JP2022023092A5 - - Google Patents
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- JP2022023092A5 JP2022023092A5 JP2021162946A JP2021162946A JP2022023092A5 JP 2022023092 A5 JP2022023092 A5 JP 2022023092A5 JP 2021162946 A JP2021162946 A JP 2021162946A JP 2021162946 A JP2021162946 A JP 2021162946A JP 2022023092 A5 JP2022023092 A5 JP 2022023092A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- preparation
- cell
- mash1
- chx10
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 46
- 238000002360 preparation method Methods 0.000 claims 30
- 239000000825 pharmaceutical preparation Substances 0.000 claims 16
- 101000854931 Homo sapiens Visual system homeobox 2 Proteins 0.000 claims 14
- 101100163882 Mus musculus Ascl1 gene Proteins 0.000 claims 14
- 102100020676 Visual system homeobox 2 Human genes 0.000 claims 14
- 238000012258 culturing Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000000853 adhesive Substances 0.000 claims 5
- 230000001070 adhesive effect Effects 0.000 claims 5
- 230000003833 cell viability Effects 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 230000001464 adherent effect Effects 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000012744 immunostaining Methods 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 108091008695 photoreceptors Proteins 0.000 claims 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 3
- 230000035899 viability Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000324 neuroprotective effect Effects 0.000 claims 2
- 230000000242 pagocytic effect Effects 0.000 claims 2
- 210000000608 photoreceptor cell Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023203590A JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793168P | 2013-03-15 | 2013-03-15 | |
| US61/793,168 | 2013-03-15 | ||
| JP2019159491A JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019159491A Division JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203590A Division JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022023092A JP2022023092A (ja) | 2022-02-07 |
| JP2022023092A5 true JP2022023092A5 (enExample) | 2022-05-24 |
Family
ID=51537881
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503223A Active JP6581966B2 (ja) | 2013-03-15 | 2014-03-14 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2021162946A Pending JP2022023092A (ja) | 2013-03-15 | 2021-10-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503223A Active JP6581966B2 (ja) | 2013-03-15 | 2014-03-14 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
| JP2019159491A Active JP7245752B2 (ja) | 2013-03-15 | 2019-09-02 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203590A Pending JP2024053564A (ja) | 2013-03-15 | 2023-12-01 | 多能性幹細胞から生成された光受容体および光受容体前駆体 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20160030490A1 (enExample) |
| EP (2) | EP2970903B1 (enExample) |
| JP (4) | JP6581966B2 (enExample) |
| KR (3) | KR102263956B1 (enExample) |
| CN (2) | CN105378070A (enExample) |
| AU (3) | AU2014233403B2 (enExample) |
| CA (2) | CA2906815A1 (enExample) |
| DK (1) | DK2970903T3 (enExample) |
| ES (1) | ES2970720T3 (enExample) |
| FI (1) | FI2970903T3 (enExample) |
| HK (1) | HK1222205A1 (enExample) |
| IL (5) | IL294897B2 (enExample) |
| PT (1) | PT2970903T (enExample) |
| WO (1) | WO2014145108A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2906815A1 (en) | 2013-03-15 | 2014-09-18 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| CN118995872A (zh) | 2015-03-23 | 2024-11-22 | 安斯泰来再生医药协会 | 改进的人视网膜色素（rpe）细胞和感光祖细胞的效能测定 |
| US20160331867A1 (en) * | 2015-05-13 | 2016-11-17 | Taipei Veterans General Hospital | Multilayered retinal cell implant |
| KR102651291B1 (ko) | 2015-08-18 | 2024-03-26 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
| CA2997528C (en) * | 2015-09-08 | 2024-02-13 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing retinal pigment epithelial cells |
| CN105567635A (zh) * | 2016-02-21 | 2016-05-11 | 中国医科大学附属第一医院 | 一种改良的Neurobasal B27培养基、制备方法及应用 |
| WO2017173064A1 (en) | 2016-03-30 | 2017-10-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| IL268666B2 (en) * | 2017-02-17 | 2025-06-01 | Univ Sorbonne | Feeder-free methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells |
| GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| JP7007686B2 (ja) | 2017-03-08 | 2022-01-25 | 大日本住友製薬株式会社 | 網膜色素上皮細胞の製造方法 |
| EP3683304A4 (en) * | 2017-09-14 | 2021-06-09 | Riken | METHOD OF REINFORCEMENT OF PIPE PHOTO RECEPTORS OR ROD PHOTO RECEPTORS WITH A DORSALIZATION SIGNAL TRANSMITTER OR VENTRALIZATION SIGNAL TRANSMITTER |
| JP7360583B2 (ja) * | 2017-09-14 | 2023-10-13 | 国立研究開発法人理化学研究所 | 網膜組織の製造方法 |
| WO2019078781A1 (en) * | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| CA3097428A1 (en) | 2018-04-20 | 2019-10-24 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| CN108795864B (zh) * | 2018-05-24 | 2021-08-24 | 中山大学中山眼科中心 | 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法 |
| KR20210058872A (ko) * | 2018-09-07 | 2021-05-24 | 헤베셀 코포레이션 | 담체 무함유 3d 구체 현탁 배양에서 망막 뉴런 생성을 위한 방법 및 조성물 |
| US12365872B2 (en) | 2018-09-19 | 2025-07-22 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| CN109486766B (zh) * | 2018-11-26 | 2021-05-07 | 中山大学 | 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法 |
| EP3914264A4 (en) | 2019-01-23 | 2022-11-23 | Asterias Biotherapeutics, Inc. | OLIGODENDROCYTE PROGENITOR CELLS DERIVED FROM THE BACK FROM HUMAN PLURIPOTENT STEM CELLS |
| BR112022024031A2 (pt) * | 2020-05-29 | 2023-01-31 | Fujifilm Cellular Dynamics Inc | Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos |
| US20230212509A1 (en) * | 2020-05-29 | 2023-07-06 | FUJIFILM Cellular Dynamics, Inc. | Bilayer of retinal pigmented epithelium and photoreceptors and use thereof |
| CN112608883B (zh) * | 2020-12-25 | 2023-02-24 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| WO2022134031A1 (zh) * | 2020-12-25 | 2022-06-30 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
| KR102525093B1 (ko) * | 2021-04-16 | 2023-04-27 | 가톨릭대학교 산학협력단 | 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물 |
| CN113388582A (zh) * | 2021-06-21 | 2021-09-14 | 香港再生医学有限公司 | 促使iPSC分化为外周神经干细胞的方法及培养基和系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2929782A1 (en) | 2004-01-23 | 2015-10-14 | Ocata Therapeutics, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| WO2006044204A2 (en) * | 2004-10-05 | 2006-04-27 | University Of Georgia Research Foundation, Inc. | Neuronal progenitors from feeder-free human embryonic stem cell culture |
| US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| WO2008045952A2 (en) | 2006-10-10 | 2008-04-17 | The Regents Of The University Of Michigan | Photoreceptor precursor cells |
| EP2128244A4 (en) * | 2007-01-18 | 2012-05-09 | Riken | PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE |
| CA3066806C (en) * | 2009-08-24 | 2023-03-07 | David M. Gamm | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| WO2011043591A2 (en) | 2009-10-06 | 2011-04-14 | Snu R&Db Foundation | Method for differentiation into retinal cells from stem cells |
| KR101972610B1 (ko) | 2011-05-18 | 2019-04-25 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 망막 질환을 치료하기 위한 조성물 및 방법 |
| ES2688019T3 (es) * | 2012-06-05 | 2018-10-30 | The Regents Of The University Of California | Métodos y composiciones para la producción acelerada de células epiteliales pigmentadas retinianas a partir de células pluripotentes |
| US20160175362A1 (en) | 2014-03-14 | 2016-06-23 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| US20160175361A1 (en) | 2014-03-14 | 2016-06-23 | Advanced Cell Technology, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| CA2906815A1 (en) | 2013-03-15 | 2014-09-18 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
-
2014
- 2014-03-14 CA CA2906815A patent/CA2906815A1/en active Pending
- 2014-03-14 KR KR1020157029814A patent/KR102263956B1/ko active Active
- 2014-03-14 HK HK16110477.3A patent/HK1222205A1/zh unknown
- 2014-03-14 IL IL294897A patent/IL294897B2/en unknown
- 2014-03-14 CA CA3177943A patent/CA3177943A1/en active Pending
- 2014-03-14 FI FIEP14764825.7T patent/FI2970903T3/fi active
- 2014-03-14 CN CN201480022584.0A patent/CN105378070A/zh active Pending
- 2014-03-14 PT PT147648257T patent/PT2970903T/pt unknown
- 2014-03-14 US US14/774,771 patent/US20160030490A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/029790 patent/WO2014145108A1/en not_active Ceased
- 2014-03-14 US US14/214,598 patent/US10307444B2/en active Active
- 2014-03-14 ES ES14764825T patent/ES2970720T3/es active Active
- 2014-03-14 JP JP2016503223A patent/JP6581966B2/ja active Active
- 2014-03-14 AU AU2014233403A patent/AU2014233403B2/en active Active
- 2014-03-14 KR KR1020237013967A patent/KR20230058556A/ko active Pending
- 2014-03-14 EP EP14764825.7A patent/EP2970903B1/en active Active
- 2014-03-14 EP EP23192245.1A patent/EP4292600A3/en active Pending
- 2014-03-14 KR KR1020217017223A patent/KR102527507B1/ko active Active
- 2014-03-14 IL IL307568A patent/IL307568A/en unknown
- 2014-03-14 DK DK14764825.7T patent/DK2970903T3/da active
- 2014-03-14 CN CN202411157822.0A patent/CN118995611A/zh active Pending
-
2015
- 2015-09-03 IL IL241177A patent/IL241177B/en active IP Right Grant
-
2019
- 2019-02-25 US US16/284,565 patent/US20190290701A1/en not_active Abandoned
- 2019-03-27 US US16/367,045 patent/US20190321414A1/en not_active Abandoned
- 2019-05-21 IL IL266775A patent/IL266775B/en active IP Right Grant
- 2019-09-02 JP JP2019159491A patent/JP7245752B2/ja active Active
- 2019-10-24 AU AU2019253874A patent/AU2019253874A1/en not_active Abandoned
-
2020
- 2020-07-20 IL IL276173A patent/IL276173B2/en unknown
-
2021
- 2021-10-01 JP JP2021162946A patent/JP2022023092A/ja active Pending
-
2022
- 2022-03-22 AU AU2022201986A patent/AU2022201986B2/en active Active
- 2022-04-13 US US17/719,473 patent/US20220347228A1/en active Pending
-
2023
- 2023-12-01 JP JP2023203590A patent/JP2024053564A/ja active Pending
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