|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
GB9115364D0
(en)
|
1991-07-16 |
1991-08-28 |
Wellcome Found |
Antibody
|
|
AU669124B2
(en)
|
1991-09-18 |
1996-05-30 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing humanized chimera antibody
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US6180377B1
(en)
|
1993-06-16 |
2001-01-30 |
Celltech Therapeutics Limited |
Humanized antibodies
|
|
US6265150B1
(en)
|
1995-06-07 |
2001-07-24 |
Becton Dickinson & Company |
Phage antibodies
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
US20030091568A1
(en)
|
2000-04-07 |
2003-05-15 |
Jurgen Frey |
Inhibitors for the formation of soluble human CD23
|
|
EP1142910A1
(en)
|
2000-04-07 |
2001-10-10 |
Jürgen Prof. Dr. Frey |
Inhibitors for the formation of soluble human CD23
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
EP1455813B1
(en)
|
2001-12-18 |
2015-07-15 |
mondoBIOTECH AG |
Interferon gamma in combination with a diagnostic array for use in the improved treatment of idiopathic pulmonary fibrosis
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US20040092466A1
(en)
|
2002-11-11 |
2004-05-13 |
Isis Pharmaceuticals Inc. |
Modulation of ADAM9 expression
|
|
DE60336149D1
(de)
|
2002-08-16 |
2011-04-07 |
Immunogen Inc |
Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
DE10337368A1
(de)
*
|
2003-08-08 |
2005-03-03 |
Technische Universität Dresden |
Verfahren und Mittel zur Diagnose und Behandlung von Pankreastumoren
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
US7829277B2
(en)
|
2004-03-01 |
2010-11-09 |
The Regents Of The University Of California |
Methods for identifying compounds that suppress chemically-induced carcinogenesis
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
WO2006084075A2
(en)
|
2005-02-02 |
2006-08-10 |
Raven Biotechnologies, Inc. |
Adam-9 modulators
|
|
US8445198B2
(en)
|
2005-12-01 |
2013-05-21 |
Medical Prognosis Institute |
Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
|
|
EP2032606B1
(en)
|
2006-05-30 |
2013-11-27 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
WO2007143752A2
(en)
|
2006-06-09 |
2007-12-13 |
The Regents Of The University Of California |
Targets in breast cancer for prognosis or therapy
|
|
KR101443214B1
(ko)
|
2007-01-09 |
2014-09-24 |
삼성전자주식회사 |
폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이
|
|
GB2453589A
(en)
|
2007-10-12 |
2009-04-15 |
King S College London |
Protease inhibition
|
|
GB0724357D0
(en)
*
|
2007-12-14 |
2008-01-23 |
Glaxosmithkline Biolog Sa |
Method for preparing protein conjugates
|
|
US8101361B2
(en)
|
2008-03-10 |
2012-01-24 |
National Jewish Health |
Markers for diagnosis of pulmonary inflammation and methods related thereto
|
|
CA2716738A1
(en)
|
2008-04-07 |
2009-10-15 |
Zymogenetics, Inc. |
Thrombin activator compositions and methods of making and using the same
|
|
US20090285840A1
(en)
*
|
2008-04-29 |
2009-11-19 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Methods for treating pathological neovascularization
|
|
NZ610239A
(en)
|
2008-04-30 |
2014-11-28 |
Immunogen Inc |
Cross-linkers and their uses
|
|
SG189817A1
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Potent conjugates and hydrophilic linkers
|
|
US20110081347A1
(en)
|
2008-06-04 |
2011-04-07 |
Macrogenics, Inc. |
Antibodies with Altered Binding to FcRn and Methods of Using Same
|
|
US20110129450A1
(en)
|
2008-08-01 |
2011-06-02 |
Orly Lazarov |
Method of promoting neurogenesis by modulating secretase activities
|
|
WO2010053539A2
(en)
|
2008-11-05 |
2010-05-14 |
The Texas A&M University System |
Methods for detecting colorectal diseases and disorders
|
|
RU2011127198A
(ru)
|
2008-12-04 |
2013-01-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двойными вариабельными доменами и их применение
|
|
CN102596922A
(zh)
*
|
2009-10-06 |
2012-07-18 |
免疫基因公司 |
有效的缀合物和亲水性连接体
|
|
EP2490715A4
(en)
*
|
2009-10-21 |
2013-06-26 |
Immunogen Inc |
NEW DOSAGE ADMINISTRATION REGIMEN AND METHOD OF TREATMENT
|
|
EP2534171A4
(en)
|
2010-02-11 |
2013-07-17 |
Univ Southern California |
MODIFIED ADAM DISINTEGRIN DOMAIN POLYPEPTIDES AND USES THEREOF
|
|
EP2542256B1
(en)
|
2010-03-04 |
2019-05-22 |
MacroGenics, Inc. |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
US20130130355A1
(en)
|
2011-09-28 |
2013-05-23 |
Armune Biosciences, Inc. |
Method and system of particle-phage epitope complex
|
|
US20140342946A1
(en)
|
2011-12-31 |
2014-11-20 |
Moni Abraham Kuriakose |
Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer
|
|
US9534058B2
(en)
|
2012-02-08 |
2017-01-03 |
Abbvie Stemcentrx Llc |
Anti-CD324 monoclonal antibodies and uses thereof
|
|
WO2014108480A1
(en)
|
2013-01-09 |
2014-07-17 |
Friedrich-Alexander-Universitaet Erlangen-Nuernberg |
Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles
|
|
US10047163B2
(en)
|
2013-02-08 |
2018-08-14 |
Abbvie Stemcentrx Llc |
Multispecific constructs
|
|
JP6847388B2
(ja)
*
|
2013-03-15 |
2021-03-31 |
レゲネロン ファーマシューティカルス,インコーポレーテッド |
生物活性分子、そのコンジュゲート、及び治療用途
|
|
JPWO2014168154A1
(ja)
|
2013-04-08 |
2017-02-16 |
三菱レイヨン株式会社 |
眼疾患を評価するためのマイクロアレイ及び眼疾患の評価方法
|
|
EP2996721B1
(en)
|
2013-05-13 |
2021-10-06 |
Tufts University |
Compositions for treatment of adam8-expressing cancer
|
|
US20160138113A1
(en)
|
2013-06-19 |
2016-05-19 |
Memorial Sloan-Kettering Cancer Center |
Methods and compositions for the diagnosis, prognosis and treatment of brain metastasis
|
|
US9567641B2
(en)
|
2013-07-03 |
2017-02-14 |
Samsung Electronics Co., Ltd. |
Combination therapy for the treatment of cancer using an anti-C-met antibody
|
|
MX2017006016A
(es)
|
2014-11-11 |
2017-06-19 |
Amunix Operating Inc |
Composiciones conjugadas de xten direccionadas y metodos para producir las mismas.
|
|
TW201731532A
(zh)
*
|
2016-02-05 |
2017-09-16 |
伊繆諾金公司 |
用於製備細胞結合劑-細胞毒性劑結合物之有效方法
|
|
PL3558391T3
(pl)
*
|
2016-12-23 |
2022-05-16 |
Immunogen, Inc. |
Immunokoniugaty skierowane wobec białka adam9 i sposoby ich stosowania
|