JP2021530478A5 - - Google Patents
Info
- Publication number
- JP2021530478A5 JP2021530478A5 JP2021500411A JP2021500411A JP2021530478A5 JP 2021530478 A5 JP2021530478 A5 JP 2021530478A5 JP 2021500411 A JP2021500411 A JP 2021500411A JP 2021500411 A JP2021500411 A JP 2021500411A JP 2021530478 A5 JP2021530478 A5 JP 2021530478A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- trifluoromethyl
- carboxamide
- alkyl
- group
- Prior art date
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024111875A JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862695571P | 2018-07-09 | 2018-07-09 | |
| US62/695,571 | 2018-07-09 | ||
| PCT/US2019/041029 WO2020014246A1 (en) | 2018-07-09 | 2019-07-09 | Pyridine carboxamide compounds for inhibiting nav1.8 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111875A Division JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021530478A JP2021530478A (ja) | 2021-11-11 |
| JPWO2020014246A5 JPWO2020014246A5 (https=) | 2022-04-12 |
| JP2021530478A5 true JP2021530478A5 (https=) | 2022-04-12 |
Family
ID=69141639
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500411A Pending JP2021530478A (ja) | 2018-07-09 | 2019-07-09 | ＮａＶ１．８を阻害するためのピリジンカルボキシアミド化合物 |
| JP2024111875A Pending JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A Pending JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111875A Pending JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A Pending JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12234221B2 (https=) |
| EP (1) | EP3820866A4 (https=) |
| JP (3) | JP2021530478A (https=) |
| KR (1) | KR20210019581A (https=) |
| CN (1) | CN112689633B (https=) |
| AU (2) | AU2019301628C1 (https=) |
| CA (1) | CA3105657A1 (https=) |
| SG (1) | SG11202100130QA (https=) |
| WO (1) | WO2020014246A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019301628C1 (en) * | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| CN112390745B (zh) * | 2019-08-19 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用 |
| GEP20247688B (en) * | 2019-09-12 | 2024-11-11 | Orion Corp | Pyridine oxynitride, preparation method therefor and use thereof |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| WO2022121805A1 (zh) * | 2020-12-07 | 2022-06-16 | 成都康弘药业集团股份有限公司 | 作为Nav1.8抑制剂的并环化合物及其用途 |
| CR20230481A (es) * | 2021-03-11 | 2024-02-26 | Latigo Biotherapeutics Inc | Compuestos de piridina y piridazina metil-sustituidos, derivados de los mismos y métodos de su uso |
| BR112023018348A2 (pt) * | 2021-03-11 | 2023-12-05 | Jiangxi Jemincare Group Co Ltd | Forma de cristal de composto de óxido de nitrogênio e piridina e uso da mesma |
| CA3221788A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| MA64856B1 (fr) | 2021-06-04 | 2026-02-27 | Vertex Pharmaceuticals Incorporated | Formes de dosage solides et regimens de dosage comprenant le [[3-(3,4-difluoro-2-méthoxy-phényl)-4,5-diméthyl-5-(trifluorométhyl) tétrahydrofuranne-2-carbonyl]amino]pyridine-2-carboxamide |
| JP2024520643A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルの調節因子としてのヒドロキシ及び（ハロ）アルコキシ置換テトラヒドロフラン |
| JP2024520646A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体 |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| WO2022256676A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| EP4472966A4 (en) * | 2022-02-04 | 2026-01-14 | Latigo Biotherapeutics Inc | SODIUM CHANNEL BLOCKING COMPOUNDS, THEIR DERIVATIVES AND METHODS OF USE |
| CN116655497B (zh) * | 2022-02-25 | 2025-06-03 | 中国科学院上海药物研究所 | 脒类衍生化合物及其制备方法和用途 |
| WO2023186102A1 (zh) * | 2022-04-02 | 2023-10-05 | 武汉人福创新药物研发中心有限公司 | Nav1.8抑制剂及其用途 |
| JP2025513452A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| AU2023257313A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| UY40234A (es) | 2022-04-22 | 2023-11-15 | Vertex Pharma | Compuestos heteroarilo para el tratamiento del dolor |
| GEAP202516634A (en) | 2022-04-22 | 2025-02-25 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
| IL316433A (en) | 2022-04-25 | 2024-12-01 | Siteone Therapeutics Inc | Bicyclic heterocyclic amide inhibitors of NA v1.8 for the treatment of pain |
| TW202400560A (zh) * | 2022-04-28 | 2024-01-01 | 南韓商愛思開生物製藥股份有限公司 | Ｎ－氧化物化合物及其用途 |
| AU2023391870A1 (en) | 2022-12-06 | 2025-06-05 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
| WO2025090516A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing compounds for treating pain and solid forms thereof |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090480A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090511A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing modulators of sodium channels and solid forms of the same for treating pain |
| WO2025122953A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain |
| WO2025160286A1 (en) | 2024-01-24 | 2025-07-31 | Siteone Therapeutics, Inc. | 2-aryl cycloalkyl and heterocycloalkyl inhibitors of nav1.8 for the treatment of pain |
| US20260001877A1 (en) | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2026013449A2 (en) | 2024-07-11 | 2026-01-15 | Sea4Us - Biotecnologia E Recursos Marinhos, Sa | Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain |
| WO2026030525A1 (en) | 2024-07-31 | 2026-02-05 | Vertex Pharmaceuticals Incorporated | Zilvetrigine dosage forms and dosing regimens for treating pain |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
| ATE163412T1 (de) | 1993-06-08 | 1998-03-15 | Sanofi Sa | Pyridazine als interleukin-1-beta verwandlungsenzym inhibitoren |
| DE19946852A1 (de) | 1999-09-30 | 2001-04-05 | Bayer Ag | Substituierte N-Phenyl-phenoxynicotinsäure-(thio)amide |
| KR100698982B1 (ko) | 2002-02-11 | 2007-03-26 | 화이자 인코포레이티드 | Ｐｄｅ4 억제제로서 유용한 니코틴아미드 유도체 |
| JP2004238361A (ja) * | 2003-02-07 | 2004-08-26 | Tosoh Corp | ピリミジン−５−カルボキサミド誘導体、その中間体及びそれらの製造方法 |
| US7504396B2 (en) * | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| CN101643458A (zh) * | 2003-08-08 | 2010-02-10 | 沃泰克斯药物股份有限公司 | 在疼痛的治疗中用作钠或钙通道阻断剂的杂芳基氨基磺酰基苯基衍生物 |
| US8202861B2 (en) | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| EP1678145A2 (en) | 2003-10-28 | 2006-07-12 | Vertex Pharmaceuticals Incorporated | Benzimidazoles useful as modulators of ion channels |
| ES2285517T3 (es) * | 2003-10-31 | 2007-11-16 | Warner-Lambert Company Llc | Pirimidinas como inhibidores de fosfoinositida-3-cinasas(pi3k). |
| ATE527251T1 (de) | 2005-05-16 | 2011-10-15 | Vertex Pharma | Bicyclische derivate als modulatoren von ionenkanälen |
| MX2007015726A (es) | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| RU2008118350A (ru) | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
| AR063280A1 (es) | 2006-10-12 | 2009-01-21 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos |
| CA2702101A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Aryl amides useful as inhibitors of voltage-gated sodium channels |
| AU2008310661A1 (en) * | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
| CN101883760A (zh) * | 2007-10-11 | 2010-11-10 | 沃泰克斯药物股份有限公司 | 用作电压-门控钠通道抑制剂的杂芳基酰胺类 |
| US8309734B2 (en) | 2008-10-29 | 2012-11-13 | Hoffmann-La Roche Inc. | Substituted pyridines as GPBAR1 agonists |
| US8703770B2 (en) | 2008-10-30 | 2014-04-22 | Merck Sharp & Dohme Corp. | Pyridazine carboxamide orexin receptor antagonists |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| WO2011026240A1 (en) | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
| US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| MX355907B (es) | 2011-02-02 | 2018-05-04 | Vertex Pharma | Pirrolopirazina-piperidina espirociclica-amidas como moduladores de canales de ionicos. |
| JP5940562B2 (ja) | 2011-02-18 | 2016-06-29 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド |
| EP2681200A4 (en) | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL |
| MX347982B (es) | 2011-03-14 | 2017-05-22 | Vertex Pharma | Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. |
| CN102850321A (zh) | 2011-06-28 | 2013-01-02 | 中国科学院上海药物研究所 | 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途 |
| JP6215230B2 (ja) | 2012-01-16 | 2017-10-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド |
| CN105073738B (zh) | 2013-01-31 | 2018-01-05 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的喹啉及喹喔啉酰胺类 |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| CA3082427A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| ES2654393T3 (es) * | 2013-07-19 | 2018-02-13 | Vertex Pharmaceuticals Incorporated | Sulfonamidas como moduladores de los canales de sodio |
| LT3080134T (lt) | 2013-12-13 | 2018-11-12 | Vertex Pharmaceuticals Incorporated | Piridono amidų provaistai, naudotini kaip natrio kanalų moduliatoriai |
| EP3102569A1 (en) | 2014-02-06 | 2016-12-14 | AbbVie Inc. | 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof |
| JP2017525677A (ja) | 2014-07-07 | 2017-09-07 | ジェネンテック， インコーポレイテッド | 治療用化合物及びその使用方法 |
| MA47460A (fr) | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| AU2019301628C1 (en) * | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
-
2019
- 2019-07-09 AU AU2019301628A patent/AU2019301628C1/en active Active
- 2019-07-09 EP EP19833816.2A patent/EP3820866A4/en active Pending
- 2019-07-09 KR KR1020217004054A patent/KR20210019581A/ko active Pending
- 2019-07-09 JP JP2021500411A patent/JP2021530478A/ja active Pending
- 2019-07-09 CN CN201980058952.XA patent/CN112689633B/zh active Active
- 2019-07-09 CA CA3105657A patent/CA3105657A1/en active Pending
- 2019-07-09 SG SG11202100130QA patent/SG11202100130QA/en unknown
- 2019-07-09 WO PCT/US2019/041029 patent/WO2020014246A1/en not_active Ceased
- 2019-07-09 US US17/256,781 patent/US12234221B2/en active Active
-
2024
- 2024-07-11 JP JP2024111875A patent/JP2024153683A/ja active Pending
-
2025
- 2025-01-13 US US19/018,680 patent/US20260001861A1/en active Pending
- 2025-01-29 AU AU2025200580A patent/AU2025200580A1/en active Pending
- 2025-09-11 JP JP2025150845A patent/JP2026009899A/ja active Pending
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