JP2022023092A5 - - Google Patents
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- JP2022023092A5 JP2022023092A5 JP2021162946A JP2021162946A JP2022023092A5 JP 2022023092 A5 JP2022023092 A5 JP 2022023092A5 JP 2021162946 A JP2021162946 A JP 2021162946A JP 2021162946 A JP2021162946 A JP 2021162946A JP 2022023092 A5 JP2022023092 A5 JP 2022023092A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- preparation
- cell
- mash1
- chx10
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 46
- 238000002360 preparation method Methods 0.000 claims 30
- 239000000825 pharmaceutical preparation Substances 0.000 claims 16
- 101000854931 Homo sapiens Visual system homeobox 2 Proteins 0.000 claims 14
- 101100163882 Mus musculus Ascl1 gene Proteins 0.000 claims 14
- 102100020676 Visual system homeobox 2 Human genes 0.000 claims 14
- 238000012258 culturing Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000000853 adhesive Substances 0.000 claims 5
- 230000001070 adhesive effect Effects 0.000 claims 5
- 230000003833 cell viability Effects 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 230000001464 adherent effect Effects 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000012744 immunostaining Methods 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 108091008695 photoreceptors Proteins 0.000 claims 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 3
- 230000035899 viability Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000324 neuroprotective effect Effects 0.000 claims 2
- 230000000242 pagocytic effect Effects 0.000 claims 2
- 210000000608 photoreceptor cell Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023203590A JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793168P | 2013-03-15 | 2013-03-15 | |
| US61/793,168 | 2013-03-15 | ||
| JP2019159491A JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019159491A Division JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203590A Division JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022023092A JP2022023092A (ja) | 2022-02-07 |
| JP2022023092A5 true JP2022023092A5 (enExample) | 2022-05-24 |
Family
ID=51537881
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503223A Active JP6581966B2 (ja) | 2013-03-15 | 2014-03-14 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2021162946A Pending JP2022023092A (ja) | 2013-03-15 | 2021-10-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503223A Active JP6581966B2 (ja) | 2013-03-15 | 2014-03-14 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20160030490A1 (enExample) |
| EP (2) | EP2970903B1 (enExample) |
| JP (4) | JP6581966B2 (enExample) |
| KR (3) | KR20230058556A (enExample) |
| CN (2) | CN118995611A (enExample) |
| AU (3) | AU2014233403B2 (enExample) |
| CA (2) | CA2906815A1 (enExample) |
| DK (1) | DK2970903T3 (enExample) |
| ES (1) | ES2970720T3 (enExample) |
| FI (1) | FI2970903T3 (enExample) |
| HK (1) | HK1222205A1 (enExample) |
| IL (5) | IL294897B2 (enExample) |
| PT (1) | PT2970903T (enExample) |
| WO (1) | WO2014145108A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118995611A (zh) | 2013-03-15 | 2024-11-22 | 安斯泰来再生医药协会 | 由多能干细胞产生的光感受器和光感受器祖细胞 |
| US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| EP3274710B1 (en) * | 2015-03-23 | 2021-06-09 | Astellas Institute for Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| TWI711455B (zh) * | 2015-05-13 | 2020-12-01 | 臺北榮民總醫院 | 多層視網膜細胞移植物 |
| JP7043392B2 (ja) | 2015-08-18 | 2022-03-29 | アステラス インスティテュート フォー リジェネレイティブ メディシン | 臨床製剤 |
| IL257794B (en) | 2015-09-08 | 2022-09-01 | Sumitomo Pharma Co Ltd | A method for producing retinal pigment epithelial cells |
| CN105567635A (zh) * | 2016-02-21 | 2016-05-11 | 中国医科大学附属第一医院 | 一种改良的Neurobasal B27培养基、制备方法及应用 |
| CN109219657A (zh) | 2016-03-30 | 2019-01-15 | 阿斯特利亚斯生物治疗股份公司 | 少突胶质细胞祖细胞组合物 |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| KR102638492B1 (ko) * | 2017-02-17 | 2024-02-19 | 쏘흐본느 유니베흐시테 | 망막 전구 세포, 망막 색소 상피 세포 및 신경 망막 세포를 얻기 위한 피더-비의존적(Feeder-free) 방법 |
| GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| CN110573610B (zh) | 2017-03-08 | 2025-01-28 | 住友制药株式会社 | 视网膜色素上皮细胞的制备方法 |
| US12090252B2 (en) | 2017-09-14 | 2024-09-17 | Riken | Method for producing retinal tissues |
| CN111094548A (zh) * | 2017-09-14 | 2020-05-01 | 国立研究开发法人理化学研究所 | 基于背侧化信号转导物质或腹侧化信号转导物质的增加视锥细胞或视杆细胞的方法 |
| WO2019078781A1 (en) | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| US12110503B2 (en) | 2018-04-20 | 2024-10-08 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| CN108795864B (zh) * | 2018-05-24 | 2021-08-24 | 中山大学中山眼科中心 | 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法 |
| US20210315938A1 (en) * | 2018-09-07 | 2021-10-14 | Hebecell Corporation | Methods and Compositions for Retinal Neuron Generation in Carrier-Free 3D Sphere Suspension Culture |
| AU2019342741B2 (en) * | 2018-09-19 | 2025-12-11 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| CN109486766B (zh) * | 2018-11-26 | 2021-05-07 | 中山大学 | 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法 |
| KR20210121112A (ko) | 2019-01-23 | 2021-10-07 | 아스테리아스 바이오세라퓨틱스, 인크. | 인간 만능 줄기 세포로부터의 배측-유래된 희소돌기아교세포 전구 세포 |
| WO2021243203A1 (en) * | 2020-05-29 | 2021-12-02 | FUJIFILM Cellular Dynamics, Inc. | Bilayer of retinal pigmented epithelium and photoreceptors and use thereof |
| CA3178949A1 (en) * | 2020-05-29 | 2021-12-02 | Andrew DIAS | Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof |
| CN112608883B (zh) * | 2020-12-25 | 2023-02-24 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| WO2022134031A1 (zh) * | 2020-12-25 | 2022-06-30 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| KR102525093B1 (ko) * | 2021-04-16 | 2023-04-27 | 가톨릭대학교 산학협력단 | 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물 |
| CN113388582A (zh) * | 2021-06-21 | 2021-09-14 | 香港再生医学有限公司 | 促使iPSC分化为外周神经干细胞的方法及培养基和系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2438815A3 (en) * | 2004-01-23 | 2012-10-03 | Advanced Cell Technology, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| AU2005296063A1 (en) * | 2004-10-05 | 2006-04-27 | University Of Georgia Research Foundation, Inc. | Neuronal progenitors from feeder-free human embryonic stem cell culture |
| US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| WO2008045952A2 (en) * | 2006-10-10 | 2008-04-17 | The Regents Of The University Of Michigan | Photoreceptor precursor cells |
| US9133435B2 (en) * | 2007-01-18 | 2015-09-15 | Riken | Method for induction/differentiation into photoreceptor cell |
| CA3066806C (en) * | 2009-08-24 | 2023-03-07 | David M. Gamm | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
| CN111265551A (zh) | 2011-05-18 | 2020-06-12 | 加利福尼亚大学董事会 | 用于治疗视网膜疾病的组合物及方法 |
| WO2013184809A1 (en) * | 2012-06-05 | 2013-12-12 | The Regents Of The University Of California | Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells |
| US20160175361A1 (en) | 2014-03-14 | 2016-06-23 | Advanced Cell Technology, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| CN118995611A (zh) | 2013-03-15 | 2024-11-22 | 安斯泰来再生医药协会 | 由多能干细胞产生的光感受器和光感受器祖细胞 |
| US20160175362A1 (en) | 2014-03-14 | 2016-06-23 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
-
2014
- 2014-03-14 CN CN202411157822.0A patent/CN118995611A/zh active Pending
- 2014-03-14 EP EP14764825.7A patent/EP2970903B1/en active Active
- 2014-03-14 CA CA2906815A patent/CA2906815A1/en active Pending
- 2014-03-14 KR KR1020237013967A patent/KR20230058556A/ko active Pending
- 2014-03-14 CA CA3177943A patent/CA3177943A1/en active Pending
- 2014-03-14 US US14/774,771 patent/US20160030490A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/029790 patent/WO2014145108A1/en not_active Ceased
- 2014-03-14 CN CN201480022584.0A patent/CN105378070A/zh active Pending
- 2014-03-14 IL IL294897A patent/IL294897B2/en unknown
- 2014-03-14 IL IL307568A patent/IL307568A/en unknown
- 2014-03-14 DK DK14764825.7T patent/DK2970903T3/da active
- 2014-03-14 AU AU2014233403A patent/AU2014233403B2/en active Active
- 2014-03-14 KR KR1020217017223A patent/KR102527507B1/ko active Active
- 2014-03-14 ES ES14764825T patent/ES2970720T3/es active Active
- 2014-03-14 KR KR1020157029814A patent/KR102263956B1/ko active Active
- 2014-03-14 US US14/214,598 patent/US10307444B2/en active Active
- 2014-03-14 HK HK16110477.3A patent/HK1222205A1/zh unknown
- 2014-03-14 PT PT147648257T patent/PT2970903T/pt unknown
- 2014-03-14 EP EP23192245.1A patent/EP4292600A3/en active Pending
- 2014-03-14 FI FIEP14764825.7T patent/FI2970903T3/fi active
- 2014-03-14 JP JP2016503223A patent/JP6581966B2/ja active Active
-
2015
- 2015-09-03 IL IL241177A patent/IL241177B/en active IP Right Grant
-
2019
- 2019-02-25 US US16/284,565 patent/US20190290701A1/en not_active Abandoned
- 2019-03-27 US US16/367,045 patent/US20190321414A1/en not_active Abandoned
- 2019-05-21 IL IL266775A patent/IL266775B/en active IP Right Grant
- 2019-09-02 JP JP2019159491A patent/JP7245752B2/ja active Active
- 2019-10-24 AU AU2019253874A patent/AU2019253874A1/en not_active Abandoned
-
2020
- 2020-07-20 IL IL276173A patent/IL276173B2/en unknown
-
2021
- 2021-10-01 JP JP2021162946A patent/JP2022023092A/ja active Pending
-
2022
- 2022-03-22 AU AU2022201986A patent/AU2022201986B2/en active Active
- 2022-04-13 US US17/719,473 patent/US20220347228A1/en active Pending
-
2023
- 2023-12-01 JP JP2023203590A patent/JP2024053564A/ja active Pending
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