CN112004820B - 具有增强的人胰腺向性的新型重组腺相关病毒衣壳 - Google Patents

具有增强的人胰腺向性的新型重组腺相关病毒衣壳 Download PDF

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CN112004820B
CN112004820B CN201980024467.0A CN201980024467A CN112004820B CN 112004820 B CN112004820 B CN 112004820B CN 201980024467 A CN201980024467 A CN 201980024467A CN 112004820 B CN112004820 B CN 112004820B
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aav
variant
capsid polypeptide
aav capsid
human
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CN112004820A (zh
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卡特娅·佩克伦
马克·A·凯
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Leland Stanford Junior University
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CN201980024467.0A 2018-03-30 2019-03-29 具有增强的人胰腺向性的新型重组腺相关病毒衣壳 Active CN112004820B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862651010P 2018-03-30 2018-03-30
US62/651,010 2018-03-30
US201862745226P 2018-10-12 2018-10-12
US62/745,226 2018-10-12
PCT/US2019/025026 WO2019191701A1 (en) 2018-03-30 2019-03-29 Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism

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CN112004820A CN112004820A (zh) 2020-11-27
CN112004820B true CN112004820B (zh) 2023-09-12

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US (2) US11608510B2 (https=)
EP (1) EP3774853A1 (https=)
JP (1) JP7378417B2 (https=)
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WO (1) WO2019191701A1 (https=)

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JP2024533174A (ja) * 2021-09-03 2024-09-12 ビオマリン プハルマセウトイカル インコーポレイテッド Ａａｖカプシド組成物及び送達方法
JP2024534888A (ja) * 2021-09-03 2024-09-26 ビオマリン プハルマセウトイカル インコーポレイテッド Ａａｖカプシド組成物及び送達方法
KR20240095539A (ko) 2021-10-08 2024-06-25 디노 테라퓨틱스, 인코포레이티드 캡시드 변이체 및 이의 사용 방법
CN114107231B (zh) * 2021-12-13 2023-08-18 重庆大学 实现全脑突触后神经元胞体标记的重组腺相关病毒及其应用
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CN116686050B (zh) * 2021-12-30 2026-01-23 京东方科技集团股份有限公司 预测大分子间相互作用的负样本集的生成方法、预测大分子间相互作用的方法、模型的训练方法
CN114561337B (zh) * 2022-03-09 2023-10-03 广州源井生物科技有限公司 一种提高HepG2细胞克隆形成率的单克隆增强培养基和方法
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CN121013858A (zh) * 2023-04-27 2025-11-25 俄勒冈健康与科学大学 靶向肾脏的aav衣壳及其使用方法
WO2024233135A1 (en) * 2023-05-05 2024-11-14 The Regents Of The University Of California Long-read sequencing of diverse dna libraries through barcode-labeled short reads
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