|
DE4302485A1
(de)
|
1993-01-29 |
1994-08-04 |
Merck Patent Gmbh |
Piperazinderivate
|
|
FR2768729A1
(fr)
|
1997-09-19 |
1999-03-26 |
Rhodia Chimie Sa |
Procede d'acylation d'un compose aromatique et complexes catalytiques
|
|
FR2768728B1
(fr)
|
1997-09-19 |
1999-12-03 |
Rhodia Chimie Sa |
Procede d'acylation d'un compose aromatique
|
|
US7629360B2
(en)
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
|
TW200621723A
(en)
|
2004-09-09 |
2006-07-01 |
Chugai Pharmaceutical Co Ltd |
Novel imidazolidine derivative and use thereof
|
|
WO2007073432A2
(en)
|
2005-10-11 |
2007-06-28 |
Chemocentryx, Inc. |
Piperidine derivatives and methods of use
|
|
WO2007136640A2
(en)
*
|
2006-05-16 |
2007-11-29 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
|
JP2012532929A
(ja)
|
2009-07-13 |
2012-12-20 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
二機能性のステープリングされたポリペプチドおよびそれらの使用
|
|
RU2434851C1
(ru)
|
2010-07-22 |
2011-11-27 |
Александр Васильевич Иващенко |
Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
|
|
US8765978B2
(en)
|
2010-12-16 |
2014-07-01 |
Transitions Optical, Inc. |
Method of making indeno-fused naphthol materials
|
|
DK2683694T3
(en)
|
2011-03-10 |
2016-07-18 |
Suzhou Kintor Pharmaceuticals Inc |
ANDROGEN RECEPTOR ANTAGONISTS AND APPLICATIONS THEREOF
|
|
US20140112922A1
(en)
|
2011-03-28 |
2014-04-24 |
Cornell University |
Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
|
|
CA2861066C
(en)
|
2012-01-12 |
2024-01-02 |
Yale University |
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
|
|
RS61242B1
(sr)
|
2012-09-04 |
2021-01-29 |
Shanghai hengrui pharmaceutical co ltd |
Derivati imidazolina, postupci njihove pripreme i njihove primene u medicini
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
CN105073738B
(zh)
|
2013-01-31 |
2018-01-05 |
沃泰克斯药物股份有限公司 |
作为钠通道调节剂的喹啉及喹喔啉酰胺类
|
|
AU2015247817C1
(en)
|
2014-04-14 |
2022-02-10 |
Arvinas Operations, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
US20160058872A1
(en)
|
2014-04-14 |
2016-03-03 |
Arvinas, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
RU2557235C1
(ru)
*
|
2014-07-08 |
2015-07-20 |
Александр Васильевич Иващенко |
Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
JP6815318B2
(ja)
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
|
JP6817962B2
(ja)
|
2015-01-20 |
2021-01-20 |
アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． |
ターゲティングされたアンドロゲン受容体分解のための化合物および方法
|
|
US10730870B2
(en)
|
2015-03-18 |
2020-08-04 |
Arvinas Operations, Inc. |
Compounds and methods for the enhanced degradation of targeted proteins
|
|
GB201506871D0
(en)
|
2015-04-22 |
2015-06-03 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
WO2017011371A1
(en)
|
2015-07-10 |
2017-01-19 |
Arvinas, Inc |
Mdm2-based modulators of proteolysis and associated methods of use
|
|
EP3337476A4
(en)
|
2015-08-19 |
2019-09-04 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
TWI726969B
(zh)
|
2016-01-11 |
2021-05-11 |
比利時商健生藥品公司 |
用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
|
|
CN109641874A
(zh)
|
2016-05-10 |
2019-04-16 |
C4医药公司 |
用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
|
|
EP3481394A1
(en)
|
2016-07-08 |
2019-05-15 |
Janssen Pharmaceutica N.V. |
Thiohydantoin androgen receptor antagonists for the treatment of cancer
|
|
TWI739888B
(zh)
|
2016-10-07 |
2021-09-21 |
美商陶氏農業科學公司 |
農藥組合物及方法
|
|
WO2018071606A1
(en)
|
2016-10-11 |
2018-04-19 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
US10925868B2
(en)
|
2016-11-10 |
2021-02-23 |
Dana-Farber Cancer Institute, Inc. |
Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use
|
|
CA3042301A1
(en)
|
2016-11-22 |
2018-05-31 |
Dana-Farber Cancer Institute, Inc. |
Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use
|
|
DK3524603T3
(da)
|
2016-12-19 |
2022-07-04 |
Abbisko Therapeutics Co Ltd |
Fgfr4-hæmmer, fremgangsmåde til fremstilling deraf og farmaceutisk anvendelse deraf
|
|
BR112019015484A2
(pt)
*
|
2017-01-31 |
2020-04-28 |
Arvinas Operations Inc |
ligantes de cereblon e compostos bifuncionais compreendendo os mesmos
|
|
EP4717317A2
(en)
|
2017-06-20 |
2026-04-01 |
C4 Therapeutics, Inc. |
N/o-linked degrons and degronimers for protein degradation
|
|
CN109422725A
(zh)
|
2017-09-04 |
2019-03-05 |
北京美倍他药物研究有限公司 |
前列腺癌治疗药物
|
|
ES2959954T3
(es)
|
2017-11-28 |
2024-02-29 |
Aarti Pharmalabs Ltd |
Proceso para la preparación de enzalutamida utilizando un nuevo intermedio
|
|
CN111163638B
(zh)
|
2017-12-05 |
2023-07-25 |
美国陶氏益农公司 |
杀有害生物组合物和方法
|
|
CA3101227A1
(en)
|
2018-05-30 |
2019-12-05 |
Jiangsu Hansoh Pharmaceutical Group Co., Ltd. |
Inhibitor containing tricyclic derivative, preparation method therefor, and application thereof
|
|
CN109651256A
(zh)
|
2018-11-20 |
2019-04-19 |
上海健康医学院 |
一种式（viii）的恩杂鲁胺的制备方法
|
|
PL3897636T3
(pl)
|
2018-12-19 |
2025-04-28 |
Celgene Corporation |
Podstawione związki 3-((3-aminofenylo)amino)piperydyno-2,6-dionu, ich kompozycje i sposoby leczenia nimi
|