JP2021519764A - 線維性疾患を処置する方法 - Google Patents
線維性疾患を処置する方法 Download PDFInfo
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- JP2021519764A JP2021519764A JP2020552324A JP2020552324A JP2021519764A JP 2021519764 A JP2021519764 A JP 2021519764A JP 2020552324 A JP2020552324 A JP 2020552324A JP 2020552324 A JP2020552324 A JP 2020552324A JP 2021519764 A JP2021519764 A JP 2021519764A
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- 0 ****CCCCCCC(*)C(NC(Cc1ccccc1)C(C(N(*)*)=O)=O)=O Chemical compound ****CCCCCCC(*)C(NC(Cc1ccccc1)C(C(N(*)*)=O)=O)=O 0.000 description 1
- MHAFQYODVBXPDA-UHFFFAOYSA-N CCOC(c1c(-c(cccc2)c2[I]=C(C(OC2(CCCC2)O2)=O)C2=O)nc(C)[o]1)=O Chemical compound CCOC(c1c(-c(cccc2)c2[I]=C(C(OC2(CCCC2)O2)=O)C2=O)nc(C)[o]1)=O MHAFQYODVBXPDA-UHFFFAOYSA-N 0.000 description 1
- VCPWVQRSQMLJIE-UHFFFAOYSA-N C[n](cc1C(NC(Cc2ccccc2)C(C(O)=O)=O)=O)nc1-c1cc(F)ccc1 Chemical compound C[n](cc1C(NC(Cc2ccccc2)C(C(O)=O)=O)=O)nc1-c1cc(F)ccc1 VCPWVQRSQMLJIE-UHFFFAOYSA-N 0.000 description 1
- YOQIXNLFKXVOBW-UHFFFAOYSA-N OC(C(C(Cc1ccccc1)NC(c1n[s]nc1-c1ccccc1)=O)=O)=O Chemical compound OC(C(C(Cc1ccccc1)NC(c1n[s]nc1-c1ccccc1)=O)=O)=O YOQIXNLFKXVOBW-UHFFFAOYSA-N 0.000 description 1
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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| JP2021519312A (ja) * | 2018-03-28 | 2021-08-10 | ブレード・セラピューティクス・インコーポレイテッド | カルパインモジュレーター及びその治療的使用 |
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| EP3481835A4 (en) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF |
| BR112019006110A2 (pt) | 2016-09-28 | 2019-09-10 | Blade Therapeutics Inc | moduladores de calpaína e usos terapêuticos dos mesmos |
| WO2020006294A1 (en) * | 2018-06-28 | 2020-01-02 | Blade Therapeutics, Inc. | Methods of treating liver fibrosis using calpain inhibitors |
| PH12022553378A1 (en) | 2020-06-10 | 2024-03-25 | Univ Leuven Kath | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| JP2024525589A (ja) | 2021-07-09 | 2024-07-12 | アリゴス セラピューティクス インコーポレイテッド | 抗ウイルス化合物 |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
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| JPH08509735A (ja) * | 1993-04-30 | 1996-10-15 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害剤 |
| WO1998028326A1 (en) * | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
| JP2001524117A (ja) * | 1997-05-02 | 2001-11-27 | アクゾ・ノベル・エヌ・ベー | セリンプロテアーゼ阻害剤 |
| JP2016502540A (ja) * | 2012-11-30 | 2016-01-28 | ノボメディックス, エルエルシーNovomedix, Llc | 置換ビアリールスルホンアミドおよびその利用 |
| JP2016539087A (ja) * | 2013-10-08 | 2016-12-15 | プロメディオール, インコーポレイテッド | 線維性癌の治療方法 |
| JP2021519312A (ja) * | 2018-03-28 | 2021-08-10 | ブレード・セラピューティクス・インコーポレイテッド | カルパインモジュレーター及びその治療的使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH09500087A (ja) * | 1992-06-24 | 1997-01-07 | コーテックス ファーマシューティカルズ インコーポレイテッド | カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法 |
| DE19817459A1 (de) * | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
| US20100094755A1 (en) * | 2008-10-09 | 2010-04-15 | Nelnet Business Solutions, Inc. | Providing payment data tokens for online transactions utilizing hosted inline frames |
| TWI519530B (zh) * | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶(calpain)抑制劑之用途 |
| WO2012076639A1 (en) * | 2010-12-09 | 2012-06-14 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors v |
| JP2015512427A (ja) * | 2012-04-03 | 2015-04-27 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | カルボキサミド化合物およびそれのカルパイン阻害薬vとしての使用 |
| BR112019006110A2 (pt) * | 2016-09-28 | 2019-09-10 | Blade Therapeutics Inc | moduladores de calpaína e usos terapêuticos dos mesmos |
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2019
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- 2019-03-25 WO PCT/US2019/023917 patent/WO2019190999A1/en not_active Ceased
- 2019-03-25 US US17/041,611 patent/US20210113560A1/en not_active Abandoned
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- 2020-09-22 IL IL277500A patent/IL277500A/en unknown
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08509735A (ja) * | 1993-04-30 | 1996-10-15 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害剤 |
| WO1998028326A1 (en) * | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
| JP2001524117A (ja) * | 1997-05-02 | 2001-11-27 | アクゾ・ノベル・エヌ・ベー | セリンプロテアーゼ阻害剤 |
| JP2016502540A (ja) * | 2012-11-30 | 2016-01-28 | ノボメディックス, エルエルシーNovomedix, Llc | 置換ビアリールスルホンアミドおよびその利用 |
| JP2016539087A (ja) * | 2013-10-08 | 2016-12-15 | プロメディオール, インコーポレイテッド | 線維性癌の治療方法 |
| JP2021519312A (ja) * | 2018-03-28 | 2021-08-10 | ブレード・セラピューティクス・インコーポレイテッド | カルパインモジュレーター及びその治療的使用 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2021519312A (ja) * | 2018-03-28 | 2021-08-10 | ブレード・セラピューティクス・インコーポレイテッド | カルパインモジュレーター及びその治療的使用 |
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| IL277500A (en) | 2020-11-30 |
| RU2020130012A (ru) | 2022-04-29 |
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| KR20200139721A (ko) | 2020-12-14 |
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| CN112166111A (zh) | 2021-01-01 |
| EP3774785A1 (en) | 2021-02-17 |
| SG11202008773PA (en) | 2020-10-29 |
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