JP2021525530A - キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 - Google Patents

キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 Download PDF

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JP2021525530A
JP2021525530A JP2020567078A JP2020567078A JP2021525530A JP 2021525530 A JP2021525530 A JP 2021525530A JP 2020567078 A JP2020567078 A JP 2020567078A JP 2020567078 A JP2020567078 A JP 2020567078A JP 2021525530 A JP2021525530 A JP 2021525530A
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car
cell
cells
gene
cytokine
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JPWO2019232425A5 (enExample
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アルン・カーター
マシュー・クーパー
ジョン・エフ・ディパージオ
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Washington University in St Louis WUSTL
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JP2020567078A 2018-06-01 2019-05-31 キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 Pending JP2021525530A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862679597P 2018-06-01 2018-06-01
US62/679,597 2018-06-01
PCT/US2019/034981 WO2019232425A1 (en) 2018-06-01 2019-05-31 Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy

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JP2021525530A true JP2021525530A (ja) 2021-09-27
JPWO2019232425A5 JPWO2019232425A5 (enExample) 2022-06-30

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US (2) US20200054675A1 (enExample)
EP (1) EP3802578A4 (enExample)
JP (1) JP2021525530A (enExample)
CN (1) CN112533942A (enExample)
WO (1) WO2019232425A1 (enExample)

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US12350349B2 (en) 2016-08-03 2025-07-08 Washington University Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors
JP2020530454A (ja) 2017-08-07 2020-10-22 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 安全な細胞治療薬を生成するためのプラットフォーム
CA3101505A1 (en) * 2018-05-31 2019-12-05 Washington University Chimeric antigen receptor t cells (car-t) for the treatment of cancer
JP2022516389A (ja) * 2018-05-31 2022-02-28 ワシントン・ユニバーシティ 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞
EP3802578A4 (en) 2018-06-01 2022-03-23 Washington University SUPPRESSION OF CYTOKINE RELEASE SYNDROME IN CHIMERIC ANTIGEN RECEPTOR CELL THERAPY
CN109735558B (zh) * 2018-12-12 2022-04-15 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
US11786553B2 (en) 2019-03-01 2023-10-17 Allogene Therapeuctics, Inc. Chimeric cytokine receptors bearing a PD-1 ectodomain
WO2021127261A1 (en) * 2019-12-17 2021-06-24 The General Hospital Corporation Engineered immune cells with reduced toxicity and uses thereof
EP3845646A1 (en) * 2019-12-30 2021-07-07 Secarna Pharmaceuticals GmbH & Co. KG Modified antisense oligonucleotide for inhibition of foxp3 expression
AU2021227191A1 (en) * 2020-02-24 2022-08-25 Allogene Therapeutics, Inc. BCMA car-T cells with enhanced activities
AU2021251113A1 (en) * 2020-04-06 2022-10-27 Celledit Llc Genetically modified immune cells expressing a chimeric antigen receptor and having reduced proinflammatory cytokine signaling
CN111548420B (zh) * 2020-05-14 2021-10-15 深圳普瑞金生物药业有限公司 一种抗间皮素嵌合抗原受体、表达基因、表达载体、t细胞及其用途
WO2022098756A1 (en) * 2020-11-03 2022-05-12 WUGEN, Inc. Chimeric antigen receptor cell therapy
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN112876535B (zh) * 2021-02-08 2023-06-30 浙江华缔药业集团医药开发有限公司 生物活性多肽及其应用
CN118056012B (zh) * 2021-08-24 2025-05-30 赛斯尔擎生物技术（上海）有限公司 一种修饰细胞的方法
CN114410686B (zh) * 2021-12-24 2023-10-03 武汉大学 一种工程化外泌体原位纳米疫苗及其制备方法和应用
WO2023225249A1 (en) * 2022-05-20 2023-11-23 President And Fellows Of Harvard College Methods and compositions relating to treatment of cns diseases
CN116102662A (zh) * 2022-10-10 2023-05-12 武汉波睿达生物科技有限公司 一种靶向ca9的融合嵌合抗原受体、重组表达载体及其应用
JP2025535448A (ja) * 2022-10-20 2025-10-24 マイクロ クリスパー プライベート リミテッド 免疫療法におけるサイトカイン放出症候群の軽減
AU2023362750A1 (en) * 2022-10-20 2025-06-05 Microcrispr Pvt Ltd. Attenuation of cytokine release syndrome in immunotherapy
CN116240173B (zh) * 2023-02-02 2024-09-27 西安电子科技大学 一种冷热肿瘤调控型car-单核/巨噬细胞及其制备方法和应用
CN117164712B (zh) * 2023-02-22 2024-05-24 成都优赛诺生物科技有限公司 一种靶向cd22的单域抗体、嵌合抗原受体及其应用
WO2025077790A1 (en) * 2023-10-11 2025-04-17 Chengdu Ucello Biotechnology Co., Limited Engineered immune cells and uses thereof
CN117186202B (zh) * 2023-11-08 2024-02-02 北京大学第三医院（北京大学第三临床医学院） 一种新细胞因子csbf及其在干眼治疗中的应用
CN117866110B (zh) * 2023-12-27 2024-06-11 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用
CN119345372A (zh) * 2024-10-28 2025-01-24 北京大学人民医院 Cd132在治疗aml中的应用

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