JP2021517557A - アオキ抽出物を含む眼球乾燥症の予防または治療用組成物 - Google Patents
アオキ抽出物を含む眼球乾燥症の予防または治療用組成物 Download PDFInfo
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- JP2021517557A JP2021517557A JP2020542144A JP2020542144A JP2021517557A JP 2021517557 A JP2021517557 A JP 2021517557A JP 2020542144 A JP2020542144 A JP 2020542144A JP 2020542144 A JP2020542144 A JP 2020542144A JP 2021517557 A JP2021517557 A JP 2021517557A
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Abstract
Description
アオキ葉と茎は、2017年6月と9月とに大韓民国済州特別自治道西帰浦市上孝洞及びドネコ渓谷一帯2ヶ所と済州市旧左邑松堂里日の出近所1ヶ所とに2次にわたって採集し、証拠標本は、大韓民国の全北大試料保管室に保管中である。
アオキ葉と茎は、2017年6月と9月とに済州特別自治道西帰浦市上孝洞及びドネコ渓谷一帯2ヶ所と済州市旧左邑松堂里日の出近所1ヶ所とに2次にわたって採集し、証拠標本は、大韓民国の全北大試料保管室に保管中である。
HPLC−DAD(high−performance liquid chromatography−diode array detector)(Shimadzu HPLC system,Shimadzu,Kyoto,Japan)分析法でアオキ抽出物に含まれたアウクビンの含量分析を行った。その結果は、下記の表1のようである。
4.1 実験動物及び実験デザイン
6週齢SDラットを(株)オリエントから購入後、1週間順化した。1週間後、深麻酔下で涙腺(exorbital lacrimal gland)を手術的に除去して、眼球乾燥症を誘発した。1週間後、フェノールレッドスレッド(phenol−red thread)涙量検査紙(FCI Opthalmics Zone Quick、Japan)をまぶた外側端部眼球表面に接触させた後、30秒後、涙によって検査紙の色が変わった長さを測定した。これらのうち、非手術群に比べて顕著に涙分比量が減少した個体のみ選別して、薬効試験を進行した。群分離後、薬物は、1日1回ずつ各群に合わせて調剤して、5日間経口投与し、対照薬物としては、眼球乾燥症に使用する健機食素材であるオメガ−3を使用した。実験動物の飼育及び実験動物を利用したあらゆる実験過程は、韓国韓医学研究院動物実験倫理委員会の承認を受け、規定によって実行した。
涙分比量は、フェノールレッドスレッド涙量検査紙(FCI Opthalmics Zone Quick、Japan)をまぶた外側端部眼球表面に接触させた後、30秒後、涙によって検査紙の色が変わった長さを測定して、涙分比量を測定した。角膜の乾燥損傷は、円形イルミネーター(ring type light illuminator)を角膜に照らして反射される形態を撮影した後、円形照明の角膜乾燥損傷によって潰れる程度を評価して分析した。
4.3.1 涙分比量増加効果
前記眼球乾燥症誘導動物モデルにアオキ30%エタノール抽出物をそれぞれ100、250mg/kg/dayの濃度で5日間経口投与した。以後、涙分比量を測定した結果、図1のように涙分比量がアオキ抽出物投与によって有意に増加することを確認した。特に、眼球乾燥症に代表的に使われるオメガ−3(omega−3)と効能を比較した結果、アオキ抽出物を投与する場合、オメガ−3よりも優れた効果を示すことを確認した。
眼球乾燥症の場合、涙の不足によって角膜の乾燥損傷が引き起こされる。したがって、前記動物モデルを用いてアオキ30%エタノール抽出物の角膜乾燥損傷の改善効果を評価した。
Claims (9)
- アオキ抽出物を有効成分として含む眼球乾燥症を予防または治療するための薬学的組成物。
- 前記アオキ抽出物は、エタノール抽出物または熱水抽出物である請求項1に記載の薬学的組成物。
- 前記エタノール抽出物は、20〜40%エタノール(w/w)抽出物である請求項2に記載の薬学的組成物。
- 前記熱水抽出物は、90〜120℃の温度から抽出した請求項2に記載の薬学的組成物。
- 前記組成物は、経口投与される請求項1に記載の薬学的組成物。
- 前記アオキ抽出物は、アオキの葉または茎の抽出物である請求項1に記載の薬学的組成物。
- アオキ抽出物を有効成分として含む眼球乾燥症を予防または改善するための健康機能食品用組成物。
- 前記アオキ抽出物は、エタノール抽出物または熱水抽出物である請求項7に記載の健康機能食品用組成物。
- 前記アオキ抽出物は、アオキの葉または茎の抽出物である請求項7に記載の健康機能食品用組成物。
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PCT/KR2018/012976 WO2019146881A1 (ko) | 2018-01-29 | 2018-10-30 | 식나무 추출물을 포함하는 안구 건조증 예방 또는 치료용 조성물 |
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