JP2021528471A5 - - Google Patents

Info

Publication number
JP2021528471A5
JP2021528471A5 JP2020573007A JP2020573007A JP2021528471A5 JP 2021528471 A5 JP2021528471 A5 JP 2021528471A5 JP 2020573007 A JP2020573007 A JP 2020573007A JP 2020573007 A JP2020573007 A JP 2020573007A JP 2021528471 A5 JP2021528471 A5 JP 2021528471A5
Authority
JP
Japan
Prior art keywords
sequence
ala
adam9
domain
val
Prior art date
Application number
JP2020573007A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020005945A5 (https=
JP2021528471A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/038992 external-priority patent/WO2020005945A1/en
Publication of JP2021528471A publication Critical patent/JP2021528471A/ja
Publication of JP2021528471A5 publication Critical patent/JP2021528471A5/ja
Publication of JPWO2020005945A5 publication Critical patent/JPWO2020005945A5/ja
Pending legal-status Critical Current

Links

JP2020573007A 2018-06-26 2019-06-25 Adam9を標的とする免疫コンジュゲート、及び、その使用の方法 Pending JP2021528471A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862690052P 2018-06-26 2018-06-26
US62/690,052 2018-06-26
US201862691342P 2018-06-28 2018-06-28
US62/691,342 2018-06-28
US201962810703P 2019-02-26 2019-02-26
US62/810,703 2019-02-26
PCT/US2019/038992 WO2020005945A1 (en) 2018-06-26 2019-06-25 Immunoconjugates targeting adam9 and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2021528471A JP2021528471A (ja) 2021-10-21
JP2021528471A5 true JP2021528471A5 (https=) 2022-07-04
JPWO2020005945A5 JPWO2020005945A5 (https=) 2022-07-04

Family

ID=67513726

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020573007A Pending JP2021528471A (ja) 2018-06-26 2019-06-25 Adam9を標的とする免疫コンジュゲート、及び、その使用の方法

Country Status (13)

Country Link
US (1) US20210275685A1 (https=)
EP (1) EP3814378A1 (https=)
JP (1) JP2021528471A (https=)
KR (1) KR20210061995A (https=)
CN (1) CN112543770A (https=)
AU (1) AU2019294510A1 (https=)
BR (1) BR112020025346A2 (https=)
CA (1) CA3104511A1 (https=)
IL (1) IL279633A (https=)
MX (1) MX2020013466A (https=)
SG (1) SG11202012257VA (https=)
TW (1) TWI831797B (https=)
WO (1) WO2020005945A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11833214B2 (en) 2019-03-21 2023-12-05 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
TW202302155A (zh) 2021-03-08 2023-01-16 美商伊繆諾金公司 用於增加靶向adam9之免疫結合物治療癌症之功效的方法
WO2024059263A1 (en) * 2022-09-15 2024-03-21 Immunogen, Inc. Methods for preparing maytansinoid derivatives with self-immolative peptide linkers
TWI876557B (zh) * 2022-09-30 2025-03-11 臺北醫學大學 用於前列腺癌診斷和早期發病的單株抗體
EP4692118A1 (en) * 2023-03-24 2026-02-11 Duality Biologics (Shanghai) Co., Ltd. Adam9-targeting humanized antibody and antibody-drug conjugate comprising same and use thereof
WO2025094146A1 (en) 2023-11-02 2025-05-08 Immunogen Switzerland Gmbh Vasconstrictors for reducing ocular toxicity of antibody-maytansinoid conjugates
CN120058950A (zh) * 2023-11-28 2025-05-30 昆山新蕴达生物科技有限公司 抗adam9的抗体及其用途
WO2025124443A1 (zh) * 2023-12-14 2025-06-19 四川科伦博泰生物医药股份有限公司 Adam9结合蛋白及其用途

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
AU669124B2 (en) 1991-09-18 1996-05-30 Kyowa Hakko Kirin Co., Ltd. Process for producing humanized chimera antibody
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US6180377B1 (en) 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
WO1998023289A1 (en) 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
HUP0204475A2 (en) 2000-02-11 2003-04-28 Merck Patent Gmbh Enhancing the circulating half-life of antibody-based fusion proteins
US20030091568A1 (en) 2000-04-07 2003-05-15 Jurgen Frey Inhibitors for the formation of soluble human CD23
EP1142910A1 (en) 2000-04-07 2001-10-10 Jürgen Prof. Dr. Frey Inhibitors for the formation of soluble human CD23
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
AU2002347182A1 (en) 2001-12-18 2003-06-30 Mondobiotech Licensing Out Ag Pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US20040092466A1 (en) 2002-11-11 2004-05-13 Isis Pharmaceuticals Inc. Modulation of ADAM9 expression
JP2006500364A (ja) 2002-08-16 2006-01-05 イムノージェン インコーポレーテッド 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
DE10337368A1 (de) * 2003-08-08 2005-03-03 Technische Universität Dresden Verfahren und Mittel zur Diagnose und Behandlung von Pankreastumoren
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
WO2005091823A2 (en) 2004-03-01 2005-10-06 The Regents Of The University Of California The use of lunasin peptide as a transcriptional activator to prevent cancer and related methods for treatment, monitoring and prognosis
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
AU2006210589B2 (en) 2005-02-02 2011-12-08 Macrogenics West, Inc. ADAM-9 modulators
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
ES2567402T3 (es) 2006-05-30 2016-04-22 Genentech, Inc. Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos
WO2007143752A2 (en) 2006-06-09 2007-12-13 The Regents Of The University Of California Targets in breast cancer for prognosis or therapy
KR101443214B1 (ko) 2007-01-09 2014-09-24 삼성전자주식회사 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
GB0724357D0 (en) * 2007-12-14 2008-01-23 Glaxosmithkline Biolog Sa Method for preparing protein conjugates
WO2009114532A2 (en) 2008-03-10 2009-09-17 National Jewish Health Markers for diagnosis of pulmonary inflammation and methods related thereto
AU2009233899A1 (en) 2008-04-07 2009-10-15 Zymogenetics, Inc. Thrombin activator compostions and methods of making and using the same
US20090285840A1 (en) * 2008-04-29 2009-11-19 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Methods for treating pathological neovascularization
KR20200058590A (ko) 2008-04-30 2020-05-27 이뮤노젠 아이엔씨 가교제 및 그 용도
EP2276506A4 (en) 2008-04-30 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
ES2675730T3 (es) 2008-06-04 2018-07-12 Macrogenics, Inc. Anticuerpos con unión alterada a FcRn y métodos de uso de los mismos
US20110129450A1 (en) 2008-08-01 2011-06-02 Orly Lazarov Method of promoting neurogenesis by modulating secretase activities
WO2010053539A2 (en) 2008-11-05 2010-05-14 The Texas A&M University System Methods for detecting colorectal diseases and disorders
MX2011005953A (es) 2008-12-04 2011-08-17 Abbott Lab Inmunoglobulinas de dominio variable dual y usos de las mismas.
EP2486023A4 (en) * 2009-10-06 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
WO2011050180A1 (en) * 2009-10-21 2011-04-28 Immunogen, Inc. Novel dosing regimen and method of treatment
WO2011100362A1 (en) 2010-02-11 2011-08-18 University Of Southern California Modified adam disintegrin domain polypeptides and uses thereof
JP5998060B2 (ja) 2010-03-04 2016-09-28 マクロジェニクス,インコーポレーテッド B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
WO2013049704A2 (en) 2011-09-28 2013-04-04 Armune Biosciences, Inc. Method and system of particle-phage epitope complex
WO2013098797A2 (en) 2011-12-31 2013-07-04 Kuriakose Moni Abraham Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
EP2943585B1 (en) 2013-01-09 2018-07-11 Friedrich-Alexander-Universität Erlangen-Nürnberg Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles
US10047163B2 (en) 2013-02-08 2018-08-14 Abbvie Stemcentrx Llc Multispecific constructs
MX379256B (es) * 2013-03-15 2025-03-10 Regeneron Pharma Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
JPWO2014168154A1 (ja) 2013-04-08 2017-02-16 三菱レイヨン株式会社 眼疾患を評価するためのマイクロアレイ及び眼疾患の評価方法
EP2996721B1 (en) 2013-05-13 2021-10-06 Tufts University Compositions for treatment of adam8-expressing cancer
EP3011050B1 (en) 2013-06-19 2017-09-06 Memorial Sloan Kettering Cancer Center Methods and compositions for the diagnosis, prognosis and treatment of brain metastasis
US9567641B2 (en) 2013-07-03 2017-02-14 Samsung Electronics Co., Ltd. Combination therapy for the treatment of cancer using an anti-C-met antibody
MX2017006016A (es) 2014-11-11 2017-06-19 Amunix Operating Inc Composiciones conjugadas de xten direccionadas y metodos para producir las mismas.
SG11201806478PA (en) * 2016-02-05 2018-08-30 Immunogen Inc Efficient process for preparing cell-binding agent-cytotoxic agent conjugates
SI3558391T1 (sl) * 2016-12-23 2022-06-30 Immunogen, Inc. Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe

Similar Documents

Publication Publication Date Title
JP2021528471A5 (https=)
JP7467610B2 (ja) カンプトテシン誘導体及びその複合体
JP2020504607A5 (https=)
JP7844591B2 (ja) バイパラトピックFR-α抗体及びイムノコンジュゲート
TW201609152A (zh) 包含細胞結合劑及細胞毒性劑之偶聯物
WO2016033324A1 (en) Internalizing moieties for treatment of cancer
JPWO2021177438A5 (https=)
US20200188525A1 (en) Anti-egfr antibody drug conjugates (adc) and uses thereof
TW201739472A (zh) 抗磷脂醯肌醇蛋白聚糖-3抗體及妥布賴森(tubulysin)類似物之抗體藥物結合物、製備及用途
US20200297863A1 (en) Anti-egfr antibody drug conjugates (adc) and uses thereof
JPWO2020005945A5 (https=)
CN115052663A (zh) Alk5抑制剂缀合物及其用途
RU2021100667A (ru) Иммуноконъюгаты, нацеленные на adam9, и способы их применения
RU2832083C2 (ru) Бипаратопные fr-альфа антитела и иммуноконъюгаты
JPWO2024110905A5 (https=)
JPWO2021231309A5 (https=)
WO2024235135A1 (zh) 大环化合物及其制备方法和用途
HK40118815A (zh) 抗体偶联药物及其用途