JP2022512332A5 - - Google Patents
Info
- Publication number
- JP2022512332A5 JP2022512332A5 JP2021532224A JP2021532224A JP2022512332A5 JP 2022512332 A5 JP2022512332 A5 JP 2022512332A5 JP 2021532224 A JP2021532224 A JP 2021532224A JP 2021532224 A JP2021532224 A JP 2021532224A JP 2022512332 A5 JP2022512332 A5 JP 2022512332A5
- Authority
- JP
- Japan
- Prior art keywords
- piggybac transposase
- seq
- nucleic acid
- piggybac
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862777325P | 2018-12-10 | 2018-12-10 | |
| US62/777,325 | 2018-12-10 | ||
| US201962925516P | 2019-10-24 | 2019-10-24 | |
| US62/925,516 | 2019-10-24 | ||
| PCT/US2019/065129 WO2020123327A1 (en) | 2018-12-10 | 2019-12-09 | Mutated piggybac transposase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512332A JP2022512332A (ja) | 2022-02-03 |
| JP2022512332A5 true JP2022512332A5 (https=) | 2022-11-01 |
| JP7441840B2 JP7441840B2 (ja) | 2024-03-01 |
Family
ID=69143664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532224A Active JP7441840B2 (ja) | 2018-12-10 | 2019-12-09 | 変異したｐｉｇｇｙｂａｃトランスポザーゼ |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12570966B2 (https=) |
| EP (1) | EP3894549B1 (https=) |
| JP (1) | JP7441840B2 (https=) |
| KR (1) | KR20210101270A (https=) |
| CN (2) | CN113195712B (https=) |
| AU (2) | AU2019398101B2 (https=) |
| BR (1) | BR112021011063A2 (https=) |
| CA (1) | CA3121268A1 (https=) |
| CL (2) | CL2021001488A1 (https=) |
| DK (1) | DK3894549T3 (https=) |
| ES (1) | ES2991895T3 (https=) |
| FI (1) | FI3894549T3 (https=) |
| HU (1) | HUE068630T2 (https=) |
| IL (1) | IL283314A (https=) |
| LT (1) | LT3894549T (https=) |
| MX (1) | MX2021006783A (https=) |
| PL (1) | PL3894549T3 (https=) |
| PT (1) | PT3894549T (https=) |
| SG (1) | SG11202106049RA (https=) |
| SI (1) | SI3894549T1 (https=) |
| TW (1) | TWI862531B (https=) |
| WO (1) | WO2020123327A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122716A1 (en) * | 2021-12-22 | 2023-06-29 | Vanderbilt University | Next generation transpososomes |
| EP4514821A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| US20230348561A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| EP4514829A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| KR20260013198A (ko) * | 2023-05-12 | 2026-01-27 | 론자 바이올로직스 피엘씨 | 고수율 생성물 생산을 위한 트랜스포사제를 이용한 하이브리드 일시적 형질감염 |
| US20250027052A1 (en) | 2023-07-21 | 2025-01-23 | Amgen Inc. | Vectors incorporating a combination of promoters driving selectable marker expression |
| WO2025096649A1 (en) | 2023-11-01 | 2025-05-08 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| CN120737218B (zh) * | 2025-08-15 | 2026-01-06 | 云南彤宁生物制药技术有限公司 | 融合蛋白、调控系统及利用该系统构建转基因细胞的方法 |
Family Cites Families (49)
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| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| ES2227669T3 (es) | 1996-01-11 | 2005-04-01 | Immunex Corporation | Elementos de secuencia que aumentan la expresion (ease) para sistemas de expresion de eurocariotas. |
| US6218185B1 (en) | 1996-04-19 | 2001-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Piggybac transposon-based genetic transformation system for insects |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| KR20030032922A (ko) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| US7105343B1 (en) | 2000-10-31 | 2006-09-12 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac |
| DE60335637D1 (de) | 2002-07-24 | 2011-02-17 | Manoa Biosciences Inc | Vektoren auf transposonbasis und verfahren zur integration von nukleinsäuren |
| US7932088B1 (en) | 2005-04-25 | 2011-04-26 | University Of Notre Dame Du Lac | High efficiency transformation of Plasmodium falciparum by the lepidopteran transposon, piggyBac |
| WO2007100821A2 (en) | 2006-02-28 | 2007-09-07 | University Of Notre Dame | Piggybac constructs in vertebrates |
| US20090042297A1 (en) | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
| AU2010206374B2 (en) | 2009-01-23 | 2013-01-17 | Gloriana Therapeutics Sarl | Improved cell lines and their use in encapsulated cell biodelivery |
| WO2010085699A2 (en) | 2009-01-23 | 2010-07-29 | The Johns Hopkins University | Mammalian piggybac transposon and methods of use |
| EP2401376A4 (en) | 2009-02-25 | 2012-11-28 | Univ Johns Hopkins | TRANSPOSON PIGGYBAC VARIANTS AND METHODS OF USE |
| US8399643B2 (en) | 2009-02-26 | 2013-03-19 | Transposagen Biopharmaceuticals, Inc. | Nucleic acids encoding hyperactive PiggyBac transposases |
| US20100311116A1 (en) | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
| ES2697535T3 (es) | 2009-06-11 | 2019-01-24 | Inter Univ Research Institute Corporation Research Organization Of Information And Systems | Procedimiento para la producción de proteína |
| CN102762585B (zh) * | 2010-02-12 | 2016-01-20 | DPx控股有限公司 | 单一单元抗体纯化 |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| GB201014169D0 (en) | 2010-08-25 | 2010-10-06 | Cambridge Entpr Ltd | In vitro hepatic differentiation |
| WO2012074758A1 (en) | 2010-11-16 | 2012-06-07 | Transposagen Bioharmaceuticals, Inc. | Hyperactive piggybac transposases |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| WO2013012824A2 (en) | 2011-07-15 | 2013-01-24 | The Johns Hopkins University | Trichoplusia ni piggybac transposases with reduced integration activity |
| US8846373B2 (en) | 2011-07-29 | 2014-09-30 | The University Of Wyoming | Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates |
| SI3366775T2 (sl) | 2011-11-18 | 2025-12-31 | Alnylam Pharmaceuticals, Inc. | Modificirana sredstva RNAI |
| FI3536797T3 (fi) | 2013-02-01 | 2023-03-23 | Selexis Sa | Siirtogeenin tehostettu ilmentäminen ja prosessointi |
| WO2014138306A1 (en) * | 2013-03-05 | 2014-09-12 | Baylor College Of Medicine | Engager cells for immunotherapy |
| CN103360464A (zh) | 2013-07-17 | 2013-10-23 | 武汉摩尔生物科技有限公司 | 多肽、编码该多肽的dna分子、载体、制备方法及应用 |
| US11306328B2 (en) | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| DK3129487T3 (da) | 2014-04-09 | 2020-11-30 | Dna Twopointo Inc | Forbedrede nukleinsyrekonstruktioner til eukaryot genekspression |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| EP3018200A1 (en) | 2014-11-07 | 2016-05-11 | Fondazione Matilde Tettamanti e Menotti de Machi Onlus | Improved method for the generation of genetically modified cells |
| CN105154473B (zh) | 2015-09-30 | 2019-03-01 | 上海细胞治疗研究院 | 一种高效安全的转座子整合系统及其用途 |
| CA3001312A1 (en) | 2015-10-08 | 2017-04-13 | Dna2.0, Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
| KR102249982B1 (ko) | 2015-12-14 | 2021-05-11 | 게놈프론티어 테라퓨틱스 인코포레이티드 | 트랜스포존 시스템, 이를 포함한 키트, 및 이들의 용도 |
| CN109312361A (zh) | 2016-02-26 | 2019-02-05 | 波赛伊达治疗学股份有限公司 | 转座子系统及应用方法 |
| EP3219800A1 (en) | 2016-03-15 | 2017-09-20 | Max-Delbrück-Centrum Für Molekulare Medizin | A transposon-based transfection system for primary cells |
| US20230183884A1 (en) | 2016-11-30 | 2023-06-15 | China Agricultural University | A method for crispr library screening |
| WO2019046815A1 (en) | 2017-08-31 | 2019-03-07 | Poseida Therapeutics, Inc. | TRANSPOSON SYSTEM AND METHODS OF USE |
| WO2020123410A1 (en) | 2018-12-10 | 2020-06-18 | Amgen Inc. | CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF |
-
2019
- 2019-12-09 AU AU2019398101A patent/AU2019398101B2/en active Active
- 2019-12-09 LT LTEPPCT/US2019/065129T patent/LT3894549T/lt unknown
- 2019-12-09 MX MX2021006783A patent/MX2021006783A/es unknown
- 2019-12-09 SG SG11202106049RA patent/SG11202106049RA/en unknown
- 2019-12-09 HU HUE19832777A patent/HUE068630T2/hu unknown
- 2019-12-09 ES ES19832777T patent/ES2991895T3/es active Active
- 2019-12-09 US US17/299,000 patent/US12570966B2/en active Active
- 2019-12-09 CN CN201980081292.7A patent/CN113195712B/zh active Active
- 2019-12-09 CA CA3121268A patent/CA3121268A1/en active Pending
- 2019-12-09 JP JP2021532224A patent/JP7441840B2/ja active Active
- 2019-12-09 CN CN202411173681.1A patent/CN118995660A/zh active Pending
- 2019-12-09 DK DK19832777.7T patent/DK3894549T3/da active
- 2019-12-09 PL PL19832777.7T patent/PL3894549T3/pl unknown
- 2019-12-09 EP EP19832777.7A patent/EP3894549B1/en active Active
- 2019-12-09 BR BR112021011063-1A patent/BR112021011063A2/pt unknown
- 2019-12-09 KR KR1020217021154A patent/KR20210101270A/ko active Pending
- 2019-12-09 WO PCT/US2019/065129 patent/WO2020123327A1/en not_active Ceased
- 2019-12-09 PT PT198327777T patent/PT3894549T/pt unknown
- 2019-12-09 SI SI201930822T patent/SI3894549T1/sl unknown
- 2019-12-09 FI FIEP19832777.7T patent/FI3894549T3/fi active
- 2019-12-10 TW TW108145098A patent/TWI862531B/zh active
-
2021
- 2021-05-20 IL IL283314A patent/IL283314A/en unknown
- 2021-06-08 CL CL2021001488A patent/CL2021001488A1/es unknown
-
2023
- 2023-11-09 CL CL2023003339A patent/CL2023003339A1/es unknown
-
2026
- 2026-03-12 AU AU2026201887A patent/AU2026201887A1/en active Pending
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