DK3129487T3 - Forbedrede nukleinsyrekonstruktioner til eukaryot genekspression - Google Patents
Forbedrede nukleinsyrekonstruktioner til eukaryot genekspression Download PDFInfo
- Publication number
- DK3129487T3 DK3129487T3 DK15776901.9T DK15776901T DK3129487T3 DK 3129487 T3 DK3129487 T3 DK 3129487T3 DK 15776901 T DK15776901 T DK 15776901T DK 3129487 T3 DK3129487 T3 DK 3129487T3
- Authority
- DK
- Denmark
- Prior art keywords
- genepression
- eukaryot
- nucleic acid
- improved nucleic
- acid constructions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/40—Vector systems having a special element relevant for transcription being an insulator
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461977474P | 2014-04-09 | 2014-04-09 | |
US201462003397P | 2014-05-27 | 2014-05-27 | |
US201462046875P | 2014-09-05 | 2014-09-05 | |
US201462046705P | 2014-09-05 | 2014-09-05 | |
US201462069656P | 2014-10-28 | 2014-10-28 | |
US201562120522P | 2015-02-25 | 2015-02-25 | |
PCT/US2015/025209 WO2015157579A2 (en) | 2014-04-09 | 2015-04-09 | Enhanced nucleic acid constructs for eukaryotic gene expression |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3129487T3 true DK3129487T3 (da) | 2020-11-30 |
Family
ID=54264598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15776901.9T DK3129487T3 (da) | 2014-04-09 | 2015-04-09 | Forbedrede nukleinsyrekonstruktioner til eukaryot genekspression |
Country Status (8)
Country | Link |
---|---|
US (5) | US9534234B2 (da) |
EP (2) | EP3129487B1 (da) |
CA (1) | CA2944887A1 (da) |
DK (1) | DK3129487T3 (da) |
ES (1) | ES2835673T3 (da) |
HU (1) | HUE052552T2 (da) |
LT (1) | LT3129487T (da) |
WO (1) | WO2015157579A2 (da) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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US10344285B2 (en) | 2014-04-09 | 2019-07-09 | Dna2.0, Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
ES2835673T3 (es) | 2014-04-09 | 2021-06-22 | Dna Twopointo Inc | Construcciones de ácido nucleico mejoradas para la expresión de genes eucariotas |
EP3974524A1 (en) | 2015-10-08 | 2022-03-30 | Dna Twopointo Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
WO2017075237A2 (en) * | 2015-10-27 | 2017-05-04 | Celltheon Corporation | Chimeric post-transcriptional regulatory element |
JP6956416B2 (ja) * | 2015-12-14 | 2021-11-02 | ゲノムフロンティア セラピューティクス,インコーポレイテッド | トランスポゾン系、それを含むキット及びそれらの使用 |
US11098310B2 (en) | 2016-01-27 | 2021-08-24 | Just-Evotec Biologics, Inc. | Expression from transposon-based vectors and uses |
EP3408397B1 (en) | 2016-01-27 | 2020-07-15 | Just-Evotec Biologics, Inc. | Hybrid promoter and uses thereof |
US11261462B2 (en) | 2016-01-27 | 2022-03-01 | Just-Evotec Biologics, Inc. | Inducible expression from transposon-based vectors and uses |
US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
WO2018013546A1 (en) * | 2016-07-11 | 2018-01-18 | The Regents Of The University Of California | Bic inhibitor of cry-cry and cry-cib oligomerization/clustering |
KR20190063468A (ko) * | 2016-09-30 | 2019-06-07 | 포세이다 테라퓨틱스, 인크. | 변형된 줄기세포 기억 t 세포, 이의 제조 방법 및 사용 방법 |
US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
CA3047313A1 (en) | 2016-12-16 | 2018-06-21 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
CA3054942A1 (en) * | 2017-03-17 | 2018-09-20 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression |
WO2019028273A1 (en) * | 2017-08-02 | 2019-02-07 | Dna2.0, Inc. Dba Atum | DNA VECTORS AND ELEMENTS FOR SUSTAINED GENE EXPRESSION IN EUKARYOTIC CELLS |
US10329543B2 (en) | 2017-10-23 | 2019-06-25 | Poseida Therapeutics, Inc. | Modified stem cell memory T cells, methods of making and methods of using same |
CN109988759A (zh) * | 2017-12-29 | 2019-07-09 | 上海细胞治疗研究院 | 一种在t细胞中具有高转录活性的嵌合启动子 |
EP3810764A2 (en) | 2018-06-21 | 2021-04-28 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
SG11202106049RA (en) * | 2018-12-10 | 2021-07-29 | Amgen Inc | Mutated piggybac transposase |
EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 VACCINES AND THEIR USES |
SG11202106900TA (en) | 2019-02-13 | 2021-07-29 | Probiogen Ag | Transposase with enhanced insertion site selection properties |
AU2020223376A1 (en) | 2019-02-15 | 2021-07-22 | Just - Evotec Biologics, Inc. | Automated biomanufacturing systems, facilities, and processes |
JP2022523564A (ja) | 2019-03-04 | 2022-04-25 | アイオーカレンツ, インコーポレイテッド | 機械学習を使用するデータ圧縮および通信 |
US11060109B2 (en) * | 2019-04-08 | 2021-07-13 | Dna Twopointo Inc. | Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois |
IL301620A (en) * | 2019-04-08 | 2023-05-01 | Dna Twopointo Inc | Integration of nucleic acid constructs in eukaryotic cells with Oryzas transposases |
CA3136470A1 (en) | 2019-05-13 | 2020-11-19 | Dna Twopointo Inc. | Modifications of mammalian cells using artificial micro-rna to alter their properties and the compositions of their products |
CA3152780A1 (en) * | 2019-09-01 | 2021-03-04 | Exuma Biotech Corp. | Methods and compositions for the modification and delivery of lymphocytes |
CN115176016A (zh) * | 2020-02-19 | 2022-10-11 | 上海药明生物技术有限公司 | 增强的表达系统及其使用方法 |
CN115698268A (zh) | 2020-05-04 | 2023-02-03 | 萨利欧基因治疗公司 | 基于转座的疗法 |
EP4182341A1 (en) | 2020-07-17 | 2023-05-24 | ProBioGen AG | Hyperactive transposons and transposases |
TW202233830A (zh) * | 2020-10-27 | 2022-09-01 | 美商Pact製藥公司 | 使用下一代工程化t細胞療法治療癌症之組合物及方法 |
CN112481289B (zh) * | 2020-12-04 | 2023-06-27 | 苏州科锐迈德生物医药科技有限公司 | 一种转录环状rna的重组核酸分子及其在蛋白表达中的应用 |
WO2022159635A1 (en) * | 2021-01-20 | 2022-07-28 | The Texas A&M University System | Systems and methods for evaluation of structure and property of polynucleotides |
AU2022212007A1 (en) | 2021-01-29 | 2023-09-07 | Merck Sharp & Dohme Llc | Compositions of programmed death receptor 1 (pd-1) antibodies and methods of obtaining the compositions thereof |
WO2022197749A1 (en) * | 2021-03-15 | 2022-09-22 | Donald Danforth Science Center | Targeted insertion via transposition |
CN113186221A (zh) * | 2021-05-24 | 2021-07-30 | 广西大学 | 水牛源lif的制备及其在水牛精原干细胞体外培养的应用 |
WO2023287707A1 (en) | 2021-07-15 | 2023-01-19 | Just-Evotec Biologics, Inc. | Bidirectional tangential flow filtration (tff) perfusion system |
WO2023081814A2 (en) * | 2021-11-04 | 2023-05-11 | Saliogen Therapeutics, Inc. | Mobile elements and chimeric constructs thereof |
WO2023154734A2 (en) * | 2022-02-08 | 2023-08-17 | Iowa State University Research Foundation, Inc. | Mrna expression and delivery systems |
WO2024068995A1 (en) | 2022-09-30 | 2024-04-04 | Boehringer Ingelheim International Gmbh | Novel transposase system |
Family Cites Families (20)
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US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
ZA973367B (en) | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
US6136597A (en) | 1997-09-18 | 2000-10-24 | The Salk Institute For Biological Studies | RNA export element |
US6897066B1 (en) * | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
US20030150007A1 (en) | 2000-03-21 | 2003-08-07 | Charalambos Savakis | Method of generating transgenic organisms using transposons |
EP1297168A2 (en) | 2000-07-03 | 2003-04-02 | Gala Design, Inc. | Expression vectors |
US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
TW200613554A (en) * | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
US8551774B2 (en) * | 2005-03-17 | 2013-10-08 | National Research Council Of Canada | Expression vectors containing a truncated epstein barr nuclear antigen 1 lacking the Gly-Gly-Ala domain for enhanced transient gene expression |
MX2007014139A (es) * | 2005-05-14 | 2008-10-09 | Univ Fudan | Piggybac como una herramienta para manipulacion genetica y analisis en vertebrados. |
TWI300441B (en) | 2005-09-21 | 2008-09-01 | Univ Chung Yuan Christian | A polynucleotide with ires activity |
WO2007100821A2 (en) | 2006-02-28 | 2007-09-07 | University Of Notre Dame | Piggybac constructs in vertebrates |
EP2134847B1 (en) * | 2007-03-07 | 2015-06-24 | Aarhus Universitet | Pig model for atherosclerosis |
US20110130444A1 (en) * | 2007-05-04 | 2011-06-02 | Stefan Moisyadi | Methods and compositions for targeted delivery of gene therapeutic vectors |
US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
GB0903207D0 (en) * | 2009-02-25 | 2009-04-08 | Ucb Pharma Sa | Method for expressing multimeric proteins |
WO2010099296A1 (en) | 2009-02-26 | 2010-09-02 | Transposagen Biopharmaceuticals, Inc. | Hyperactive piggybac transposases |
US9790489B2 (en) | 2009-10-26 | 2017-10-17 | Chang Gung University | Method for performing genetic modification under a drug-free environment and components thereof |
KR102184947B1 (ko) | 2012-07-31 | 2020-12-01 | 에이지엑스 쎄라퓨틱스, 인크. | Hla g-변형된 세포 및 방법 |
ES2835673T3 (es) | 2014-04-09 | 2021-06-22 | Dna Twopointo Inc | Construcciones de ácido nucleico mejoradas para la expresión de genes eucariotas |
-
2015
- 2015-04-09 ES ES15776901T patent/ES2835673T3/es active Active
- 2015-04-09 US US14/683,126 patent/US9534234B2/en active Active
- 2015-04-09 CA CA2944887A patent/CA2944887A1/en active Pending
- 2015-04-09 EP EP15776901.9A patent/EP3129487B1/en active Active
- 2015-04-09 US US14/683,121 patent/US9428767B2/en active Active
- 2015-04-09 US US14/683,097 patent/US20150291975A1/en not_active Abandoned
- 2015-04-09 LT LTEP15776901.9T patent/LT3129487T/lt unknown
- 2015-04-09 EP EP19218261.6A patent/EP3670660A1/en active Pending
- 2015-04-09 DK DK15776901.9T patent/DK3129487T3/da active
- 2015-04-09 WO PCT/US2015/025209 patent/WO2015157579A2/en active Application Filing
- 2015-04-09 HU HUE15776901A patent/HUE052552T2/hu unknown
-
2016
- 2016-07-28 US US15/222,830 patent/US9580697B2/en active Active
- 2016-08-02 US US15/195,905 patent/US9574209B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015157579A3 (en) | 2015-12-17 |
US20150291975A1 (en) | 2015-10-15 |
WO2015157579A2 (en) | 2015-10-15 |
LT3129487T (lt) | 2020-12-28 |
US9580697B2 (en) | 2017-02-28 |
ES2835673T3 (es) | 2021-06-22 |
HUE052552T2 (hu) | 2021-05-28 |
EP3670660A1 (en) | 2020-06-24 |
US20160333328A1 (en) | 2016-11-17 |
US9428767B2 (en) | 2016-08-30 |
US9574209B2 (en) | 2017-02-21 |
EP3129487B1 (en) | 2020-10-07 |
US9534234B2 (en) | 2017-01-03 |
EP3129487A4 (en) | 2017-09-13 |
US20150291976A1 (en) | 2015-10-15 |
US20160340691A1 (en) | 2016-11-24 |
CA2944887A1 (en) | 2015-10-15 |
US20150291977A1 (en) | 2015-10-15 |
EP3129487A2 (en) | 2017-02-15 |
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