JP2021522206A5 - - Google Patents

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Publication number
JP2021522206A5
JP2021522206A5 JP2020558018A JP2020558018A JP2021522206A5 JP 2021522206 A5 JP2021522206 A5 JP 2021522206A5 JP 2020558018 A JP2020558018 A JP 2020558018A JP 2020558018 A JP2020558018 A JP 2020558018A JP 2021522206 A5 JP2021522206 A5 JP 2021522206A5
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disease
group
pharmaceutically acceptable
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acceptable salt
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JP2020558018A
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JP2021522206A (ja
JP7398391B2 (ja
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Priority claimed from PCT/US2019/028011 external-priority patent/WO2019204537A1/en
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JP2020558018A 2018-04-20 2019-04-18 Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物 Active JP7398391B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862660397P 2018-04-20 2018-04-20
US62/660,397 2018-04-20
PCT/US2019/028011 WO2019204537A1 (en) 2018-04-20 2019-04-18 N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)

Publications (3)

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JP2021522206A JP2021522206A (ja) 2021-08-30
JP2021522206A5 true JP2021522206A5 (enExample) 2022-04-22
JP7398391B2 JP7398391B2 (ja) 2023-12-14

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JP2020558018A Active JP7398391B2 (ja) 2018-04-20 2019-04-18 Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物

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US (1) US11634436B2 (enExample)
EP (1) EP3781571B1 (enExample)
JP (1) JP7398391B2 (enExample)
CN (1) CN112074519B (enExample)
WO (1) WO2019204537A1 (enExample)

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TW202214617A (zh) 2020-06-02 2022-04-16 法商賽諾菲公司 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
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JP7775288B2 (ja) * 2020-08-18 2025-11-25 ハチメド リミテッド ピリミジノン化合物およびその使用
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CN115806557B (zh) * 2021-09-14 2025-02-14 中国科学院上海有机化学研究所 抑制细胞程序性死亡的化合物及其制备方法
JP2024544533A (ja) 2021-11-11 2024-12-03 ジェンザイム・コーポレーション Ｒｉｐｋ１阻害剤としてのイソオキサゾリジン及びその使用
CN116265452A (zh) * 2021-12-17 2023-06-20 中国科学院上海药物研究所 含氮杂环化合物、其制备方法及其用途
CN116640156B (zh) * 2022-02-22 2025-10-24 上海齐鲁制药研究中心有限公司 Ripk1抑制剂
CN117645579A (zh) * 2022-09-02 2024-03-05 科辉智药生物科技(深圳)有限公司 作为ripk1抑制剂的氮杂䓬类稠环化合物及其应用

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