JP2021515784A5 - - Google Patents
Info
- Publication number
- JP2021515784A5 JP2021515784A5 JP2020547392A JP2020547392A JP2021515784A5 JP 2021515784 A5 JP2021515784 A5 JP 2021515784A5 JP 2020547392 A JP2020547392 A JP 2020547392A JP 2020547392 A JP2020547392 A JP 2020547392A JP 2021515784 A5 JP2021515784 A5 JP 2021515784A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide according
- chimeric oligonucleotide
- nucleoside
- nucleic acid
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642499P | 2018-03-13 | 2018-03-13 | |
| US62/642,499 | 2018-03-13 | ||
| PCT/EP2019/056312 WO2019175260A2 (en) | 2018-03-13 | 2019-03-13 | Modified oligonucleotides and methods of use in tauopathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021515784A JP2021515784A (ja) | 2021-06-24 |
| JP2021515784A5 true JP2021515784A5 (enExample) | 2022-03-14 |
Family
ID=65861258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547392A Pending JP2021515784A (ja) | 2018-03-13 | 2019-03-13 | 修飾オリゴヌクレオチド及びタウオパチーにおける使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11453881B2 (enExample) |
| EP (2) | EP3922637A1 (enExample) |
| JP (1) | JP2021515784A (enExample) |
| KR (1) | KR20200131263A (enExample) |
| CN (1) | CN111868068A (enExample) |
| AU (1) | AU2019233612A1 (enExample) |
| BR (1) | BR112020018365A2 (enExample) |
| CA (1) | CA3091979A1 (enExample) |
| EA (1) | EA202092156A1 (enExample) |
| ES (1) | ES3063421T3 (enExample) |
| IL (1) | IL277238A (enExample) |
| MA (1) | MA52149A (enExample) |
| MX (1) | MX2020009532A (enExample) |
| SG (1) | SG11202008895WA (enExample) |
| WO (1) | WO2019175260A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2866392C (en) | 2012-03-30 | 2023-10-24 | Washington University | Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome |
| TWI702046B (zh) | 2013-07-19 | 2020-08-21 | 美商Ionis製藥公司 | 用於調節τ蛋白表現之組合物 |
| US20230250125A1 (en) * | 2020-04-01 | 2023-08-10 | Janssen Biopharma, Inc. | Nucleic acid polymers |
| US20250320493A1 (en) * | 2021-07-23 | 2025-10-16 | Biogen Ma Inc. | Methods for reducing tau expression |
| AU2024313057A1 (en) * | 2023-06-22 | 2025-10-30 | Denali Therapeutics Inc. | Compositions and methods for modulating tau expression |
| WO2025212467A1 (en) | 2024-03-31 | 2025-10-09 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of microtubule associated protein tau (mapt), compositions thereof, and methods of use |
| WO2026025082A1 (en) * | 2024-07-25 | 2026-01-29 | Biogen Ma Inc. | Methods for treating alzheimer's disease |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| BRPI0008131B8 (pt) | 1999-02-12 | 2021-05-25 | Daiichi Sankyo Co Ltd | composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| ATE356824T1 (de) | 1999-05-04 | 2007-04-15 | Santaris Pharma As | L-ribo-lna analoge |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| HK1049339B (en) * | 1999-09-10 | 2008-06-27 | Geron Corporation | Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| ES2415665T3 (es) * | 2004-06-21 | 2013-07-26 | Proteome Sciences Plc | Procedimientos de cribado usando c-abl, fyn y sky en combinación con la proteína tau |
| GB0605337D0 (en) | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| US9663784B2 (en) * | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| US9228189B2 (en) * | 2012-10-26 | 2016-01-05 | Geron Corporation | C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders |
| BR112015022156A2 (pt) * | 2013-03-14 | 2017-11-14 | Isis Pharmaceuticals Inc | composições e métodos para modular a expressão de tau |
| TWI702046B (zh) * | 2013-07-19 | 2020-08-21 | 美商Ionis製藥公司 | 用於調節τ蛋白表現之組合物 |
| HK1244030A1 (en) * | 2014-12-29 | 2018-07-27 | 东丽株式会社 | Composition containing nucleic acid molecule stably |
| CA2975525A1 (en) * | 2015-02-04 | 2016-08-11 | F. Hoffmann-La Roche Ag | Tau antisense oligomers and uses thereof |
| KR20250112919A (ko) | 2015-12-21 | 2025-07-24 | 노파르티스 아게 | 타우 발현을 감소시키기 위한 조성물 및 방법 |
-
2019
- 2019-03-13 SG SG11202008895WA patent/SG11202008895WA/en unknown
- 2019-03-13 MA MA052149A patent/MA52149A/fr unknown
- 2019-03-13 KR KR1020207027936A patent/KR20200131263A/ko not_active Ceased
- 2019-03-13 WO PCT/EP2019/056312 patent/WO2019175260A2/en not_active Ceased
- 2019-03-13 EP EP21170299.8A patent/EP3922637A1/en active Pending
- 2019-03-13 US US16/980,389 patent/US11453881B2/en active Active
- 2019-03-13 JP JP2020547392A patent/JP2021515784A/ja active Pending
- 2019-03-13 CN CN201980018910.3A patent/CN111868068A/zh active Pending
- 2019-03-13 MX MX2020009532A patent/MX2020009532A/es unknown
- 2019-03-13 CA CA3091979A patent/CA3091979A1/en active Pending
- 2019-03-13 ES ES19712535T patent/ES3063421T3/es active Active
- 2019-03-13 AU AU2019233612A patent/AU2019233612A1/en not_active Abandoned
- 2019-03-13 EA EA202092156A patent/EA202092156A1/ru unknown
- 2019-03-13 BR BR112020018365-2A patent/BR112020018365A2/pt not_active Application Discontinuation
- 2019-03-13 EP EP19712535.4A patent/EP3765476B1/en active Active
-
2020
- 2020-09-09 IL IL277238A patent/IL277238A/en unknown
-
2022
- 2022-09-26 US US17/935,518 patent/US20240011029A1/en active Pending
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