JP2022058610A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022058610A5 JP2022058610A5 JP2022003838A JP2022003838A JP2022058610A5 JP 2022058610 A5 JP2022058610 A5 JP 2022058610A5 JP 2022003838 A JP2022003838 A JP 2022003838A JP 2022003838 A JP2022003838 A JP 2022003838A JP 2022058610 A5 JP2022058610 A5 JP 2022058610A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- carbothioyl
- amino
- chloro
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
- VPEOFGGTYXSDTR-UHFFFAOYSA-N 1-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]cyclopropane-1-carboxylic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C1(CC1)C(=O)O VPEOFGGTYXSDTR-UHFFFAOYSA-N 0.000 claims 1
- SRQXVSQNJYRWHX-UHFFFAOYSA-N 2-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]-2-methylpropanoic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C(C(=O)O)(C)C SRQXVSQNJYRWHX-UHFFFAOYSA-N 0.000 claims 1
- VZUOXVMAJYLIMN-UHFFFAOYSA-N 2-[3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]-4-fluorophenyl]propanoic acid Chemical compound CC1=C(C(=CC(=C1)OCCC1OCCCC1)C)C(=S)NC=1C=C(C=CC1F)C(C(=O)O)C VZUOXVMAJYLIMN-UHFFFAOYSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-UHFFFAOYSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCCC1OCCCC1)C LHEBDWFMNXQYHT-UHFFFAOYSA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-UHFFFAOYSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCCC1OCCCC1)C SUSIFHLMOQXCFJ-UHFFFAOYSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-LJQANCHMSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2R)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCC[C@@H]1OCCCC1)C LHEBDWFMNXQYHT-LJQANCHMSA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-GOSISDBHSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2R)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCC[C@@H]1OCCCC1)C SUSIFHLMOQXCFJ-GOSISDBHSA-N 0.000 claims 1
- LHEBDWFMNXQYHT-IBGZPJMESA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2S)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]-2-methylpropanoic acid Chemical compound ClC1=C(C=C(C=C1)C(C(=O)O)(C)C)NC(=S)C1=C(C=C(C=C1C)OCC[C@H]1OCCCC1)C LHEBDWFMNXQYHT-IBGZPJMESA-N 0.000 claims 1
- SUSIFHLMOQXCFJ-SFHVURJKSA-N 2-[4-chloro-3-[[2,6-dimethyl-4-[2-[(2S)-oxan-2-yl]ethoxy]benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCC[C@H]1OCCCC1)C SUSIFHLMOQXCFJ-SFHVURJKSA-N 0.000 claims 1
- HSWYJYRHWVMHRL-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclohexylethoxy)-2,6-dimethylbenzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1C)OCCC1CCCCC1)C HSWYJYRHWVMHRL-UHFFFAOYSA-N 0.000 claims 1
- HDOPJHZISGMQOH-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclohexylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1CCCCC1)C(F)(F)F HDOPJHZISGMQOH-UHFFFAOYSA-N 0.000 claims 1
- MYJADEDAMLJBGK-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-cyclopropylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1CC1)C(F)(F)F MYJADEDAMLJBGK-UHFFFAOYSA-N 0.000 claims 1
- GXHLQNMECMHTLV-UHFFFAOYSA-N 2-[4-chloro-3-[[4-(2-phenylethoxy)-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1=CC=CC=C1)C(F)(F)F GXHLQNMECMHTLV-UHFFFAOYSA-N 0.000 claims 1
- BDSTXMUAMCTJNU-UHFFFAOYSA-N 2-[4-chloro-3-[[4-[2-(oxan-2-yl)ethoxy]-2-(trifluoromethyl)benzenecarbothioyl]amino]phenyl]acetic acid Chemical compound ClC1=C(C=C(C=C1)CC(=O)O)NC(=S)C1=C(C=C(C=C1)OCCC1OCCCC1)C(F)(F)F BDSTXMUAMCTJNU-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018175758 | 2018-09-20 | ||
| JP2018175758 | 2018-09-20 | ||
| JP2020548589A JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Division JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022058610A JP2022058610A (ja) | 2022-04-12 |
| JP2022058610A5 true JP2022058610A5 (enExample) | 2022-08-29 |
| JP7338711B2 JP7338711B2 (ja) | 2023-09-05 |
Family
ID=69888481
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Active JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
| JP2022003838A Active JP7338711B2 (ja) | 2018-09-20 | 2022-01-13 | Ｄｐアンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548589A Active JP7021709B2 (ja) | 2018-09-20 | 2019-09-19 | Ｄｐアンタゴニスト |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11319296B2 (enExample) |
| EP (1) | EP3854781B1 (enExample) |
| JP (2) | JP7021709B2 (enExample) |
| KR (2) | KR102425709B1 (enExample) |
| CN (1) | CN112739680A (enExample) |
| AU (1) | AU2019341082A1 (enExample) |
| BR (1) | BR112021005260A2 (enExample) |
| CA (1) | CA3113210A1 (enExample) |
| ES (1) | ES2982217T3 (enExample) |
| IL (2) | IL310383A (enExample) |
| MX (1) | MX2021003131A (enExample) |
| NZ (1) | NZ774113A (enExample) |
| PH (1) | PH12021550549A1 (enExample) |
| SG (1) | SG11202102566YA (enExample) |
| TW (2) | TWI822457B (enExample) |
| WO (1) | WO2020059790A1 (enExample) |
| ZA (1) | ZA202101887B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102425709B1 (ko) * | 2018-09-20 | 2022-07-28 | 오노 야꾸힝 고교 가부시키가이샤 | Dp 길항제 |
| TW202146394A (zh) * | 2020-03-19 | 2021-12-16 | 日商小野藥品工業股份有限公司 | 苯乙酸化合物之結晶 |
| JP2024016311A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | Ｅｐ２アンタゴニスト |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63159342A (ja) | 1985-04-03 | 1988-07-02 | Yamanouchi Pharmaceut Co Ltd | 新規カルボン酸化合物 |
| US4994479A (en) * | 1985-04-03 | 1991-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Phenylene derivatives and anti-allergic use thereof |
| NZ535309A (en) * | 2002-03-19 | 2006-05-26 | Ono Pharmaceutical Co | Carboxylic acid compounds and drugs containing the compounds as the active ingredient |
| WO2005028455A1 (ja) * | 2003-09-17 | 2005-03-31 | Ono Pharmaceutical Co., Ltd. | カルボン酸化合物およびそれらを有効成分として含有する医薬組成物 |
| WO2005080367A1 (en) * | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| US7803786B2 (en) | 2004-06-17 | 2010-09-28 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
| TWI410410B (zh) * | 2007-08-10 | 2013-10-01 | Ono Pharmaceutical Co | Phenylacetic acid compounds |
| MX2014003386A (es) | 2011-09-26 | 2014-06-23 | Grünenthal GmbH | Derivados de metansulfonamida sustituidos con amina como ligandos del receptor de vanilloide. |
| EP3558978A1 (en) | 2016-12-20 | 2019-10-30 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| JP6533249B2 (ja) | 2017-04-21 | 2019-06-19 | 山佐株式会社 | 遊技機用基板ケースの取り付け構造及び遊技機 |
| CN110785408A (zh) | 2017-06-28 | 2020-02-11 | 葛兰素史克知识产权开发有限公司 | 吲哚胺2,3-双加氧酶的调节剂 |
| KR102425709B1 (ko) * | 2018-09-20 | 2022-07-28 | 오노 야꾸힝 고교 가부시키가이샤 | Dp 길항제 |
-
2019
- 2019-09-19 KR KR1020217008017A patent/KR102425709B1/ko active Active
- 2019-09-19 AU AU2019341082A patent/AU2019341082A1/en not_active Abandoned
- 2019-09-19 US US17/276,284 patent/US11319296B2/en active Active
- 2019-09-19 NZ NZ774113A patent/NZ774113A/en unknown
- 2019-09-19 WO PCT/JP2019/036725 patent/WO2020059790A1/ja not_active Ceased
- 2019-09-19 JP JP2020548589A patent/JP7021709B2/ja active Active
- 2019-09-19 KR KR1020227025551A patent/KR20220107330A/ko not_active Withdrawn
- 2019-09-19 BR BR112021005260-7A patent/BR112021005260A2/pt not_active Application Discontinuation
- 2019-09-19 SG SG11202102566YA patent/SG11202102566YA/en unknown
- 2019-09-19 TW TW111143026A patent/TWI822457B/zh active
- 2019-09-19 IL IL310383A patent/IL310383A/en unknown
- 2019-09-19 CA CA3113210A patent/CA3113210A1/en active Pending
- 2019-09-19 CN CN201980061636.8A patent/CN112739680A/zh active Pending
- 2019-09-19 ES ES19862361T patent/ES2982217T3/es active Active
- 2019-09-19 MX MX2021003131A patent/MX2021003131A/es unknown
- 2019-09-19 EP EP19862361.3A patent/EP3854781B1/en active Active
- 2019-09-19 TW TW108133822A patent/TWI784199B/zh not_active IP Right Cessation
-
2021
- 2021-03-11 IL IL281433A patent/IL281433A/en unknown
- 2021-03-12 PH PH12021550549A patent/PH12021550549A1/en unknown
- 2021-03-19 ZA ZA2021/01887A patent/ZA202101887B/en unknown
-
2022
- 2022-01-13 JP JP2022003838A patent/JP7338711B2/ja active Active
- 2022-03-15 US US17/695,796 patent/US20220204468A1/en not_active Abandoned
-
2024
- 2024-10-14 US US18/915,276 patent/US20250042870A1/en active Pending