드신 암의 치료를 위한 면역조절 치료제로서 면역 세포에서 src-3의 표적화
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
EP4039808A1 (en) * 2021-02-08 2022-08-10 Ospedale San Raffaele S.r.l. Guide rnas and uses thereof
CN112980800A (zh) * 2021-03-08 2021-06-18 河北森朗生物科技有限公司 Car-t细胞、其构建方法及其应用
CN113061624B (zh) * 2021-03-09 2023-08-18 矫士平 一种敲除Tim-3基因以延长T细胞体内生存的方法
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
US20250170240A1 (en) * 2022-02-23 2025-05-29 Tinkeso Therapeutics, Inc. Modified invariant natural killer t cells expressing a chimeric antigen receptor and uses thereof
CA3264498A1 (en) * 2022-08-23 2024-02-29 Imperial College Innovations Limited CHIMERIC ANTIGENIC RECEPTOR (CAR) WITH A VARIABLE REGION OF TCR BETA CHAIN

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017088012A1 (en) * 2015-11-27 2017-06-01 Cartherics Pty. Ltd. Genetically modified cells and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2575824A4 (en) * 2010-05-24 2014-02-19 Childrens Medical Center METHOD FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES
US20170029777A1 (en) * 2014-01-27 2017-02-02 St. Jude Children's Research Hospital, Inc. Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof
JP7086375B2 (ja) * 2015-04-23 2022-06-20 ベイラー カレッジ オブ メディスン 生体内での存続性及び治療活性及びその増殖のためのｎｋｔ細胞サブセット
CA3010236A1 (en) * 2016-01-20 2017-07-27 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
WO2018106595A1 (en) * 2016-12-05 2018-06-14 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
WO2018195339A1 (en) * 2017-04-19 2018-10-25 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
CN107384949B (zh) * 2017-06-27 2019-01-15 闾民 表达GPC3嵌合抗原受体的iNKT细胞及制备、应用
JP2021525530A (ja) * 2018-06-01 2021-09-27 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制
WO2020232427A2 (en) * 2019-05-16 2020-11-19 Arch Oncology, Inc. Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017088012A1 (en) * 2015-11-27 2017-06-01 Cartherics Pty. Ltd. Genetically modified cells and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COOPER等: "Off-The-Shelf fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies", vol. 32, no. 9, pages 1970 - 1983 *
HECZEY等: "Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer Immunotherapy", BLOOD, vol. 124, no. 18, pages 2824 - 2833, XP055467113, DOI: 10.1182/blood-2013-11-541235 *
HECZEY等: "Invariant NKT cells with chmeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy", vol. 124, no. 18, pages 2824 - 2833, XP055467113, DOI: 10.1182/blood-2013-11-541235 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109735558A (zh) * 2018-12-12 2019-05-10 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
CN112961854A (zh) * 2021-02-20 2021-06-15 中国人民解放军总医院第五医学中心 一种靶向IL-16基因的sgRNA、质粒组及基因敲除方法和应用
CN115989244A (zh) * 2021-08-06 2023-04-18 上海驯鹿生物技术有限公司 Cd5和cd7双靶点的全人源嵌合抗原受体(car)及其应用
CN114644716A (zh) * 2022-04-07 2022-06-21 苏州大学 一种抗bxmas1嵌合抗原受体及其修饰的免疫细胞及应用
CN119529098A (zh) * 2025-01-22 2025-02-28 北京可瑞生物科技有限公司 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白

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