JP2021534833A - 食用油を含有する安定化された組成物及び食品中でのその使用 - Google Patents
食用油を含有する安定化された組成物及び食品中でのその使用 Download PDFInfo
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- JP2021534833A JP2021534833A JP2021536426A JP2021536426A JP2021534833A JP 2021534833 A JP2021534833 A JP 2021534833A JP 2021536426 A JP2021536426 A JP 2021536426A JP 2021536426 A JP2021536426 A JP 2021536426A JP 2021534833 A JP2021534833 A JP 2021534833A
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- Japan
- Prior art keywords
- weight
- oil
- composition
- lactose
- mannitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000008101 lactose Substances 0.000 claims abstract description 38
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 35
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Abstract
Description
つ粉末に噴霧乾燥されることを可能にしながら、良好な味(すなわち組成物が酸敗に対する向上された安定性を有する)、良好な匂い(特に保管後)、安定なDHA含有量(特に保管中)を有することも必要とする。
− (i)10〜40重量%、好ましくは20〜30重量%の食用油、
− (ii)ラクトース、及び
− (iii)マンニトール
を含む組成物であって、食用油は、少なくとも20重量%、好ましくは25〜40重量%、典型的には30〜35重量%の多価不飽和脂肪酸を含み、及びラクトースとマンニトールとの重量比は、1:3〜3:1、好ましくは1:2〜2:1、より好ましくは1:1である、組成物に関する。
られた粉末中に残留する水分は、2〜3%の水分である。粉末の水分活性(aw)も低く、特におよそ0.1〜0.4である。したがって、好ましい実施形態では、本発明の組成物は、少なくとも2年の保存寿命を有する。
− 1種以上の乳化剤、好ましくは2又は3種の乳化剤、
− 1種以上のカプセル化剤、好ましくは3種のカプセル化剤、
− 1種以上の抗酸化剤、好ましくは3種の抗酸化剤、
− 1種以上の自由流動剤、好ましくは1種の自由流動剤、及び
− 1種以上のキレート剤、好ましくは1種のキレート剤
も含む。
ルビル及びビタミンEの中から選択され、より好ましくは天然ビタミンEである。
− 20〜30重量%の食用油、
− 15〜25重量%のラクトース、
− 15〜25重量%のマンニトール、
− 20〜40重量%のカプセル化剤、特に3種のカプセル化剤、
− 1〜5重量%の乳化剤、特に2又は3種の乳化剤、
− 1〜5重量%の抗酸化剤、特に3種の抗酸化剤、
− 0.5〜5重量%の自由流動剤、及び
− 1〜5重量%のキレート剤
を含む。
− 20〜30重量%の微細藻類油、
− 15〜25重量%のラクトース、
− 15〜25重量%のマンニトール、
− 30〜40重量%の濃縮乳清タンパク質、分離乳清タンパク質及び脱塩乳清粉、
− 1〜5重量%のモノ及びジステアリン酸グリセリル及びレシチン、
− 1〜5重量%のアスコルビン酸ナトリウム、L−パルミチン酸アスコルビル及びビタミンE、
− 0.5〜5重量%のリン酸三カルシウム、及び
− 1〜5重量%のクエン酸ナトリウム
を含む。
− 少なくとも30重量%のDHAを有する、25重量%の微細藻類油、
− 19重量%のラクトース、
− 19重量%のマンニトール、
− 12重量%の濃縮乳清タンパク質、
− 5重量%の分離乳清タンパク質、
− 15重量%の脱塩乳清粉、
− 0.60重量%のモノ及びジステアリン酸グリセリル、
− 0.40重量%のレシチン、
− 1重量%のアスコルビン酸ナトリウム、
− 0.15重量%のL−パルミチン酸アスコルビル、
− 0.06重量%のビタミンE、
− 0.50重量%のリン酸三カルシウム、及び
− 2重量%のクエン酸ナトリウム
を含む。
油エーテルでの2回の抽出が達成され、次いで2つの溶媒相を組み合わせ、蒸発させ、真空オーブン中で乾燥させる。したがって、全粉末の遊離の油の比を算出することができる。
65℃の空気への12日の曝露後若しくは45℃の空気への48日の曝露後の、ISO 3960に基づく5Meq/kg以下の過酸化物価及び/又は65℃の空気への12日の曝露後若しくは45℃の空気への48日の曝露後の、ISO 6885に基づく20以下、好ましくは10以下、より好ましくは8以下、さらに一層好ましくは7以下のp−アニシジン値を有する組成物は、酸化に対する増大された安定性を有するとみなされる。
DHA組成物及びその粉末の安定性に対する、マンニトール及びラクトースとのその混合物の効果を研究するために、0%、50%及び100%のラクトースをマンニトールと置き換えた。試験された組成物を下の表1に記載する。
次の通りに記載した工程により、組成物及びその粉末を得た:すべての水溶性の成分を純水(最後に45〜50%の乾燥物質を作製するために、100gの組成物に対して例えば100〜122gの水)に溶解し、低温殺菌した。DHAを含有する食用油を他の油溶性成分と混合して、均質な溶液を生成した。調製した水相及び油相を混合した。混合物を、明らかな油滴がなくなる(すなわち油滴が肉眼で認識できなくなる)まで高速せん断することによってエマルジョンを作製し、次いでホモジナイズした。エマルジョンを噴霧乾燥させ、噴霧乾燥粉末にリン酸三カルシウムを添加した。
次いで、組成物及びその粉末を分析した。標準の値を表2に示す。
結果を下の表3並びに図1及び2にまとめる。
− 官能検査:
*魚臭:100%置き換え<50%置き換え<対照
*カラメル色:対照<50%置き換え<100%置き換え
− 表面油:対照<50%置き換え<100%置き換え
− 全酸化:50%置き換え<100%置き換え<対照(油の酸化的劣化を評価する場合、全酸化値又は「totox」値(TV)が有用であり得る。その算出は、次の通りである(過酸化物価は、Meq/kgで表される):TV=2*POV+AV;POVは、過酸化物価であり、AVは、p−アニシジン値である)。
− DHA含有量:3つすべての組成物について、明らかな変化は見られなかった。
DHA組成物及びその粉末の安定性に対する、マンニトール及びラクトースとのその混合物の効果を研究するために、0%、50%及び100%のラクトースをマンニトールと置き換えた。試験された組成物を下の表4に記載する。
工程は、実施例1と同じである。
次いで、組成物及びその粉末を分析した。標準の値を表5に示す。
結果を下の表6にまとめる。
− 官能検査:
*魚臭:100%置き換え<50%置き換え<対照
*カラメル色:対照<50%置き換え<100%置き換え
− 表面油:対照<50%置き換え<100%置き換え
− 全酸化:50%置き換え<100%置き換え<対照(油の酸化的劣化を評価する場合、全酸化値又は「totox」値(TV)が有用であり得る。その算出は、次の通りである(過酸化物価は、Meq/kgで表される):TV=2*POV+AV;POVは、過
酸化物価であり、AVは、p−アニシジン値である)。
Claims (11)
- − (i)10〜40重量%、好ましくは20〜30重量%の食用油、
− (ii)ラクトース、及び
− (iii)マンニトール
を含む組成物であって、前記食用油は、少なくとも20重量%、好ましくは25〜40重量%、典型的には30〜35重量%の多価不飽和脂肪酸を含み、及びラクトースとマンニトールとの重量比は、1:3〜3:1、好ましくは1:2〜2:1、より好ましくは1:1である、組成物。 - 前記食用油は、魚油、オキアミ油、微細藻類油、好ましくは微細藻類油である、請求項1に記載の組成物。
- 前記多価不飽和脂肪酸は、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)、アラキドン酸(ARA)、ドコサペンタエン酸(DPA)、ステアリドン酸、リノレン酸及びそれらの混合物からなる群において選択され、好ましくはDHA、EPA及びそれらの混合物から選択される、請求項1又は2に記載の組成物。
- 噴霧乾燥される、請求項1〜3のいずれか一項に記載の組成物。
- 粉末である、請求項1〜4のいずれか一項に記載の組成物。
- (i)、(ii)及び(iii)に加えて、
− モノ及びジステアリン酸グリセリル、レシチンなどの1種以上の乳化剤、
− 1種以上のカプセル化剤、例えば乳清タンパク質などのタンパク質又はその加水分解産物及びデンプン又はその誘導体を含む薬剤、
− アスコルビン酸ナトリウム、L−パルミチン酸アスコルビル、ビタミンEなどの1種以上の抗酸化剤、
− リン酸三カルシウムなどの1種以上の自由流動剤、及び
− アスコルビン酸、クエン酸、クエン酸ナトリウム、ホスフェート及びクエン酸エステルなどの1種以上のキレート剤
を含む、請求項1〜5のいずれか一項に記載の組成物。 - ラクトースと前記マンニトールとの組み合わされた量は、20〜60重量%、好ましくは35〜55重量%、より好ましくは35〜40重量%である、請求項1〜6のいずれか一項に記載の組成物。
- 食用油、ラクトース、マンニトールを含む組成物を生成するプロセスであって、請求項1〜7のいずれか一項に記載の成分のエマルジョン又は水性分散系を生成するステップと、前記エマルジョン又は水性分散系を噴霧乾燥させるステップとを含むプロセス。
- 10〜40重量%の食用油であって、少なくとも20重量%の多価不飽和脂肪酸を含む食用油を含む組成物の酸化に対する安定性を増大させるための、1:3〜3:1、好ましくは1:2〜2:1、より好ましくは1:1の各重量比でのラクトースとマンニトールとの混合物の使用。
- 栄養サプリメント又は栄養補助食品、特に栄養飲料及び咀嚼錠の調製のための、請求項1〜7のいずれか一項に記載の組成物の使用。
- 最大で100重量%の、請求項1〜7のいずれか一項に記載の組成物を含む食品又は栄
養製品。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08259943A (ja) * | 1995-03-21 | 1996-10-08 | Nippon Suisan Kaisha Ltd | 乳化油脂用酸化安定剤 |
CN102210474A (zh) * | 2011-03-31 | 2011-10-12 | 无锡健特药业有限公司 | 一种护眼健脑泡腾片剂 |
US20120128831A1 (en) * | 2009-07-17 | 2012-05-24 | Van Seeventer Paul Bastiaan | Method for encapsulation of an edible oil, compositions comprising edible oil and the use thereof |
CN105748416A (zh) * | 2016-04-15 | 2016-07-13 | 国家海洋局第三海洋研究所 | 一种dha纳米乳冻干粉及其制备方法 |
CN108185023A (zh) * | 2017-12-21 | 2018-06-22 | 陇南市朝华核桃产业开发有限公司 | 一种促进婴幼儿发育的核桃油滴丸及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5813541A (ja) | 1981-07-16 | 1983-01-26 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はドコサヘキサエン酸のシクロデキストリン包接化合物 |
US4963385A (en) | 1989-06-02 | 1990-10-16 | Nabisco Brands, Inc. | Stabilized emulsions containing highly unsaturated oils |
DK88692D0 (da) | 1992-07-06 | 1992-07-06 | Danochemo As | Fremgangsmaade til fremstilling af mikrokapsler |
PT1300394E (pt) * | 2000-07-13 | 2004-06-30 | Wild Gmbh & Co Kg Rudolf | Metodo para a producao de uma formulacao dispersivel em agua contendo carotenoides |
US6638557B2 (en) | 2001-08-14 | 2003-10-28 | Cerestar Holding B.V. | Dry, edible oil and starch composition |
EP1616486A1 (en) | 2004-07-13 | 2006-01-18 | Friesland Brands B.V. | Powdered compositions containing an edible oil and their use in food products |
WO2013067603A1 (en) * | 2011-11-10 | 2013-05-16 | Clover Corporation Limited | Encapsulation of food ingredients supplements and pharmaceuticals |
US11179333B2 (en) * | 2014-08-29 | 2021-11-23 | Fuji Chemical Industries Co., Ltd. | Emulsion composition |
CN107441044A (zh) * | 2017-08-29 | 2017-12-08 | 辅必成(上海)医药科技有限公司 | 一种纳米脂肪乳剂 |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08259943A (ja) * | 1995-03-21 | 1996-10-08 | Nippon Suisan Kaisha Ltd | 乳化油脂用酸化安定剤 |
US20120128831A1 (en) * | 2009-07-17 | 2012-05-24 | Van Seeventer Paul Bastiaan | Method for encapsulation of an edible oil, compositions comprising edible oil and the use thereof |
CN102210474A (zh) * | 2011-03-31 | 2011-10-12 | 无锡健特药业有限公司 | 一种护眼健脑泡腾片剂 |
CN105748416A (zh) * | 2016-04-15 | 2016-07-13 | 国家海洋局第三海洋研究所 | 一种dha纳米乳冻干粉及其制备方法 |
CN108185023A (zh) * | 2017-12-21 | 2018-06-22 | 陇南市朝华核桃产业开发有限公司 | 一种促进婴幼儿发育的核桃油滴丸及其制备方法 |
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