|
US5919676A
(en)
|
1993-06-24 |
1999-07-06 |
Advec, Inc. |
Adenoviral vector system comprising Cre-loxP recombination
|
|
US6379943B1
(en)
|
1999-03-05 |
2002-04-30 |
Merck & Co., Inc. |
High-efficiency Cre/loxp based system for construction of adenovirus vectors
|
|
AU2319497A
(en)
|
1996-03-07 |
1997-09-22 |
Regents Of The University Of California, The |
Helper-free, totally defective adenovirus for gene therapy
|
|
AU722375B2
(en)
|
1996-09-06 |
2000-08-03 |
Trustees Of The University Of Pennsylvania, The |
Methods using cre-lox for production of recombinant adeno-associated viruses
|
|
JP2001500497A
(ja)
|
1996-09-06 |
2001-01-16 |
トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスに指図される遺伝子治療の方法
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
DE19933719A1
(de)
|
1999-07-19 |
2001-01-25 |
Medigene Ag |
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
|
|
US6429001B1
(en)
|
2000-01-26 |
2002-08-06 |
Chiron Corporation |
Recombinant AAV packaging systems
|
|
ATE318923T1
(de)
|
2000-06-01 |
2006-03-15 |
Univ North Carolina |
Doppelsträngige parvovirus-vektoren
|
|
US6410271B1
(en)
|
2000-06-23 |
2002-06-25 |
Genetastix Corporation |
Generation of highly diverse library of expression vectors via homologous recombination in yeast
|
|
US7749492B2
(en)
*
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
US20070172460A1
(en)
|
2003-03-19 |
2007-07-26 |
Jurgen Kleinschmidt |
Random peptide library displayed on aav vectors
|
|
US8927269B2
(en)
|
2003-05-19 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Avian adenoassociated virus and uses thereof
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
WO2006099615A2
(en)
|
2005-03-16 |
2006-09-21 |
The Johns Hopkins University |
Adenoviral fiber exchange shuttle system
|
|
US7588772B2
(en)
*
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
CN103849629B
(zh)
|
2006-06-21 |
2017-06-09 |
尤尼克尔Ip股份有限公司 |
具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体
|
|
EP2132309A4
(en)
|
2007-02-23 |
2011-01-05 |
Univ Florida |
COMPOSITIONS AND METHODS OF TREATING GLYCOLOGICAL MEMORY DISEASES
|
|
WO2008106694A2
(en)
|
2007-03-01 |
2008-09-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Systems, methods and compositions for optical stimulation of target cells
|
|
EP2176283B1
(en)
|
2007-07-14 |
2016-11-02 |
University of Iowa Research Foundation |
Methods and compositions for treating brain diseases
|
|
US9018138B2
(en)
|
2007-08-16 |
2015-04-28 |
The Johns Hopkins University |
Compositions and methods for generating and screening adenoviral libraries
|
|
WO2009108274A2
(en)
*
|
2008-02-26 |
2009-09-03 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for adeno-associated virus (aav) with hi loop mutations
|
|
JP5801188B2
(ja)
|
2008-04-23 |
2015-10-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
標的細胞を光刺激するためのシステム、方法、および組成物
|
|
US20110223635A1
(en)
|
2008-08-11 |
2011-09-15 |
Karl Deisseroth |
Method and Composition for Controlling Gene Expression
|
|
EP2547762B1
(en)
|
2010-03-17 |
2018-04-25 |
The Board of Trustees of the Leland Stanford Junior University |
Light-sensitive ion-passing molecules
|
|
EP2561073B1
(en)
|
2010-04-23 |
2016-08-24 |
University of Massachusetts |
Cns targeting aav vectors and methods of use thereof
|
|
US20140030192A1
(en)
|
2011-01-28 |
2014-01-30 |
Karl A. Deisseroth |
Functional Targeted Brain Endoskeletonization
|
|
CN105755044A
(zh)
|
2011-04-22 |
2016-07-13 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
ES2857773T5
(es)
|
2011-08-24 |
2024-06-04 |
Univ Leland Stanford Junior |
Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
|
|
ES2724803T3
(es)
|
2011-12-16 |
2019-09-16 |
Univ Leland Stanford Junior |
Polipéptidos opsinas y métodos de utilización de los mismos
|
|
CN104363961B
(zh)
|
2012-02-21 |
2017-10-03 |
斯坦福大学托管董事会 |
用于治疗盆底神经源性病症的组合物和方法
|
|
EP2900686B1
(en)
|
2012-09-28 |
2020-06-10 |
The University of North Carolina At Chapel Hill |
Aav vectors targeted to oligodendrocytes
|
|
CN115120746A
(zh)
|
2013-05-15 |
2022-09-30 |
明尼苏达大学董事会 |
腺相关病毒介导的基因向中枢神经系统转移
|
|
ES2739288T3
(es)
|
2013-09-13 |
2020-01-30 |
California Inst Of Techn |
Recuperación selectiva
|
|
JP6013654B2
(ja)
|
2013-09-19 |
2016-10-25 |
クルセル ホランド ベー ヴェー |
改良されたアデノウイルス製剤
|
|
EP3047271B1
(en)
|
2013-09-20 |
2022-05-11 |
California Institute Of Technology |
Methods for phenotyping of intact whole tissues
|
|
US10794802B2
(en)
|
2013-09-20 |
2020-10-06 |
California Institute Of Technology |
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
|
|
US10072251B2
(en)
|
2014-02-19 |
2018-09-11 |
University Of Massachusetts |
Recombinant AAVS having useful transcytosis properties
|
|
WO2015164757A1
(en)
|
2014-04-25 |
2015-10-29 |
Oregon Health & Science University |
Methods of viral neutralizing antibody epitope mapping
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
CN107073051B
(zh)
|
2014-10-21 |
2021-08-24 |
马萨诸塞大学 |
重组aav变体及其用途
|
|
EP4344741A3
(en)
|
2014-11-21 |
2024-08-28 |
The University of North Carolina at Chapel Hill |
Aav vectors targeted to the central nervous system
|
|
JP6836999B2
(ja)
|
2015-03-24 |
2021-03-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ |
アデノ随伴ウイルス変異体及びその使用方法
|
|
ES2865487T3
(es)
*
|
2015-09-28 |
2021-10-15 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores virales que evaden los anticuerpos
|
|
WO2017075335A1
(en)
|
2015-10-28 |
2017-05-04 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
MX2018004755A
(es)
|
2015-10-29 |
2018-12-19 |
Voyager Therapeutics Inc |
Entrega de polinucleotidos dirigidos al sistema nervioso central.
|
|
KR102423442B1
(ko)
*
|
2015-12-11 |
2022-07-20 |
캘리포니아 인스티튜트 오브 테크놀로지 |
아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드
|
|
EP3411484B1
(en)
|
2016-02-05 |
2023-10-04 |
Emory University |
Injection of single-stranded or self-complementary adeno-associated virus 9 into the cerebrospinal fluid
|
|
JP6947739B2
(ja)
|
2016-02-16 |
2021-10-13 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
既存のヒト中和抗体に対して耐性である新規組換えアデノ随伴ウイルスカプシド
|
|
US11866462B2
(en)
|
2016-05-04 |
2024-01-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
US11364308B2
(en)
|
2016-05-13 |
2022-06-21 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and methods of use thereof
|
|
MA44546B1
(fr)
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
AU2017302013B2
(en)
|
2016-07-29 |
2022-05-26 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
US9927975B2
(en)
|
2016-08-03 |
2018-03-27 |
Micron Technology, Inc. |
Hybrid memory drives, computer system, and related method for operating a multi-mode hybrid drive
|
|
JP7610923B2
(ja)
|
2016-09-02 |
2025-01-09 |
スパーク セラピューティクス インコーポレイテッド |
Ｃｎｓ障害を治療するための方法及びベクター
|
|
AU2017341849B2
(en)
|
2016-10-13 |
2024-03-21 |
University Of Massachusetts |
AAV capsid designs
|
|
CA3041548A1
(en)
|
2016-11-04 |
2018-05-11 |
The Children's Hospital Of Philadelphia |
Gene transfer compositions, methods and uses for treating neurodegenerative diseases
|
|
WO2018119330A2
(en)
|
2016-12-22 |
2018-06-28 |
Oregon Health & Science University |
Adeno associated viral vectors
|
|
US11905312B2
(en)
|
2017-02-15 |
2024-02-20 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for gene transfer across the vasculature
|
|
JP2020510424A
(ja)
*
|
2017-02-28 |
2020-04-09 |
アドヴェラム バイオテクノロジーズ， インコーポレイテッド |
改変ａａｖカプシドおよびその使用
|
|
US10550405B2
(en)
*
|
2017-03-15 |
2020-02-04 |
The University Of North Carolina At Chapel Hill |
Rational polyploid adeno-associated virus vectors and methods of making and using the same
|
|
MX2019011772A
(es)
|
2017-04-03 |
2020-01-09 |
Encoded Therapeutics Inc |
Expresion transgenica selectiva de tejidos.
|
|
JP2020518258A
(ja)
*
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
筋萎縮性側索硬化症（ａｌｓ）治療組成物および方法
|
|
WO2018222503A1
(en)
|
2017-05-31 |
2018-12-06 |
The Regents Of The University Of California |
Adeno-associated virus with variant capsid and methods of use thereof
|
|
CA3053154A1
(en)
|
2017-06-30 |
2019-01-03 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsids and methods of use thereof
|
|
EP3808849A1
(en)
|
2017-08-03 |
2021-04-21 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
JP2020534788A
(ja)
|
2017-08-28 |
2020-12-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
アデノ随伴ウイルスカプシド変異体及びその使用方法
|
|
RU2770922C2
(ru)
|
2017-09-20 |
2022-04-25 |
4Д Молекьюлар Терапьютикс Инк. |
Капсиды вариантов аденоассоциированных вирусов и методы их применения
|
|
CN111770999A
(zh)
|
2017-11-27 |
2020-10-13 |
4D分子治疗有限公司 |
腺相关病毒变体衣壳和用于抑制血管生成的应用
|
|
EP3774853A1
(en)
|
2018-03-30 |
2021-02-17 |
The Board of Trustees of the Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism
|
|
US20210363193A1
(en)
|
2018-04-27 |
2021-11-25 |
Universität Heidelberg |
Modified aav capsid polypeptides for treatment of muscular diseases
|
|
WO2019222329A1
(en)
|
2018-05-15 |
2019-11-21 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
US20210207167A1
(en)
|
2018-05-16 |
2021-07-08 |
Voyager Therapeutics, Inc. |
Aav serotypes for brain specific payload delivery
|
|
US20210214749A1
(en)
|
2018-05-16 |
2021-07-15 |
Voyager Therapeutics, Inc. |
Directed evolution
|
|
WO2020028751A2
(en)
|
2018-08-03 |
2020-02-06 |
Voyager Therapeutics, Inc. |
Aav variants with enhanced tropism
|
|
US11858969B2
(en)
|
2018-09-18 |
2024-01-02 |
California Institute Of Technology |
Engineered light-sensitive proteins
|
|
CN113966399A
(zh)
|
2018-09-26 |
2022-01-21 |
加州理工学院 |
用于靶向基因疗法的腺相关病毒组合物
|
|
US20210371470A1
(en)
|
2018-10-12 |
2021-12-02 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
KR102934700B1
(ko)
|
2019-03-28 |
2026-03-09 |
더 제너럴 하스피탈 코포레이션 |
트랜스진 발현을 위한 조작된 아데노-연관 (aav) 벡터
|
|
TW202102526A
(zh)
|
2019-04-04 |
2021-01-16 |
美商銳進科斯生物股份有限公司 |
重組腺相關病毒及其用途
|
|
JP2022526018A
(ja)
|
2019-04-11 |
2022-05-20 |
カリフォルニア インスティテュート オブ テクノロジー |
脳内への特異性が増強されたウイルス組成物
|
|
EP3952924A4
(en)
|
2019-04-12 |
2023-05-24 |
Encoded Therapeutics, Inc. |
COMPOSITIONS AND METHODS OF ADMINISTRATION OF THERAPEUTIC PRODUCTS
|
|
JP2022530457A
(ja)
|
2019-04-26 |
2022-06-29 |
サンガモ セラピューティクス， インコーポレイテッド |
遺伝子操作ａａｖ
|
|
PL3976798T3
(pl)
|
2019-05-29 |
2026-04-07 |
Encoded Therapeutics, Inc. |
Kompozycje i sposoby selektywnej regulacji genów
|