JP2021535227A5 - - Google Patents
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- Publication number
- JP2021535227A5 JP2021535227A5 JP2021536681A JP2021536681A JP2021535227A5 JP 2021535227 A5 JP2021535227 A5 JP 2021535227A5 JP 2021536681 A JP2021536681 A JP 2021536681A JP 2021536681 A JP2021536681 A JP 2021536681A JP 2021535227 A5 JP2021535227 A5 JP 2021535227A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023189771A JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726741P | 2018-09-04 | 2018-09-04 | |
| US62/726,741 | 2018-09-04 | ||
| PCT/US2019/049565 WO2020051223A1 (en) | 2018-09-04 | 2019-09-04 | Compositions and methods for organ specific delivery of nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189771A Division JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021535227A JP2021535227A (ja) | 2021-12-16 |
| JPWO2020051223A5 JPWO2020051223A5 (https=) | 2022-09-13 |
| JP2021535227A5 true JP2021535227A5 (https=) | 2022-09-13 |
| JP7425066B2 JP7425066B2 (ja) | 2024-01-30 |
Family
ID=69722750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536681A Active JP7425066B2 (ja) | 2018-09-04 | 2019-09-04 | 核酸を臓器特異的送達するための組成物および方法 |
| JP2023189771A Active JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189771A Active JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (9) | US11229609B2 (https=) |
| EP (1) | EP3846822A4 (https=) |
| JP (2) | JP7425066B2 (https=) |
| CN (2) | CN112996519B (https=) |
| AU (2) | AU2019336679B2 (https=) |
| CA (1) | CA3111484A1 (https=) |
| GB (3) | GB2606038B (https=) |
| WO (1) | WO2020051223A1 (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| EP4316588A3 (en) | 2016-05-27 | 2024-05-15 | Transcriptx, Inc. | Treatment of primary ciliary dyskinesia with synthetic messenger rna |
| EP3515928B1 (en) | 2016-09-23 | 2026-01-28 | Duke University | Unstructured non-repetitive polypeptides having lcst behavior |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| EP3675826B1 (en) * | 2017-08-31 | 2023-05-31 | Life Technologies Corporation | Cationic lipid compositions for tissue-specific delivery |
| US12296018B2 (en) | 2018-01-26 | 2025-05-13 | Duke University | Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| WO2020051220A1 (en) | 2018-09-04 | 2020-03-12 | The Board of the Regents of the University of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| CN112996519B (zh) | 2018-09-04 | 2025-02-28 | 德克萨斯大学系统董事会 | 用于核酸的器官特异性递送的组合物和方法 |
| WO2020051541A1 (en) | 2018-09-07 | 2020-03-12 | Duke University | Nanoparticulate drug delivery systems |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| WO2021216577A1 (en) * | 2020-04-20 | 2021-10-28 | Board Of Regents, The University Of Texas System | Lipid nanoparticle (lnp) delivery systems and uses thereof |
| JP2023527163A (ja) * | 2020-05-19 | 2023-06-27 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | 核酸送達用の脂質粒子およびその臨床応用 |
| JP2023546175A (ja) * | 2020-10-14 | 2023-11-01 | ジョージ・メイソン・リサーチ・ファウンデーション・インコーポレイテッド | 脂質ナノ粒子製造の方法及びそれに由来する組成物 |
| WO2022140404A1 (en) * | 2020-12-22 | 2022-06-30 | Cornell University | Zwitterionic lipid nanoparticle compositions, and methods of use |
| KR20230175204A (ko) * | 2021-03-22 | 2023-12-29 | 리코드 테라퓨틱스, 인크. | 폴리뉴클레오티드 조성물, 관련된 제제, 및 이의 사용 방법 |
| WO2022204043A1 (en) * | 2021-03-22 | 2022-09-29 | The Board Of Regents Of The University Of Texas System | Compositions and methods for targeted delivery to cells |
| JP2024511463A (ja) | 2021-03-22 | 2024-03-13 | リコード セラピューティクス，インク． | 細胞への標的送達のための組成物および方法 |
| EP4313004A4 (en) * | 2021-03-23 | 2025-01-15 | Recode Therapeutics, Inc. | Compositions and methods for targeted systemic delivery to cells |
| JP2024511437A (ja) | 2021-03-23 | 2024-03-13 | リコード セラピューティクス，インク． | ポリヌクレオチド組成物、関連製剤、およびその使用方法 |
| WO2022226344A1 (en) * | 2021-04-22 | 2022-10-27 | The Board Of Regents Of The University Of Texas System | All-in-one dendrimer-based lipid nanoparticles enable precise hdr-mediated gene editing in vivo |
| CN117642155A (zh) * | 2021-06-01 | 2024-03-01 | 内诺维什疗法股份有限公司 | 使用脂质纳米颗粒的dna载体递送 |
| CN118201605A (zh) * | 2021-10-25 | 2024-06-14 | 杜克大学 | 基于poegma的脂质纳米粒子 |
| AU2022425201A1 (en) * | 2021-12-27 | 2024-07-18 | The Board Of Regents Of The University Of Texas System | Compositions and methods for targeted delivery to cells |
| WO2023158738A2 (en) * | 2022-02-16 | 2023-08-24 | Trustees Of Tufts College | Lipid nanoparticles for delivery to the eye or ear |
| WO2023165583A1 (zh) * | 2022-03-04 | 2023-09-07 | 益杰立科(上海)生物科技有限公司 | 靶向眼部细胞的递送系统和方法 |
| AU2023238223A1 (en) | 2022-03-23 | 2024-10-10 | Nanovation Therapeutics Inc. | High sterol-containing lipid nanoparticles |
| US20250312430A1 (en) * | 2022-03-30 | 2025-10-09 | The Johns Hopkins University | Compositions of lipid nanoparticles for plasmid dna delivery to the liver and methods for preparing the same |
| CN119654166A (zh) * | 2022-04-01 | 2025-03-18 | 内诺维什疗法股份有限公司 | mRNA递送方法及其组合物 |
| WO2023218420A1 (en) | 2022-05-13 | 2023-11-16 | Janssen Pharmaceuticals, Inc. | Mrna compositions for inducing latent hiv-1 reversal |
| CN114887070B (zh) * | 2022-06-06 | 2023-09-22 | 郑州大学第一附属医院 | 一种脾脏靶向的纳米药物 |
| CN114887071B (zh) * | 2022-06-06 | 2023-09-22 | 郑州大学第一附属医院 | 一种靶向脾脏的纳米递送载体 |
| CN114891808B (zh) * | 2022-06-21 | 2023-10-27 | 珠海丽凡达生物技术有限公司 | 编码ALDH2多肽的mRNA分子、应用及mRNA药物 |
| US20250382640A1 (en) * | 2022-06-29 | 2025-12-18 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| EP4551199A1 (en) | 2022-07-08 | 2025-05-14 | PolyPlus Transfection | Lipid nanoparticles comprising an imidazolium-based cationic lipid |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US20250360083A1 (en) * | 2022-09-21 | 2025-11-27 | Board Of Regents Of The University Of Nebraska | Lipid nanoparticle formulations and methods of use thereof |
| WO2024108740A1 (zh) * | 2022-11-21 | 2024-05-30 | 成都诺恩基因科技有限公司 | 适合于肌注给药的核酸-脂质纳米颗粒、制剂及其应用 |
| EP4400491A4 (en) * | 2022-11-24 | 2025-05-07 | Themedium Therapeutics Co., Ltd | Novel lipids used for nucleic acid delivery and lipid nanoparticle composition |
| EP4630057A1 (en) | 2022-12-08 | 2025-10-15 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| CN116270534B (zh) * | 2022-12-13 | 2024-11-26 | 山东大学 | 一种组织选择性递送核酸药物的类脂质纳米颗粒及其制备方法和应用 |
| WO2024124660A1 (zh) * | 2022-12-14 | 2024-06-20 | 北京剂泰医药科技有限公司 | 脂质基质局部注射制剂 |
| EP4385523A1 (en) * | 2022-12-14 | 2024-06-19 | Beijing Jitai Pharmaceutical Technology Co., Ltd. | Lipid-based topical injection formulations |
| EP4638417A1 (en) | 2022-12-22 | 2025-10-29 | Nanovation Therapeutics Inc. | Sulfur-containing ionizable lipids for the delivery of nucleic acids and other therapeutic agents |
| CN116199646B (zh) * | 2023-03-07 | 2024-01-26 | 山东大学 | 一种基于Tris的可电离脂质及其制备方法与应用 |
| CN116271105B (zh) * | 2023-05-18 | 2023-08-25 | 上海贝斯昂科生物科技有限公司 | 一种适于rpe细胞转染的脂质纳米颗粒及其应用 |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025029927A1 (en) * | 2023-07-31 | 2025-02-06 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle |
| WO2025036297A1 (zh) | 2023-08-11 | 2025-02-20 | 浙江海昶生物医药技术有限公司 | 一种具有靶向性的脂质组合物及其制备方法 |
| US12343429B2 (en) | 2023-10-05 | 2025-07-01 | Nanovation Therapeutics Inc. | Method of delivery of DNA or RNA cargo unshielded lipid nanoparticles and compositions thereof |
| WO2025073056A1 (en) * | 2023-10-05 | 2025-04-10 | Nanovation Therapeutics Inc. | Haematopoietic stem and/or progenitor cell delivery method and compositions for use thereof |
| WO2025081189A1 (en) * | 2023-10-12 | 2025-04-17 | Georgia Tech Research Corporation | Methods and compositions for lipid nanoparticle (lnp) mediated delivery of mrna encoded synthetic antigens for universal tumor targeting by car t cells |
| WO2025088597A1 (en) * | 2023-10-26 | 2025-05-01 | New Phase Ltd. | Nanoparticle combination therapy for tumors |
| WO2025108545A1 (en) * | 2023-11-22 | 2025-05-30 | Danmarks Tekniske Universitet | Delivery of nucleotides from injectable biomaterial |
| US12364773B2 (en) * | 2023-12-01 | 2025-07-22 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| US12553042B2 (en) | 2023-12-01 | 2026-02-17 | Recode Therapeutics, Inc. | Method for quantifying an amount of capped messenger RNA |
| WO2025133684A1 (en) * | 2023-12-21 | 2025-06-26 | Vilnius University | Liposomal nanoparticles for crispr/cas9 delivery |
| CN120398741A (zh) * | 2024-01-29 | 2025-08-01 | 江苏中天药业有限公司 | 一种用于递送核酸物质的脂肪酸衍生物及其合成方法 |
| CN118001254B (zh) | 2024-04-09 | 2024-07-26 | 北京悦康科创医药科技股份有限公司 | 靶向抗原呈递细胞的脂质组合物及其应用 |
| WO2025213271A1 (en) * | 2024-04-11 | 2025-10-16 | Nanovation Therapeutics Inc. | Method of delivering nucleic acid to macrophages and/or monocytes and compositions for use thereof |
| WO2025226642A1 (en) * | 2024-04-25 | 2025-10-30 | Eli Lilly And Company | Lipid nano delivery particles for targeted transport of nucleic acids and methods of making and using the same |
| WO2025228975A1 (en) * | 2024-04-29 | 2025-11-06 | BioNTech SE | Particles, compositions and methods |
| WO2025228979A1 (en) | 2024-04-30 | 2025-11-06 | Neovac Ltd. | Lipids nanoparticle formulations suitable for lung targeting |
| WO2026025110A1 (en) * | 2024-07-26 | 2026-01-29 | Trevi Therapeutics, Inc. | Treatment of refractory chronic cough |
| CN118750468B (zh) * | 2024-09-05 | 2025-02-18 | 北京悦康科创医药科技股份有限公司 | 一种核酸-脂质纳米颗粒冻干组合物及其制备方法和应用 |
| KR20260043575A (ko) * | 2024-09-24 | 2026-03-31 | 주식회사 녹십자 | 선택적 장기 표적 지질을 포함하는 조성물 |
| CN121610533B (zh) * | 2026-02-03 | 2026-04-17 | 中国海洋大学三亚海洋研究院 | 用于鱼类在体皮肤基因编辑的脂质纳米颗粒及其应用 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US7053150B2 (en) | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
| US7314956B2 (en) | 2001-08-08 | 2008-01-01 | Vaxim, Inc. | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell |
| US8871709B2 (en) * | 2003-02-05 | 2014-10-28 | Queensland University of Technolgy | Synthetic chimeric proteins comprising epidermal growth factor and vitronectin |
| US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| SI1771206T1 (en) | 2004-05-05 | 2018-06-29 | Silence Therapeutics Gmbh | Lipids, lipid complexes and use thereof |
| US7799565B2 (en) | 2004-06-07 | 2010-09-21 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| US9006487B2 (en) | 2005-06-15 | 2015-04-14 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| WO2007073489A2 (en) | 2005-12-22 | 2007-06-28 | Trustees Of Boston University | Molecules for gene delivery and gene therapy, and methods of use thereof |
| CA2658768C (en) | 2006-07-21 | 2016-05-17 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
| CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| US20110165223A1 (en) | 2008-01-02 | 2011-07-07 | The Johns Hopkins University | Antitumor Immunization by Liposomal Delivery of Vaccine to the Spleen |
| AU2009238175C1 (en) | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| US8163861B2 (en) | 2009-01-15 | 2012-04-24 | Living Proof, Inc. | Beta-amino ester compounds and uses thereof |
| JP5889783B2 (ja) | 2009-05-05 | 2016-03-22 | テクミラ ファーマシューティカルズ コーポレイションＴｅｋｍｉｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | 免疫細胞へオリゴヌクレオチドを送達する方法 |
| AP2012006053A0 (en) | 2009-06-02 | 2012-02-29 | Brian Charles Keller | Pure peg-lipid conjugates. |
| CN101591428B (zh) | 2009-06-29 | 2011-05-25 | 浙江大学 | 一种聚酯树枝状大分子的制备方法 |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| US9326939B2 (en) * | 2010-07-31 | 2016-05-03 | The Scripps Research Institute | Liposome targeting compounds and related uses |
| WO2012090223A1 (en) | 2010-12-29 | 2012-07-05 | Indian Institute Of Science | Poly(ether imine) dendrimers and uses thereof |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| CN107043334B (zh) | 2011-06-08 | 2020-06-16 | 日东电工株式会社 | 用于定向药物输送和增强siRNA活性的化合物 |
| JP6294229B2 (ja) | 2011-10-18 | 2018-03-14 | ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | アミン陽イオン性脂質およびその使用 |
| ES2762873T3 (es) | 2012-03-29 | 2020-05-26 | Translate Bio Inc | Lípidos catiónicos ionizables |
| US20160289674A1 (en) * | 2012-04-02 | 2016-10-06 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of membrane proteins |
| CA2868391A1 (en) * | 2012-04-02 | 2013-10-10 | Stephane Bancel | Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same |
| US9750819B2 (en) | 2012-05-23 | 2017-09-05 | Ohio State Innovation Foundation | Lipid nanoparticle compositions and methods of making and methods of using the same |
| EP2885318A4 (en) | 2012-08-14 | 2016-03-30 | Angiochem Inc | PEPTIDE DENDRIMER CONJUGATES AND ITS USES |
| JP6241193B2 (ja) | 2012-10-23 | 2017-12-06 | コニカミノルタ株式会社 | 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子 |
| US20140186332A1 (en) * | 2012-12-28 | 2014-07-03 | NX Pharmagen | Biomarkers of preterm birth |
| US20140187501A1 (en) * | 2012-12-28 | 2014-07-03 | Blend Therapeutics, Inc. | Targeted Conjugates Encapsulated in Particles and Formulations Thereof |
| US9820942B2 (en) | 2013-03-06 | 2017-11-21 | Biomics Biotechnologies Co., Ltd. | Lipidosome preparation, preparation method and application thereof |
| KR20210122917A (ko) * | 2013-03-14 | 2021-10-12 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| US10130649B2 (en) | 2013-03-15 | 2018-11-20 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| AU2014361781B2 (en) | 2013-12-12 | 2021-04-01 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing |
| US20170143848A1 (en) | 2014-03-24 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Mrna therapy for the treatment of ocular diseases |
| US9833416B2 (en) | 2014-04-04 | 2017-12-05 | Ohio State Innovation Foundation | Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same |
| SG10201912038TA (en) | 2014-04-23 | 2020-02-27 | Modernatx Inc | Nucleic acid vaccines |
| WO2015191693A2 (en) * | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| CN103999853B (zh) | 2014-06-11 | 2015-07-22 | 中国农业大学 | 荧光树枝状纳米大分子在制备药物载体中的应用 |
| EP3169309B1 (en) * | 2014-07-16 | 2023-05-10 | Novartis AG | Method of encapsulating a nucleic acid in a lipid nanoparticle host |
| US10583201B2 (en) | 2014-10-10 | 2020-03-10 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
| WO2016090262A1 (en) | 2014-12-05 | 2016-06-09 | Shire Human Genetic Therapies, Inc. | Messenger rna therapy for treatment of articular disease |
| AU2015360794B2 (en) | 2014-12-08 | 2021-07-08 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| US11219634B2 (en) | 2015-01-21 | 2022-01-11 | Genevant Sciences Gmbh | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| WO2016118725A1 (en) * | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| EP3319976B1 (en) * | 2015-07-09 | 2021-09-01 | Insmed Incorporated | Compositions and methods for treating lung diseases and lung injury |
| EP3349802B1 (en) | 2015-09-14 | 2021-08-04 | The Board of Regents of the University of Texas System | Lipocationic dendrimers and uses thereof |
| EP3353309A4 (en) | 2015-09-25 | 2019-04-10 | Tarveda Therapeutics, Inc. | COMPOSITIONS AND METHOD FOR GENERIC EDITING |
| JP2018530587A (ja) * | 2015-10-16 | 2018-10-18 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法 |
| WO2017070620A2 (en) * | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| TWI773666B (zh) * | 2016-03-30 | 2022-08-11 | 美商英特利亞醫療公司 | Crispr/cas 組分之脂質奈米粒子調配物 |
| US20190167811A1 (en) * | 2016-04-13 | 2019-06-06 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| CN109414451B (zh) | 2016-05-16 | 2022-08-12 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
| KR102469450B1 (ko) * | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | 인터류킨-12 (il12)를 코딩하는 폴리뉴클레오티드 및 그의 용도 |
| WO2018029586A1 (en) * | 2016-08-07 | 2018-02-15 | Novartis Ag | Mrna-mediated immunization methods |
| BR112019008481A2 (pt) * | 2016-10-26 | 2020-03-03 | Curevac Ag | Vacinas de mrna de nanopartículas lipídicas |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| CA3103528A1 (en) * | 2018-06-19 | 2019-12-26 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mrna and long nucleic acids |
| WO2020051220A1 (en) | 2018-09-04 | 2020-03-12 | The Board of the Regents of the University of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| CN112996519B (zh) | 2018-09-04 | 2025-02-28 | 德克萨斯大学系统董事会 | 用于核酸的器官特异性递送的组合物和方法 |
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2019
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