MX2020010034A - Metodo de tratamiento de enfermedad fibrotica. - Google Patents

Metodo de tratamiento de enfermedad fibrotica.

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Publication number
MX2020010034A
MX2020010034A MX2020010034A MX2020010034A MX2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A
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MX
Mexico
Prior art keywords
treating fibrotic
methods
fibrotic disease
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Prior art date
Application number
MX2020010034A
Other languages
English (en)
Inventor
Brad Owen Buckman
Prabha Ibrahim
P T Ravi Rajagopalan
Original Assignee
Blade Therapeutics Inc
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Publication date
Application filed by Blade Therapeutics Inc filed Critical Blade Therapeutics Inc
Publication of MX2020010034A publication Critical patent/MX2020010034A/es

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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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Abstract

En la presente se describen métodos para tratar trastornos fibróticos por la administración de compuestos selectivos para CAPN1, CAPN2, y/o CAPN9 tal que se reduzcan al mínimo los efectos secundarios, interacciones fuera de ruta, y/o toxicidades. Estos métodos pueden, por ejemplo, reducir al mínimo los efectos no deseados de compuestos terapéuticos al proporcionar dosificación y formas de dosificación que reducen al mínimo el nivel de fármaco no unido dentro de los tejidos pertinentes de un paciente que se somete a tratamiento.
MX2020010034A 2018-03-28 2019-03-25 Metodo de tratamiento de enfermedad fibrotica. MX2020010034A (es)

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MX2020010033A (es) * 2018-03-28 2020-10-14 Blade Therapeutics Inc Moduladores calpaina y usos terapeuticos de los mismos.
AU2019295763A1 (en) * 2018-06-28 2021-01-21 Blade Therapeutics, Inc. Methods of treating liver fibrosis using calpain inhibitors
KR20230038457A (ko) 2020-06-10 2023-03-20 알리고스 테라퓨틱스 인코포레이티드 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds
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TWI519530B (zh) * 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
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