JP2021510545A5 - - Google Patents
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- JP2021510545A5 JP2021510545A5 JP2020559043A JP2020559043A JP2021510545A5 JP 2021510545 A5 JP2021510545 A5 JP 2021510545A5 JP 2020559043 A JP2020559043 A JP 2020559043A JP 2020559043 A JP2020559043 A JP 2020559043A JP 2021510545 A5 JP2021510545 A5 JP 2021510545A5
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| WO2022011065A1 (en) * | 2020-07-07 | 2022-01-13 | The Nemours Foundation | Tumor-activated alloreactive and xenoreactive t cells and their use in immunotherapy against cancer |
| CN114075562A (zh) * | 2021-03-10 | 2022-02-22 | 北京肿瘤医院(北京大学肿瘤医院) | Mage-c3抑制剂及其作为制备治疗和/或预防食管鳞状细胞癌药物的用途 |
| CN113416729B (zh) * | 2021-05-18 | 2022-11-22 | 遵义医科大学附属医院 | 一种肝脏靶向调控甲胎蛋白基因的shRNA和cDNA及其应用 |
| CN113403208A (zh) * | 2021-06-15 | 2021-09-17 | 江西科技师范大学 | 高效鉴定米曲霉CRISPR/Cas9突变体的方法 |
| AU2022299474A1 (en) * | 2021-06-23 | 2023-12-21 | Versameb Ag | Compositions and methods for modulating expression of genes |
| AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| WO2023147776A1 (en) * | 2022-02-07 | 2023-08-10 | Hangzhou Qihan Biotechnology Co., Ltd. | Systems and methods for enhanced immunotherapies |
| EP4282963A1 (en) | 2022-05-23 | 2023-11-29 | Eberhard Karls Universität Tübingen, Medizinische Fakultät | Nucleic acid modified biological cell with expansion-dependent gene expression |
| CN114836428B (zh) * | 2022-06-08 | 2024-03-26 | 华东师范大学 | 一种tigit基因干扰的嵌合抗原受体nk细胞及其应用 |
| WO2023238103A1 (en) * | 2022-06-10 | 2023-12-14 | Curocell Inc. | Car-t therapy for treating cancer |
| CN116983322B (zh) * | 2022-09-15 | 2026-04-07 | 圣诺生物医药技术(苏州)有限公司 | 用于治疗肺癌、胰腺癌、肝癌和结直肠癌的小核酸干扰药物 |
| KR20250158048A (ko) | 2023-03-03 | 2025-11-05 | 아스널 바이오사이언시스, 인크. | Psma 및 ca9을 표적으로 하는 시스템 |
| WO2024218204A1 (en) * | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| CN116515836B (zh) * | 2023-05-09 | 2023-12-01 | 中国人民解放军军事科学院军事医学研究院 | 抑制MerTK表达的shRNA、腺相关病毒及其应用 |
| CN117587014B (zh) * | 2023-11-24 | 2025-01-24 | 上海恩凯细胞技术有限公司 | 多功能基因修饰载体及其制备的多功能基因修饰免疫细胞和它们的应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| CA2406864A1 (en) | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| US20080293142A1 (en) * | 2007-04-19 | 2008-11-27 | The Board Of Regents For Oklahoma State University | Multiple shRNA Expression Vectors and Methods of Construction |
| EP2152874A2 (en) | 2007-04-26 | 2010-02-17 | University of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
| ES2739804T3 (es) | 2011-02-12 | 2020-02-04 | Univ Iowa Res Found | Compuestos terapéuticos |
| EP3549611B1 (en) | 2011-07-29 | 2021-06-30 | The Trustees of the University of Pennsylvania | Switch costimulatory receptors |
| WO2013040557A2 (en) | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Rna engineered t cells for the treatment of cancer |
| DK2958943T3 (da) | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2014191128A1 (en) | 2013-05-29 | 2014-12-04 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| ES2897579T3 (es) | 2013-06-10 | 2022-03-01 | Dana Farber Cancer Inst Inc | Métodos y composiciones para reducir la inmunosupresión por células tumorales |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| AU2015244039B2 (en) * | 2014-04-07 | 2021-10-21 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
| JP6663859B2 (ja) | 2014-05-20 | 2020-03-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | ハンチントン病の治療化合物 |
| WO2016069282A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| ES2592578B1 (es) | 2015-05-07 | 2017-12-18 | Dode, S.A. | Mejoras introducidas en la patente de invención "Procedimiento para el tratamiento de granos de maíz destinados a la obtención de palomitas de maíz por medio de aparatos microondas y producto obtenido" |
| WO2017040945A1 (en) * | 2015-09-04 | 2017-03-09 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| US10711282B2 (en) * | 2015-11-23 | 2020-07-14 | Novartis Ag | Optimized lentiviral transfer vectors and uses thereof |
| JP6908528B2 (ja) | 2015-12-11 | 2021-07-28 | ローム株式会社 | 半導体装置 |
| CN106967681B (zh) * | 2016-01-13 | 2020-06-05 | 北京马力喏生物科技有限公司 | 治疗脑胶质母细胞瘤的治疗组合物 |
| CN106967685B (zh) | 2016-01-13 | 2020-06-02 | 北京马力喏生物科技有限公司 | 共表达抗EGFRvIII嵌合抗原受体和免疫检查点抑制分子的转基因淋巴细胞及其用途 |
| EP3219800A1 (en) * | 2016-03-15 | 2017-09-20 | Max-Delbrück-Centrum Für Molekulare Medizin | A transposon-based transfection system for primary cells |
| US11111505B2 (en) * | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| WO2018012895A1 (ko) * | 2016-07-14 | 2018-01-18 | 주식회사 큐로셀 | 면역관문을 극복한 면역세포 및 상기 면역세포를 포함한 약제학적 조성물 |
| EP3512950A1 (en) * | 2016-09-14 | 2019-07-24 | Benitec Biopharma Limited | REAGENTS FOR PRODUCING T-CELLS WITH NON-FUNCTIONAL T-CELL RECEPTORS (TCRs) COMPOSITIONS COMPRISING SAME AND USE THEREOF |
| US12447213B2 (en) * | 2016-10-07 | 2025-10-21 | The Broad Institute, Inc. | Modulation of novel immune checkpoint targets |
| CN107058390A (zh) * | 2017-01-17 | 2017-08-18 | 上海交通大学医学院附属第九人民医院 | 一种慢病毒载体、重组慢病毒质粒、病毒及病毒的应用 |
| EP3585398A4 (en) * | 2017-02-23 | 2020-08-19 | Board of Regents of the University of Nebraska | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
| PT3737765T (pt) | 2018-01-12 | 2022-03-11 | Curocell Inc | Células imunitárias melhoradas utilizando shrna duplo e composição incluindo as mesmas |
| CN110904045A (zh) | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| KR20220081972A (ko) | 2019-07-17 | 2022-06-16 | 주식회사 큐로셀 | 이중 shrna를 이용하는 향상된 면역 세포 및 이를 포함하는 조성물 |
-
2019
- 2019-01-10 PT PT197388663T patent/PT3737765T/pt unknown
- 2019-01-10 AU AU2019206425A patent/AU2019206425B2/en active Active
- 2019-01-10 SG SG11202006606YA patent/SG11202006606YA/en unknown
- 2019-01-10 ES ES21207719T patent/ES2990966T3/es active Active
- 2019-01-10 FI FIEP19738866.3T patent/FI3737765T4/fi active
- 2019-01-10 WO PCT/IB2019/050194 patent/WO2019138354A1/en not_active Ceased
- 2019-01-10 CN CN201980016378.1A patent/CN111801421B/zh active Active
- 2019-01-10 JP JP2020559043A patent/JP7068498B2/ja active Active
- 2019-01-10 EP EP21207719.2A patent/EP4006153B1/en active Active
- 2019-01-10 KR KR1020207023221A patent/KR102327512B1/ko active Active
- 2019-01-10 KR KR1020217036928A patent/KR102805915B1/ko active Active
- 2019-01-10 EP EP19738866.3A patent/EP3737765B2/en active Active
- 2019-01-10 US US16/958,649 patent/US11679129B2/en active Active
- 2019-01-10 ES ES19738866T patent/ES2908324T5/es active Active
- 2019-01-10 DK DK19738866.3T patent/DK3737765T4/da active
- 2019-01-10 CA CA3088234A patent/CA3088234A1/en active Pending
- 2019-01-10 PL PL19738866.3T patent/PL3737765T5/pl unknown
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2021
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