JP2021519791A5 - - Google Patents
Info
- Publication number
- JP2021519791A5 JP2021519791A5 JP2020553490A JP2020553490A JP2021519791A5 JP 2021519791 A5 JP2021519791 A5 JP 2021519791A5 JP 2020553490 A JP2020553490 A JP 2020553490A JP 2020553490 A JP2020553490 A JP 2020553490A JP 2021519791 A5 JP2021519791 A5 JP 2021519791A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- mutant
- capsid polypeptide
- aav capsid
- vector
- Prior art date
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862651010P | 2018-03-30 | 2018-03-30 | |
| US62/651,010 | 2018-03-30 | ||
| US201862745226P | 2018-10-12 | 2018-10-12 | |
| US62/745,226 | 2018-10-12 | ||
| PCT/US2019/025026 WO2019191701A1 (en) | 2018-03-30 | 2019-03-29 | Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021519791A JP2021519791A (ja) | 2021-08-12 |
| JPWO2019191701A5 JPWO2019191701A5 (https=) | 2022-02-21 |
| JP2021519791A5 true JP2021519791A5 (https=) | 2022-02-21 |
| JP7378417B2 JP7378417B2 (ja) | 2023-11-13 |
Family
ID=66440120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020553490A Active JP7378417B2 (ja) | 2018-03-30 | 2019-03-29 | 増強されたヒト膵臓トロピズムを有する新規な組換えアデノ随伴ウイルスキャプシド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11608510B2 (https=) |
| EP (1) | EP3774853A1 (https=) |
| JP (1) | JP7378417B2 (https=) |
| CN (1) | CN112004820B (https=) |
| WO (1) | WO2019191701A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11608510B2 (en) * | 2018-03-30 | 2023-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
| WO2020068990A1 (en) | 2018-09-26 | 2020-04-02 | California Institute Of Technology | Adeno-associated virus compositions for targeted gene therapy |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| TW202142554A (zh) * | 2020-02-25 | 2021-11-16 | 澳洲兒童醫學研究所 | 腺相關病毒蛋白殼多肽及載體 |
| JP2023518415A (ja) * | 2020-03-19 | 2023-05-01 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 組換えａａｖにおいてｃａｐおよびｒｅｐ配列の逆パッケージングを低減するための組成物および方法 |
| CN117377500A (zh) * | 2021-04-26 | 2024-01-09 | 阿雷克森国际制药有限公司 | 具有改善的组织向性的腺相关病毒载体衣壳 |
| TW202309066A (zh) * | 2021-04-27 | 2023-03-01 | 賓州大學委員會 | 衍生自豬的腺相關病毒衣殼及其用途 |
| CA3219847A1 (en) * | 2021-06-02 | 2022-12-08 | Sander Jan Hendrik Van Deventer | Adeno-associated virus vectors modified to bind high-density lipoprotein |
| CA3222911A1 (en) * | 2021-06-18 | 2022-12-22 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| JP2024527496A (ja) * | 2021-06-18 | 2024-07-25 | ダイノ セラピューティクス インコーポレイテッド | カプシドバリアント及びそれを使用する方法 |
| WO2023034990A1 (en) * | 2021-09-03 | 2023-03-09 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| WO2023034980A1 (en) * | 2021-09-03 | 2023-03-09 | Bomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| US20240376496A1 (en) * | 2021-09-03 | 2024-11-14 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| US20240384242A1 (en) * | 2021-09-03 | 2024-11-21 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| WO2023034994A1 (en) * | 2021-09-03 | 2023-03-09 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| MX2024004217A (es) | 2021-10-08 | 2024-06-26 | Dyno Therapeutics Inc | Variantes de cápside y métodos de uso de estas. |
| CN114107231B (zh) * | 2021-12-13 | 2023-08-18 | 重庆大学 | 实现全脑突触后神经元胞体标记的重组腺相关病毒及其应用 |
| WO2023114835A1 (en) * | 2021-12-15 | 2023-06-22 | Fractyl Health, Inc. | Gene therapies for metabolic disorders |
| CN116686050B (zh) * | 2021-12-30 | 2026-01-23 | 京东方科技集团股份有限公司 | 预测大分子间相互作用的负样本集的生成方法、预测大分子间相互作用的方法、模型的训练方法 |
| CN114561337B (zh) * | 2022-03-09 | 2023-10-03 | 广州源井生物科技有限公司 | 一种提高HepG2细胞克隆形成率的单克隆增强培养基和方法 |
| GB202304767D0 (en) * | 2023-03-30 | 2023-05-17 | Ucl Business Ltd | Synthetic AAV Capsid |
| AU2024262827A1 (en) * | 2023-04-27 | 2025-10-16 | Oregon Health & Science University | Kidney-targeting aav capsids and methods of use thereof |
| WO2024233135A1 (en) * | 2023-05-05 | 2024-11-14 | The Regents Of The University Of California | Long-read sequencing of diverse dna libraries through barcode-labeled short reads |
| WO2025019295A2 (en) * | 2023-07-17 | 2025-01-23 | Oregon Health & Science University | Renal pelvic injection for drug delivery to the kidney |
| GB202407863D0 (en) | 2024-06-03 | 2024-07-17 | Purespring Therapeutics Ltd | Methods |
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| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| AU722624B2 (en) | 1996-09-06 | 2000-08-10 | Trustees Of The University Of Pennsylvania, The | An inducible method for production of recombinant adeno-associated viruses utilizing T7 polymerase |
| CA2265460A1 (en) | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Aav4 vector and uses thereof |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| WO2003042361A2 (en) | 2001-11-09 | 2003-05-22 | Government Of The United States Of America, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| DK2359869T3 (en) | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| SI3235827T1 (sl) * | 2003-06-19 | 2021-05-31 | Genzyme Corporation | AAV virioni z zmanjšano imunoreaktivnostjo in uporaba za ta namen |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US8106180B2 (en) | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| US20050266552A1 (en) | 2003-12-05 | 2005-12-01 | Doench John G | Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi |
| KR100614827B1 (ko) | 2004-05-06 | 2006-08-25 | 재단법인서울대학교산학협력재단 | 양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체 |
| ES2385679T3 (es) | 2006-08-24 | 2012-07-30 | Virovek, Inc. | Expresión de células de insecto de genes con marcos de lectura abiertos superpuestos, métodos y composiciones de éstos |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| ES2857773T5 (es) * | 2011-08-24 | 2024-06-04 | Univ Leland Stanford Junior | Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos |
| WO2013170078A1 (en) | 2012-05-09 | 2013-11-14 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| US11136557B2 (en) * | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| KR20240090694A (ko) | 2013-07-22 | 2024-06-21 | 더 칠드런스 호스피탈 오브 필라델피아 | 변종 ａａｖ 및 조성물, 세포, 기관 및 조직으로의 유전자 전이를 위한 방법 및 용도 |
| US10711270B2 (en) | 2014-10-03 | 2020-07-14 | University Of Massachusetts | High efficiency library-identified AAV vectors |
| AU2015335923B2 (en) | 2014-10-21 | 2021-04-29 | University Of Massachusetts | Recombinant AAV variants and uses thereof |
| GB201508026D0 (en) * | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| US10179176B2 (en) | 2016-02-16 | 2019-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies |
| US11608510B2 (en) * | 2018-03-30 | 2023-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
-
2019
- 2019-03-29 US US16/370,735 patent/US11608510B2/en active Active
- 2019-03-29 JP JP2020553490A patent/JP7378417B2/ja active Active
- 2019-03-29 CN CN201980024467.0A patent/CN112004820B/zh active Active
- 2019-03-29 EP EP19722733.3A patent/EP3774853A1/en active Pending
- 2019-03-29 WO PCT/US2019/025026 patent/WO2019191701A1/en not_active Ceased
-
2022
- 2022-12-06 US US18/062,333 patent/US12467065B2/en active Active
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