JP2022130552A5 - - Google Patents
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- JP2022130552A5 JP2022130552A5 JP2022102442A JP2022102442A JP2022130552A5 JP 2022130552 A5 JP2022130552 A5 JP 2022130552A5 JP 2022102442 A JP2022102442 A JP 2022102442A JP 2022102442 A JP2022102442 A JP 2022102442A JP 2022130552 A5 JP2022130552 A5 JP 2022130552A5
- Authority
- JP
- Japan
- Prior art keywords
- pga
- antibody
- nucleic acid
- composition
- positively charged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010020346 Polyglutamic Acid Proteins 0.000 claims 17
- 229920002643 polyglutamic acid Polymers 0.000 claims 17
- 238000000034 method Methods 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 11
- 239000002539 nanocarrier Substances 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 229940127121 immunoconjugate Drugs 0.000 claims 5
- 230000007935 neutral effect Effects 0.000 claims 5
- 238000010459 TALEN Methods 0.000 claims 4
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 3
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 3
- 210000000777 hematopoietic system Anatomy 0.000 claims 3
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 2
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 2
- 102100027642 DNA-binding protein inhibitor ID-2 Human genes 0.000 claims 2
- 102100030751 Eomesodermin homolog Human genes 0.000 claims 2
- 108010009306 Forkhead Box Protein O1 Proteins 0.000 claims 2
- 102000009561 Forkhead Box Protein O1 Human genes 0.000 claims 2
- 101001081582 Homo sapiens DNA-binding protein inhibitor ID-2 Proteins 0.000 claims 2
- 101001064167 Homo sapiens Eomesodermin homolog Proteins 0.000 claims 2
- 101000653540 Homo sapiens Transcription factor 7 Proteins 0.000 claims 2
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 claims 2
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 claims 2
- 102100030627 Transcription factor 7 Human genes 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 239000008241 heterogeneous mixture Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024140719A JP2024164142A (ja) | 2016-04-14 | 2024-08-22 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662322581P | 2016-04-14 | 2016-04-14 | |
| US62/322,581 | 2016-04-14 | ||
| US201762442890P | 2017-01-05 | 2017-01-05 | |
| US62/442,890 | 2017-01-05 | ||
| PCT/US2017/027767 WO2017181110A1 (en) | 2016-04-14 | 2017-04-14 | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| JP2018553912A JP7118340B2 (ja) | 2016-04-14 | 2017-04-14 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553912A Division JP7118340B2 (ja) | 2016-04-14 | 2017-04-14 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024140719A Division JP2024164142A (ja) | 2016-04-14 | 2024-08-22 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022130552A JP2022130552A (ja) | 2022-09-06 |
| JP2022130552A5 true JP2022130552A5 (https=) | 2022-11-07 |
Family
ID=60042027
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553912A Active JP7118340B2 (ja) | 2016-04-14 | 2017-04-14 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
| JP2022102442A Pending JP2022130552A (ja) | 2016-04-14 | 2022-06-27 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
| JP2024140719A Pending JP2024164142A (ja) | 2016-04-14 | 2024-08-22 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553912A Active JP7118340B2 (ja) | 2016-04-14 | 2017-04-14 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024140719A Pending JP2024164142A (ja) | 2016-04-14 | 2024-08-22 | 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20240285797A1 (https=) |
| EP (3) | EP4711465A2 (https=) |
| JP (3) | JP7118340B2 (https=) |
| KR (3) | KR20240144489A (https=) |
| CN (1) | CN109121413A (https=) |
| AU (2) | AU2017250295B2 (https=) |
| BR (1) | BR112018071221A2 (https=) |
| CA (1) | CA3020857A1 (https=) |
| CL (1) | CL2018002905A1 (https=) |
| CO (1) | CO2018012099A2 (https=) |
| CR (1) | CR20180503A (https=) |
| IL (2) | IL300282A (https=) |
| MX (2) | MX392977B (https=) |
| SG (1) | SG11201807593TA (https=) |
| WO (1) | WO2017181110A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| JP7348063B2 (ja) | 2017-01-05 | 2023-09-20 | フレッド ハッチンソン キャンサー センター | ワクチン効力を改善するためのシステム及び方法 |
| CA3067382A1 (en) | 2017-06-15 | 2018-12-20 | The Regents Of The University Of California | Targeted non-viral dna insertions |
| KR102503130B1 (ko) | 2017-10-27 | 2023-02-24 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 내인성 t 세포 수용체의 표적화된 대체 |
| CN111629715A (zh) | 2018-01-18 | 2020-09-04 | 弗莱德哈钦森癌症研究中心 | 通过调节细胞活化状态改变体内免疫细胞的炎症状态 |
| CN108383914A (zh) * | 2018-02-23 | 2018-08-10 | 北京美康基免生物科技有限公司 | 一种基于cd19的嵌合抗原受体及其应用 |
| JP2021523110A (ja) * | 2018-05-01 | 2021-09-02 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子発現のためのナノ粒子及びその使用 |
| CN121555430A (zh) | 2018-05-11 | 2026-02-24 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统取代病原性氨基酸的方法 |
| WO2020224475A1 (zh) * | 2019-05-05 | 2020-11-12 | 复旦大学 | 药物递送载体以及使用其的药物制剂 |
| TW202110463A (zh) * | 2019-05-15 | 2021-03-16 | 美商永生生技股份有限公司 | 高濃度細胞包裝和運送 |
| SE544015C2 (en) * | 2019-06-18 | 2021-11-02 | Tx Medic Ab | Allogenic car-t cell therapy |
| CN111925448B (zh) * | 2020-08-03 | 2022-06-21 | 山东大学 | 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用 |
| GB202017555D0 (en) * | 2020-11-06 | 2020-12-23 | Harbour Antibodies Bv | Antibody-conjugated nanoparticles |
| CN112870370A (zh) * | 2021-03-05 | 2021-06-01 | 广州贝奥吉因生物科技股份有限公司 | 一种基于黑磷纳米片的靶向载药体系及其制备方法 |
| AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| CN114246986B (zh) * | 2021-12-29 | 2022-08-23 | 中国人民解放军陆军军医大学 | 一种基于原位调控免疫反应的心血管植入物及其制备方法 |
| WO2023201097A1 (en) * | 2022-04-15 | 2023-10-19 | Turn Biotechnologies, Inc. | Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells |
| EP4514363A4 (en) * | 2022-04-25 | 2026-04-22 | Univ Leland Stanford Junior | COMPOSITIONS AND METHODS FOR PREVENTING T LYMPHOCYTE DEPLETION |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025006799A1 (en) * | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| WO2025171122A1 (en) * | 2024-02-08 | 2025-08-14 | Cedars-Sinai Medical Center | Enhanced regulatory t cells and methods of use thereof |
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| US1999A (en) | 1841-03-12 | Improvement in seed-planters | ||
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| US2003A (en) | 1841-03-12 | Improvement in horizontal windivhlls | ||
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4078052A (en) | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| CH621479A5 (https=) | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
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| JP7348063B2 (ja) * | 2017-01-05 | 2023-09-20 | フレッド ハッチンソン キャンサー センター | ワクチン効力を改善するためのシステム及び方法 |
-
2017
- 2017-04-14 AU AU2017250295A patent/AU2017250295B2/en active Active
- 2017-04-14 EP EP26153565.2A patent/EP4711465A2/en active Pending
- 2017-04-14 JP JP2018553912A patent/JP7118340B2/ja active Active
- 2017-04-14 WO PCT/US2017/027767 patent/WO2017181110A1/en not_active Ceased
- 2017-04-14 KR KR1020247031845A patent/KR20240144489A/ko active Pending
- 2017-04-14 IL IL300282A patent/IL300282A/en unknown
- 2017-04-14 MX MX2018012556A patent/MX392977B/es unknown
- 2017-04-14 KR KR1020187032542A patent/KR102542533B1/ko active Active
- 2017-04-14 CR CR20180503A patent/CR20180503A/es unknown
- 2017-04-14 EP EP17783314.2A patent/EP3442585B1/en active Active
- 2017-04-14 SG SG11201807593TA patent/SG11201807593TA/en unknown
- 2017-04-14 EP EP22199369.4A patent/EP4166161B1/en active Active
- 2017-04-14 BR BR112018071221-3A patent/BR112018071221A2/pt active IP Right Grant
- 2017-04-14 KR KR1020237019209A patent/KR102711238B1/ko active Active
- 2017-04-14 CA CA3020857A patent/CA3020857A1/en active Pending
- 2017-04-14 CN CN201780023532.9A patent/CN109121413A/zh active Pending
-
2018
- 2018-10-11 CL CL2018002905A patent/CL2018002905A1/es unknown
- 2018-10-12 MX MX2022006948A patent/MX2022006948A/es unknown
- 2018-10-14 IL IL262361A patent/IL262361B2/en unknown
- 2018-11-08 CO CONC2018/0012099A patent/CO2018012099A2/es unknown
-
2022
- 2022-06-27 JP JP2022102442A patent/JP2022130552A/ja active Pending
- 2022-11-23 AU AU2022275453A patent/AU2022275453B9/en active Active
-
2024
- 2024-01-12 US US18/412,351 patent/US20240285797A1/en active Pending
- 2024-08-22 JP JP2024140719A patent/JP2024164142A/ja active Pending
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