JP2021529755A5 - - Google Patents
Info
- Publication number
- JP2021529755A5 JP2021529755A5 JP2020572976A JP2020572976A JP2021529755A5 JP 2021529755 A5 JP2021529755 A5 JP 2021529755A5 JP 2020572976 A JP2020572976 A JP 2020572976A JP 2020572976 A JP2020572976 A JP 2020572976A JP 2021529755 A5 JP2021529755 A5 JP 2021529755A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- substituted
- compound according
- pharmaceutical composition
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024006536A JP2024055873A (ja) | 2018-06-27 | 2024-01-19 | 非分岐リンカーを伴うアミノ酸化合物およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690939P | 2018-06-27 | 2018-06-27 | |
| US62/690,939 | 2018-06-27 | ||
| PCT/US2019/039624 WO2020006315A1 (en) | 2018-06-27 | 2019-06-27 | Amino acid compounds with unbranched linkers and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024006536A Division JP2024055873A (ja) | 2018-06-27 | 2024-01-19 | 非分岐リンカーを伴うアミノ酸化合物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529755A JP2021529755A (ja) | 2021-11-04 |
| JP2021529755A5 true JP2021529755A5 (enExample) | 2022-07-05 |
| JP7425757B2 JP7425757B2 (ja) | 2024-01-31 |
Family
ID=68987528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020572976A Active JP7425757B2 (ja) | 2018-06-27 | 2019-06-27 | 非分岐リンカーを伴うアミノ酸化合物およびその使用方法 |
| JP2024006536A Withdrawn JP2024055873A (ja) | 2018-06-27 | 2024-01-19 | 非分岐リンカーを伴うアミノ酸化合物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024006536A Withdrawn JP2024055873A (ja) | 2018-06-27 | 2024-01-19 | 非分岐リンカーを伴うアミノ酸化合物およびその使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11396506B2 (enExample) |
| EP (1) | EP3813818A4 (enExample) |
| JP (2) | JP7425757B2 (enExample) |
| KR (1) | KR20210043561A (enExample) |
| CN (1) | CN112689507B (enExample) |
| AU (1) | AU2019295769B2 (enExample) |
| BR (1) | BR112020026278A2 (enExample) |
| CA (1) | CA3104682A1 (enExample) |
| CL (1) | CL2020003382A1 (enExample) |
| CR (1) | CR20210041A (enExample) |
| CU (1) | CU24693B1 (enExample) |
| DO (1) | DOP2020000255A (enExample) |
| EA (1) | EA202190134A1 (enExample) |
| EC (1) | ECSP21005655A (enExample) |
| IL (2) | IL279717B2 (enExample) |
| JO (1) | JOP20200330A1 (enExample) |
| MX (1) | MX2020014086A (enExample) |
| PE (1) | PE20210137A1 (enExample) |
| PH (1) | PH12020552260A1 (enExample) |
| SA (1) | SA520420897B1 (enExample) |
| SG (1) | SG11202013027RA (enExample) |
| TW (1) | TWI841573B (enExample) |
| WO (1) | WO2020006315A1 (enExample) |
| ZA (1) | ZA202100211B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109996541A (zh) | 2016-09-07 | 2019-07-09 | 普利安特治疗公司 | N-酰基氨基酸化合物及其使用方法 |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| CA3045491A1 (en) | 2016-12-29 | 2018-07-19 | Indalo Therapeutics, Inc. | Integrin antagonists |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| EP4159727B1 (en) | 2017-02-28 | 2026-04-08 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| CU24684B1 (es) | 2018-03-07 | 2023-10-06 | Pliant Therapeutics Inc | Compuestos de aminoácidos como inhibidores de la integrina |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| CN112654621B (zh) | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| TWI776067B (zh) | 2018-06-29 | 2022-09-01 | 美商維托平面玻璃有限責任公司 | 可燒除保護性塗層 |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| AU2019327475B2 (en) | 2018-08-29 | 2025-06-05 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
| PT3844162T (pt) | 2018-08-29 | 2025-03-28 | Morphic Therapeutic Inc | Inibidores da integrina alfa v beta6 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| EP3952902A4 (en) | 2019-04-08 | 2022-12-21 | Pliant Therapeutics, Inc. | DOSAGE FORMS AND THERAPY SCHEMES FOR AMINO ACID COMPOUNDS |
| EP4076454A1 (en) * | 2019-12-20 | 2022-10-26 | Novartis AG | Combination treatment of liver diseases using integrin inhibitors |
| IL293895A (en) * | 2019-12-20 | 2022-08-01 | Novartis Ag | Combination treatment of liver diseases using integrin inhibitors |
| GB202010626D0 (en) * | 2020-07-10 | 2020-08-26 | Univ Nottingham | Compound |
| TW202235417A (zh) | 2020-11-19 | 2022-09-16 | 美商普萊恩醫療公司 | 整合素抑制劑及其用途 |
| GB202209228D0 (en) | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Modified amino acids and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK9192000A3 (en) | 1997-12-17 | 2001-03-12 | Merck & Co Inc | Integrin receptor antagonists |
| US6048861A (en) * | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6329372B1 (en) * | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のａ５ｂ１アンタゴニストとしてのＮ−（ベンゾイル）−Ｏ−［２−（ピリジン−２−イルアミノ）エチル］−Ｌ−チロシン誘導体と関連化合物 |
| WO2008093064A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5 BETA 1 ANTAGONISTS |
| GB201305668D0 (en) * | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| AU2016228852A1 (en) | 2015-03-10 | 2017-10-19 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| CN104817604B (zh) | 2015-03-16 | 2017-08-04 | 邦泰生物工程(深圳)有限公司 | 一种β‑烟酰胺单核苷酸的纯化方法 |
| JP2018514568A (ja) * | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
| KR20190026001A (ko) | 2016-07-05 | 2019-03-12 | 더 락커펠러 유니버시티 | 테트라하이드로나프티리딘펜탄아미드 인테그린 길항물질 |
| CN109996541A (zh) | 2016-09-07 | 2019-07-09 | 普利安特治疗公司 | N-酰基氨基酸化合物及其使用方法 |
| CN110167934B (zh) * | 2016-11-08 | 2022-06-10 | 百时美施贵宝公司 | 作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物 |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| EP4159727B1 (en) | 2017-02-28 | 2026-04-08 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| US11046685B2 (en) * | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| CU24684B1 (es) | 2018-03-07 | 2023-10-06 | Pliant Therapeutics Inc | Compuestos de aminoácidos como inhibidores de la integrina |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| EP3843728B1 (en) | 2018-08-29 | 2025-04-30 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| AU2019327475B2 (en) | 2018-08-29 | 2025-06-05 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| EP3952902A4 (en) | 2019-04-08 | 2022-12-21 | Pliant Therapeutics, Inc. | DOSAGE FORMS AND THERAPY SCHEMES FOR AMINO ACID COMPOUNDS |
| CN115151566A (zh) | 2019-11-15 | 2022-10-04 | 普利安特治疗公司 | 用于活化整合素的组合物和方法 |
| KR20230049584A (ko) | 2020-05-07 | 2023-04-13 | 플라이언트 테라퓨틱스, 인크. | 아미노산 화합물을 사용한 호흡기 질환의 치료 |
| TW202235417A (zh) | 2020-11-19 | 2022-09-16 | 美商普萊恩醫療公司 | 整合素抑制劑及其用途 |
| US20230028658A1 (en) | 2021-04-30 | 2023-01-26 | Pliant Therapeutics, Inc. | Expanded dosage regimens for integrin inhibitors |
| US20240350494A1 (en) | 2021-09-03 | 2024-10-24 | Pliant Therapeutics, Inc. | Therapeutic modulation of integrins |
| JP2024539645A (ja) | 2021-10-14 | 2024-10-29 | プライアント・セラピューティクス・インコーポレイテッド | インテグリン阻害剤及び他の薬剤と組み合わせたその使用 |
-
2019
- 2019-06-26 TW TW108122460A patent/TWI841573B/zh active
- 2019-06-27 JO JOP/2020/0330A patent/JOP20200330A1/ar unknown
- 2019-06-27 WO PCT/US2019/039624 patent/WO2020006315A1/en not_active Ceased
- 2019-06-27 EP EP19826330.3A patent/EP3813818A4/en active Pending
- 2019-06-27 CR CR20210041A patent/CR20210041A/es unknown
- 2019-06-27 CN CN201980050125.6A patent/CN112689507B/zh active Active
- 2019-06-27 JP JP2020572976A patent/JP7425757B2/ja active Active
- 2019-06-27 SG SG11202013027RA patent/SG11202013027RA/en unknown
- 2019-06-27 IL IL279717A patent/IL279717B2/en unknown
- 2019-06-27 US US16/455,490 patent/US11396506B2/en active Active
- 2019-06-27 MX MX2020014086A patent/MX2020014086A/es unknown
- 2019-06-27 KR KR1020217002250A patent/KR20210043561A/ko not_active Withdrawn
- 2019-06-27 IL IL308960A patent/IL308960A/en unknown
- 2019-06-27 AU AU2019295769A patent/AU2019295769B2/en active Active
- 2019-06-27 BR BR112020026278-1A patent/BR112020026278A2/pt unknown
- 2019-06-27 CU CU2021000001A patent/CU24693B1/es unknown
- 2019-06-27 PE PE2020002165A patent/PE20210137A1/es unknown
- 2019-06-27 EA EA202190134A patent/EA202190134A1/ru unknown
- 2019-06-27 CA CA3104682A patent/CA3104682A1/en active Pending
-
2020
- 2020-12-23 CL CL2020003382A patent/CL2020003382A1/es unknown
- 2020-12-23 DO DO2020000255A patent/DOP2020000255A/es unknown
- 2020-12-23 PH PH12020552260A patent/PH12020552260A1/en unknown
- 2020-12-26 SA SA520420897A patent/SA520420897B1/ar unknown
-
2021
- 2021-01-12 ZA ZA2021/00211A patent/ZA202100211B/en unknown
- 2021-01-26 EC ECSENADI20215655A patent/ECSP21005655A/es unknown
-
2022
- 2022-02-23 US US17/679,002 patent/US11858931B2/en active Active
-
2023
- 2023-11-15 US US18/509,872 patent/US20240294520A1/en active Pending
-
2024
- 2024-01-19 JP JP2024006536A patent/JP2024055873A/ja not_active Withdrawn
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