JP2021533198A5 - - Google Patents

Info

Publication number
JP2021533198A5
JP2021533198A5 JP2021529259A JP2021529259A JP2021533198A5 JP 2021533198 A5 JP2021533198 A5 JP 2021533198A5 JP 2021529259 A JP2021529259 A JP 2021529259A JP 2021529259 A JP2021529259 A JP 2021529259A JP 2021533198 A5 JP2021533198 A5 JP 2021533198A5
Authority
JP
Japan
Prior art keywords
muscle
oligonucleotide
transferrin receptor
complex according
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021529259A
Other languages
English (en)
Japanese (ja)
Other versions
JP7576542B2 (ja
JP2021533198A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/044982 external-priority patent/WO2020028857A1/en
Publication of JP2021533198A publication Critical patent/JP2021533198A/ja
Publication of JP2021533198A5 publication Critical patent/JP2021533198A5/ja
Priority to JP2024184975A priority Critical patent/JP7708957B2/ja
Application granted granted Critical
Publication of JP7576542B2 publication Critical patent/JP7576542B2/ja
Priority to JP2025112731A priority patent/JP2025175995A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021529259A 2018-08-02 2019-08-02 筋標的化複合体およびそれらの使用 Active JP7576542B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024184975A JP7708957B2 (ja) 2018-08-02 2024-10-21 筋標的化複合体およびそれらの使用
JP2025112731A JP2025175995A (ja) 2018-08-02 2025-07-03 筋標的化複合体およびそれらの使用

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862714010P 2018-08-02 2018-08-02
US62/714,010 2018-08-02
US201862779173P 2018-12-13 2018-12-13
US62/779,173 2018-12-13
US201962855781P 2019-05-31 2019-05-31
US62/855,781 2019-05-31
US201962858925P 2019-06-07 2019-06-07
US62/858,925 2019-06-07
US201962859694P 2019-06-10 2019-06-10
US62/859,694 2019-06-10
PCT/US2019/044982 WO2020028857A1 (en) 2018-08-02 2019-08-02 Muscle-targeting complexes and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024184975A Division JP7708957B2 (ja) 2018-08-02 2024-10-21 筋標的化複合体およびそれらの使用

Publications (3)

Publication Number Publication Date
JP2021533198A JP2021533198A (ja) 2021-12-02
JP2021533198A5 true JP2021533198A5 (enExample) 2022-08-10
JP7576542B2 JP7576542B2 (ja) 2024-10-31

Family

ID=69232332

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021529259A Active JP7576542B2 (ja) 2018-08-02 2019-08-02 筋標的化複合体およびそれらの使用
JP2024184975A Active JP7708957B2 (ja) 2018-08-02 2024-10-21 筋標的化複合体およびそれらの使用
JP2025112731A Pending JP2025175995A (ja) 2018-08-02 2025-07-03 筋標的化複合体およびそれらの使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024184975A Active JP7708957B2 (ja) 2018-08-02 2024-10-21 筋標的化複合体およびそれらの使用
JP2025112731A Pending JP2025175995A (ja) 2018-08-02 2025-07-03 筋標的化複合体およびそれらの使用

Country Status (11)

Country Link
US (2) US20210261680A1 (enExample)
EP (1) EP3829649A4 (enExample)
JP (3) JP7576542B2 (enExample)
KR (1) KR20210086602A (enExample)
CN (1) CN112930197A (enExample)
AU (1) AU2019315593B2 (enExample)
CA (1) CA3108335A1 (enExample)
IL (3) IL314102B2 (enExample)
MX (1) MX2021001282A (enExample)
SG (1) SG11202100931QA (enExample)
WO (1) WO2020028857A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102775461B1 (ko) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. 핵산-폴리펩타이드 조성물 및 이의 용도
CN118638787A (zh) 2017-12-06 2024-09-13 艾维迪提生物科学公司 治疗肌萎缩和强直性肌营养不良的组合物和方法
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
CA3108386A1 (en) * 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating friedreich's ataxia
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
AU2019315593B2 (en) * 2018-08-02 2026-05-21 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof
WO2020028832A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
EP3830259A4 (en) 2018-08-02 2022-05-04 Dyne Therapeutics, Inc. MUSCLE TARGETED COMPLEXES AND THEIR USES IN THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
EP4087653A4 (en) * 2020-01-10 2024-06-19 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2021154477A1 (en) 2020-01-31 2021-08-05 Dyne Therapeutics, Inc. Anti-transferrin receptor (tfr) antibody and uses thereof
KR102927945B1 (ko) 2020-03-27 2026-02-23 어비디티 바이오사이언시스 인크. 근이영양증의 치료용 조성물 및 방법
US20230330246A1 (en) * 2020-05-05 2023-10-19 Avidity Biosciences, Inc. Compositions and methods of treating pompe disease
WO2021226454A1 (en) * 2020-05-08 2021-11-11 Mpeg La, L.L.C. Linker compounds
MX2023000984A (es) * 2020-07-23 2023-05-03 Dyne Therapeutics Inc Complejos dirigidos al musculo y usos de los mismos para el tratamiento de distrofinopatias.
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
MX2023000958A (es) * 2020-07-23 2023-04-14 Dyne Therapeutics Inc Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica.
US11672872B2 (en) 2021-07-09 2023-06-13 Dyne Therapeutics, Inc. Anti-transferrin receptor antibody and uses thereof
AU2021313058A1 (en) * 2020-07-23 2023-03-30 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
KR20230117182A (ko) * 2020-12-04 2023-08-07 다인 세라퓨틱스, 인크. 항체-올리고뉴클레오티드 복합체 및 그의 용도
AU2021414227A1 (en) * 2020-12-31 2023-07-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2022197554A1 (en) * 2021-03-16 2022-09-22 University Of Massachusetts Photocaged citrulline analogs and methods for site-specific incorporation of citrulline into proteins
EP4359534A4 (en) * 2021-06-21 2026-07-22 Dyne Therapeutics Inc MUSCLE TARGETTING COMPLEXES AND THEIR USES IN THE TREATMENT OF POMPE DISEASE
CA3222816A1 (en) * 2021-06-21 2022-12-29 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating friedreich's ataxia
CA3226301A1 (en) * 2021-07-09 2023-01-12 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
JP2024525613A (ja) * 2021-07-09 2024-07-12 ダイン セラピューティクス,インコーポレーテッド 筋標的化複合体およびジストロフィノパチーを処置するためのその使用
WO2023283623A1 (en) 2021-07-09 2023-01-12 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating dystrophinopathies
EP4366774A4 (en) * 2021-07-09 2025-11-19 Dyne Therapeutics Inc MUSCLE TARGETTING COMPLEXES AND THEIR USES FOR MODULATING GENES ASSOCIATED WITH MUSCLE HEALTH
US20240318176A1 (en) * 2021-07-09 2024-09-26 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2023023031A2 (en) * 2021-08-17 2023-02-23 Blaze Bioscience, Inc. Transferrin receptor targeting peptide oligonucleotide complexes and methods of use thereof
CA3230796A1 (en) 2021-09-01 2023-03-09 Biogen Ma Inc. Anti-transferrin receptor antibodies and uses thereof
KR20240067118A (ko) * 2021-09-29 2024-05-16 아이오니스 파마수티컬즈, 인코포레이티드 접합된 올리고뉴클레오타이드 및 이의 용도
CA3240612A1 (en) 2021-12-22 2023-06-29 Miriam Verena Bujny Targeted saponin-nucleic acid conjugates for treatment of muscle wasting disorders
US20250082759A1 (en) 2021-12-22 2025-03-13 Sapreme Technologies B.V. Compositions comprising therapeutic nucleic acid and targeted saponin for the treatment of muscle-wasting disorders
EP4452281A1 (en) 2021-12-22 2024-10-30 Sapreme Technologies B.V. Compositions comprising therapeutic nucleic acid and saponin for the treatment of muscle-wasting disorders
IL314093A (en) * 2022-01-07 2024-09-01 Mirecule Inc Agents used for tissue-specific imaging and as therapeutic agents targeting proteins expressed on the surface of muscle cells
IL316143A (en) 2022-04-15 2024-12-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of myotonic dystrophy
AU2023371614A1 (en) * 2022-11-04 2025-05-15 Regeneron Pharmaceuticals, Inc. Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
EP4480964A1 (en) * 2023-06-22 2024-12-25 Vect-Horus Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat muscular diseases
WO2024261332A2 (en) * 2023-06-22 2024-12-26 Vect-Horus Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat muscular diseases
US12527877B2 (en) 2024-01-24 2026-01-20 Arrowhead Pharmaceuticals, Inc. Anti-transferrin receptor antibodies, conjugates thereof, and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040063654A1 (en) * 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
US20120122801A1 (en) * 2005-01-05 2012-05-17 Prosensa B.V. Mannose-6-phosphate receptor mediated gene transfer into muscle cells
AU2010306940A1 (en) * 2009-10-12 2012-06-07 Smith, Larry Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
WO2012178173A1 (en) * 2011-06-24 2012-12-27 Centrose, Llc Extracellular targeted drug conjugates
HRP20180268T4 (hr) * 2012-10-23 2026-03-27 Synaffix B.V. Modificirano antitijelo, konjugat antitijela i postupak za njihovu pripremu
EP3922643A1 (en) * 2013-01-07 2021-12-15 Omniox, Inc. Polymeric forms of h-nox proteins
GB201507926D0 (en) * 2015-05-08 2015-06-24 Proqr Therapeutics N V Improved treatments using oligonucleotides
DK3473270T5 (da) * 2016-06-20 2024-09-09 Genahead Bio Inc Konjugat af antistof-lægemiddel
KR20240172236A (ko) * 2017-01-06 2024-12-09 어비디티 바이오사이언시스 인크. 핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법
AU2019315593B2 (en) 2018-08-02 2026-05-21 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof

Similar Documents

Publication Publication Date Title
JP2021533197A5 (enExample)
JP2021533199A5 (enExample)
JP2021533200A5 (enExample)
JP2025067909A5 (enExample)
JP2021532832A5 (enExample)
JP2023535073A5 (enExample)
JP7536328B2 (ja) 抗体-薬物コンジュゲート
JP2023510351A5 (enExample)
JP2021532831A5 (enExample)
JP2023535074A5 (enExample)
JP2023535078A5 (enExample)
EP2451480B1 (en) A complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
Klein et al. Centyrin ligands for extrahepatic delivery of siRNA
JP2023512442A5 (enExample)
JP2024501872A5 (enExample)
Uherek et al. DNA-carrier proteins for targeted gene delivery
JP2023535444A5 (enExample)
JP2023509793A5 (enExample)
JP2023512441A5 (enExample)
TW202202173A (zh) 治療肌肉萎縮症之組合物及方法
CN112930193A (zh) 肌肉靶向复合物及其在治疗肌肉萎缩中的用途
CN112955154A (zh) 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途
CN112912399A (zh) 肌肉靶向复合物及其用于治疗蓬佩病的用途
CN113166240A (zh) 肌肉靶向复合物及其用于治疗弗里德赖希共济失调的用途
JP2020505330A5 (enExample)