JP7118340B2 - 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 - Google Patents

標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 Download PDF

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JP7118340B2
JP7118340B2 JP2018553912A JP2018553912A JP7118340B2 JP 7118340 B2 JP7118340 B2 JP 7118340B2 JP 2018553912 A JP2018553912 A JP 2018553912A JP 2018553912 A JP2018553912 A JP 2018553912A JP 7118340 B2 JP7118340 B2 JP 7118340B2
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antibody
cells
cell
nucleic acid
gene
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JP2019511234A (ja
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シュテファン，マティーアス
モフェット，ハウエル・エフ
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Fred Hutchinson Cancer Center
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JP2018553912A 2016-04-14 2017-04-14 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法 Active JP7118340B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022102442A JP2022130552A (ja) 2016-04-14 2022-06-27 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法
JP2024140719A JP2024164142A (ja) 2016-04-14 2024-08-22 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法

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US201662322581P 2016-04-14 2016-04-14
US62/322,581 2016-04-14
US201762442890P 2017-01-05 2017-01-05
US62/442,890 2017-01-05
PCT/US2017/027767 WO2017181110A1 (en) 2016-04-14 2017-04-14 Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers

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JP7118340B2 true JP7118340B2 (ja) 2022-08-16

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JP2022102442A Pending JP2022130552A (ja) 2016-04-14 2022-06-27 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法
JP2024140719A Pending JP2024164142A (ja) 2016-04-14 2024-08-22 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法

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JP2024140719A Pending JP2024164142A (ja) 2016-04-14 2024-08-22 標的化核酸ナノ担体を使用して治療用細胞をプログラムするための組成物及び方法

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US (1) US20240285797A1 (https=)
EP (3) EP4711465A2 (https=)
JP (3) JP7118340B2 (https=)
KR (3) KR20240144489A (https=)
CN (1) CN109121413A (https=)
AU (2) AU2017250295B2 (https=)
BR (1) BR112018071221A2 (https=)
CA (1) CA3020857A1 (https=)
CL (1) CL2018002905A1 (https=)
CO (1) CO2018012099A2 (https=)
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IL (2) IL300282A (https=)
MX (2) MX392977B (https=)
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AU2013302799B2 (en) 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
JP7348063B2 (ja) 2017-01-05 2023-09-20 フレッド ハッチンソン キャンサー センター ワクチン効力を改善するためのシステム及び方法
CA3067382A1 (en) 2017-06-15 2018-12-20 The Regents Of The University Of California Targeted non-viral dna insertions
KR102503130B1 (ko) 2017-10-27 2023-02-24 더 리전트 오브 더 유니버시티 오브 캘리포니아 내인성 t 세포 수용체의 표적화된 대체
CN111629715A (zh) 2018-01-18 2020-09-04 弗莱德哈钦森癌症研究中心 通过调节细胞活化状态改变体内免疫细胞的炎症状态
CN108383914A (zh) * 2018-02-23 2018-08-10 北京美康基免生物科技有限公司 一种基于cd19的嵌合抗原受体及其应用
JP2021523110A (ja) * 2018-05-01 2021-09-02 フレッド ハッチンソン キャンサー リサーチ センター 遺伝子発現のためのナノ粒子及びその使用
CN121555430A (zh) 2018-05-11 2026-02-24 比姆医疗股份有限公司 使用可编程碱基编辑器系统取代病原性氨基酸的方法
WO2020224475A1 (zh) * 2019-05-05 2020-11-12 复旦大学 药物递送载体以及使用其的药物制剂
TW202110463A (zh) * 2019-05-15 2021-03-16 美商永生生技股份有限公司 高濃度細胞包裝和運送
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
CN111925448B (zh) * 2020-08-03 2022-06-21 山东大学 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用
GB202017555D0 (en) * 2020-11-06 2020-12-23 Harbour Antibodies Bv Antibody-conjugated nanoparticles
CN112870370A (zh) * 2021-03-05 2021-06-01 广州贝奥吉因生物科技股份有限公司 一种基于黑磷纳米片的靶向载药体系及其制备方法
AU2022366987A1 (en) 2021-10-14 2024-05-16 Arsenal Biosciences, Inc. Immune cells having co-expressed shrnas and logic gate systems
CN114246986B (zh) * 2021-12-29 2022-08-23 中国人民解放军陆军军医大学 一种基于原位调控免疫反应的心血管植入物及其制备方法
WO2023201097A1 (en) * 2022-04-15 2023-10-19 Turn Biotechnologies, Inc. Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells
EP4514363A4 (en) * 2022-04-25 2026-04-22 Univ Leland Stanford Junior COMPOSITIONS AND METHODS FOR PREVENTING T LYMPHOCYTE DEPLETION
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025006799A1 (en) * 2023-06-27 2025-01-02 Capstan Therapeutics, Inc. Extracorporeal and ex vivo engineering of select cell populations from peripheral blood
WO2025171122A1 (en) * 2024-02-08 2025-08-14 Cedars-Sinai Medical Center Enhanced regulatory t cells and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504353A (ja) 2003-05-28 2007-03-01 マサチューセッツ インスティチュート オブ テクノロジー 生分解性ポリ（β−アミノエステル）およびその使用
WO2014153114A1 (en) 2013-03-14 2014-09-25 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1999A (en) 1841-03-12 Improvement in seed-planters
US527016A (en) 1894-10-02 Worth
US2003A (en) 1841-03-12 Improvement in horizontal windivhlls
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
CH621479A5 (https=) 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (https=) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4241046A (en) 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4699784A (en) * 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5866322A (en) * 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5527894A (en) 1990-06-11 1996-06-18 Nexstar Pharmacueticals, Inc. Ligands of HIV-1 tat protein
EP0786469B1 (en) 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
US5270160A (en) 1990-12-21 1993-12-14 Toray Industries, Inc. Polyester film and photosensitive material
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
ES2229236T3 (es) 1994-01-11 2005-04-16 Dyax Corporation Inhibidores de la plasmina humana derivados de los dominios de kunitz.
US6306393B1 (en) * 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
US8361794B2 (en) 2004-06-29 2013-01-29 Immunocore Limited Cells expressing a modified T cell receptor
US8663599B1 (en) 2004-10-05 2014-03-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
CN103555733A (zh) 2005-01-05 2014-02-05 F-星生物技术研究与开发有限公司 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
GB0504767D0 (en) 2005-03-08 2005-04-13 Ares Trading Sa Lipocalin protein
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
JP5038763B2 (ja) 2006-04-04 2012-10-03 株式会社リコー インクジェット記録装置と画像処理方法、画像処理制御プログラムと記録媒体および高浸透性顔料インク
KR20090021217A (ko) 2006-06-14 2009-02-27 추가이 세이야쿠 가부시키가이샤 조혈 줄기세포 증가 촉진제
AR062435A1 (es) * 2006-08-18 2008-11-05 Xoma Technology Ltd Anticuerpo especifico prlr (receptor de prolactina) y sus usos
WO2008109806A2 (en) * 2007-03-08 2008-09-12 Massachusetts Institute Of Technology Electrostatic coating of particles for drug delivery
CA2700391A1 (en) 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
US20120192298A1 (en) * 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
HUE041436T2 (hu) * 2009-12-10 2019-05-28 Univ Minnesota Tal-effektor-közvetített DNS-módosítás
GB201006096D0 (en) * 2010-04-13 2010-05-26 Alligator Bioscience Ab Novel compositions and uses thereof
CN102851304A (zh) * 2011-06-30 2013-01-02 复旦大学 基于静电包衣的三元非病毒核酸递释系统及其制备方法
US9828582B2 (en) * 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
US10000746B2 (en) * 2013-05-31 2018-06-19 Cellectis LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
AU2017368320A1 (en) * 2016-12-02 2019-05-02 Cartesian Therapeutics, Inc. Cancer immuno therapy with highly enriched CD8+ chimeric antigen receptor T cells
JP7348063B2 (ja) * 2017-01-05 2023-09-20 フレッド ハッチンソン キャンサー センター ワクチン効力を改善するためのシステム及び方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504353A (ja) 2003-05-28 2007-03-01 マサチューセッツ インスティチュート オブ テクノロジー 生分解性ポリ（β−アミノエステル）およびその使用
WO2014153114A1 (en) 2013-03-14 2014-09-25 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Expert Opin Drug Deliv, 2010 Apr, vol. 7, no. 4, pp. 535-550
Nat Nanotechnol, 2017 Aug (Epub 2017 Apr 17), vol. 12, no. 8, pp. 813-820

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