JP2021525800A5 - - Google Patents
Info
- Publication number
- JP2021525800A5 JP2021525800A5 JP2021516850A JP2021516850A JP2021525800A5 JP 2021525800 A5 JP2021525800 A5 JP 2021525800A5 JP 2021516850 A JP2021516850 A JP 2021516850A JP 2021516850 A JP2021516850 A JP 2021516850A JP 2021525800 A5 JP2021525800 A5 JP 2021525800A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- pharmaceutical composition
- pharmaceutically acceptable
- epilepsy
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023133988A JP7603118B2 (ja) | 2018-05-30 | 2023-08-21 | イオンチャネルモジュレーター |
| JP2024048085A JP7738930B2 (ja) | 2018-05-30 | 2024-03-25 | イオンチャネルモジュレーター |
| JP2024192056A JP2025013427A (ja) | 2018-05-30 | 2024-10-31 | イオンチャネルモジュレーター |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862677903P | 2018-05-30 | 2018-05-30 | |
| US62/677,903 | 2018-05-30 | ||
| US201862738508P | 2018-09-28 | 2018-09-28 | |
| US62/738,508 | 2018-09-28 | ||
| PCT/US2019/034653 WO2019232209A1 (en) | 2018-05-30 | 2019-05-30 | Ion channel modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133988A Division JP7603118B2 (ja) | 2018-05-30 | 2023-08-21 | イオンチャネルモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021525800A JP2021525800A (ja) | 2021-09-27 |
| JP2021525800A5 true JP2021525800A5 (enExample) | 2022-06-07 |
| JP7359847B2 JP7359847B2 (ja) | 2023-10-11 |
Family
ID=68696775
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021516850A Active JP7359847B2 (ja) | 2018-05-30 | 2019-05-30 | イオンチャネルモジュレーター |
| JP2023133988A Active JP7603118B2 (ja) | 2018-05-30 | 2023-08-21 | イオンチャネルモジュレーター |
| JP2024048085A Active JP7738930B2 (ja) | 2018-05-30 | 2024-03-25 | イオンチャネルモジュレーター |
| JP2024192056A Withdrawn JP2025013427A (ja) | 2018-05-30 | 2024-10-31 | イオンチャネルモジュレーター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133988A Active JP7603118B2 (ja) | 2018-05-30 | 2023-08-21 | イオンチャネルモジュレーター |
| JP2024048085A Active JP7738930B2 (ja) | 2018-05-30 | 2024-03-25 | イオンチャネルモジュレーター |
| JP2024192056A Withdrawn JP2025013427A (ja) | 2018-05-30 | 2024-10-31 | イオンチャネルモジュレーター |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US11866439B2 (enExample) |
| EP (2) | EP4487916A3 (enExample) |
| JP (4) | JP7359847B2 (enExample) |
| KR (2) | KR102809796B1 (enExample) |
| CN (4) | CN112423760A (enExample) |
| AU (2) | AU2019278814B2 (enExample) |
| BR (1) | BR112020024379A2 (enExample) |
| CA (1) | CA3101324A1 (enExample) |
| IL (3) | IL309843B1 (enExample) |
| MX (3) | MX2020012838A (enExample) |
| SG (1) | SG11202011879RA (enExample) |
| TW (2) | TW202436298A (enExample) |
| WO (1) | WO2019232209A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| MX2020012838A (es) | 2018-05-30 | 2021-07-16 | Praxis Prec Medicines Inc | Moduladores de los canales ionicos. |
| BR112021003224A2 (pt) | 2018-08-20 | 2021-07-20 | Rogcon, Inc. | oligonucleotídeos antissentido direcionados a scn2a para o tratamento de encefalopatias por scn1a |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) * | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| CN114980899A (zh) * | 2019-11-26 | 2022-08-30 | 普拉西斯精密医药公司 | 离子通道调节剂 |
| PE20221280A1 (es) * | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
| KR20250005348A (ko) * | 2022-04-26 | 2025-01-09 | 프락시스 프리시젼 메디신즈, 인크. | 신경 장애의 치료 |
| EP4514357A4 (en) * | 2022-04-26 | 2026-04-29 | Praxis Prec Medicines Inc | METHODS OF TREATING NEUROLOGICAL DISORDERS |
| JP2025514192A (ja) * | 2022-04-26 | 2025-05-02 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | 神経障害の治療 |
| WO2025059464A1 (en) * | 2023-09-15 | 2025-03-20 | Praxis Precision Medicines, Inc. | Determining effect of a drug based on brain activity and a trained machine learning model |
| WO2025207826A1 (en) * | 2024-03-26 | 2025-10-02 | Praxis Precision Medicines, Inc. | Methods of treatment of neurological disorders |
| WO2026082004A1 (zh) * | 2024-10-14 | 2026-04-23 | 上海京新生物医药有限公司 | 稠合杂芳基衍生物及其制备方法与应用 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4230705A (en) * | 1976-09-22 | 1980-10-28 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
| CA1080712A (en) | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
| US4112095A (en) | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
| US4242515A (en) | 1979-03-28 | 1980-12-30 | American Cyanamid Company | Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| GB9507348D0 (en) * | 1995-04-08 | 1995-05-31 | Knoll Ag | Therapeutic agents |
| WO2002006286A2 (en) * | 2000-07-14 | 2002-01-24 | Bristol-Myers Squibb Pharma Company | IMIDAZO[1,2-a]PYRAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| WO2006061428A2 (en) | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
| EP1904630A4 (en) | 2005-06-16 | 2009-10-21 | Bionomics Ltd | METHODS OF TREATING AND DIAGNOSING EPILEPSY BY DETECTING MUTATIONS OF THE SCN1A GENE |
| HRP20170103T1 (hr) * | 2005-12-21 | 2017-03-24 | Janssen Pharmaceutica N.V. | Triazolopiridazini kao modulatori tirozin kinaze |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| KR100858357B1 (ko) | 2006-10-02 | 2008-09-11 | (주) 디지탈바이오텍 | 벤조퓨란계 유도체 화합물을 유효성분으로 함유하는인지기능 장애의 예방 및 치료용 조성물 |
| FR2915198B1 (fr) | 2007-04-18 | 2009-12-18 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique. |
| CA2713521A1 (en) | 2008-02-06 | 2009-08-13 | Gilead Palo Alto, Inc. | Use of ranolazine for treating pain |
| WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
| WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
| US20100125091A1 (en) | 2008-11-14 | 2010-05-20 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds as ion channel modulators |
| MX342128B (es) | 2008-12-24 | 2016-09-14 | Bial - Portela & C A S A | Compuestos farmaceuticos. |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| ES2642586T3 (es) | 2009-07-27 | 2017-11-16 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de canales iónicos |
| WO2011056985A2 (en) | 2009-11-04 | 2011-05-12 | Gilead Sciences, Inc. | Substituted heterocyclic compounds |
| FR2953520B1 (fr) | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
| US20130315895A1 (en) * | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| EP2588197B1 (en) | 2010-07-02 | 2014-11-05 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| WO2012065297A1 (en) | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| WO2012151136A1 (en) | 2011-05-03 | 2012-11-08 | Merck Sharp & Dohme Corp. | Aminomethyl biaryl benzotriazole derivatives |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| WO2013043925A1 (en) | 2011-09-21 | 2013-03-28 | Gilead Sciences, Inc. | Sodium channel blockers reduce glucagon secretion |
| WO2013045519A1 (en) | 2011-09-27 | 2013-04-04 | Genfit | Derivatives of 6-substituted triazolopyridazines as rev-erb agonists |
| JP2016511744A (ja) | 2012-12-21 | 2016-04-21 | エピザイム，インコーポレイティド | Ｐｒｍｔ５を阻害する方法 |
| US9550775B2 (en) * | 2013-03-14 | 2017-01-24 | Genentech, Inc. | Substituted triazolopyridines and methods of use thereof |
| WO2014179492A1 (en) | 2013-05-01 | 2014-11-06 | Gilead Sciences, Inc. | Combination therapy for the treatment of arrhythmias or heart failure |
| SI3010503T1 (sl) | 2013-06-21 | 2020-07-31 | Zenith Epigenetics Ltd. | Novi biciklični inhibitorji bromodomene |
| DK3035926T3 (da) | 2013-08-19 | 2020-08-31 | Univ California | Forbindelser og fremgangsmåder til behandling af en epilepsilidelse |
| GB201321740D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| NZ720651A (en) | 2013-12-19 | 2017-12-22 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators |
| WO2015157955A1 (en) | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| ES2912073T3 (es) | 2014-06-20 | 2022-05-24 | Mitsubishi Chem Corp | Policarbonatodiol, método para producir el mismo, y poliuretano producido usando el mismo |
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| AU2015279377B2 (en) | 2014-06-26 | 2019-09-12 | F. Hoffmann-La Roche Ag | Indolin-2-one or pyrrolo-pyridin-2-one derivatives |
| JP2017001991A (ja) | 2015-06-11 | 2017-01-05 | 大日本住友製薬株式会社 | 新規ベンズオキサゾロン化合物 |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途 |
| WO2018098500A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| EA201991306A1 (ru) | 2017-08-30 | 2020-03-20 | Праксис Пресижн Медсинз, Инк. | Соединения и способы их применения |
| MX2020012838A (es) | 2018-05-30 | 2021-07-16 | Praxis Prec Medicines Inc | Moduladores de los canales ionicos. |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| CN114980899A (zh) | 2019-11-26 | 2022-08-30 | 普拉西斯精密医药公司 | 离子通道调节剂 |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| PE20221280A1 (es) | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
-
2019
- 2019-05-30 MX MX2020012838A patent/MX2020012838A/es unknown
- 2019-05-30 JP JP2021516850A patent/JP7359847B2/ja active Active
- 2019-05-30 CN CN201980047216.4A patent/CN112423760A/zh active Pending
- 2019-05-30 CN CN202411285923.6A patent/CN119371426A/zh active Pending
- 2019-05-30 EP EP24200923.1A patent/EP4487916A3/en active Pending
- 2019-05-30 AU AU2019278814A patent/AU2019278814B2/en active Active
- 2019-05-30 WO PCT/US2019/034653 patent/WO2019232209A1/en not_active Ceased
- 2019-05-30 TW TW113103893A patent/TW202436298A/zh unknown
- 2019-05-30 CA CA3101324A patent/CA3101324A1/en active Pending
- 2019-05-30 TW TW108118813A patent/TWI831786B/zh active
- 2019-05-30 KR KR1020207037964A patent/KR102809796B1/ko active Active
- 2019-05-30 EP EP19810530.6A patent/EP3801535A4/en active Pending
- 2019-05-30 CN CN202411285845.XA patent/CN119350320A/zh active Pending
- 2019-05-30 KR KR1020257015904A patent/KR20250070142A/ko active Pending
- 2019-05-30 IL IL309843A patent/IL309843B1/en unknown
- 2019-05-30 US US17/058,187 patent/US11866439B2/en active Active
- 2019-05-30 CN CN202311479943.2A patent/CN117756800A/zh active Pending
- 2019-05-30 BR BR112020024379-5A patent/BR112020024379A2/pt unknown
- 2019-05-30 SG SG11202011879RA patent/SG11202011879RA/en unknown
-
2020
- 2020-11-24 US US17/102,586 patent/US11014931B2/en active Active
- 2020-11-27 MX MX2024000150A patent/MX2024000150A/es unknown
- 2020-11-27 MX MX2025001282A patent/MX2025001282A/es unknown
- 2020-11-29 IL IL279064A patent/IL279064B1/en unknown
-
2021
- 2021-03-26 US US17/214,343 patent/US11731976B2/en active Active
-
2022
- 2022-03-23 US US17/702,518 patent/US11731978B2/en active Active
-
2023
- 2023-08-21 US US18/236,156 patent/US12325711B2/en active Active
- 2023-08-21 JP JP2023133988A patent/JP7603118B2/ja active Active
-
2024
- 2024-03-25 JP JP2024048085A patent/JP7738930B2/ja active Active
- 2024-10-31 JP JP2024192056A patent/JP2025013427A/ja not_active Withdrawn
-
2025
- 2025-05-08 US US19/202,859 patent/US20250376475A1/en active Pending
- 2025-11-25 AU AU2025271306A patent/AU2025271306B2/en active Active
- 2025-12-23 IL IL325565A patent/IL325565A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021525800A5 (enExample) | ||
| JP2023144130A5 (enExample) | ||
| JP2022502442A5 (enExample) | ||
| JP2018531963A5 (enExample) | ||
| JP7279057B6 (ja) | Ｐｄ１／ｐｄ－ｌ１活性化の阻害剤としてのピリミジン誘導体 | |
| RU2606497C2 (ru) | Тиазолилфенилбензолсульфонамидопроизводные в качестве ингибиторов киназ | |
| CA3208313A1 (en) | Isoindolinone compounds | |
| RU2460730C2 (ru) | Новые производные n-(8-гетероарилтетрагидронафталин-2-ил)-или n-(5-гетероарилхроман-3-ил)-карбоксамида для лечения боли | |
| RU2005103244A (ru) | Производные 1h-1,2,4-триазол-3-карбоксамида в качестве лигандов рецептора каннабиноидов (cb1) | |
| WO1997037989A1 (en) | Indole derivatives as 5-ht receptor antagonist | |
| JP2010501003A5 (enExample) | ||
| JP2018501253A5 (enExample) | ||
| JP2020511467A5 (enExample) | ||
| RU2014145544A (ru) | Солевая форма ингибитора гистон-метилтрансферазы ezh2 человека | |
| RU2010114828A (ru) | Производные урацила или тимина для лечения гепатита с | |
| JP2023518838A5 (enExample) | ||
| JP2016512515A5 (enExample) | ||
| RU2013156074A (ru) | Диазакарбазолы и способы применения | |
| EA031655B1 (ru) | Бензимидазол-2-амины в качестве ингибиторов midhi | |
| JP2013536188A5 (enExample) | ||
| JP2016527208A5 (enExample) | ||
| WO2006053112A1 (en) | Process for preparing trisubstituted pyrimidine compounds | |
| JP2021522330A5 (enExample) | ||
| Prasad et al. | Effect of inductive effect on the formation of cocrystals and eutectics | |
| JP2023539390A5 (enExample) |