JP2009501530A5 - - Google Patents
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- Publication number
- JP2009501530A5 JP2009501530A5 JP2008521706A JP2008521706A JP2009501530A5 JP 2009501530 A5 JP2009501530 A5 JP 2009501530A5 JP 2008521706 A JP2008521706 A JP 2008521706A JP 2008521706 A JP2008521706 A JP 2008521706A JP 2009501530 A5 JP2009501530 A5 JP 2009501530A5
- Authority
- JP
- Japan
- Prior art keywords
- polymerase
- dna polymerase
- chimeric dna
- binding region
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 38
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 37
- 230000004568 DNA-binding Effects 0.000 claims 21
- 230000035772 mutation Effects 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 101000844742 Saccharolobus shibatae DNA-binding protein 7b Proteins 0.000 claims 4
- 101500011469 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) DNA-binding protein 7a Proteins 0.000 claims 4
- 101000844753 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) DNA-binding protein 7d Proteins 0.000 claims 4
- 101000844750 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) DNA-binding protein 7e Proteins 0.000 claims 4
- 102200120791 rs183974372 Human genes 0.000 claims 4
- 102220093586 rs876661278 Human genes 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102200091760 rs1043302 Human genes 0.000 claims 3
- 102220047519 rs587777841 Human genes 0.000 claims 3
- 102220612220 Brain-specific homeobox protein homolog_K63R_mutation Human genes 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 102220277390 rs587779008 Human genes 0.000 claims 2
- 102200132327 rs769653717 Human genes 0.000 claims 2
- 102220170748 rs886052366 Human genes 0.000 claims 2
- 108020004634 Archaeal DNA Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 230000006820 DNA synthesis Effects 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060002716 Exonuclease Proteins 0.000 claims 1
- 102220564778 Killer cell immunoglobulin-like receptor 2DS4_V93D_mutation Human genes 0.000 claims 1
- 108010002747 Pfu DNA polymerase Proteins 0.000 claims 1
- 108010006785 Taq Polymerase Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 102000013165 exonuclease Human genes 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69993705P | 2005-07-15 | 2005-07-15 | |
| US60/699,937 | 2005-07-15 | ||
| PCT/US2006/027739 WO2007011891A2 (en) | 2005-07-15 | 2006-07-17 | Dna binding protein-polymerase chimeras |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009501530A JP2009501530A (ja) | 2009-01-22 |
| JP2009501530A5 true JP2009501530A5 (https=) | 2009-09-03 |
| JP5241493B2 JP5241493B2 (ja) | 2013-07-17 |
Family
ID=37669479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008521706A Expired - Fee Related JP5241493B2 (ja) | 2005-07-15 | 2006-07-17 | Ｄｎａ結合タンパク質−ポリメラーゼのキメラ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9040276B2 (https=) |
| EP (1) | EP1910534A4 (https=) |
| JP (1) | JP5241493B2 (https=) |
| CA (1) | CA2615151A1 (https=) |
| WO (1) | WO2007011891A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110020877A1 (en) * | 2008-01-11 | 2011-01-27 | Genesys Limited | Cren7 chimeric protein |
| GB0803628D0 (en) | 2008-02-28 | 2008-04-02 | Genesys Ltd | Enzyme |
| GB0804722D0 (en) * | 2008-03-14 | 2008-04-16 | Genesys Ltd | Enzyme |
| GB0804721D0 (en) * | 2008-03-14 | 2008-04-16 | Genesys Ltd | Enzyme |
| EP2382321A4 (en) * | 2009-01-08 | 2012-12-19 | Bio Rad Laboratories | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF NUCLEIC ACID AMPLIFICATION REACTIONS |
| ES2359058B1 (es) | 2009-07-02 | 2012-03-27 | Consejo Superior De Investigaciones Cient�?Ficas (Csic) | Quimera de adn polimerasa del fago ph1 29. |
| KR20120093882A (ko) * | 2009-09-16 | 2012-08-23 | 마쎄이 유니버시티 | 융합 폴리펩티드 및 이들의 용도 |
| US8715987B2 (en) | 2011-05-02 | 2014-05-06 | New England Biolabs, Inc. | Solubilized phospholipids for stabilizing nucleic acid polymerases |
| FR2974816A1 (fr) * | 2011-05-04 | 2012-11-09 | Centre Nat Rech Scient | Methode de generation de proteines |
| US8470573B2 (en) | 2011-06-21 | 2013-06-25 | Bio-Rad Laboratories, Inc. | Hybrid polymerases having the ability to produce long amplicons |
| US9109226B2 (en) | 2011-09-01 | 2015-08-18 | New England Biolabs, Inc. | Synthetic nucleic acids for polymerization reactions |
| WO2013154898A1 (en) * | 2012-04-12 | 2013-10-17 | Ong, Jennifer | Synthetic nucleic acids for polymerization reactions |
| EP2986719B1 (en) | 2013-12-06 | 2020-07-29 | Bio-Rad Laboratories, Inc. | Fusion polymerases |
| US10273511B2 (en) * | 2014-06-30 | 2019-04-30 | Wisconsin Alumni Research Foundation | Enzymes for producing non-straight-chain fatty acids |
| US10131898B2 (en) | 2014-07-22 | 2018-11-20 | Bio-Rad Laboratories, Inc. | Buffers for use with polymerases |
| JP6594955B2 (ja) * | 2014-08-27 | 2019-10-23 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | シントン形成 |
| US9963687B2 (en) | 2014-08-27 | 2018-05-08 | New England Biolabs, Inc. | Fusion polymerase and method for using the same |
| US10364420B2 (en) | 2015-12-07 | 2019-07-30 | Bio-Rad Laboratories, Inc | Dimeric reverse transcriptase |
| CN107841492A (zh) * | 2016-09-21 | 2018-03-27 | 北京擎科新业生物技术有限公司 | 一种增强型Pfu DNA聚合酶及相关应用 |
| US20200002689A1 (en) | 2017-02-13 | 2020-01-02 | Qiagen Sciences, Llc | Polymerase enzyme from 9°n |
| EP3632924A1 (en) * | 2018-10-07 | 2020-04-08 | Affilogic | Binders for inhibiting formation of multimeric proteins |
| CN109266628B (zh) * | 2018-10-09 | 2020-04-14 | 南京市胸科医院 | 一种融合的TaqDNA聚合酶及其应用 |
| CN109679932B (zh) * | 2018-12-05 | 2020-03-17 | 广州奇辉生物科技有限公司 | 一种dna聚合酶、重组载体及它们的制备方法和应用 |
| CN111718418B (zh) * | 2019-03-19 | 2021-08-27 | 华东师范大学 | 一种增强基因编辑的融合蛋白及其应用 |
| WO2020231504A1 (en) * | 2019-05-16 | 2020-11-19 | Massachusetts Institute Of Technology | Glycan-binding proteins and related compositions and methods |
| CN111690626B (zh) * | 2020-07-02 | 2021-03-26 | 南京诺唯赞生物科技股份有限公司 | 一种融合型Taq DNA聚合酶及其制备方法和应用 |
| CN113774039B (zh) * | 2021-09-07 | 2022-06-21 | 北京擎科生物科技有限公司 | 重组型dna聚合酶及其应用 |
| CN118541477A (zh) * | 2021-11-15 | 2024-08-23 | 深圳华大生命科学研究院 | 嵌合dna聚合酶及其应用 |
| AU2023282924A1 (en) * | 2022-06-10 | 2025-01-02 | Element Biosciences, Inc. | Engineered polymerases with improved thermal stability |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6627424B1 (en) * | 2000-05-26 | 2003-09-30 | Mj Bioworks, Inc. | Nucleic acid modifying enzymes |
| JP4575160B2 (ja) | 2002-07-25 | 2010-11-04 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | ハイブリッドタンパク質方法および組成物 |
| US7666645B2 (en) * | 2002-10-23 | 2010-02-23 | Bio-Rad Laboratories, Inc. | Sso7-polymerase conjugate proteins |
| US7960157B2 (en) * | 2002-12-20 | 2011-06-14 | Agilent Technologies, Inc. | DNA polymerase blends and uses thereof |
| JP4722035B2 (ja) | 2003-03-25 | 2011-07-13 | アジレント・テクノロジーズ・インク | Ｄｎａポリメラーゼ融合物およびその使用 |
| AU2006204006A1 (en) * | 2005-01-06 | 2006-07-13 | Applera Corporation | Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification |
-
2006
- 2006-07-17 JP JP2008521706A patent/JP5241493B2/ja not_active Expired - Fee Related
- 2006-07-17 US US11/488,535 patent/US9040276B2/en not_active Expired - Fee Related
- 2006-07-17 EP EP06787626A patent/EP1910534A4/en not_active Withdrawn
- 2006-07-17 WO PCT/US2006/027739 patent/WO2007011891A2/en not_active Ceased
- 2006-07-17 CA CA002615151A patent/CA2615151A1/en not_active Abandoned
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