JP2021513510A - 歯科用組成物のためのフッ化銀溶液 - Google Patents
歯科用組成物のためのフッ化銀溶液 Download PDFInfo
- Publication number
- JP2021513510A JP2021513510A JP2020540300A JP2020540300A JP2021513510A JP 2021513510 A JP2021513510 A JP 2021513510A JP 2020540300 A JP2020540300 A JP 2020540300A JP 2020540300 A JP2020540300 A JP 2020540300A JP 2021513510 A JP2021513510 A JP 2021513510A
- Authority
- JP
- Japan
- Prior art keywords
- silver
- silver fluoride
- solution
- fluoride
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- REYHXKZHIMGNSE-UHFFFAOYSA-M silver monofluoride Chemical compound [F-].[Ag+] REYHXKZHIMGNSE-UHFFFAOYSA-M 0.000 title claims abstract description 28
- 229940096017 silver fluoride Drugs 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 title claims description 4
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims description 24
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 229910017604 nitric acid Inorganic materials 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 238000010586 diagram Methods 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 16
- 239000000047 product Substances 0.000 description 9
- 229910021529 ammonia Inorganic materials 0.000 description 8
- 229910052709 silver Inorganic materials 0.000 description 7
- 239000004332 silver Substances 0.000 description 7
- 210000005239 tubule Anatomy 0.000 description 7
- 210000004872 soft tissue Anatomy 0.000 description 6
- 208000002925 dental caries Diseases 0.000 description 4
- 210000004268 dentin Anatomy 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- -1 silver ions Chemical class 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 150000003378 silver Chemical class 0.000 description 3
- JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 description 2
- 208000009043 Chemical Burns Diseases 0.000 description 2
- 229910021612 Silver iodide Inorganic materials 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 229940045105 silver iodide Drugs 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- KWVVTSALYXIJSS-UHFFFAOYSA-L silver(ii) fluoride Chemical compound [F-].[F-].[Ag+2] KWVVTSALYXIJSS-UHFFFAOYSA-L 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 101710134784 Agnoprotein Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 208000035154 Hyperesthesia Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- JFHFZBKYJDSONI-UHFFFAOYSA-L fluoro(iodo)silver Chemical compound F[Ag]I JFHFZBKYJDSONI-UHFFFAOYSA-L 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- MSFPLIAKTHOCQP-UHFFFAOYSA-M silver iodide Chemical class I[Ag] MSFPLIAKTHOCQP-UHFFFAOYSA-M 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
(1)AgF溶液は、保管時に溶液から沈殿が生じる傾向がある。沈殿物は、保管容器(ボトルなど)の内面に層を形成する傾向があり、および/または、底に沈殿する。これにより可溶性イオンの濃度が低下すると、歯科治療の効果が低下する。
(2)AgF溶液は、アンモニアを添加してフッ化ジアンミン銀(SDF)を形成することにより安定化できる。アンモニアは、銀イオンと結合して、ジアンミン銀イオン、[Ag(NH3)2]+と呼ばれる錯イオンを生成する。これは可逆反応であるが、複合体は非常に安定である。しかしながら、アンモニア含有組成物は、アンモニアの高い揮発性のために保管が難しい。ボトルとコンテナは、特に高温での保管時にアンモニアを容易に失い、残ったAgF溶液が不安定になる(沈殿が生じる)。
実施例1:保管時の良好な安定性、良好な細管閉塞、生物学的に適合したpH(軟組織への刺激なし)。
比較例1:保管時の貧弱な安定性、良好な細管閉塞、生物学的に適合したpH(軟組織への刺激なし)。
比較例2:保管時の良好な安定性、良好な細管閉塞、生物学的に不適合なpH(軟組織への刺激)。
Claims (5)
- pH4.0〜5.3のフッ化銀(AgF)含有水溶液。
- 組成物が酸で安定化されている、請求項1に記載のフッ化銀水溶液。
- 酸が硝酸である、請求項2に記載のフッ化銀水溶液。
- フッ化銀が0〜50%w/vの量で含まれる、請求項1に記載のフッ化銀水溶液。
- ヨウ化物含有溶液のその後の塗布を適用して染色を低減することができる、請求項1に記載のフッ化銀水溶液。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2018900432A AU2018900432A0 (en) | 2018-02-12 | Silver fluoride solutions for dental compositions | |
AU2018900432 | 2018-02-12 | ||
PCT/AU2019/000014 WO2019153033A1 (en) | 2018-02-12 | 2019-02-07 | Silver fluoride solutions for dental compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021513510A true JP2021513510A (ja) | 2021-05-27 |
JP7308212B2 JP7308212B2 (ja) | 2023-07-13 |
Family
ID=67547777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020540300A Active JP7308212B2 (ja) | 2018-02-12 | 2019-02-07 | 歯科用組成物のためのフッ化銀溶液 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20220218743A1 (ja) |
EP (1) | EP3752169A4 (ja) |
JP (1) | JP7308212B2 (ja) |
CN (1) | CN111698996A (ja) |
AU (1) | AU2019217656C1 (ja) |
WO (1) | WO2019153033A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023016544A1 (en) * | 2021-08-13 | 2023-02-16 | The University Of Hong Kong | Silver complex fluoride {bis (1, 3, 5-triaza-7-phosphaadamantane) silver fluoride} -a new therapeutic agent for caries management |
GB2610009B (en) | 2022-02-28 | 2023-11-08 | R And K Bedi Ltd | Stable compositions for the treatment of dental caries |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4247575A (en) * | 1979-10-29 | 1981-01-27 | American Hospital Supply Corporation | Method of silver plating a tooth structure |
JPH11349459A (ja) * | 1998-06-01 | 1999-12-21 | Lion Corp | 歯磨組成物 |
US20050239004A1 (en) * | 2002-10-29 | 2005-10-27 | Siegfried Gahler | Coating composition, particularly for glass surfaces, and methods for the production and use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH480841A (de) * | 1965-02-10 | 1969-11-15 | Procter & Gamble | Zahnpflegemittel |
GB1291325A (en) * | 1970-09-07 | 1972-10-04 | Reiichi Yamaga | Silver ammine fluoride solution and method of its use |
AU554112B2 (en) * | 1982-08-06 | 1986-08-07 | Agson Chemical Export Pty. Ltd. | Silver fluoride compositions for treatment of dental caries |
DE3530375C1 (de) * | 1985-08-24 | 1986-12-18 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von Silber (II, III)-oxid |
US6461161B1 (en) * | 2001-05-25 | 2002-10-08 | Gc Corporation | Tooth surface treatment method |
CN106900991A (zh) * | 2015-12-22 | 2017-06-30 | 青岛城轨交通装备科技有限公司 | 饲料酸度调节剂 |
DE112017004932T5 (de) * | 2016-09-30 | 2019-07-04 | R.M Creighton Dental Pty Ltd | Dentale Karies-Statusanzeige-Lösungen |
CN106974834B (zh) * | 2017-04-01 | 2020-10-27 | 首都医科大学附属北京口腔医院 | 一种利用延迟反应在牙本质小管内形成矿物质的材料及其应用 |
-
2019
- 2019-02-07 JP JP2020540300A patent/JP7308212B2/ja active Active
- 2019-02-07 US US17/615,093 patent/US20220218743A1/en active Pending
- 2019-02-07 AU AU2019217656A patent/AU2019217656C1/en active Active
- 2019-02-07 CN CN201980012753.5A patent/CN111698996A/zh active Pending
- 2019-02-07 EP EP19750734.6A patent/EP3752169A4/en active Pending
- 2019-02-07 WO PCT/AU2019/000014 patent/WO2019153033A1/en active Search and Examination
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4247575A (en) * | 1979-10-29 | 1981-01-27 | American Hospital Supply Corporation | Method of silver plating a tooth structure |
JPH11349459A (ja) * | 1998-06-01 | 1999-12-21 | Lion Corp | 歯磨組成物 |
US20050239004A1 (en) * | 2002-10-29 | 2005-10-27 | Siegfried Gahler | Coating composition, particularly for glass surfaces, and methods for the production and use thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2019153033A1 (en) | 2019-08-15 |
JP7308212B2 (ja) | 2023-07-13 |
AU2019217656C1 (en) | 2023-02-16 |
CN111698996A (zh) | 2020-09-22 |
EP3752169A1 (en) | 2020-12-23 |
AU2019217656B2 (en) | 2021-08-19 |
US20220218743A1 (en) | 2022-07-14 |
AU2019217656A1 (en) | 2020-09-03 |
EP3752169A4 (en) | 2021-12-01 |
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