CA3093749A1 - Method of treating fibrotic disease - Google Patents

Method of treating fibrotic disease Download PDF

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Publication number
CA3093749A1
CA3093749A1 CA3093749A CA3093749A CA3093749A1 CA 3093749 A1 CA3093749 A1 CA 3093749A1 CA 3093749 A CA3093749 A CA 3093749A CA 3093749 A CA3093749 A CA 3093749A CA 3093749 A1 CA3093749 A1 CA 3093749A1
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Canada
Prior art keywords
optionally substituted
compound
nhc
days
aryl
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CA3093749A
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English (en)
French (fr)
Inventor
Brad Owen BUCKMAN
Prabha Ibrahim
P.T. Ravi Rajagopalan
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Blade Therapeutics Inc
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Blade Therapeutics Inc
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Publication of CA3093749A1 publication Critical patent/CA3093749A1/en
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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CA3095164A1 (en) * 2018-03-28 2019-10-03 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2020006294A1 (en) * 2018-06-28 2020-01-02 Blade Therapeutics, Inc. Methods of treating liver fibrosis using calpain inhibitors
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