KR102263956B1 - 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 - Google Patents

만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 Download PDF

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KR102263956B1
KR102263956B1 KR1020157029814A KR20157029814A KR102263956B1 KR 102263956 B1 KR102263956 B1 KR 102263956B1 KR 1020157029814 A KR1020157029814 A KR 1020157029814A KR 20157029814 A KR20157029814 A KR 20157029814A KR 102263956 B1 KR102263956 B1 KR 102263956B1
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cells
photoreceptor
progenitor cells
cell
photoreceptor progenitor
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KR20160002779A (ko
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로버트 피. 란자
시지앙 루
웨이 왕
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아스텔라스 인스티튜트 포 리제너러티브 메디슨
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KR1020157029814A 2013-03-15 2014-03-14 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 Active KR102263956B1 (ko)

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US201361793168P 2013-03-15 2013-03-15
US61/793,168 2013-03-15
PCT/US2014/029790 WO2014145108A1 (en) 2013-03-15 2014-03-14 Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL307568A (en) 2013-03-15 2023-12-01 Astellas Inst For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
CN107889507B (zh) * 2015-03-23 2021-11-26 安斯泰来再生医药协会 改进的人视网膜色素(rpe)细胞和感光祖细胞的效能测定
TWI711455B (zh) * 2015-05-13 2020-12-01 臺北榮民總醫院 多層視網膜細胞移植物
TW202417023A (zh) 2015-08-18 2024-05-01 美商安斯泰來再生醫藥協會 臨床調配物
ES2922475T3 (es) * 2015-09-08 2022-09-15 Sumitomo Pharma Co Ltd Método para producir células epiteliales pigmentarias de la retina
CN105567635A (zh) * 2016-02-21 2016-05-11 中国医科大学附属第一医院 一种改良的Neurobasal B27培养基、制备方法及应用
WO2017173064A1 (en) 2016-03-30 2017-10-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
JP7260475B2 (ja) * 2017-02-17 2023-04-18 ソルボンヌ・ユニヴェルシテ 網膜前駆体、網膜色素上皮細胞及び神経網膜細胞を得るフィーダーフリーの方法
GB201703058D0 (en) 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
CN110573610B (zh) 2017-03-08 2025-01-28 住友制药株式会社 视网膜色素上皮细胞的制备方法
CN111094548A (zh) * 2017-09-14 2020-05-01 国立研究开发法人理化学研究所 基于背侧化信号转导物质或腹侧化信号转导物质的增加视锥细胞或视杆细胞的方法
EP3683306A4 (en) * 2017-09-14 2021-06-09 Riken METHOD FOR MANUFACTURING RETINAGE TISSUE
WO2019078781A1 (en) * 2017-10-17 2019-04-25 National University Of Singapore SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS
US12110503B2 (en) 2018-04-20 2024-10-08 FUJIFILM Cellular Dynamics, Inc. Method for differentiation of ocular cells and use thereof
CN108795864B (zh) * 2018-05-24 2021-08-24 中山大学中山眼科中心 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法
WO2020051429A1 (en) * 2018-09-07 2020-03-12 Hebecell Corporation Methods and compositions for retinal neuron generation in carrier-free 3d sphere suspension culture
AU2019342741B2 (en) * 2018-09-19 2025-12-11 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
CN109486766B (zh) * 2018-11-26 2021-05-07 中山大学 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法
AU2020210757A1 (en) 2019-01-23 2021-08-05 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
JP2023536210A (ja) * 2020-05-29 2023-08-24 フジフィルム セルラー ダイナミクス,インコーポレイテッド 網膜色素上皮及び光受容体の二重層、並びにその使用
CN116033912A (zh) * 2020-05-29 2023-04-28 富士胶片细胞动力公司 视网膜色素上皮和感光器双细胞聚集物及其使用方法
CN112608883B (zh) * 2020-12-25 2023-02-24 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
US20240052305A1 (en) * 2020-12-25 2024-02-15 Iregene Therapeutics Ltd Chemical induction method for photoreceptor neuron cells
KR102525093B1 (ko) * 2021-04-16 2023-04-27 가톨릭대학교 산학협력단 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물
CN113388582A (zh) * 2021-06-21 2021-09-14 香港再生医学有限公司 促使iPSC分化为外周神经干细胞的方法及培养基和系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070011A2 (en) * 2004-01-23 2005-08-04 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
WO2006044204A2 (en) * 2004-10-05 2006-04-27 University Of Georgia Research Foundation, Inc. Neuronal progenitors from feeder-free human embryonic stem cell culture
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
WO2008045952A2 (en) * 2006-10-10 2008-04-17 The Regents Of The University Of Michigan Photoreceptor precursor cells
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE
EP2470645B1 (en) * 2009-08-24 2019-06-26 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
KR101268741B1 (ko) 2009-10-06 2013-06-04 김지연 줄기세포를 망막세포로 분화시키는 방법
JP6223963B2 (ja) 2011-05-18 2017-11-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 網膜疾患を処置するための組成物および方法
ES2688019T3 (es) * 2012-06-05 2018-10-30 The Regents Of The University Of California Métodos y composiciones para la producción acelerada de células epiteliales pigmentadas retinianas a partir de células pluripotentes
US20160175361A1 (en) 2014-03-14 2016-06-23 Advanced Cell Technology, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
IL307568A (en) 2013-03-15 2023-12-01 Astellas Inst For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US20160175362A1 (en) 2014-03-14 2016-06-23 Ocata Therapeutics, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Proc Natl Acad Sci U S A. 106(39):16698-703 (2009.09.29.)*
Stem Cells. 30(4):673-86 (2012.04.)*

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

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