|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5521173A
(en)
|
1995-01-17 |
1996-05-28 |
American Home Products Corporation |
Tricyclic benzazepine vasopressin antagonists
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ES2153031T4
(es)
|
1995-04-20 |
2001-05-16 |
Pfizer |
Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf.
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
WO1997029079A1
(en)
|
1996-02-06 |
1997-08-14 |
Japan Tobacco Inc. |
Novel compounds and pharmaceutical use thereof
|
|
NZ331191A
(en)
|
1996-03-05 |
2000-03-27 |
Zeneca Ltd |
4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
|
|
US5795909A
(en)
|
1996-05-22 |
1998-08-18 |
Neuromedica, Inc. |
DHA-pharmaceutical agent conjugates of taxanes
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EA199900021A1
(ru)
|
1996-07-13 |
1999-08-26 |
Глаксо, Груп Лимитед |
Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
AR007857A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen.
|
|
KR20000067904A
(ko)
|
1996-07-18 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
매트릭스 메탈로프로테아제의 포스피네이트계 억제제
|
|
KR20000068248A
(ko)
|
1996-08-23 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
아릴설포닐아미노 하이드록삼산 유도체
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
DZ2376A1
(fr)
|
1996-12-19 |
2002-12-28 |
Smithkline Beecham Plc |
Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
|
|
JP3338064B2
(ja)
|
1997-01-06 |
2002-10-28 |
ファイザー・インク |
環状スルホン誘導体
|
|
NZ336840A
(en)
|
1997-02-03 |
2001-01-26 |
Pfizer Prod Inc |
Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
EP0960098A1
(en)
|
1997-02-11 |
1999-12-01 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
JP2002511852A
(ja)
|
1997-05-07 |
2002-04-16 |
スージェン・インコーポレーテッド |
蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体
|
|
JP2002501532A
(ja)
|
1997-05-30 |
2002-01-15 |
メルク エンド カンパニー インコーポレーテッド |
新規血管形成阻害薬
|
|
CA2299355C
(en)
|
1997-08-08 |
2005-09-27 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
|
ES2289791T3
(es)
|
1997-08-22 |
2008-02-01 |
Astrazeneca Ab |
Derivados de oxindolilquinazolina como inhibidores de la angiogenesis.
|
|
AU744939B2
(en)
|
1997-09-26 |
2002-03-07 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
EP1028964A1
(en)
|
1997-11-11 |
2000-08-23 |
Pfizer Products Inc. |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
SK287132B6
(sk)
|
1998-05-29 |
2009-12-07 |
Sugen, Inc. |
Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
EP1004578B1
(en)
|
1998-11-05 |
2004-02-25 |
Pfizer Products Inc. |
5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
|
|
EP1143957A3
(en)
|
1998-12-16 |
2002-02-27 |
Warner-Lambert Company |
Treatment of arthritis with mek inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
PL349839A1
(en)
|
1999-02-11 |
2002-09-23 |
Pfizer Prod Inc |
Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
GB9924862D0
(en)
|
1999-10-20 |
1999-12-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
EP1248869A2
(en)
*
|
2000-01-07 |
2002-10-16 |
Transform Pharmaceuticals, Inc. |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
JP3663382B2
(ja)
|
2000-02-15 |
2005-06-22 |
スージェン・インコーポレーテッド |
ピロール置換2−インドリノン蛋白質キナーゼ阻害剤
|
|
AU3704101A
(en)
|
2000-02-17 |
2001-08-27 |
Amgen Inc |
Kinase inhibitors
|
|
US6440207B1
(en)
|
2000-03-03 |
2002-08-27 |
Bayer Corporation |
Method for preparing organic pigments
|
|
EP1275657A4
(en)
|
2000-04-14 |
2006-06-28 |
Nippon Shinyaku Co Ltd |
PEPTIDE DERIVATIVES AND MEDICINAL COMPOSITIONS
|
|
AU5889701A
(en)
|
2000-06-05 |
2001-12-17 |
Dong A Pharm Co Ltd |
Novel oxazolidinone derivatives and a process for the preparation thereof
|
|
JP3811775B2
(ja)
|
2000-07-19 |
2006-08-23 |
ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー |
4−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
WO2002094766A1
(en)
|
2001-05-18 |
2002-11-28 |
Nihon Nohyaku Co., Ltd. |
Phthalamide derivative, agricultural or horticultural insecticide, and use thereof
|
|
WO2003003009A1
(en)
|
2001-06-29 |
2003-01-09 |
7Tm Pharma A/S |
Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
US6897208B2
(en)
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
|
BR0213562A
(pt)
|
2001-10-26 |
2004-08-31 |
Aventis Pharma Inc |
Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
|
|
WO2003055477A1
(en)
|
2001-12-21 |
2003-07-10 |
7Tm Pharma A/S |
Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
|
|
RU2343148C2
(ru)
|
2002-02-01 |
2009-01-10 |
Райджел Фармасьютикалз, Инк |
Соединения 2,4-пиримидиндиаминов и их применение
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
CN1653059A
(zh)
|
2002-03-08 |
2005-08-10 |
卫材株式会社 |
用作医药品的大环化合物
|
|
KR100984595B1
(ko)
|
2002-03-13 |
2010-09-30 |
어레이 바이오파마 인크. |
Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
|
US7348318B2
(en)
|
2002-03-25 |
2008-03-25 |
Nippon Kayaku Kabushiki Kaisha |
α-Amino-N-(diaminophosphinyl)lactam derivatives
|
|
AR039241A1
(es)
|
2002-04-04 |
2005-02-16 |
Biogen Inc |
Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
|
|
US7005449B2
(en)
|
2002-04-23 |
2006-02-28 |
Pharmacia & Upjohn Company |
Tolterodine salts
|
|
WO2003095448A1
(en)
|
2002-05-06 |
2003-11-20 |
Bayer Pharmaceuticals Corporation |
Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
|
|
RU2322449C2
(ru)
|
2002-08-09 |
2008-04-20 |
Тайсо Фармасьютикал Ко., Лтд. |
ПРОИЗВОДНЫЕ АРИЛ 5-ТИО-β-D-ГЛЮКОПИРАНОЗИДА И ТЕРАПЕВТИЧЕСКИЕ СРЕДСТВА ПРИ ДИАБЕТЕ, СОДЕРЖАЩИЕ ИХ
|
|
UA80295C2
(en)
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Pyrazolopyridines and using the same
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
AU2003287880A1
(en)
|
2002-12-11 |
2004-06-30 |
7Tm Pharma A/S |
Cyclic quinoline compounds for use in mch receptor related disorders
|
|
ES2325440T3
(es)
|
2003-02-20 |
2009-09-04 |
Smithkline Beecham Corporation |
Compuestos de pirimidina.
|
|
JP2007524596A
(ja)
|
2003-02-28 |
2007-08-30 |
トランスフォーム・ファーマシューティカルズ・インコーポレイテッド |
共結晶医薬組成物
|
|
BRPI0300660B8
(pt)
|
2003-02-28 |
2021-07-27 |
Fapesp Fund De Amparo A Pesquisa Do Estado De Sao Paulo |
método para quantificar liberação mitocondrial de citocromo c e kit para detectar liberação mitocondrial de citocromo c
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
EP1636335B1
(en)
|
2003-05-28 |
2012-07-11 |
Mito Tek, LLC |
Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
|
|
US20050070554A1
(en)
|
2003-08-27 |
2005-03-31 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
US20070105839A1
(en)
|
2003-09-18 |
2007-05-10 |
Patricia Imbach |
2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
WO2005092049A2
(en)
|
2004-03-22 |
2005-10-06 |
Op-Marks, Inc. |
Surgical site marking assembly and method of using same
|
|
CA2561311A1
(en)
|
2004-04-09 |
2005-10-27 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
AU2005280168A1
(en)
|
2004-08-31 |
2006-03-09 |
Biogen Idec Ma Inc. |
Pyrimidinylimidazoles as TGF-beta inhibitors
|
|
US7786153B2
(en)
|
2005-03-02 |
2010-08-31 |
Abbott Laboratories Inc. |
Compounds that are useful for improving pharmacokinetics
|
|
EP1883302A4
(en)
|
2005-05-03 |
2009-05-20 |
Rigel Pharmaceuticals Inc |
JAK KINASE HEMMER AND ITS USE
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
US20070032514A1
(en)
|
2005-07-01 |
2007-02-08 |
Zahn Stephan K |
2,4-diamino-pyrimidines as aurora inhibitors
|
|
CA2618218C
(en)
|
2005-07-21 |
2015-06-30 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
JP5191391B2
(ja)
|
2005-11-01 |
2013-05-08 |
ターゲジェン インコーポレーティッド |
キナーゼのビ−アリールメタ−ピリミジン阻害剤
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
KR20080098490A
(ko)
|
2006-01-13 |
2008-11-10 |
파마시클릭스, 인코포레이티드 |
티로신 키나제 억제제 및 이의 용도
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
KR20080110998A
(ko)
|
2006-01-30 |
2008-12-22 |
엑셀리시스, 인코포레이티드 |
Jak2 조절자로서 4아릴2아미노피리미딘 또는 4아릴2아미노알킬피리미딘 및 이들을 포함하는 약제학적 조성물
|
|
ES2622493T3
(es)
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
US20060223820A1
(en)
|
2006-03-21 |
2006-10-05 |
Chemagis Ltd. |
Crystalline aripiprazole salts and processes for preparation and purification thereof
|
|
EA015127B1
(ru)
|
2006-06-08 |
2011-06-30 |
Эли Лилли Энд Компани |
Антагонисты мсн-рецепторов
|
|
RU2008152195A
(ru)
|
2006-06-15 |
2010-07-20 |
БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) |
2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа
|
|
DK2526933T3
(en)
|
2006-09-22 |
2015-05-18 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
|
ES2555803T3
(es)
|
2006-10-23 |
2016-01-08 |
Cephalon, Inc. |
Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met
|
|
CA2668286C
(en)
|
2006-11-03 |
2014-09-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
PE20081636A1
(es)
|
2007-01-26 |
2009-01-10 |
Smithkline Beecham Corp |
Inhibidores de antranilamida para aurora quinasa
|
|
PT2114900T
(pt)
|
2007-01-31 |
2019-01-17 |
Ym Biosciences Australia Pty |
Compostos à base de tiopirimidina e as suas utilizações
|
|
JP2010520222A
(ja)
|
2007-03-01 |
2010-06-10 |
スーパージェン, インコーポレイテッド |
ピリミジン−2,4−ジアミン誘導体およびjak2キナーゼ阻害剤としてのピリミジン−2,4−ジアミン誘導体の使用
|
|
CN101657431A
(zh)
|
2007-03-01 |
2010-02-24 |
休普基因公司 |
嘧啶-2,4-二胺衍生物及其作为jak2激酶抑制剂的用途
|
|
US7834024B2
(en)
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
SG10202107066WA
(en)
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US20120101114A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
WO2008124085A2
(en)
|
2007-04-03 |
2008-10-16 |
Exelixis, Inc. |
Methods of using combinations of mek and jak-2 inhibitors
|
|
EP2139869A2
(en)
|
2007-04-13 |
2010-01-06 |
SuperGen, Inc. |
Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders
|
|
KR101122481B1
(ko)
|
2007-05-04 |
2012-02-29 |
아이알엠 엘엘씨 |
C-kit 및 pdgfr 키나제 억제제로서의 피리미딘 유도체 및 조성물
|
|
WO2009010794A1
(en)
|
2007-07-19 |
2009-01-22 |
Astrazeneca Ab |
2,4-diamino-pyrimidine derivatives
|
|
EP2205242B1
(en)
|
2007-09-12 |
2015-04-15 |
Genentech, Inc. |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
JP5348725B2
(ja)
|
2007-10-25 |
2013-11-20 |
ジェネンテック, インコーポレイテッド |
チエノピリミジン化合物の製造方法
|
|
EP2249831A2
(en)
|
2007-12-10 |
2010-11-17 |
Sunesis Pharmaceuticals, Inc. |
Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
|
|
CA2710118A1
(en)
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
MX353308B
(es)
|
2008-05-21 |
2018-01-08 |
Ariad Pharma Inc |
Derivados fosforosos como inhibidores de cinasa.
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
CA2730930C
(en)
|
2008-07-16 |
2015-01-13 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
CN102159559A
(zh)
|
2008-07-18 |
2011-08-17 |
赛诺菲-安万特 |
新型咪唑并[1,2-a]吡啶衍生物、其制备方法、其作为药物的用途、其药物组合物和新型用途特别是作为MET抑制剂的新型用途
|
|
WO2010011349A2
(en)
|
2008-07-25 |
2010-01-28 |
Supergen, Inc. |
Pyrimidine-2,4-diamine jak2 kinase inhibiting anti-inflammation use
|
|
AU2009279825A1
(en)
|
2008-08-05 |
2010-02-11 |
Targegen, Inc. |
Methods of treating thalassemia
|
|
BRPI1006942A2
(pt)
|
2009-01-23 |
2016-04-12 |
Rigel Pharmaceuticals Inc |
composto, composição farmacêutica, kit, métodos para inibir uma atividade de uma jak quinase, para tratar uma doença, para tratar a rejeição de transplante de aloenxerto em um receptor de transplante, para tratar uma reação de hipersensibilidade, e para inibir uma cascata de transdução de sinal, e, uso do composto
|
|
TW201041892A
(en)
|
2009-02-09 |
2010-12-01 |
Supergen Inc |
Pyrrolopyrimidinyl Axl kinase inhibitors
|
|
CA2758614A1
(en)
|
2009-04-14 |
2010-10-21 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
JP2013504325A
(ja)
|
2009-09-09 |
2013-02-07 |
アビラ セラピューティクス, インコーポレイテッド |
Pi3キナーゼインヒビターおよびその使用
|
|
US9556426B2
(en)
|
2009-09-16 |
2017-01-31 |
Celgene Avilomics Research, Inc. |
Protein kinase conjugates and inhibitors
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
EP2488503A1
(en)
|
2009-10-12 |
2012-08-22 |
Myrexis, Inc. |
Amino - pyrimidine compounds as inhibitors of tbkl and/or ikk epsilon
|
|
HRP20141190T1
(hr)
|
2010-01-29 |
2015-01-30 |
Otsuka Pharmaceutical Co., Ltd. |
Disupstituirani derivati piridina kao antikancerogena sredstva
|
|
WO2011106168A1
(en)
|
2010-02-24 |
2011-09-01 |
Dcam Pharma Inc |
Purine compounds for treating autoimmune and demyelinating diseases
|
|
TW201202242A
(en)
|
2010-03-30 |
2012-01-16 |
Sanofi Aventis |
6-(alkyl-or cycloalkyl-triazolopyridazine-sulfanyl)benzo-thiazole derivatives: preparation, and use as medicaments and as MET inhibitors
|
|
WO2012170546A1
(en)
|
2011-06-06 |
2012-12-13 |
University Of Iowa Research Foundation |
Methods of inhibiting muscle atrophy
|
|
CA3007787C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
RU2577986C2
(ru)
|
2010-06-18 |
2016-03-20 |
Дженентек, Инк. |
Антитела против axl и способы их применения
|
|
WO2012135641A2
(en)
|
2011-03-30 |
2012-10-04 |
H. Lee Moffitt Cancer Center And Research Institute |
Aurora kinase inhibitors and methods of making and using thereof
|
|
JP6147727B2
(ja)
|
2011-04-01 |
2017-06-14 |
ユニヴァーシティー オブ ユタ リサーチ ファウンデーション |
チロシン受容体キナーゼbtk阻害剤としての置換n−(3−(ピリミジン−4−イル)フェニル)アクリルアミド類似体
|
|
ES2759615T3
(es)
|
2011-04-01 |
2020-05-11 |
Univ Utah Res Found |
Análogos de N-fenilpirimidina-2-amina sustituidos como inhibidores de la quinasa AXL
|
|
JP2014520863A
(ja)
|
2011-07-13 |
2014-08-25 |
ファーマサイクリックス,インク. |
Bruton型チロシンキナーゼの阻害剤
|
|
AU2012281281B2
(en)
|
2011-07-13 |
2017-06-01 |
Tiumbio Co., Ltd |
2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
|
|
MX391121B
(es)
|
2011-10-19 |
2025-03-19 |
Pharmacyclics Llc |
Uso de inhibidores de la tirosina cinasa de bruton (btk).
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
WO2013173518A1
(en)
|
2012-05-16 |
2013-11-21 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
KR20210033067A
(ko)
|
2012-06-04 |
2021-03-25 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나아제 저해제의 결정 형태
|
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
|
US8703981B2
(en)
|
2012-08-03 |
2014-04-22 |
Xerox Corporation |
Lignosulfonate compounds for solid ink applications
|
|
EP3170825B1
(en)
|
2012-08-06 |
2019-04-10 |
ACEA Biosciences Inc. |
Novel pyrrolopyrimidine compounds as inhibitors of protein kinases
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
AU2013323736A1
(en)
|
2012-09-26 |
2015-04-09 |
Mannkind Corporation |
Multiple kinase pathway inhibitors
|
|
EA201590855A1
(ru)
|
2012-11-15 |
2015-11-30 |
Фармасайкликс, Инк. |
Соединения пирролопиримидина как ингибиторы киназ
|
|
MX2015009952A
(es)
|
2013-02-08 |
2015-10-05 |
Celgene Avilomics Res Inc |
Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos.
|
|
WO2014130411A1
(en)
|
2013-02-22 |
2014-08-28 |
Emory University |
Tgf-beta enhancing compositions for cartilage repair and methods related thereto
|
|
US9708326B2
(en)
|
2013-02-25 |
2017-07-18 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
EP2964651A4
(en)
|
2013-03-04 |
2016-11-30 |
Brigham & Womens Hospital |
BMP HEMMER AND METHOD OF USE THEREOF
|
|
HK1224173A1
(zh)
|
2013-03-14 |
2017-08-18 |
Pharmacyclics Llc |
布鲁顿氏酪氨酸激酶抑制剂和cyp3a4抑制剂的组合
|
|
MX394360B
(es)
|
2013-03-14 |
2025-03-24 |
Sumitomo Pharma Oncology Inc |
Inhibidores de jak2 y alk2 y metodos para su uso.
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
CA2904393A1
(en)
|
2013-03-15 |
2014-09-25 |
Araxes Pharma Llc |
Covalent inhibitors of kras g12c
|
|
EP2983670A4
(en)
|
2013-04-08 |
2017-03-08 |
Pharmacyclics LLC |
Ibrutinib combination therapy
|
|
WO2015002894A1
(en)
|
2013-07-02 |
2015-01-08 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
BR112016006978A2
(pt)
|
2013-09-30 |
2017-08-01 |
Pharmacyclics Llc |
inibidores de tirosina quinase de bruton
|
|
EP3055290B1
(en)
|
2013-10-10 |
2019-10-02 |
Araxes Pharma LLC |
Inhibitors of kras g12c
|
|
TWI582083B
(zh)
|
2014-10-07 |
2017-05-11 |
美國禮來大藥廠 |
胺基吡啶基氧基吡唑化合物
|
|
MX2017008430A
(es)
|
2014-12-23 |
2018-03-23 |
Cephalon Inc |
Métodos para preparar derivados de 2,4-diaminopirimidina bíclica fusionada.
|
|
WO2016146651A1
(en)
|
2015-03-16 |
2016-09-22 |
Oncodesign Sa |
Macrocyclic activin-like receptor kinase inhibitors
|
|
US10179777B2
(en)
|
2015-04-16 |
2019-01-15 |
Merck Patent Gmbh |
3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives
|
|
KR102608921B1
(ko)
|
2015-05-18 |
2023-12-01 |
스미토모 파마 온콜로지, 인크. |
생체 이용률이 증가된 알보시딥 프로드러그
|
|
CN109311889B
(zh)
|
2016-04-15 |
2021-11-16 |
缆图药品公司 |
激活素受体样激酶抑制剂
|
|
WO2018124001A1
(ja)
|
2016-12-27 |
2018-07-05 |
国立研究開発法人理化学研究所 |
Bmpシグナル阻害化合物
|
|
AR112027A1
(es)
|
2017-06-15 |
2019-09-11 |
Biocryst Pharm Inc |
Inhibidores de alk 2 quinasa que contienen imidazol
|
|
KR20210003780A
(ko)
|
2018-04-05 |
2021-01-12 |
스미토모 다이니폰 파마 온콜로지, 인크. |
Axl 키나제 억제제 및 그의 용도
|
|
AU2019310590A1
(en)
|
2018-07-26 |
2021-01-14 |
Sumitomo Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
|
CA3124714A1
(en)
|
2019-01-10 |
2020-07-16 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alk5 inhibitors for treating myelodysplastic syndrome
|