|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
US4870009A
(en)
|
1982-11-22 |
1989-09-26 |
The Salk Institute For Biological Studies |
Method of obtaining gene product through the generation of transgenic animals
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
US4736866B1
(en)
|
1984-06-22 |
1988-04-12 |
|
Transgenic non-human mammals
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
DE122007000007I2
(de)
|
1986-04-09 |
2010-12-30 |
Genzyme Corp |
Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
JP2972257B2
(ja)
|
1990-01-24 |
1999-11-08 |
株式会社日立製作所 |
パケット交換機
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
US5116742A
(en)
|
1986-12-03 |
1992-05-26 |
University Patents, Inc. |
RNA ribozyme restriction endoribonucleases and methods
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5013653A
(en)
|
1987-03-20 |
1991-05-07 |
Creative Biomolecules, Inc. |
Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
ATE243754T1
(de)
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5272057A
(en)
|
1988-10-14 |
1993-12-21 |
Georgetown University |
Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
FR2646438B1
(fr)
|
1989-03-20 |
2007-11-02 |
Pasteur Institut |
Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5459039A
(en)
|
1989-05-12 |
1995-10-17 |
Duke University |
Methods for mapping genetic mutations
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5272071A
(en)
|
1989-12-22 |
1993-12-21 |
Applied Research Systems Ars Holding N.V. |
Method for the modification of the expression characteristics of an endogenous gene of a given cell line
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
AU7247191A
(en)
|
1990-01-11 |
1991-08-05 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
MA22668A1
(fr)
|
1990-07-10 |
1993-07-01 |
Smithkline Beecham Corp |
Procede de preparation d'oxamides .
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
CA2092323A1
(en)
|
1990-10-01 |
1992-04-02 |
George Y. Wu |
Targeting viruses and cells for selective internalization by cells
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
CA2103064A1
(en)
|
1991-05-14 |
1992-11-15 |
George Y. Wu |
Targeted delivery of genes encoding immunogenic proteins
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
DK0587738T3
(da)
|
1991-06-05 |
2000-12-18 |
Univ Connecticut |
Destineret levering af gener, som koder for sekretionsproteiner
|
|
WO1992022324A1
(en)
|
1991-06-14 |
1992-12-23 |
Xoma Corporation |
Microbially-produced antibody fragments and their conjugates
|
|
WO1993004169A1
(en)
|
1991-08-20 |
1993-03-04 |
Genpharm International, Inc. |
Gene targeting in animal cells using isogenic dna constructs
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
AU3434393A
(en)
|
1992-01-17 |
1993-08-03 |
Regents Of The University Of Michigan, The |
Targeted virus
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
EP0633943A4
(en)
|
1992-04-03 |
1997-05-02 |
Alexander T Young |
GENTHERAPY USING TARGETED VIRAL VECTORS.
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
FR2694851B1
(fr)
|
1992-08-12 |
1994-12-23 |
Sgs Thomson Microelectronics |
Circuit de tirage vers un état déterminé d'une entrée de circuit intégré.
|
|
CA2141602A1
(en)
|
1992-08-26 |
1994-03-03 |
Philip Leder |
Use of the cytokine ip-10 as an anti-tumor agent
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
ES2157225T3
(es)
|
1992-10-09 |
2001-08-16 |
Advanced Tissue Sciences Inc |
Celulas hepaticas de reserva.
|
|
WO1994010300A1
(en)
|
1992-10-30 |
1994-05-11 |
The General Hospital Corporation |
Interaction trap system for isolating novel proteins
|
|
EP1024198A3
(en)
|
1992-12-03 |
2002-05-29 |
Genzyme Corporation |
Pseudo-adenoviral vectors for the gene therapy of haemophiliae
|
|
DE69433811T2
(de)
|
1993-01-07 |
2005-06-23 |
Sequenom, Inc., San Diego |
Dns - sequenzierung durch massenspektronomie
|
|
US5424286A
(en)
|
1993-05-24 |
1995-06-13 |
Eng; John |
Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
US5498531A
(en)
|
1993-09-10 |
1996-03-12 |
President And Fellows Of Harvard College |
Intron-mediated recombinant techniques and reagents
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
EP0702553A1
(en)
|
1993-12-27 |
1996-03-27 |
BAXTER INTERNATIONAL INC. (a Delaware corporation) |
Water soluble non-immunogenic polyamide cross-linking agents
|
|
DE69534347T2
(de)
|
1994-01-31 |
2006-05-24 |
Trustees Of Boston University, Boston |
Bibliotheken aus Polyklonalen Antikörpern
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
GB9517780D0
(en)
|
1995-08-31 |
1995-11-01 |
Roslin Inst Edinburgh |
Biological manipulation
|
|
GB9517779D0
(en)
|
1995-08-31 |
1995-11-01 |
Roslin Inst Edinburgh |
Biological manipulation
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
IL128332A0
(en)
|
1996-08-30 |
2000-01-31 |
Novo Nordisk As |
GLP-1 derivatives
|
|
US6034217A
(en)
|
1996-09-17 |
2000-03-07 |
Wako Pure Chemical Industries, Ltd. |
Peptidoglycan recognition proteins and their production
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
WO1998039446A2
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
70 human secreted proteins
|
|
US6878687B1
(en)
|
1997-03-07 |
2005-04-12 |
Human Genome Sciences, Inc. |
Protein HMAAD57
|
|
US20030049618A1
(en)
|
1997-03-07 |
2003-03-13 |
Ruben Steven M. |
186 human secreted proteins
|
|
WO1998039448A2
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
186 human secreted proteins
|
|
US20030175858A1
(en)
|
1997-03-07 |
2003-09-18 |
Ruben Steven M. |
186 human secreted proteins
|
|
US6420526B1
(en)
|
1997-03-07 |
2002-07-16 |
Human Genome Sciences, Inc. |
186 human secreted proteins
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
EP0979102A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6172211B1
(en)
|
1997-07-11 |
2001-01-09 |
Boehringer Ingelheim International Gmbh |
Nucleic acid encoding tag7 polypeptide
|
|
EP1022286A4
(en)
|
1997-10-07 |
2003-04-09 |
Ono Pharmaceutical Co |
POLYPEPTIDES, FOR ENDING CODNA AND THEIR USE
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
WO2000000610A2
(en)
|
1998-06-26 |
2000-01-06 |
Incyte Pharmaceuticals, Inc. |
Human signal peptide-containing proteins
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US20030211510A1
(en)
|
1999-06-30 |
2003-11-13 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US20020197669A1
(en)
|
2000-12-13 |
2002-12-26 |
Bangur Chaitanya S. |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US6504010B1
(en)
|
1999-06-30 |
2003-01-07 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US20030170255A1
(en)
|
1999-06-30 |
2003-09-11 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US20020172952A1
(en)
|
1999-06-30 |
2002-11-21 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US6509448B2
(en)
|
1999-06-30 |
2003-01-21 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
US6858204B2
(en)
|
1999-06-30 |
2005-02-22 |
Corxia Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
EP1074563A1
(en)
|
1999-08-02 |
2001-02-07 |
F. Hoffmann-La Roche Ag |
Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
|
|
CA2402563A1
(en)
|
1999-12-23 |
2001-07-26 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
AU2001274888A1
(en)
|
2000-05-19 |
2001-12-03 |
Human Genome Sciences, Inc. |
Nucleic acids, proteins, and antibodies
|
|
US6725230B2
(en)
|
2000-07-18 |
2004-04-20 |
Aegis Analytical Corporation |
System, method and computer program for assembling process data of multi-database origins using a hierarchical display
|
|
US20030134283A1
(en)
|
2000-10-03 |
2003-07-17 |
Peterson David P. |
Genes regulated in dendritic cell differentiation
|
|
EP1351702B1
(en)
|
2000-12-08 |
2015-03-04 |
Bioprovar Corporation |
Trem-1 splice variant for use in modifying immune responses
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2342376C
(en)
|
2001-03-20 |
2013-11-12 |
Marco Colonna |
A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8231878B2
(en)
|
2001-03-20 |
2012-07-31 |
Cosmo Research & Development S.P.A. |
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US6989452B2
(en)
|
2001-05-31 |
2006-01-24 |
Medarex, Inc. |
Disulfide prodrugs and linkers and stabilizers useful therefor
|
|
AU2002359236A1
(en)
|
2001-07-13 |
2003-04-14 |
Advanced Research And Technology Institute |
Peptidoglycan recognition protein encoding nucleic acids and methods of use thereof
|
|
AU2002330039A1
(en)
|
2001-09-17 |
2003-04-01 |
Eos Biotechnology, Inc. |
Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
|
|
CA2462883A1
(en)
|
2001-10-12 |
2003-04-17 |
Schering Corporation |
Use of bispecific antibodies to regulate immune responses
|
|
AU2002364586A1
(en)
|
2001-12-21 |
2003-07-30 |
Delta Biotechnology Limited |
Albumin fusion proteins
|
|
EP1329227A1
(en)
|
2002-01-22 |
2003-07-23 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Diagnostic conjugate useful for intercellular imaging and for differentiating between tumor- and non-tumor cells
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US8658773B2
(en)
*
|
2011-05-02 |
2014-02-25 |
Immunomedics, Inc. |
Ultrafiltration concentration of allotype selected antibodies for small-volume administration
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
EP1530590A2
(en)
|
2002-03-22 |
2005-05-18 |
Bioxell S.p.a. |
Triggering receptors expressed on myeloid cells (trem)-4 and -5 and uses thereof
|
|
DK1534335T4
(en)
|
2002-08-14 |
2015-10-05 |
Macrogenics Inc |
FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF
|
|
WO2004020591A2
(en)
|
2002-08-29 |
2004-03-11 |
Five Prime Therapeutics, Inc. |
Methods of use for novel human polypeptides encoded by polynucleotides
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
DK1562972T3
(da)
|
2002-10-15 |
2010-12-06 |
Facet Biotech Corp |
Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese
|
|
CA2512729C
(en)
|
2003-01-09 |
2014-09-16 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
|
GB0305478D0
(en)
|
2003-03-10 |
2003-04-16 |
Bioxell Spa |
Diagnostic and prognostic compounds and method
|
|
US20050255114A1
(en)
|
2003-04-07 |
2005-11-17 |
Nuvelo, Inc. |
Methods and diagnosis for the treatment of preeclampsia
|
|
DE10316701A1
(de)
|
2003-04-09 |
2004-11-04 |
Hinzmann, Bernd, Dr. |
Humane Nukleinsäuresequenzen aus Bronchialkarzinomen
|
|
US20060019256A1
(en)
|
2003-06-09 |
2006-01-26 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
WO2005040219A1
(en)
|
2003-10-28 |
2005-05-06 |
Novo Nordisk A/S |
Laminin-5 gamma2-binding peptides, related compositions, and use thereof
|
|
US20070083333A1
(en)
|
2003-11-17 |
2007-04-12 |
Vitiello Maria A |
Modeling of systemic inflammatory response to infection
|
|
SI1706424T1
(sl)
|
2004-01-12 |
2010-01-29 |
Applied Molecular Evolution |
Variante fc regij
|
|
GB0401730D0
(en)
|
2004-01-27 |
2004-03-03 |
Bioxell Spa |
Diagnosis method
|
|
JP2007531715A
(ja)
|
2004-03-17 |
2007-11-08 |
イーライ リリー アンド カンパニー |
グリコール結合ｆｇｆ−２１化合物
|
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
|
EP2194064A1
(en)
|
2004-05-13 |
2010-06-09 |
Eli Lilly & Company |
FGF-21 fusion proteins
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
JP4806680B2
(ja)
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
AU2005274905B2
(en)
|
2004-08-04 |
2010-12-23 |
Mentrik Biotech, Llc |
Variant Fc regions
|
|
US7622445B2
(en)
|
2004-09-02 |
2009-11-24 |
Eli Lilly And Company |
Muteins of fibroblast growth factor 21
|
|
KR100854198B1
(ko)
|
2004-09-02 |
2008-08-26 |
일라이 릴리 앤드 캄파니 |
섬유아세포 성장 인자 21의 뮤테인
|
|
GB0426146D0
(en)
|
2004-11-29 |
2004-12-29 |
Bioxell Spa |
Therapeutic peptides and method
|
|
US7655627B2
(en)
|
2004-12-14 |
2010-02-02 |
Eli Lilly And Company |
Muteins of fibroblast growth factor 21
|
|
EP1846019A2
(en)
|
2005-01-21 |
2007-10-24 |
Eli Lilly And Company |
Method for treating cardiovascular disease
|
|
TWI362392B
(en)
|
2005-03-18 |
2012-04-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
AU2006259583A1
(en)
|
2005-06-13 |
2006-12-28 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
US20070099209A1
(en)
|
2005-06-13 |
2007-05-03 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
EP2354163A3
(en)
|
2005-09-26 |
2013-04-24 |
Medarex, Inc. |
Conjugates of duocarmycin and anti-CD70 or anti-PSMA antibodies
|
|
RS52100B
(sr)
|
2005-10-26 |
2012-06-30 |
Medarex, Inc. |
Postupci i jedinjenja za pripremu analoga cc-1065
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
NZ573646A
(en)
|
2006-06-12 |
2012-04-27 |
Wyeth Llc |
Single-chain multivalent binding proteins with effector function
|
|
CA3058450A1
(en)
|
2006-10-19 |
2008-04-24 |
Baylor College Of Medicine |
Generating an immune response by inducing cd40 and pattern recognition receptors
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
EP2121750A2
(en)
|
2007-01-16 |
2009-11-25 |
Wyeth |
Inflammation treatment, detection and monitoring via trem-1
|
|
AR065404A1
(es)
|
2007-02-21 |
2009-06-03 |
Medarex Inc |
Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
|
|
CN107501407B
(zh)
|
2007-03-30 |
2022-03-18 |
Ambrx公司 |
经修饰fgf-21多肽和其用途
|
|
KR20100058509A
(ko)
|
2007-07-31 |
2010-06-03 |
메디뮨 엘엘씨 |
다중특이적 에피토프 결합 단백질 및 이의 용도
|
|
US20110034373A1
(en)
|
2007-08-03 |
2011-02-10 |
Eli Lilly And Company |
Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity
|
|
JP2010536341A
(ja)
|
2007-08-15 |
2010-12-02 |
アムニクス， インコーポレイテッド |
生物学的に活性なポリペプチドの特性を改変するための組成物および方法
|
|
WO2009030771A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
JP2011503000A
(ja)
|
2007-11-02 |
2011-01-27 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用
|
|
US7914734B2
(en)
|
2007-12-19 |
2011-03-29 |
Singulex, Inc. |
Scanning analyzer for single molecule detection and methods of use
|
|
CA2716522A1
(en)
|
2008-03-05 |
2009-10-15 |
Singulex, Inc. |
Methods and compositions for highly sensitive detection of molecules
|
|
ES2506116T3
(es)
|
2008-05-23 |
2014-10-13 |
Biocartis Nv |
Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo
|
|
CN102149825B
(zh)
|
2008-07-08 |
2015-07-22 |
Abbvie公司 |
前列腺素e2双重可变结构域免疫球蛋白及其用途
|
|
ES2445892T3
(es)
|
2008-08-25 |
2014-03-05 |
Janssen Biotech, Inc. |
Biomarcadores para el tratamiento anti-TNF en colitis ulcerosa y trastornos relacionados
|
|
CA2739615C
(en)
|
2008-10-10 |
2017-12-05 |
Amgen Inc. |
Fgf21 mutants comprising polyethylene glycol and uses thereof
|
|
WO2010065439A1
(en)
|
2008-12-05 |
2010-06-10 |
Eli Lilly And Company |
Variants of fibroblast growth factor 21
|
|
CN102361647B
(zh)
|
2009-01-23 |
2018-02-16 |
诺沃-诺迪斯克有限公司 |
具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用
|
|
WO2010132370A2
(en)
|
2009-05-11 |
2010-11-18 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Soluble tlt-1 for the treatment and diagnosis of sepsis
|
|
WO2010141469A2
(en)
|
2009-06-01 |
2010-12-09 |
Case Western Reserve University |
Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseases
|
|
JP2012529463A
(ja)
|
2009-06-11 |
2012-11-22 |
ノヴォ ノルディスク アー／エス |
２型糖尿病を治療するための、ｇｌｐ−１とｆｇｆ２１との組合せ
|
|
EP2711018A1
(en)
|
2009-06-22 |
2014-03-26 |
MedImmune, LLC |
Engineered Fc regions for site-specific conjugation
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
WO2011047097A2
(en)
|
2009-10-13 |
2011-04-21 |
Sigalov Alexander B |
Inhibition of trem receptor signaling with peptide variants
|
|
KR101251023B1
(ko)
|
2009-11-05 |
2013-04-03 |
주식회사유한양행 |
신규한 단일클론항체를 포함하는 박테리아 감염 검출용 키트
|
|
CN102770456B
(zh)
|
2009-12-04 |
2018-04-06 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
WO2011091078A2
(en)
|
2010-01-19 |
2011-07-28 |
Xencor, Inc. |
Antibody fc variants with enhanced complement activity
|
|
BR112012027917A2
(pt)
|
2010-04-30 |
2017-11-28 |
Alexion Pharma Inc |
anticorpos que apresentam reduzida imunogenicidade em um indivíduo humano
|
|
WO2012064733A2
(en)
|
2010-11-09 |
2012-05-18 |
Medimmune, Llc |
Antibody scaffold for homogenous conjugation
|
|
UY33826A
(es)
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión con dominios trivariables y sus usos
|
|
US20120201746A1
(en)
|
2010-12-22 |
2012-08-09 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
EP2673297A2
(en)
|
2011-02-11 |
2013-12-18 |
Zyngenia, Inc. |
Monovalent and multivalent multispecific complexes and uses thereof
|
|
LT3485903T
(lt)
|
2011-09-23 |
2023-02-27 |
Mereo Biopharma 5, Inc. |
Vegf/ dll4 surišantys agentai ir jų panaudojimas
|
|
US9550830B2
(en)
|
2012-02-15 |
2017-01-24 |
Novo Nordisk A/S |
Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
|
|
JP6411218B2
(ja)
|
2012-02-15 |
2018-10-24 |
ノヴォ ノルディスク アー／エス |
骨髄細胞で発現されるトリガー受容体１（ｔｒｅｍ−１）に結合し、それを遮断する抗体
|
|
SG11201408538PA
(en)
|
2012-07-13 |
2015-02-27 |
Roche Glycart Ag |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
CA2890483A1
(en)
|
2012-11-09 |
2014-05-15 |
Robert ARCH |
Platelet-derived growth factor b specific antibodies and compositions and uses thereof
|
|
GB201317622D0
(en)
|
2013-10-04 |
2013-11-20 |
Star Biotechnology Ltd F |
Cancer biomarkers and uses thereof
|
|
CN109535254B
(zh)
|
2013-12-24 |
2022-06-24 |
安斯泰来制药株式会社 |
抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物
|
|
EP3699195A3
(en)
*
|
2014-03-28 |
2020-11-04 |
Xencor, Inc. |
Bispecific antibodies that bind to cd38 and cd3
|
|
PE20170441A1
(es)
|
2014-06-06 |
2017-04-26 |
Bristol Myers Squibb Co |
Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos
|
|
EP2966085A1
(en)
|
2014-07-11 |
2016-01-13 |
Boehringer Ingelheim International GmbH |
Antibody IgG1 with a modified heavy chain constant region
|
|
EA037844B1
(ru)
*
|
2014-07-17 |
2021-05-27 |
Ново Нордиск А/С |
Сайт-направленный мутагенез антител к trem-1
|
|
EP2975056A1
(en)
|
2014-07-17 |
2016-01-20 |
Novo Nordisk A/S |
Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity
|
|
AU2015349878A1
(en)
*
|
2014-11-21 |
2017-05-25 |
Bristol-Myers Squibb Company |
Antibodies against CD73 and uses thereof
|
|
JP6180663B2
(ja)
|
2014-12-23 |
2017-08-16 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
Ｔｉｇｉｔに対する抗体
|
|
AU2016356780A1
(en)
|
2015-11-19 |
2018-06-28 |
Bristol-Myers Squibb Company |
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
|
|
WO2017152102A2
(en)
|
2016-03-04 |
2017-09-08 |
Alector Llc |
Anti-trem1 antibodies and methods of use thereof
|
|
CN109757103B
(zh)
|
2016-07-14 |
2024-01-02 |
百时美施贵宝公司 |
针对tim3的抗体及其用途
|
|
US11220550B2
(en)
|
2017-05-25 |
2022-01-11 |
Bristol-Myers Squibb Company |
Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity
|
|
US20200148779A1
(en)
|
2017-05-25 |
2020-05-14 |
Bristol-Myers Squibb Company |
MODIFIED IgG1 Fc DOMAINS AND ANTI-CD40 DOMAIN ANTIBODY FUSIONS THEREWITH
|
|
US20200299400A1
(en)
|
2017-05-25 |
2020-09-24 |
Bristol-Myers Squibb Company |
Antibodies comprising modified heavy constant regions
|
|
WO2019195126A1
(en)
|
2018-04-02 |
2019-10-10 |
Bristol-Myers Squibb Company |
Anti-trem-1 antibodies and uses thereof
|